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Aliases for SIGLEC9 Gene
Aliases for SIGLEC9 Gene
External Ids for SIGLEC9 Gene
- HGNC: 10878
- NCBI Entrez Gene: 27180
- Ensembl: ENSG00000129450
- OMIM®: 605640
- UniProtKB/Swiss-Prot: Q9Y336
Previous GeneCards Identifiers for SIGLEC9 Gene
- GC19P052258
- GC19P051989
- GC19P056304
- GC19P056319
- GC19P051628
- GC19P047961
Summaries for SIGLEC9 Gene
GeneCards Summary for SIGLEC9 Gene
SIGLEC9 (Sialic Acid Binding Ig Like Lectin 9) is a Protein Coding gene. Among its related pathways are Innate Immune System and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is SIGLEC7.
UniProtKB/Swiss-Prot Summary for SIGLEC9 Gene
-
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Additional gene information for SIGLEC9 Gene
- HGNC (10878)
- NCBI Entrez Gene (27180)
- Ensembl (ENSG00000129450)
- OMIM® (605640)
- UniProtKB/Swiss-Prot (Q9Y336)
- Open Targets Platform(ENSG00000129450)
- Search for SIGLEC9 at DataMed
- Search for SIGLEC9 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SIGLEC9 Gene
Genomics for SIGLEC9 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SIGLEC9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SIGLEC9 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SIGLEC9
- Top Transcription factor binding sites by QIAGEN in the SIGLEC9 gene promoter:
-
- AML1a
- AP-1
- ARP-1
- HOXA3
- N-Myc
- PPAR-gamma1
- PPAR-gamma2
- STAT3
- STAT5A
- TGIF
Genomic Locations for SIGLEC9 Gene
Latest Assembly
- chr19:51,124,880-51,140,480
- (GRCh38/hg38)
- Size:
- 15,601 bases
- Orientation:
- Plus strand
Previous Assembly
- chr19:51,628,137-51,639,520
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 11,384 bases
- Orientation:
- Plus strand
- chr19:51,628,165-51,639,908
- (GRCh37/hg19 by Ensembl)
- Size:
- 11,744 bases
- Orientation:
- Plus strand
Genomic View for SIGLEC9 Gene
Genes around SIGLEC9 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.3-q13.4 by HGNC
- 19q13.41 by Entrez Gene
- 19q13.41 by Ensembl
SIGLEC9 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SIGLEC9 Gene
Proteins for SIGLEC9 Gene
-
Protein details for SIGLEC9 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y336-SIGL9_HUMAN
- Recommended name:
- Sialic acid-binding Ig-like lectin 9
- Protein Accession:
- Q9Y336
- Q6GTU4
- Q9BYI9
Protein attributes for SIGLEC9 Gene
- Size:
- 463 amino acids
- Molecular mass:
- 50082 Da
- Quaternary structure:
- No Data Available
Protein Expression for SIGLEC9 Gene
Post-translational modifications for SIGLEC9 Gene
Other Protein References for SIGLEC9 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences SIGLEC9 Monoclonal Antibody (LS-B11017) and SIGLEC9 Monoclonal Antibody (LS-B11016)
- G Biosciences Immunotag™ SIGL9 Polyclonal Antibody
-
BioLegend
- Siglec-9 Antibody (351504)
- Siglec-9 Antibody (351503)
- Siglec-9 Antibody (351502)
- Siglec-9 Antibody (351506)
- Siglec-9 Antibody (351505)
- Siglec-9 Antibody (351508)
- Siglec-9 Antibody (351507)
- Siglec-9 Antibody (351512)
- Siglec-9 Antibody (351511)
- Siglec-9 Antibody (351519)
- PerCP/Cyanine5.5 Siglec-9 Antibody (351518)
- APC/Fire(TM) 750 Siglec-9 Antibody (351513)
- PerCP/Cyanine5.5 Siglec-9 Antibody (351517)
- Siglec-9 Antibody (351516)
- Siglec-9 Antibody (351515)
- APC/Fire(TM) 750 Siglec-9 Antibody (351514)
- Siglec-9 Antibody (351510)
- Siglec-9 Antibody (351520)
- Siglec-9 Antibody (351509)
- GeneTex Anti-SIGLEC9 antibody [N1C1]
-
Custom Antibody ServicesOriGene Antibodies for SIGLEC9
- Novus Biologicals Antibodies for SIGLEC9
-
Abcam antibodies for SIGLEC9
- Invitrogen Antibodies for SIGLEC9 (AFLGC-SIGLEC9)
- antibodies-online: Show 54 available SIGLEC9 Antibodies ranked by validation data
-
Boster Bio Antibodies for SIGLEC9
Protein products for research
-
OriGene Purified Proteins for SIGLEC9
- Search Origene for MassSpec and Protein Over-expression Lysates for SIGLEC9
- Origene Custom Protein Services for SIGLEC9
- ProSpec Recombinant Proteins for SIGLEC9
- antibodies-online: Show 8 available SIGLEC9 Proteins ranked by validation data
- Compare Top SIGLEC9 Proteins
-
Quality Products:
-
ProSci Proteins for SIGLEC9
-
Abcam proteins for SIGLEC9
Assay products for research
- RayBiotech Human Siglec-9 ELISA
No data available for DME Specific Peptides for SIGLEC9 Gene
Domains & Families for SIGLEC9 Gene
Gene Families for SIGLEC9 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for SIGLEC9 Gene
- InterPro:
- Blocks:
-
- Immunoglobulin subtype
- ProtoNet:
Suggested Antigen Peptide Sequences for SIGLEC9 Gene
- GenScript: Design optimal peptide antigens:
-
- Protein FOAP-9 (SIGL9_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9Y336UniProtKB/Swiss-Prot:
SIGL9_HUMAN :- Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
- Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
- Domain:
-
- Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
- Family:
-
- Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Function for SIGLEC9 Gene
Molecular function for SIGLEC9 Gene
- UniProtKB/Swiss-Prot Function:
- Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Phenotypes From GWAS Catalog for SIGLEC9 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 25187624 |
| GO:0030246 | carbohydrate binding | NAS | 10801860 |
| GO:0033691 | sialic acid binding | IBA | 21873635 |
Phenotypes for SIGLEC9 Gene
- MGI mutant phenotypes for SIGLEC9:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for SIGLEC9:
Animal Models for SIGLEC9 Gene
- MGI Knock Outs for SIGLEC9:
-
- Siglece Siglece<tm1Croc>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SIGLEC9 - Starting at $85 >
- * SIGLEC9 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SIGLEC9
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SIGLEC9
-
Santa Cruz Biotechnology (SCBT) CRISPR for SIGLEC9
miRNA for SIGLEC9 Gene
- miRTarBase miRNAs that target SIGLEC9
-
- hsa-miR-340-5p (MIRT545592)
- hsa-miR-555 (MIRT545593)
- hsa-miR-5787 (MIRT545594)
- hsa-miR-5589-5p (MIRT545595)
- hsa-miR-4505 (MIRT545596)
- hsa-miR-6884-5p (MIRT545597)
- hsa-miR-3188 (MIRT545598)
- hsa-miR-2467-5p (MIRT545599)
- hsa-miR-485-5p (MIRT545600)
- hsa-miR-3975 (MIRT545601)
- hsa-miR-6861-5p (MIRT545602)
- hsa-miR-4649-3p (MIRT545603)
- hsa-miR-5590-3p (MIRT545604)
- hsa-miR-142-5p (MIRT545605)
- hsa-miR-32-3p (MIRT545606)
- hsa-miR-583 (MIRT545607)
- hsa-miR-186-5p (MIRT545608)
- hsa-miR-3133 (MIRT545609)
- hsa-miR-4279 (MIRT621234)
- hsa-miR-1976 (MIRT621235)
- hsa-miR-3653-5p (MIRT621236)
- hsa-miR-150-5p (MIRT621237)
- hsa-miR-6747-3p (MIRT621238)
- hsa-miR-6727-3p (MIRT621239)
- hsa-miR-4722-3p (MIRT621240)
- hsa-miR-6814-5p (MIRT621241)
- hsa-miR-5697 (MIRT621242)
- hsa-miR-4759 (MIRT621243)
- hsa-miR-451b (MIRT621244)
- hsa-miR-5571-5p (MIRT621245)
- hsa-miR-562 (MIRT621246)
- hsa-miR-6778-3p (MIRT632073)
- hsa-miR-129-5p (MIRT637940)
- hsa-miR-514b-3p (MIRT637941)
- hsa-miR-514a-3p (MIRT637942)
- hsa-miR-642b-3p (MIRT637943)
- hsa-miR-642a-3p (MIRT637944)
- hsa-miR-4459 (MIRT650207)
- hsa-miR-6516-5p (MIRT650208)
- hsa-miR-4443 (MIRT650209)
- hsa-miR-455-3p (MIRT650210)
- hsa-miR-7703 (MIRT650211)
- hsa-miR-6807-5p (MIRT650212)
- hsa-miR-6720-5p (MIRT650213)
- hsa-miR-6512-3p (MIRT650214)
- hsa-miR-25-5p (MIRT650215)
- hsa-miR-650 (MIRT650216)
- hsa-miR-3612 (MIRT650217)
- hsa-miR-658 (MIRT650218)
- hsa-miR-4252 (MIRT650219)
- hsa-miR-6499-3p (MIRT650220)
- hsa-miR-6086 (MIRT650221)
- hsa-miR-377-5p (MIRT650222)
- hsa-miR-6087 (MIRT650223)
- hsa-miR-4793-3p (MIRT650224)
- hsa-miR-766-3p (MIRT650225)
- hsa-miR-4254 (MIRT650226)
- hsa-miR-4308 (MIRT650227)
- hsa-miR-6849-3p (MIRT650228)
- hsa-miR-1273g-3p (MIRT650229)
- hsa-miR-3940-3p (MIRT650230)
- hsa-miR-508-5p (MIRT650231)
- hsa-miR-504-5p (MIRT650232)
- hsa-miR-6732-3p (MIRT650233)
- hsa-miR-196a-3p (MIRT664991)
- hsa-miR-2681-5p (MIRT711828)
- hsa-miR-4735-5p (MIRT711829)
- hsa-miR-652-5p (MIRT711830)
- hsa-miR-106a-3p (MIRT761113)
- hsa-miR-1247-3p (MIRT761568)
- hsa-miR-1281 (MIRT762150)
- hsa-miR-1304-3p (MIRT762429)
- hsa-miR-130a-3p (MIRT762489)
- hsa-miR-130b-3p (MIRT762507)
- hsa-miR-183-5p (MIRT763164)
- hsa-miR-216a-5p (MIRT763885)
- hsa-miR-301a-3p (MIRT764414)
- hsa-miR-301b-3p (MIRT764432)
- hsa-miR-3666 (MIRT766552)
- hsa-miR-4295 (MIRT768466)
- hsa-miR-4485-5p (MIRT769620)
- hsa-miR-4532 (MIRT770088)
- hsa-miR-454-3p (MIRT770248)
- hsa-miR-4772-3p (MIRT772208)
- hsa-miR-498 (MIRT772860)
- hsa-miR-5197-5p (MIRT773670)
- hsa-miR-5586-3p (MIRT774775)
- hsa-miR-6736-3p (MIRT778048)
- hsa-miR-6787-3p (MIRT779207)
- hsa-miR-6890-3p (MIRT781146)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SIGLEC9
- Browse OriGene Inhibitory RNA Products For SIGLEC9
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIGLEC9
Clone products for research
- Applied Biological Materials (abm): Clones for SIGLEC9 - Starting at $45 >
- * SIGLEC9 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
OriGene ORF clones in human for SIGLEC9
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SIGLEC9
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SIGLEC9
Cell Lines for research
-
Horizon Cell Lines for SIGLEC9
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIGLEC9 Gene
Localization for SIGLEC9 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC9 Gene
- Membrane. Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 3 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | NAS | 10801860 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0030667 | secretory granule membrane | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for SIGLEC9 Gene
Pathways & Interactions for SIGLEC9 Gene
Pathways by source for SIGLEC9 Gene
5 Reactome pathways for SIGLEC9 Gene
1 KEGG pathway for SIGLEC9 Gene
Interacting Proteins for SIGLEC9 Gene
Selected Interacting proteins:
Q9Y336-SIGL9_HUMAN
ENSP00000413861
for SIGLEC9 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for SIGLEC9
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007155 | cell adhesion | IBA | 21873635 |
| GO:0007166 | cell surface receptor signaling pathway | NAS | 10801860 |
| GO:0043312 | neutrophil degranulation | TAS | -- |
| GO:0050776 | regulation of immune response | TAS | -- |
No data available for SIGNOR curated interactions for SIGLEC9 Gene
Transcripts for SIGLEC9 Gene
mRNA/cDNA for SIGLEC9 Gene
- 2 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000250360 1692 nts (view in UCSC)
- ENST00000440804 1960 nts (view in UCSC)
- ENST00000599948 614 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SIGLEC9 - Starting at $85 >
- * SIGLEC9 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SIGLEC9
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SIGLEC9
-
Santa Cruz Biotechnology (SCBT) CRISPR for SIGLEC9
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SIGLEC9
- Browse OriGene Inhibitory RNA Products For SIGLEC9
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIGLEC9
Clone products for research
- Applied Biological Materials (abm): Clones for SIGLEC9 - Starting at $45 >
- * SIGLEC9 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
OriGene ORF clones in human for SIGLEC9
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SIGLEC9
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SIGLEC9
Relevant External Links for SIGLEC9 Gene
- GeneLoc Exon Structure for
- SIGLEC9
Expression for SIGLEC9 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for SIGLEC9 Gene
This gene is overexpressed in Whole Blood (x29.1) and Spleen (x4.4).
This gene is overexpressed in Monocytes (43.5) and Peripheral blood mononuclear cells (20.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SIGLEC9 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SIGLEC9
SOURCE GeneReport for Unigene cluster for SIGLEC9 Gene:
Hs.245828mRNA Expression by UniProt/SwissProt for SIGLEC9 Gene:
Q9Y336-SIGL9_HUMAN
Tissue specificity:
Expressed by peripheral blood leukocytes (neutrophils and monocytes but not eosinophils). Found in liver, fetal liver, bone marrow, placenta, spleen and in lower levels in skeletal muscle, fetal brain, stomach, lung, thymus, prostate, brain, mammary, adrenal gland, colon, trachea, cerebellum, testis, small intestine and spinal cordon.
Evidence on tissue expression from TISSUES for SIGLEC9 Gene
- Blood(4.5)
- Nervous system(4.3)
- Bone marrow(4.3)
- Spleen(2.2)
Primer products for research
-
OriGene qPCR primer pairs for SIGLEC9
-
OriGene qPCR primer pairs and template standards for SIGLEC9
Gene Expression Assays for research
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SIGLEC9 Gene
Orthologs for SIGLEC9 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SIGLEC9 30 |
|
||
| SIGLEC13 31 |
|
ManyToMany | |||
| Mouse (Mus musculus) |
Mammalia | Siglece 30 17 31 |
|
OneToMany | |
| Cow (Bos Taurus) |
Mammalia | -- 31 |
|
OneToMany | |
| Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany |
- Species where no ortholog for SIGLEC9 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for SIGLEC9 Gene
- ENSEMBL:
- Gene Tree for SIGLEC9 (if available)
- TreeFam:
- Gene Tree for SIGLEC9 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SIGLEC9: view image
Paralogs for SIGLEC9 Gene
Paralogs for SIGLEC9 Gene
(10) SIMAP similar genes for SIGLEC9 Gene using alignment to 2 proteins:
- SIGL9_HUMAN
- M0R2D4_HUMAN
Variants for SIGLEC9 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SIGLEC9 Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs144700400 | Benign: not provided | 51,128,486(+) |
C/T NM_001198558.1(SIGLEC9):c.1179C>T (p.Asn393=) |
SYNONYMOUS | |
| rs200658 | Benign: not provided. - | 51,125,348(+) |
G/Ap.Ser125Asn NM_001198558.1(SIGLEC9):c.374G>A (p.Ser125Asn) |
MISSENSE | |
| rs867190 | Benign: not provided | 51,128,453(+) |
G/A NM_001198558.1(SIGLEC9):c.1146G>A (p.Ala382=) |
SYNONYMOUS | |
| rs16988910 | - |
p.Lys131Gln |
|||
| rs2075803 | - |
p.Lys100Glu |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv34104 | CNV | loss | 18971310 |
| nsv1140251 | OTHER | inversion | 24896259 |
Residual Variation Intolerance Score:
83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.60;
65.30% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SIGLEC9 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SIGLEC9
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIGLEC9 Gene
Disorders for SIGLEC9 Gene
Additional Disease Information for SIGLEC9
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No disorders were found for SIGLEC9 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIGLEC9 Gene
Publications for SIGLEC9 Gene
- Siglec-9, a novel sialic acid binding member of the immunoglobulin superfamily expressed broadly on human blood leukocytes. (PMID: 10801862) Zhang JQ … Crocker PR (The Journal of biological chemistry 2000) 3 4 23
- Identification and molecular characterization of a novel member of the siglec family (SIGLEC9). (PMID: 10903842) Foussias G … Diamandis EP (Genomics 2000) 2 3 4
- The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
- Cloning, characterization, and phylogenetic analysis of siglec-9, a new member of the CD33-related group of siglecs. Evidence for co-evolution with sialic acid synthesis pathways. (PMID: 10801860) Angata T … Varki A (The Journal of biological chemistry 2000) 3 4
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Products for SIGLEC9 Gene
- View all 18 R&D Systems SIGLEC9 (Siglec-9) Products
- View all R&D Systems SIGLEC9 (Siglec-9) Proteins and Enzymes
- View all 13 R&D Systems SIGLEC9 (Siglec-9) Primary Antibodies
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- View all R&D Systems SIGLEC9 (Siglec-9) Simple Plex Assays
- View all R&D Systems SIGLEC9 (Siglec-9) Proteome Profiler Antibody Arrays
- View all R&D Systems SIGLEC9 (Siglec-9) cDNA Clones
- Learn more about R&D Systems custom SIGLEC9 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for SIGLEC9
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- OriGene qPCR primer pairs for SIGLEC9
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SIGLEC9
- Sino Biological Human cDNA Clone for SIGLEC9
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- VectorBuilder Custom and pre-made DNA vectors for SIGLEC9 (ie. gene expression, shRNA knockdown, CRISPR)
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- VectorBuilder Virus packaging for SIGLEC9 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for SIGLEC9
- antibodies-online: Show 54 available SIGLEC9 Antibodies ranked by validation data
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- antibodies-online: Show 8 available SIGLEC9 Proteins ranked by validation data
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- Browse Santa Cruz Biotechnology (SCBT) Antibodies
- Search Santa Cruz Biotechnology (SCBT) for SIGLEC9 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SIGLEC9
- Custom Antibody ServicesProSci Antibodies for SIGLEC9
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SIGLEC9
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- Boster Bio Antibodies for SIGLEC9
- Browse Boster Bio ELISA Kits
Sources for SIGLEC9 Gene
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