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Aliases for SIK2 Gene
Aliases for SIK2 Gene
External Ids for SIK2 Gene
- HGNC: 21680
- Entrez Gene: 23235
- Ensembl: ENSG00000170145
- OMIM: 608973
- UniProtKB: Q9H0K1
Previous HGNC Symbols for SIK2 Gene
- SNF1LK2
Previous GeneCards Identifiers for SIK2 Gene
- GC11U900483
- GC11P111011
- GC11P110978
- GC11P111473
- GC11P107397
Summaries for SIK2 Gene
GeneCards Summary for SIK2 Gene
SIK2 (Salt Inducible Kinase 2) is a Protein Coding gene. Diseases associated with SIK2 include Diabetes Mellitus, Noninsulin-Dependent. Among its related pathways are Glucose / Energy Metabolism and Glucagon signaling pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is SIK1.
UniProtKB/Swiss-Prot Summary for SIK2 Gene
-
Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
Additional gene information for SIK2 Gene
- HGNC(21680)
- Entrez Gene(23235)
- Ensembl(ENSG00000170145)
- OMIM(608973)
- UniProtKB(Q9H0K1)
- Open Targets Platform(ENSG00000170145)
- Monarch Initiative
- Search for SIK2 at DataMed
- Search for SIK2 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SIK2 Gene
Genomics for SIK2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SIK2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SIK2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SIK2
- Top Transcription factor binding sites by QIAGEN in the SIK2 gene promoter:
-
- C/EBPbeta
- CREB
- deltaCREB
- GCNF-1
- GCNF-2
- Nkx2-5
- RFX1
- XBP-1
Genomic Locations for SIK2 Gene
Genomic Locations for SIK2 Gene
- chr11:111,602,449-111,730,855
- (GRCh38/hg38)
- Size:
- 128,407 bases
- Orientation:
- Plus strand
- chr11:111,473,115-111,601,577
- (GRCh37/hg19)
- Size:
- 128,463 bases
- Orientation:
- Plus strand
Genomic View for SIK2 Gene
Genes around SIK2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q23.1 by HGNC
- 11q23.1 by Entrez Gene
- 11q23.1 by Ensembl
SIK2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SIK2 Gene
Proteins for SIK2 Gene
-
Protein details for SIK2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H0K1-SIK2_HUMAN
- Recommended name:
- Serine/threonine-protein kinase SIK2
- Protein Accession:
- Q9H0K1
- A8K5B8
- B0YJ94
- O94878
- Q17RV0
- Q6AZE2
- Q76N03
- Q8NCV7
- Q96CZ8
Protein attributes for SIK2 Gene
- Size:
- 926 amino acids
- Molecular mass:
- 103915 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Interacts with and phosphorylates TORC2/CRTC2.
- SequenceCaution:
-
- Sequence=BAA34501.3; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for SIK2 Gene
Selected DME Specific Peptides for SIK2 Gene
- Q9H0K1:
-
- LYQVMET
- NLEKIYREVQ
- HPHIIKL
- EGRRASDTSLTQG
- SYNHFAAIY
- VAIKIIDKSQLD
- GNFAVVK
- LRQRVLEGRFRIP
- VLYVLVCG
- VAIKIID
- GSPPYAAPE
- IIKLYQV
- IVHRDLK
Post-translational modifications for SIK2 Gene
- Phosphorylated at Thr-175 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.
- Acetylation at Lys-53 inhibits kinase activity. Deacetylated by HDAC6.
-
Ubiquitination at Lys692
- NX_Q9H0K1 (NX_Q9H0K1-1)
- Modification sites at PhosphoSitePlus
Other Protein References for SIK2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences SIK2 / SNF1LK2 Monoclonal Antibody and SIK2 / SNF1LK2 Antibody
- G Biosciences Immunotag™ SNF1LK2 Antibody
- BioLegend SIK2 Antibody
-
Custom Antibody ServicesOriGene Antibodies for SIK2
- Novus Biologicals Antibodies for SIK2
-
Abcam antibodies for SIK2
- Invitrogen Antibodies for SIK2 (AFLGC-SIK2)
-
Biorbyt antibodies for SIK2
-
Boster Bio Antibodies for SIK2
-
Custom Antibody ServicesProSci Antibodies for SIK2
-
Santa Cruz Biotechnology (SCBT) Antibodies for SIK2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for SIK2
- Origene Custom Protein Services for SIK2
- antibodies-online: Show 11 available SIK2 Proteins ranked by validation data
- Compare Top SIK2 Proteins
-
Quality Products:
-
Signalway Proteins for SIK2
-
Abcam proteins for SIK2
Assay Products
- antibodies-online: Show 13 available SIK2 Elisa Kits ranked by validation data
- Compare Top SIK2 Elisa Kits
-
Quality Products:
-
Signalway ELISA kits for SIK2
Domains & Families for SIK2 Gene
Gene Families for SIK2 Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted membrane proteins
Protein Domains for SIK2 Gene
- InterPro:
- Blocks:
-
- Ubiquitin-associated domain
- ProtoNet:
Suggested Antigen Peptide Sequences for SIK2 Gene
- GenScript: Design optimal peptide antigens:
-
- Serine/threonine-protein kinase SNF1-like kinase 2 (SIK2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9H0K1UniProtKB/Swiss-Prot:
SIK2_HUMAN :- Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Function for SIK2 Gene
Molecular function for SIK2 Gene
- UniProtKB/Swiss-Prot Function:
- Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:14976552};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:14976552};.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by phosphorylation on Thr-175.
Enzyme Numbers (IUBMB) for SIK2 Gene
Phenotypes From GWAS Catalog for SIK2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0000287 | magnesium ion binding | IDA | 14976552 |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IBA,IDA | 14976552 |
| GO:0005515 | protein binding | IPI | 20708153 |
Phenotypes for SIK2 Gene
- MGI mutant phenotypes for SIK2:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for SIK2:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- shRNA abundance <= 50%
- Decreased viability
- Decreased NF-kappaB reporter expression
- Increased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased viability in ovarian lineage
- Increased cell death in DLD-1 cells
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Decreased cell proliferation
- Decreased CYP1A1 activity after TCDD stimulation
Animal Models for SIK2 Gene
- MGI Knock Outs for SIK2:
-
- Sik2 Sik2<tm1Htake>
Animal Model Products
-
Taconic Biosciences Mouse Models for SIK2
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SIK2 - Select products 50% OFF >
- * SIK2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SIK2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SIK2
-
Santa Cruz Biotechnology (SCBT) CRISPR for SIK2
miRNA for SIK2 Gene
- miRTarBase miRNAs that target SIK2
-
- hsa-miR-1229-3p (MIRT036375)
- hsa-miR-125b-5p (MIRT045926)
- hsa-miR-181a-5p (MIRT047302)
- hsa-miR-142-3p (MIRT439636)
- hsa-miR-218-5p (MIRT439637)
- hsa-miR-4786-3p (MIRT495227)
- hsa-miR-575 (MIRT495228)
- hsa-miR-4676-5p (MIRT495229)
- hsa-miR-6809-3p (MIRT630938)
- hsa-miR-6833-3p (MIRT630939)
- hsa-miR-4768-5p (MIRT630940)
- hsa-miR-3679-3p (MIRT630941)
- hsa-miR-6873-3p (MIRT630942)
- hsa-miR-4436b-5p (MIRT630943)
- hsa-miR-3124-3p (MIRT630944)
- hsa-miR-6845-3p (MIRT630945)
- hsa-miR-5698 (MIRT672243)
- hsa-miR-8057 (MIRT672244)
- hsa-miR-891a-3p (MIRT672245)
- hsa-miR-143-5p (MIRT672246)
- hsa-miR-4430 (MIRT672247)
- hsa-miR-3652 (MIRT672248)
- hsa-miR-24-3p (MIRT672249)
- hsa-miR-4284 (MIRT672250)
- hsa-miR-564 (MIRT672251)
- hsa-miR-122-5p (MIRT672252)
- hsa-miR-504-3p (MIRT672253)
- hsa-miR-3135b (MIRT672254)
- hsa-miR-6499-3p (MIRT672255)
- hsa-miR-2276-3p (MIRT672256)
- hsa-miR-1304-3p (MIRT672257)
- hsa-miR-5693 (MIRT672258)
- hsa-miR-6890-3p (MIRT672259)
- hsa-miR-4279 (MIRT679359)
- hsa-miR-7151-3p (MIRT679360)
- hsa-miR-5095 (MIRT679361)
- hsa-miR-6778-3p (MIRT679362)
- hsa-miR-6789-3p (MIRT679363)
- hsa-miR-1976 (MIRT679364)
- hsa-miR-3653-5p (MIRT679365)
- hsa-miR-6747-3p (MIRT679366)
- hsa-miR-6727-3p (MIRT679367)
- hsa-miR-4722-3p (MIRT679368)
- hsa-miR-4740-3p (MIRT679369)
- hsa-miR-4438 (MIRT679370)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SIK2
- Browse OriGene Inhibitory RNA Products For SIK2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIK2
Clone Products
- Applied Biological Materials (abm): Clones for SIK2 - Select products 50% OFF >
- * SIK2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SIK2
- Addgene plasmids for SIK2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SIK2
Cell Line Products
-
Horizon Cell Lines for SIK2
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIK2 Gene
Localization for SIK2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SIK2 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| cytosol | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| golgi apparatus | 2 |
| extracellular | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
- Golgi apparatus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005737 | cytoplasm | IBA,ISS | -- |
Pathways & Interactions for SIK2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Glucose / Energy Metabolism | ||
| 2 | Glucagon signaling pathway | ||
| 3 | LKB1 signaling events | ||
Pathways by source for SIK2 Gene
1 BioSystems pathway for SIK2 Gene
1 KEGG pathway for SIK2 Gene
1 Cell Signaling Technology pathway for SIK2 Gene
Interacting Proteins for SIK2 Gene
Selected Interacting proteins:
Q9H0K1-SIK2_HUMAN
ENSP00000305976
for SIK2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for SIK2
SIGNOR curated interactions for SIK2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IDA | 14976552 |
| GO:0016310 | phosphorylation | IEA | -- |
| GO:0035556 | intracellular signal transduction | IDA | 14976552 |
| GO:0046626 | regulation of insulin receptor signaling pathway | ISS | -- |
| GO:0046777 | protein autophosphorylation | IDA | 18348280 |
Drugs & Compounds for SIK2 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) ApexBio Compounds for SIK2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| HG-9-91-01 | Pan-SIK (salt-inducible kinases) inhibitor | 1456858-58-4 |
Transcripts for SIK2 Gene
mRNA/cDNA for SIK2 Gene
- 1 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000304987 9622 nts (view in UCSC)
- ENST00000533868 544 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SIK2 - Select products 50% OFF >
- * SIK2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SIK2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SIK2
-
Santa Cruz Biotechnology (SCBT) CRISPR for SIK2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SIK2
- Browse OriGene Inhibitory RNA Products For SIK2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIK2
Clone Products
- Applied Biological Materials (abm): Clones for SIK2 - Select products 50% OFF >
- * SIK2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SIK2
- Addgene plasmids for SIK2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SIK2
Relevant External Links for SIK2 Gene
- GeneLoc Exon Structure for
- SIK2
Expression for SIK2 Gene
mRNA differential expression in normal tissues according to GTEx for SIK2 Gene
This gene is overexpressed in Muscle - Skeletal (x4.6).
This gene is overexpressed in Lung (51.5) and Heart (9.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SIK2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SIK2
SOURCE GeneReport for Unigene cluster for SIK2 Gene:
Hs.269128Evidence on tissue expression from TISSUES for SIK2 Gene
- Liver(4.6)
- Nervous system(3.3)
- Muscle(2.6)
- Kidney(2.3)
- Pancreas(2.3)
- Adrenal gland(2.1)
- Skin(2.1)
- Heart(2.1)
Primer Products
-
OriGene qPCR primer pairs for SIK2
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIK2 Gene
Orthologs for SIK2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SIK2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SIK2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Sik2 30 17 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SIK2 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | SIK2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SIK2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | SIK2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | SIK2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | sik2 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | sik2b 30 31 |
|
OneToMany | |
| sik2a 31 |
|
OneToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | KP78b 31 |
|
ManyToMany | |
| Sik3 31 |
|
ManyToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | kin-29 31 |
|
OneToMany |
- Species where no ortholog for SIK2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for SIK2 Gene
- ENSEMBL:
- Gene Tree for SIK2 (if available)
- TreeFam:
- Gene Tree for SIK2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SIK2: view image
Paralogs for SIK2 Gene
Paralogs for SIK2 Gene
(11) SIMAP similar genes for SIK2 Gene using alignment to 1 proteins:
- SIK2_HUMAN
Pseudogenes.org Pseudogenes for SIK2 Gene
Variants for SIK2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SIK2 Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 716321 | Benign: not provided | 111,720,918(+) | A/G | SYNONYMOUS_VARIANT | |
| rs34223841 | - | p.Arg809Gln | |||
| rs35789057 | - | p.Thr458Ile | |||
| rs45520245 | - | p.Pro828Leu | |||
| rs45586732 | - | p.Pro829Ser |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2745076 | CNV | deletion | 23290073 |
| esv3627742 | CNV | loss | 21293372 |
| nsv510273 | OTHER | sequence alteration | 20534489 |
| nsv832269 | CNV | loss | 17160897 |
| nsv975978 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
10.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.24;
24.91% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SIK2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SIK2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIK2 Gene
Disorders for SIK2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| diabetes mellitus, noninsulin-dependent |
|
Search SIK2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SIK2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for SIK2 Gene
Publications for SIK2 Gene
- Identification and characterization of human FOXN5 and rat Foxn5 genes in silico. (PMID: 15067358) Katoh M … Katoh M (International journal of oncology 2004) 2 3 23
- Reversible acetylation regulates salt-inducible kinase (SIK2) and its function in autophagy. (PMID: 23322770) Yang FC … Lee SC (The Journal of biological chemistry 2013) 3 4
- Amplification at 11q23 targets protein kinase SIK2 in diffuse large B-cell lymphoma. (PMID: 20367563) Nagel S … Macleod RA (Leukemia & lymphoma 2010) 3 23
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
ExternalLinks
Products for SIK2 Gene
- Custom Antibody ServicesOriGene Antibodies for SIK2
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for SIK2
- Origene Custom Protein Services for SIK2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SIK2
- Browse OriGene Inhibitory RNA Products For SIK2
- OriGene qPCR primer pairs for SIK2
- OriGene CRISPR knockouts for SIK2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SIK2
- Sino Biological Human cDNA Clone for SIK2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for SIK2
- Novus Biologicals proteins and lysates for SIK2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for SIK2
- Abcam proteins for SIK2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for SIK2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for SIK2 (AFLGC-SIK2)
- ApexBio compounds for SIK2
- VectorBuilder Custom and pre-made DNA vectors for SIK2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for SIK2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for SIK2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for SIK2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for SIK2
- Addgene plasmids for SIK2
- antibodies-online: Show 62 available SIK2 Antibodies ranked by validation data
- Compare Top SIK2 Antibodies
- antibodies-online: Show 13 available SIK2 Elisa Kits ranked by validation data
- Compare Top SIK2 Elisa Kits
- Quality Products:
- antibodies-online: Show 11 available SIK2 Proteins ranked by validation data
- Compare Top SIK2 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for SIK2
- Search Santa Cruz Biotechnology (SCBT) for SIK2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SIK2
- Custom Antibody ServicesProSci Antibodies for SIK2
- Search for SIK2 Proteins at ProSci
- Horizon Cell Lines for SIK2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SIK2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SIK2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SIK2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIK2
- Boster Bio Antibodies for SIK2
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for SIK2
Sources for SIK2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB