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Aliases for SIGLEC9 Gene

Aliases for SIGLEC9 Gene

  • Sialic Acid Binding Ig Like Lectin 9 2 3 5
  • Protein FOAP-9 3 4
  • Siglec-9 3 4
  • CDw329 3 4
  • Sialic Acid Binding Ig-Like Lectin 9 2
  • Sialic Acid-Binding Ig-Like Lectin 9 3
  • CD329 Antigen 4
  • OBBP-LIKE 3
  • FOAP-9 3
  • CD329 3

External Ids for SIGLEC9 Gene

Previous GeneCards Identifiers for SIGLEC9 Gene

  • GC19P052258
  • GC19P051989
  • GC19P056304
  • GC19P056319
  • GC19P051628
  • GC19P047961

Summaries for SIGLEC9 Gene

GeneCards Summary for SIGLEC9 Gene

SIGLEC9 (Sialic Acid Binding Ig Like Lectin 9) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is SIGLEC7.

UniProtKB/Swiss-Prot for SIGLEC9 Gene

  • Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Gene Wiki entry for SIGLEC9 Gene

Additional gene information for SIGLEC9 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIGLEC9 Gene

Genomics for SIGLEC9 Gene

GeneHancer (GH) Regulatory Elements for SIGLEC9 Gene

Promoters and enhancers for SIGLEC9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I051121 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 565.2 +1.3 1255 10.3 PKNOX1 ATF1 FOXA2 TCF12 FOS ATF7 RXRA MBD2 MEF2D ATF4 SIGLEC9 ZNF613 ZNF841 ZNF577 POLD1 SIGLEC18P KLK11 CTU1 C19orf81 SIGLEC10
GH19I051131 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 18.2 +7.4 7427 1.4 HDAC1 ATF1 RAD21 ZBTB40 YY1 TCF12 ZNF766 ATF7 RXRA ZBTB11 SIGLEC9 CTU1 SIGLEC10 C19orf81 SIGLEC17P SIGLEC7 CD33 SIGLEC12 ENSG00000267990
GH19I051136 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.5 +15.8 15821 9.4 PKNOX1 NFRKB ZBTB40 YY1 ZNF766 SMAD5 ZBTB11 CEBPB GTF2B USF2 SIGLEC7 SIGLEC17P CTU1 POLD1 SIGLEC9 ZNF616 KLK14 KLK10 SIGLEC10 CD33
GH19I051106 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 5.6 -16.8 -16776 2.4 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 IRF4 YY1 ZNF766 CTU1 SIGLEC9 SIGLEC14 PIR34748
GH19I051393 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE 4.3 +270.2 270167 2.8 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A IRF4 YY1 POLR2B ENSG00000268889 LOC105372446 ZNF841 ZNF766 ZNF577 ZNF616 ZNF175 ZNF836 ZNF432 ZNF614
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SIGLEC9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SIGLEC9 gene promoter:

Genomic Locations for SIGLEC9 Gene

Genomic Locations for SIGLEC9 Gene
chr19:51,124,880-51,141,020
(GRCh38/hg38)
Size:
16,141 bases
Orientation:
Plus strand
chr19:51,628,137-51,639,908
(GRCh37/hg19)

Genomic View for SIGLEC9 Gene

Genes around SIGLEC9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIGLEC9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIGLEC9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLEC9 Gene

Proteins for SIGLEC9 Gene

  • Protein details for SIGLEC9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y336-SIGL9_HUMAN
    Recommended name:
    Sialic acid-binding Ig-like lectin 9
    Protein Accession:
    Q9Y336
    Secondary Accessions:
    • Q6GTU4
    • Q9BYI9

    Protein attributes for SIGLEC9 Gene

    Size:
    463 amino acids
    Molecular mass:
    50082 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SIGLEC9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIGLEC9 Gene

Post-translational modifications for SIGLEC9 Gene

  • Glycosylation at posLast=101101, isoforms=2138, isoforms=2161, posLast=225225, isoforms=2231, isoforms=2238, posLast=256256, and isoforms=2334
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SIGLEC9 Gene

Domains & Families for SIGLEC9 Gene

Protein Domains for SIGLEC9 Gene

Suggested Antigen Peptide Sequences for SIGLEC9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y336

UniProtKB/Swiss-Prot:

SIGL9_HUMAN :
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Domain:
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with SIGLEC9: view

Function for SIGLEC9 Gene

Molecular function for SIGLEC9 Gene

UniProtKB/Swiss-Prot Function:
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Phenotypes From GWAS Catalog for SIGLEC9 Gene

Gene Ontology (GO) - Molecular Function for SIGLEC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding NAS 10801860
genes like me logo Genes that share ontologies with SIGLEC9: view
genes like me logo Genes that share phenotypes with SIGLEC9: view

Animal Models for SIGLEC9 Gene

MGI Knock Outs for SIGLEC9:

Animal Model Products

miRNA for SIGLEC9 Gene

miRTarBase miRNAs that target SIGLEC9

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIGLEC9 Gene

Localization for SIGLEC9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC9 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIGLEC9 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SIGLEC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 10801860
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030667 secretory granule membrane TAS --
genes like me logo Genes that share ontologies with SIGLEC9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SIGLEC9 Gene

Pathways & Interactions for SIGLEC9 Gene

genes like me logo Genes that share pathways with SIGLEC9: view

Gene Ontology (GO) - Biological Process for SIGLEC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007166 cell surface receptor signaling pathway NAS 10801860
GO:0043312 neutrophil degranulation TAS --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with SIGLEC9: view

No data available for SIGNOR curated interactions for SIGLEC9 Gene

Drugs & Compounds for SIGLEC9 Gene

No Compound Related Data Available

Transcripts for SIGLEC9 Gene

Unigene Clusters for SIGLEC9 Gene

Sialic acid binding Ig-like lectin 9:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC9 Gene

No ASD Table

Relevant External Links for SIGLEC9 Gene

GeneLoc Exon Structure for
SIGLEC9
ECgene alternative splicing isoforms for
SIGLEC9

Expression for SIGLEC9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SIGLEC9 Gene

mRNA differential expression in normal tissues according to GTEx for SIGLEC9 Gene

This gene is overexpressed in Whole Blood (x29.1) and Spleen (x4.4).

Protein differential expression in normal tissues from HIPED for SIGLEC9 Gene

This gene is overexpressed in Monocytes (43.5) and Peripheral blood mononuclear cells (20.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SIGLEC9 Gene



Protein tissue co-expression partners for SIGLEC9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SIGLEC9 Gene:

SIGLEC9

SOURCE GeneReport for Unigene cluster for SIGLEC9 Gene:

Hs.245828

mRNA Expression by UniProt/SwissProt for SIGLEC9 Gene:

Q9Y336-SIGL9_HUMAN
Tissue specificity: Expressed by peripheral blood leukocytes (neutrophils and monocytes but not eosinophils). Found in liver, fetal liver, bone marrow, placenta, spleen and in lower levels in skeletal muscle, fetal brain, stomach, lung, thymus, prostate, brain, mammary, adrenal gland, colon, trachea, cerebellum, testis, small intestine and spinal cordon.

Evidence on tissue expression from TISSUES for SIGLEC9 Gene

  • Blood(4.4)
  • Bone marrow(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with SIGLEC9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIGLEC9 Gene

Orthologs for SIGLEC9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SIGLEC9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIGLEC9 33
  • 98.16 (n)
SIGLEC13 34
  • 65 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Siglece 33 16 34
  • 66.97 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 65 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 49 (a)
OneToMany
Species where no ortholog for SIGLEC9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SIGLEC9 Gene

ENSEMBL:
Gene Tree for SIGLEC9 (if available)
TreeFam:
Gene Tree for SIGLEC9 (if available)

Paralogs for SIGLEC9 Gene

(10) SIMAP similar genes for SIGLEC9 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SIGLEC9: view

Variants for SIGLEC9 Gene

Sequence variations from dbSNP and Humsavar for SIGLEC9 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000992911 -- 51,124,511(+) G/T upstream_transcript_variant
rs1001211537 -- 51,124,007(+) C/T upstream_transcript_variant
rs1001337297 -- 51,128,947(+) C/T coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant, missense_variant
rs1001457836 -- 51,133,874(+) C/T genic_downstream_transcript_variant, intron_variant
rs1001535775 -- 51,134,374(+) G/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SIGLEC9 Gene

Variant ID Type Subtype PubMed ID
esv34104 CNV loss 18971310
nsv1140251 OTHER inversion 24896259

Variation tolerance for SIGLEC9 Gene

Residual Variation Intolerance Score: 83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.60; 65.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SIGLEC9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIGLEC9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIGLEC9 Gene

Disorders for SIGLEC9 Gene

Additional Disease Information for SIGLEC9

No disorders were found for SIGLEC9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIGLEC9 Gene

Publications for SIGLEC9 Gene

  1. Identification and molecular characterization of a novel member of the siglec family (SIGLEC9). (PMID: 10903842) Foussias G … Diamandis EP (Genomics 2000) 2 3 4 58
  2. Siglec-9, a novel sialic acid binding member of the immunoglobulin superfamily expressed broadly on human blood leukocytes. (PMID: 10801862) Zhang JQ … Crocker PR (The Journal of biological chemistry 2000) 3 4 22 58
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. Cloning, characterization, and phylogenetic analysis of siglec-9, a new member of the CD33-related group of siglecs. Evidence for co-evolution with sialic acid synthesis pathways. (PMID: 10801860) Angata T … Varki A (The Journal of biological chemistry 2000) 3 4 58

Products for SIGLEC9 Gene

Sources for SIGLEC9 Gene

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