Aliases for SIGLEC7 Gene

Aliases for SIGLEC7 Gene

  • Sialic Acid Binding Ig Like Lectin 7 2 3 5
  • Sialic Acid-Binding Ig-Like Lectin 7 3 4
  • QA79 Membrane Protein 3 4
  • P75/AIRM1 2 3
  • D-Siglec 3 4
  • SIGLEC-7 2 3
  • CDw328 3 4
  • AIRM-1 3 4
  • AIRM1 3 4
  • CD328 2 3
  • QA79 2 3
  • P75 3 4
  • Sialic Acid Binding Ig-Like Lectin 19, Pseudogene 2
  • Adhesion Inhibitory Receptor Molecule 1, Siglec-7 3
  • Sialic Acid Binding Ig-Like Lectin, Pseudogene 2 2
  • Sialic Acid Binding Immunoglobulin-Like Lectin 7 3
  • Adhesion Inhibitory Receptor Molecule 1 4
  • Sialic Acid Binding Ig-Like Lectin 7 2
  • CD328 Antigen 4
  • SIGLEC19P 3
  • SIGLECP2 3
  • Siglec-7 4
  • SIGLEC7 5

External Ids for SIGLEC7 Gene

Previous HGNC Symbols for SIGLEC7 Gene

  • SIGLEC19P
  • SIGLECP2

Previous GeneCards Identifiers for SIGLEC7 Gene

  • GC19P052276
  • GC19P052006
  • GC19P056321
  • GC19P056337
  • GC19P056299
  • GC19P051645
  • GC19P047978

Summaries for SIGLEC7 Gene

GeneCards Summary for SIGLEC7 Gene

SIGLEC7 (Sialic Acid Binding Ig Like Lectin 7) is a Protein Coding gene. Diseases associated with SIGLEC7 include Congenital Disorder Of Glycosylation, Type Iic. Among its related pathways are Hematopoietic Stem Cells and Lineage-specific Markers and Innate Immune System. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is SIGLEC12.

UniProtKB/Swiss-Prot Summary for SIGLEC7 Gene

  • Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).

Gene Wiki entry for SIGLEC7 Gene

Additional gene information for SIGLEC7 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SIGLEC7 Gene

Genomics for SIGLEC7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SIGLEC7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J051141 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE dbSUPER 608.5 +1.0 1043 3.8 IKZF1 GABPA NR2F2 EZH2 SIGLEC7 ENSG00000267895 NONHSAG026348.2 lnc-SIGLEC9-3 CD33
GH19J051140 Promoter/Enhancer 0.5 Ensembl dbSUPER 600.7 -1.9 -1859 0.4 HSALNG0127182 SIGLEC7 SIGLEC17P CTU1 KLK14 KLK10 ENSG00000267990 lnc-SIGLEC9-1 SIGLEC9
GH19J051136 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 6.9 -4.3 -4289 3.7 ARHGAP35 IKZF1 MTA2 PKNOX1 ZNF24 REST POLR2A MNT ZNF766 NFE2 ENSG00000267990 lnc-SIGLEC9-1 SIGLEC17P CTU1 SIGLEC9 KLK14 KLK10 SIGLEC7 SIGLEC10 CD33
GH19J051570 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 2.8 +430.0 429967 3.6 PRDM10 ZNF629 REST SIX5 IKZF1 ZNF692 JUND STAT3 GABPA ZNF143 ZNF175 ZNF766 ZNF701 ZNF350 ZNF616 ZNF808 ZNF841 SIGLEC14 SIGLEC5 RPL7P51
GH19J051466 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE 3 +325.4 325374 2.7 HNRNPL ZNF512 RFX1 LEF1 IKZF1 ETV6 JUND DDX20 MTA2 PHF21A ENSG00000268957 SIGLEC26P lnc-SIGLEC8-1 SIGLEC6 ZNF175 SIGLEC14 SIGLEC5 RPL7P51 FPR3 SIGLEC12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SIGLEC7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SIGLEC7

Top Transcription factor binding sites by QIAGEN in the SIGLEC7 gene promoter:
  • Arnt
  • ARP-1
  • CREB
  • CUTL1
  • deltaCREB
  • PPAR-gamma1
  • PPAR-gamma2
  • TGIF

Genomic Locations for SIGLEC7 Gene

Genomic Locations for SIGLEC7 Gene
chr19:51,142,260-51,153,526
(GRCh38/hg38)
Size:
11,267 bases
Orientation:
Plus strand
chr19:51,645,556-51,656,783
(GRCh37/hg19)
Size:
11,228 bases
Orientation:
Plus strand

Genomic View for SIGLEC7 Gene

Genes around SIGLEC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIGLEC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIGLEC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLEC7 Gene

Proteins for SIGLEC7 Gene

  • Protein details for SIGLEC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y286-SIGL7_HUMAN
    Recommended name:
    Sialic acid-binding Ig-like lectin 7
    Protein Accession:
    Q9Y286
    Secondary Accessions:
    • Q9NZQ1
    • Q9UJ86
    • Q9UJ87
    • Q9Y502

    Protein attributes for SIGLEC7 Gene

    Size:
    467 amino acids
    Molecular mass:
    51143 Da
    Quaternary structure:
    • Interacts with PTPN6/SHP-1 upon phosphorylation.
    SequenceCaution:
    • Sequence=AAF44346.1; Type=Frameshift; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Three dimensional structures from OCA and Proteopedia for SIGLEC7 Gene

    Alternative splice isoforms for SIGLEC7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIGLEC7 Gene

Post-translational modifications for SIGLEC7 Gene

  • Tyrosine phosphorylated.
  • Glycosylation at Asn105, Asn142, Asn242, Asn165, Asn260, Asn229, Asn235, and Asn334
  • Modification sites at PhosphoSitePlus

Other Protein References for SIGLEC7 Gene

Antibody Products

  • Boster Bio Antibodies for SIGLEC7

No data available for DME Specific Peptides for SIGLEC7 Gene

Domains & Families for SIGLEC7 Gene

Gene Families for SIGLEC7 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SIGLEC7 Gene

InterPro:
Blocks:
  • Immunoglobulin C-2 type
  • Immunoglobulin V-set
ProtoNet:

Suggested Antigen Peptide Sequences for SIGLEC7 Gene

GenScript: Design optimal peptide antigens:
  • p75 (SIGL7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y286

UniProtKB/Swiss-Prot:

SIGL7_HUMAN :
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Domain:
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with SIGLEC7: view

Function for SIGLEC7 Gene

Molecular function for SIGLEC7 Gene

UniProtKB/Swiss-Prot Function:
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
GENATLAS Biochemistry:
sialic acid binding Ig-like lectin 7,inhibitory receptor expressed in natural killer cells and monocytes,sialoadhesin,Ig superfamily

Phenotypes From GWAS Catalog for SIGLEC7 Gene

Gene Ontology (GO) - Molecular Function for SIGLEC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding TAS,IEA --
GO:0033691 sialic acid binding IBA 21873635
GO:0038023 signaling receptor activity TAS 10499918
genes like me logo Genes that share ontologies with SIGLEC7: view
genes like me logo Genes that share phenotypes with SIGLEC7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIGLEC7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SIGLEC7 Gene

Localization for SIGLEC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC7 Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIGLEC7 gene
Compartment Confidence
plasma membrane 5
extracellular 3
lysosome 2
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SIGLEC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10567377
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SIGLEC7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SIGLEC7 Gene

Pathways & Interactions for SIGLEC7 Gene

genes like me logo Genes that share pathways with SIGLEC7: view

Pathways by source for SIGLEC7 Gene

Gene Ontology (GO) - Biological Process for SIGLEC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IBA 21873635
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with SIGLEC7: view

No data available for SIGNOR curated interactions for SIGLEC7 Gene

Drugs & Compounds for SIGLEC7 Gene

(3) Drugs for SIGLEC7 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
N-acetyl-alpha-D-glucosamine Experimental Pharma Target 0
mannose Investigational Pharma 0
genes like me logo Genes that share compounds with SIGLEC7: view

Transcripts for SIGLEC7 Gene

mRNA/cDNA for SIGLEC7 Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIGLEC7

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: -
SP2: - -
SP3: - - - - -
SP4: - - - - - -
SP5:

Relevant External Links for SIGLEC7 Gene

GeneLoc Exon Structure for
SIGLEC7

Expression for SIGLEC7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SIGLEC7 Gene

mRNA differential expression in normal tissues according to GTEx for SIGLEC7 Gene

This gene is overexpressed in Whole Blood (x22.0) and Spleen (x9.2).

Protein differential expression in normal tissues from HIPED for SIGLEC7 Gene

This gene is overexpressed in NK cells (24.8), Monocytes (23.9), CD8 Tcells (6.5), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SIGLEC7 Gene



Protein tissue co-expression partners for SIGLEC7 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SIGLEC7

SOURCE GeneReport for Unigene cluster for SIGLEC7 Gene:

Hs.655393

mRNA Expression by UniProt/SwissProt for SIGLEC7 Gene:

Q9Y286-SIGL7_HUMAN
Tissue specificity: Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for SIGLEC7 Gene

  • Spleen(4.5)
  • Blood(4.5)
  • Lymph node(4.4)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with SIGLEC7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIGLEC7 Gene

Orthologs for SIGLEC7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SIGLEC7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SIGLEC7 30
  • 98.69 (n)
-- 31
  • 45 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 65 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Siglece 31
  • 53 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 47 (a)
ManyToMany
Species where no ortholog for SIGLEC7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SIGLEC7 Gene

ENSEMBL:
Gene Tree for SIGLEC7 (if available)
TreeFam:
Gene Tree for SIGLEC7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SIGLEC7: view image

Paralogs for SIGLEC7 Gene

(9) SIMAP similar genes for SIGLEC7 Gene using alignment to 2 proteins:

  • SIGL7_HUMAN
  • M0QY65_HUMAN

Pseudogenes.org Pseudogenes for SIGLEC7 Gene

genes like me logo Genes that share paralogs with SIGLEC7: view

Variants for SIGLEC7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SIGLEC7 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
777506 Benign: not provided 51,144,513(+) A/G MISSENSE_VARIANT,INTRON_VARIANT
VAR_035523 A colorectal cancer sample p.Leu215Pro

Additional dbSNP identifiers (rs#s) for SIGLEC7 Gene

Structural Variations from Database of Genomic Variants (DGV) for SIGLEC7 Gene

Variant ID Type Subtype PubMed ID
nsv1140251 OTHER inversion 24896259

Variation tolerance for SIGLEC7 Gene

Residual Variation Intolerance Score: 70.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SIGLEC7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIGLEC7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIGLEC7 Gene

Disorders for SIGLEC7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SIGLEC7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
congenital disorder of glycosylation, type iic
  • rhs
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SIGLEC7

genes like me logo Genes that share disorders with SIGLEC7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SIGLEC7 Gene

Publications for SIGLEC7 Gene

  1. Identification and characterization of a novel siglec, siglec-7, expressed by human natural killer cells and monocytes. (PMID: 10567377) Nicoll G … Crocker PR (The Journal of biological chemistry 1999) 2 3 4 23
  2. The decreased expression of Siglec-7 represents an early marker of dysfunctional natural killer-cell subsets associated with high levels of HIV-1 viremia. (PMID: 19710502) Brunetta E … Mavilio D (Blood 2009) 3 23
  3. The structure of siglec-7 in complex with sialosides: leads for rational structure-based inhibitor design. (PMID: 16623661) Attrill H … van Aalten DM (The Biochemical journal 2006) 3 4
  4. Structure of the saccharide-binding domain of the human natural killer cell inhibitory receptor p75/AIRM1. (PMID: 14747738) Dimasi N … Mariuzza RA (Acta crystallographica. Section D, Biological crystallography 2004) 3 4
  5. High resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec family. (PMID: 12438315) Alphey MS … van Aalten DM (The Journal of biological chemistry 2003) 3 4

Products for SIGLEC7 Gene

  • Boster Bio Antibodies for SIGLEC7
  • Boster Bio ELISA Kits for SIGLEC7

Sources for SIGLEC7 Gene