Aliases for SIK2 Gene

Aliases for SIK2 Gene

  • Salt Inducible Kinase 2 2 3 5
  • QIK 2 3 4
  • Serine/Threonine-Protein Kinase SNF1-Like Kinase 2 3 4
  • Serine/Threonine-Protein Kinase SIK2 3 4
  • SNF1-Like Kinase 2 2 3
  • Qin-Induced Kinase 3 4
  • EC 2.7.11.1 4 51
  • LOH11CR1I 2 3
  • KIAA0781 2 4
  • SNF1LK2 3 4
  • SIK-2 3 4
  • Salt-Inducible Serine/Threonine Kinase 2 3
  • Salt-Inducible Protein Kinase 2 3
  • Salt-Inducible Kinase 2 4
  • DKFZp434K1115 2
  • EC 2.7.11 51
  • SIK2 5

External Ids for SIK2 Gene

Previous HGNC Symbols for SIK2 Gene

  • SNF1LK2

Previous GeneCards Identifiers for SIK2 Gene

  • GC11U900483
  • GC11P111011
  • GC11P110978
  • GC11P111473
  • GC11P107397

Summaries for SIK2 Gene

GeneCards Summary for SIK2 Gene

SIK2 (Salt Inducible Kinase 2) is a Protein Coding gene. Diseases associated with SIK2 include Diabetes Mellitus, Noninsulin-Dependent. Among its related pathways are Glucose / Energy Metabolism and Glucagon signaling pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is SIK1.

UniProtKB/Swiss-Prot Summary for SIK2 Gene

  • Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.

Gene Wiki entry for SIK2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SIK2 Gene

Genomics for SIK2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SIK2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J111601 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 611.6 +1.0 952 4 SP1 GATAD2A CTCF HNRNPL PRDM10 ZNF629 RFX1 ZNF692 POLR2A BACH1 SIK2 lnc-BTG4-4 piR-31264 ALG9 ENSG00000235286 PPP2R1B
GH11J111764 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 20.9 +163.6 163567 3.3 HNRNPL PRDM10 ZNF629 REST IKZF1 POLR2A ZNF692 BACH1 LARP7 PRDM1 PPP2R1B lnc-SIK2-3 ALG9 SIK2 PIH1D2 NKAPD1 LAYN BTG4 HOATZ MIR34B
GH11J111693 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 20.1 +94.5 94451 7.8 ZNF629 IKZF1 JUND PRDM1 PKNOX1 RCOR1 ZNF24 DPF2 GATAD2B TCF12 HSALNG0087128 SIK2 PPP2R1B NKAPD1 BTG4 HOATZ MIR34B MIR34C LAYN RN7SKP273
GH11J111622 Enhancer 1.2 Ensembl ENCODE dbSUPER 23.2 +21.9 21945 2.9 GATAD2A ZNF7 IRF2 IKZF2 SP1 TRIM22 SCRT2 SOX13 DPF2 RELB SIK2 ALG9 PPP2R1B lnc-BTG4-4 ENSG00000235286
GH11J111629 Enhancer 1.2 Ensembl ENCODE dbSUPER 22.9 +31.0 30952 8.4 GATAD2A PRDM10 SOX13 FOXA1 POLR2A SP1 CEBPA FOXK2 SCRT2 TCF7 SIK2 PPP2R1B lnc-BTG4-4 ENSG00000235286
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SIK2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SIK2

Top Transcription factor binding sites by QIAGEN in the SIK2 gene promoter:
  • C/EBPbeta
  • CREB
  • deltaCREB
  • GCNF-1
  • GCNF-2
  • Nkx2-5
  • RFX1
  • XBP-1

Genomic Locations for SIK2 Gene

Genomic Locations for SIK2 Gene
chr11:111,602,449-111,730,855
(GRCh38/hg38)
Size:
128,407 bases
Orientation:
Plus strand
chr11:111,473,115-111,601,577
(GRCh37/hg19)
Size:
128,463 bases
Orientation:
Plus strand

Genomic View for SIK2 Gene

Genes around SIK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIK2 Gene

Proteins for SIK2 Gene

  • Protein details for SIK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0K1-SIK2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase SIK2
    Protein Accession:
    Q9H0K1
    Secondary Accessions:
    • A8K5B8
    • B0YJ94
    • O94878
    • Q17RV0
    • Q6AZE2
    • Q76N03
    • Q8NCV7
    • Q96CZ8

    Protein attributes for SIK2 Gene

    Size:
    926 amino acids
    Molecular mass:
    103915 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with and phosphorylates TORC2/CRTC2.
    SequenceCaution:
    • Sequence=BAA34501.3; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SIK2 Gene

Selected DME Specific Peptides for SIK2 Gene

Q9H0K1:
  • LYQVMET
  • NLEKIYREVQ
  • HPHIIKL
  • EGRRASDTSLTQG
  • SYNHFAAIY
  • VAIKIIDKSQLD
  • GNFAVVK
  • LRQRVLEGRFRIP
  • VLYVLVCG
  • VAIKIID
  • GSPPYAAPE
  • IIKLYQV
  • IVHRDLK

Post-translational modifications for SIK2 Gene

  • Phosphorylated at Thr-175 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.
  • Acetylation at Lys-53 inhibits kinase activity. Deacetylated by HDAC6.
  • Ubiquitination at Lys692
  • Modification sites at PhosphoSitePlus

Other Protein References for SIK2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Boster Bio Antibodies for SIK2
  • Santa Cruz Biotechnology (SCBT) Antibodies for SIK2

Domains & Families for SIK2 Gene

Gene Families for SIK2 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for SIK2 Gene

Suggested Antigen Peptide Sequences for SIK2 Gene

GenScript: Design optimal peptide antigens:
  • Serine/threonine-protein kinase SNF1-like kinase 2 (SIK2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H0K1

UniProtKB/Swiss-Prot:

SIK2_HUMAN :
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
genes like me logo Genes that share domains with SIK2: view

Function for SIK2 Gene

Molecular function for SIK2 Gene

UniProtKB/Swiss-Prot Function:
Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:14976552};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:14976552};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on Thr-175.

Enzyme Numbers (IUBMB) for SIK2 Gene

Phenotypes From GWAS Catalog for SIK2 Gene

Gene Ontology (GO) - Molecular Function for SIK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000287 magnesium ion binding IDA 14976552
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA,IDA 14976552
GO:0005515 protein binding IPI 20708153
genes like me logo Genes that share ontologies with SIK2: view
genes like me logo Genes that share phenotypes with SIK2: view

Animal Models for SIK2 Gene

MGI Knock Outs for SIK2:
  • Sik2 Sik2<tm1Htake>

Animal Model Products

  • Taconic Biosciences Mouse Models for SIK2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIK2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIK2 Gene

Localization for SIK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIK2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIK2 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
golgi apparatus 2
extracellular 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SIK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA,ISS --
genes like me logo Genes that share ontologies with SIK2: view

Pathways & Interactions for SIK2 Gene

genes like me logo Genes that share pathways with SIK2: view

Pathways by source for SIK2 Gene

1 BioSystems pathway for SIK2 Gene
1 KEGG pathway for SIK2 Gene
1 Cell Signaling Technology pathway for SIK2 Gene

SIGNOR curated interactions for SIK2 Gene

Activates:
Inactivates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for SIK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 14976552
GO:0016310 phosphorylation IEA --
GO:0035556 intracellular signal transduction IDA 14976552
GO:0046626 regulation of insulin receptor signaling pathway ISS --
GO:0046777 protein autophosphorylation IDA 18348280
genes like me logo Genes that share ontologies with SIK2: view

Drugs & Compounds for SIK2 Gene

(17) Drugs for SIK2 Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Magnesium Approved, Experimental, Investigational Pharma 0
HG-9-91-01 Pharma Pan-SIK (salt-inducible kinases) inhibitor 0

(9) Additional Compounds for SIK2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for SIK2 Gene

Compound Action Cas Number
HG-9-91-01 Pan-SIK (salt-inducible kinases) inhibitor 1456858-58-4
genes like me logo Genes that share compounds with SIK2: view

Drug Products

Transcripts for SIK2 Gene

mRNA/cDNA for SIK2 Gene

1 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIK2

Alternative Splicing Database (ASD) splice patterns (SP) for SIK2 Gene

No ASD Table

Relevant External Links for SIK2 Gene

GeneLoc Exon Structure for
SIK2

Expression for SIK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SIK2 Gene

mRNA differential expression in normal tissues according to GTEx for SIK2 Gene

This gene is overexpressed in Muscle - Skeletal (x4.6).

Protein differential expression in normal tissues from HIPED for SIK2 Gene

This gene is overexpressed in Lung (51.5) and Heart (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SIK2 Gene



Protein tissue co-expression partners for SIK2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SIK2

SOURCE GeneReport for Unigene cluster for SIK2 Gene:

Hs.269128

Evidence on tissue expression from TISSUES for SIK2 Gene

  • Liver(4.6)
  • Nervous system(3.3)
  • Muscle(2.6)
  • Kidney(2.3)
  • Pancreas(2.3)
  • Adrenal gland(2.1)
  • Skin(2.1)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with SIK2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIK2 Gene

Orthologs for SIK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SIK2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SIK2 30 31
  • 99.89 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SIK2 30 31
  • 89.18 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Sik2 30 17 31
  • 88.7 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SIK2 30 31
  • 88.57 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SIK2 31
  • 87 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SIK2 31
  • 55 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SIK2 30 31
  • 74.31 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SIK2 31
  • 69 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia sik2 30
  • 70.52 (n)
Zebrafish
(Danio rerio)
Actinopterygii sik2b 30 31
  • 65.15 (n)
OneToMany
sik2a 31
  • 64 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta KP78b 31
  • 32 (a)
ManyToMany
Sik3 31
  • 20 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea kin-29 31
  • 28 (a)
OneToMany
Species where no ortholog for SIK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SIK2 Gene

ENSEMBL:
Gene Tree for SIK2 (if available)
TreeFam:
Gene Tree for SIK2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SIK2: view image

Paralogs for SIK2 Gene

(11) SIMAP similar genes for SIK2 Gene using alignment to 1 proteins:

  • SIK2_HUMAN

Pseudogenes.org Pseudogenes for SIK2 Gene

genes like me logo Genes that share paralogs with SIK2: view

Variants for SIK2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SIK2 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
716321 Benign: not provided 111,720,918(+) A/G SYNONYMOUS_VARIANT
rs34223841 - p.Arg809Gln
rs35789057 - p.Thr458Ile
rs45520245 - p.Pro828Leu
rs45586732 - p.Pro829Ser

Additional dbSNP identifiers (rs#s) for SIK2 Gene

Structural Variations from Database of Genomic Variants (DGV) for SIK2 Gene

Variant ID Type Subtype PubMed ID
esv2745076 CNV deletion 23290073
esv3627742 CNV loss 21293372
nsv510273 OTHER sequence alteration 20534489
nsv832269 CNV loss 17160897
nsv975978 CNV duplication 23825009

Variation tolerance for SIK2 Gene

Residual Variation Intolerance Score: 10.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SIK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIK2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIK2 Gene

Disorders for SIK2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SIK2 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
diabetes mellitus, noninsulin-dependent
  • niddm
- elite association - COSMIC cancer census association via MalaCards
Search SIK2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SIK2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SIK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SIK2 Gene

Publications for SIK2 Gene

  1. Identification and characterization of human FOXN5 and rat Foxn5 genes in silico. (PMID: 15067358) Katoh M … Katoh M (International journal of oncology 2004) 2 3 23
  2. Reversible acetylation regulates salt-inducible kinase (SIK2) and its function in autophagy. (PMID: 23322770) Yang FC … Lee SC (The Journal of biological chemistry 2013) 3 4
  3. Amplification at 11q23 targets protein kinase SIK2 in diffuse large B-cell lymphoma. (PMID: 20367563) Nagel S … Macleod RA (Leukemia & lymphoma 2010) 3 23
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for SIK2 Gene

  • Signalway ELISA kits for SIK2
  • Signalway Proteins for SIK2

Sources for SIK2 Gene