Aliases for SIGLEC9 Gene

Aliases for SIGLEC9 Gene

  • Sialic Acid Binding Ig Like Lectin 9 2 3 5
  • Sialic Acid-Binding Ig-Like Lectin 9 3 4
  • Protein FOAP-9 3 4
  • Siglec-9 3 4
  • CDw329 3 4
  • CD329 2 3
  • Sialic Acid Binding Ig-Like Lectin 9 2
  • CD329 Antigen 4
  • OBBP-LIKE 3
  • SIGLEC9 5
  • FOAP-9 3

External Ids for SIGLEC9 Gene

Previous GeneCards Identifiers for SIGLEC9 Gene

  • GC19P052258
  • GC19P051989
  • GC19P056304
  • GC19P056319
  • GC19P051628
  • GC19P047961

Summaries for SIGLEC9 Gene

GeneCards Summary for SIGLEC9 Gene

SIGLEC9 (Sialic Acid Binding Ig Like Lectin 9) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is SIGLEC7.

UniProtKB/Swiss-Prot Summary for SIGLEC9 Gene

  • Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Gene Wiki entry for SIGLEC9 Gene

Additional gene information for SIGLEC9 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SIGLEC9 Gene

Genomics for SIGLEC9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SIGLEC9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SIGLEC9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SIGLEC9

Top Transcription factor binding sites by QIAGEN in the SIGLEC9 gene promoter:
  • AML1a
  • AP-1
  • ARP-1
  • HOXA3
  • N-Myc
  • PPAR-gamma1
  • PPAR-gamma2
  • STAT3
  • STAT5A
  • TGIF

Genomic Locations for SIGLEC9 Gene

Genomic Locations for SIGLEC9 Gene
chr19:51,124,880-51,140,480
(GRCh38/hg38)
Size:
15,601 bases
Orientation:
Plus strand
chr19:51,628,137-51,639,908
(GRCh37/hg19)
Size:
11,772 bases
Orientation:
Plus strand

Genomic View for SIGLEC9 Gene

Genes around SIGLEC9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIGLEC9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIGLEC9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLEC9 Gene

Proteins for SIGLEC9 Gene

  • Protein details for SIGLEC9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y336-SIGL9_HUMAN
    Recommended name:
    Sialic acid-binding Ig-like lectin 9
    Protein Accession:
    Q9Y336
    Secondary Accessions:
    • Q6GTU4
    • Q9BYI9

    Protein attributes for SIGLEC9 Gene

    Size:
    463 amino acids
    Molecular mass:
    50082 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SIGLEC9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIGLEC9 Gene

Post-translational modifications for SIGLEC9 Gene

  • Glycosylation at Asn101, Asn138, Asn161, Asn225, Asn231, Asn238, Asn256, and Asn334
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for SIGLEC9
  • Boster Bio Antibodies for SIGLEC9

No data available for DME Specific Peptides for SIGLEC9 Gene

Domains & Families for SIGLEC9 Gene

Gene Families for SIGLEC9 Gene

Protein Domains for SIGLEC9 Gene

InterPro:
Blocks:
  • Immunoglobulin subtype
ProtoNet:

Suggested Antigen Peptide Sequences for SIGLEC9 Gene

GenScript: Design optimal peptide antigens:
  • Protein FOAP-9 (SIGL9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y336

UniProtKB/Swiss-Prot:

SIGL9_HUMAN :
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Domain:
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with SIGLEC9: view

Function for SIGLEC9 Gene

Molecular function for SIGLEC9 Gene

UniProtKB/Swiss-Prot Function:
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Phenotypes From GWAS Catalog for SIGLEC9 Gene

Gene Ontology (GO) - Molecular Function for SIGLEC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25187624
GO:0030246 carbohydrate binding NAS 10801860
GO:0033691 sialic acid binding IBA 21873635
genes like me logo Genes that share ontologies with SIGLEC9: view
genes like me logo Genes that share phenotypes with SIGLEC9: view

Animal Models for SIGLEC9 Gene

MGI Knock Outs for SIGLEC9:

CRISPR Products

miRNA for SIGLEC9 Gene

miRTarBase miRNAs that target SIGLEC9

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIGLEC9

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIGLEC9 Gene

Localization for SIGLEC9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC9 Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIGLEC9 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SIGLEC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 10801860
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030667 secretory granule membrane TAS --
genes like me logo Genes that share ontologies with SIGLEC9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SIGLEC9 Gene

Pathways & Interactions for SIGLEC9 Gene

genes like me logo Genes that share pathways with SIGLEC9: view

Gene Ontology (GO) - Biological Process for SIGLEC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IBA 21873635
GO:0007166 cell surface receptor signaling pathway NAS 10801860
GO:0043312 neutrophil degranulation TAS --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with SIGLEC9: view

No data available for SIGNOR curated interactions for SIGLEC9 Gene

Drugs & Compounds for SIGLEC9 Gene

No Compound Related Data Available

Transcripts for SIGLEC9 Gene

mRNA/cDNA for SIGLEC9 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIGLEC9

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC9 Gene

No ASD Table

Relevant External Links for SIGLEC9 Gene

GeneLoc Exon Structure for
SIGLEC9

Expression for SIGLEC9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SIGLEC9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Blood (Hematopoietic System)

mRNA differential expression in normal tissues according to GTEx for SIGLEC9 Gene

This gene is overexpressed in Whole Blood (x29.1) and Spleen (x4.4).

Protein differential expression in normal tissues from HIPED for SIGLEC9 Gene

This gene is overexpressed in Monocytes (43.5) and Peripheral blood mononuclear cells (20.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SIGLEC9 Gene



Protein tissue co-expression partners for SIGLEC9 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SIGLEC9

SOURCE GeneReport for Unigene cluster for SIGLEC9 Gene:

Hs.245828

mRNA Expression by UniProt/SwissProt for SIGLEC9 Gene:

Q9Y336-SIGL9_HUMAN
Tissue specificity: Expressed by peripheral blood leukocytes (neutrophils and monocytes but not eosinophils). Found in liver, fetal liver, bone marrow, placenta, spleen and in lower levels in skeletal muscle, fetal brain, stomach, lung, thymus, prostate, brain, mammary, adrenal gland, colon, trachea, cerebellum, testis, small intestine and spinal cordon.

Evidence on tissue expression from TISSUES for SIGLEC9 Gene

  • Blood(4.5)
  • Nervous system(4.4)
  • Bone marrow(4.3)
  • Spleen(2.4)
genes like me logo Genes that share expression patterns with SIGLEC9: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SIGLEC9 Gene

Orthologs for SIGLEC9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SIGLEC9 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SIGLEC9 30
  • 98.16 (n)
SIGLEC13 31
  • 65 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Siglece 30 17 31
  • 66.97 (n)
OneToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 65 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 49 (a)
OneToMany
Species where no ortholog for SIGLEC9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SIGLEC9 Gene

ENSEMBL:
Gene Tree for SIGLEC9 (if available)
TreeFam:
Gene Tree for SIGLEC9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SIGLEC9: view image

Paralogs for SIGLEC9 Gene

(10) SIMAP similar genes for SIGLEC9 Gene using alignment to 2 proteins:

  • SIGL9_HUMAN
  • M0R2D4_HUMAN
genes like me logo Genes that share paralogs with SIGLEC9: view

Variants for SIGLEC9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SIGLEC9 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
775423 Benign: not provided 51,125,348(+) G/A MISSENSE_VARIANT
783849 Benign: not provided 51,128,453(+) G/A SYNONYMOUS_VARIANT
787143 Benign: not provided 51,128,486(+) C/T SYNONYMOUS_VARIANT
rs16988910 - p.Lys131Gln
rs200658 - p.Ser125Asn

Additional dbSNP identifiers (rs#s) for SIGLEC9 Gene

Structural Variations from Database of Genomic Variants (DGV) for SIGLEC9 Gene

Variant ID Type Subtype PubMed ID
esv34104 CNV loss 18971310
nsv1140251 OTHER inversion 24896259

Variation tolerance for SIGLEC9 Gene

Residual Variation Intolerance Score: 83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.60; 65.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SIGLEC9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIGLEC9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIGLEC9 Gene

Disorders for SIGLEC9 Gene

Additional Disease Information for SIGLEC9

No disorders were found for SIGLEC9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIGLEC9 Gene

Publications for SIGLEC9 Gene

  1. Siglec-9, a novel sialic acid binding member of the immunoglobulin superfamily expressed broadly on human blood leukocytes. (PMID: 10801862) Zhang JQ … Crocker PR (The Journal of biological chemistry 2000) 3 4 23
  2. Identification and molecular characterization of a novel member of the siglec family (SIGLEC9). (PMID: 10903842) Foussias G … Diamandis EP (Genomics 2000) 2 3 4
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
  5. Cloning, characterization, and phylogenetic analysis of siglec-9, a new member of the CD33-related group of siglecs. Evidence for co-evolution with sialic acid synthesis pathways. (PMID: 10801860) Angata T … Varki A (The Journal of biological chemistry 2000) 3 4

Products for SIGLEC9 Gene

Sources for SIGLEC9 Gene