Aliases for SIK2 Gene
External Ids for SIK2 Gene
Previous HGNC Symbols for SIK2 Gene
Previous GeneCards Identifiers for SIK2 Gene
GeneCards Summary for SIK2 Gene
SIK2 (Salt Inducible Kinase 2) is a Protein Coding gene. Diseases associated with SIK2 include Diabetes Mellitus, Noninsulin-Dependent. Among its related pathways are Glucose / Energy Metabolism and Glucagon signaling pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is SIK1.
UniProtKB/Swiss-Prot Summary for SIK2 Gene
Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.