Aliases for SIGLECL1 Gene

Aliases for SIGLECL1 Gene

  • SIGLEC Family Like 1 2 3 5
  • Sialic Acid Binding Ig-Like Lectin, Pseudogene 7 2 3
  • SIGLEC Family-Like Protein 1 3 4
  • C19orf75 3 4
  • Sialic Acid Binding Ig-Like Lectin 23, Pseudogene 2
  • Chromosome 19 Open Reading Frame 75 2
  • SIGLEC23P 3
  • SIGLECP7 3
  • SIGLECL1 5
  • FLJ40235 2

External Ids for SIGLECL1 Gene

Previous HGNC Symbols for SIGLECL1 Gene

  • C19orf75
  • SIGLEC23P
  • SIGLECP7

Previous GeneCards Identifiers for SIGLECL1 Gene

  • GC19M052625
  • GC19M052355
  • GC19M056670
  • GC19M056686
  • GC19P051761

Summaries for SIGLECL1 Gene

GeneCards Summary for SIGLECL1 Gene

SIGLECL1 (SIGLEC Family Like 1) is a Protein Coding gene. An important paralog of this gene is SIGLEC10.

Additional gene information for SIGLECL1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SIGLECL1 Gene

Genomics for SIGLECL1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SIGLECL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J051245 Enhancer 0.9 Ensembl ENCODE 250.7 -1.3 -1331 5.6 IKZF1 BHLHE40 NBN TAL1 ZNF316 SPI1 NFE2 POLR2A MAX NRF1 SIGLECL1 piR-56580-017 ENSG00000268595 CD33 HSALNG0127194 LOC107985327
GH19J051271 Promoter/Enhancer 0.9 EPDnew Ensembl 35.1 +26.3 26269 2.8 ZNF316 SPI1 MYC MAX ZBTB33 NFE2 MAFF ZMYM3 YY1 BCOR ENSG00000268595 LINC01872 LOC107985327 SIGLECL1 VSIG10L CEACAM18 RPL7P51 SIGLEC14 SIGLEC5 SIGLEC24P
GH19J051223 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 20.1 -20.6 -20572 2.9 IKZF1 SMAD5 NONO ARNT GABPA SIN3B VEZF1 NBN ELF1 ZEB2 CD33 piR-33103-011 SIGLECL1 RPL7P51 SIGLEC14 SIGLEC5 piR-40605-005
GH19J051219 Enhancer 0.5 Ensembl 20.6 -26.8 -26831 1 BCL11A SPI1 BATF IKZF1 SMARCE1 IKZF2 MTA2 DPF2 SIGLECL1 RPL7P51 SIGLEC14 SIGLEC5 lnc-CD33-1 piR-33103-011 CD33
GH19J051310 Promoter 1 Ensembl CraniofacialAtlas 9.2 +65.8 65769 2.2 ZNF740 VEZF1 ZSCAN29 CTBP1 POLR2A IGLON5 ENSG00000268595 SIGLECL1 LOC105372440 HSALNG0127201 VSIG10L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SIGLECL1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SIGLECL1

Genomic Locations for SIGLECL1 Gene

Latest Assembly
chr19:51,246,332-51,269,330
(GRCh38/hg38)
Size:
22,999 bases
Orientation:
Plus strand

Previous Assembly
chr19:51,749,587-51,772,584
(GRCh37/hg19 by Entrez Gene)
Size:
22,998 bases
Orientation:
Plus strand

chr19:51,749,603-51,772,584
(GRCh37/hg19 by Ensembl)
Size:
22,982 bases
Orientation:
Plus strand

Genomic View for SIGLECL1 Gene

Genes around SIGLECL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIGLECL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIGLECL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLECL1 Gene

Proteins for SIGLECL1 Gene

  • Protein details for SIGLECL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7X8-SIGL1_HUMAN
    Recommended name:
    SIGLEC family-like protein 1
    Protein Accession:
    Q8N7X8

    Protein attributes for SIGLECL1 Gene

    Size:
    197 amino acids
    Molecular mass:
    21283 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SIGLECL1 Gene

Post-translational modifications for SIGLECL1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SIGLECL1 Gene

Domains & Families for SIGLECL1 Gene

Gene Families for SIGLECL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SIGLECL1 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with SIGLECL1: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SIGLECL1 Gene

Function for SIGLECL1 Gene

Phenotypes From GWAS Catalog for SIGLECL1 Gene

Gene Ontology (GO) - Molecular Function for SIGLECL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
GO:0033691 sialic acid binding IBA 21873635
genes like me logo Genes that share ontologies with SIGLECL1: view
genes like me logo Genes that share phenotypes with SIGLECL1: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIGLECL1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SIGLECL1 Gene

Localization for SIGLECL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLECL1 Gene

Membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIGLECL1 gene
Compartment Confidence
plasma membrane 4
extracellular 1
peroxisome 1
cytosol 1
mitochondrion 0
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for SIGLECL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SIGLECL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SIGLECL1 Gene

Pathways & Interactions for SIGLECL1 Gene

PathCards logo

SuperPathways for SIGLECL1 Gene

No Data Available

Interacting Proteins for SIGLECL1 Gene

Gene Ontology (GO) - Biological Process for SIGLECL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IBA 21873635
genes like me logo Genes that share ontologies with SIGLECL1: view

No data available for Pathways by source and SIGNOR curated interactions for SIGLECL1 Gene

Drugs & Compounds for SIGLECL1 Gene

No Compound Related Data Available

Transcripts for SIGLECL1 Gene

mRNA/cDNA for SIGLECL1 Gene

5 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIGLECL1

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLECL1 Gene

No ASD Table

Relevant External Links for SIGLECL1 Gene

GeneLoc Exon Structure for
SIGLECL1

Expression for SIGLECL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SIGLECL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for SIGLECL1 Gene

This gene is overexpressed in Testis (x51.8).

Protein differential expression in normal tissues from HIPED for SIGLECL1 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SIGLECL1 Gene



Protein tissue co-expression partners for SIGLECL1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SIGLECL1

SOURCE GeneReport for Unigene cluster for SIGLECL1 Gene:

Hs.381087
genes like me logo Genes that share expression patterns with SIGLECL1: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIGLECL1 Gene

Orthologs for SIGLECL1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SIGLECL1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SIGLECL1 30 31
  • 99.15 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SIGLECL1 30 31
  • 80.95 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Gm2511 30
  • 71.43 (n)
4931406B18Rik 31
  • 21 (a)
OneToOne
Siglecl1 17
Rat
(Rattus norvegicus)
Mammalia Siglecl1 30
  • 70.68 (n)
Cow
(Bos Taurus)
Mammalia SIGLECL1 31
  • 61 (a)
OneToOne
Species where no ortholog for SIGLECL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SIGLECL1 Gene

ENSEMBL:
Gene Tree for SIGLECL1 (if available)
TreeFam:
Gene Tree for SIGLECL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SIGLECL1: view image

Paralogs for SIGLECL1 Gene

(3) SIMAP similar genes for SIGLECL1 Gene using alignment to 4 proteins:

  • SIGL1_HUMAN
  • M0QY48_HUMAN
  • M0QY54_HUMAN
  • M0R2N8_HUMAN

Pseudogenes.org Pseudogenes for SIGLECL1 Gene

genes like me logo Genes that share paralogs with SIGLECL1: view

Variants for SIGLECL1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SIGLECL1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SIGLECL1 Gene

Variant ID Type Subtype PubMed ID
nsv1060026 CNV gain 25217958
nsv1123274 CNV deletion 24896259
nsv1140251 OTHER inversion 24896259
nsv518134 CNV loss 19592680
nsv519982 CNV loss 19592680
nsv819924 CNV loss 19587683

Variation tolerance for SIGLECL1 Gene

Residual Variation Intolerance Score: 70% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SIGLECL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIGLECL1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SIGLECL1 Gene

Disorders for SIGLECL1 Gene

Additional Disease Information for SIGLECL1

No disorders were found for SIGLECL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIGLECL1 Gene

Publications for SIGLECL1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  4. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. (PMID: 23362303) Wu JH … Mozaffarian D (Circulation. Cardiovascular genetics 2013) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for SIGLECL1 Gene

Sources for SIGLECL1 Gene