Aliases for SIGLEC6 Gene
External Ids for SIGLEC6 Gene
Previous HGNC Symbols for SIGLEC6 Gene
Previous GeneCards Identifiers for SIGLEC6 Gene
This gene encodes a member of the SIGLEC (sialic acid binding immunoglobulin-like lectin) family of proteins. The encoded transmembrane receptor binds sialyl-TN glycans and leptin. Placental expression of the encoded protein is upregulated in preeclampsia. [provided by RefSeq, Jul 2016]
GeneCards Summary for SIGLEC6 Gene
SIGLEC6 (Sialic Acid Binding Ig Like Lectin 6) is a Protein Coding gene. Diseases associated with SIGLEC6 include Non-Gestational Choriocarcinoma. Among its related pathways are Innate Immune System and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is SIGLEC5.
UniProtKB/Swiss-Prot Summary for SIGLEC6 Gene
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.