This gene encodes a member of the SIGLEC (sialic acid binding immunoglobulin-like lectin) family of proteins. The encoded transmembrane receptor binds sialyl-TN glycans and leptin. Placental expression of the encoded protein is upregulated in preeclampsia. [provided by RefSeq, Jul 2016] See more...

Aliases for SIGLEC6 Gene

Aliases for SIGLEC6 Gene

  • Sialic Acid Binding Ig Like Lectin 6 2 3 5
  • Sialic Acid-Binding Ig-Like Lectin 6 3 4
  • Obesity-Binding Protein 1 3 4
  • CD33 Antigen-Like 1 3 4
  • CD33L1 3 4
  • OB-BP1 2 4
  • CD327 2 3
  • CD33L 3 4
  • OBBP1 3 4
  • Sialic Acid Binding Ig-Like Lectin 6 2
  • CD327 Antigen 4
  • SIGLEC-6 2
  • Siglec-6 4
  • SIGLEC6 5
  • CD33L2 3
  • CDW327 3
  • CDw327 4

External Ids for SIGLEC6 Gene

Previous HGNC Symbols for SIGLEC6 Gene

  • CD33L
  • CD33L1

Previous GeneCards Identifiers for SIGLEC6 Gene

  • GC19M052651
  • GC19M052382
  • GC19M056696
  • GC19M056712
  • GC19M052020
  • GC19M048355

Summaries for SIGLEC6 Gene

Entrez Gene Summary for SIGLEC6 Gene

  • This gene encodes a member of the SIGLEC (sialic acid binding immunoglobulin-like lectin) family of proteins. The encoded transmembrane receptor binds sialyl-TN glycans and leptin. Placental expression of the encoded protein is upregulated in preeclampsia. [provided by RefSeq, Jul 2016]

GeneCards Summary for SIGLEC6 Gene

SIGLEC6 (Sialic Acid Binding Ig Like Lectin 6) is a Protein Coding gene. Diseases associated with SIGLEC6 include Non-Gestational Choriocarcinoma. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is ENSG00000268500.

UniProtKB/Swiss-Prot Summary for SIGLEC6 Gene

  • Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SIGLEC6 Gene

Genomics for SIGLEC6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SIGLEC6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SIGLEC6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SIGLEC6

Top Transcription factor binding sites by QIAGEN in the SIGLEC6 gene promoter:
  • GATA-1
  • Ik-3
  • LUN-1
  • NF-kappaB
  • NF-kappaB1
  • NRSF form 1
  • NRSF form 2
  • RelA
  • USF-1
  • USF1

Genomic Locations for SIGLEC6 Gene

Genomic Locations for SIGLEC6 Gene
chr19:51,517,819-51,531,856
(GRCh38/hg38)
Size:
14,038 bases
Orientation:
Minus strand
chr19:52,022,779-52,035,110
(GRCh37/hg19)
Size:
12,332 bases
Orientation:
Minus strand

Genomic View for SIGLEC6 Gene

Genes around SIGLEC6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIGLEC6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIGLEC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLEC6 Gene

Proteins for SIGLEC6 Gene

  • Protein details for SIGLEC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43699-SIGL6_HUMAN
    Recommended name:
    Sialic acid-binding Ig-like lectin 6
    Protein Accession:
    O43699
    Secondary Accessions:
    • A8MV71
    • B2RTS8
    • C9JBE5
    • F8WA78
    • O15388
    • O43700

    Protein attributes for SIGLEC6 Gene

    Size:
    453 amino acids
    Molecular mass:
    49913 Da
    Quaternary structure:
    • Interacts with LEP.
    SequenceCaution:
    • Sequence=AAB70702.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH35359.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI40799.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA24983.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA24984.1; Type=Erroneous initiation; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 2]: Should not be confused with SIGLEC5 which has been called CD33L2.

    Alternative splice isoforms for SIGLEC6 Gene

neXtProt entry for SIGLEC6 Gene

Post-translational modifications for SIGLEC6 Gene

  • Glycosylation at Asn103, Asn149, Asn163, and Asn233
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SIGLEC6 Gene

Domains & Families for SIGLEC6 Gene

Gene Families for SIGLEC6 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SIGLEC6 Gene

Suggested Antigen Peptide Sequences for SIGLEC6 Gene

GenScript: Design optimal peptide antigens:
  • Obesity-binding protein 1 (SIGL6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43699

UniProtKB/Swiss-Prot:

SIGL6_HUMAN :
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Domain:
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with SIGLEC6: view

Function for SIGLEC6 Gene

Molecular function for SIGLEC6 Gene

UniProtKB/Swiss-Prot Function:
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
GENATLAS Biochemistry:
sialic acid binding Ig-like lectin 6,expressed in placenta,spleen,peripheral blood leukocytes and small intestine,mediating cell-cell recognition,also binding leptin and potentially modulator of leptin levels,sialoadhesin family,Ig superfamily

Phenotypes From GWAS Catalog for SIGLEC6 Gene

Gene Ontology (GO) - Molecular Function for SIGLEC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0030246 carbohydrate binding IEA --
GO:0033691 sialic acid binding IBA 21873635
genes like me logo Genes that share ontologies with SIGLEC6: view
genes like me logo Genes that share phenotypes with SIGLEC6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIGLEC6

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SIGLEC6 Gene

Localization for SIGLEC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC6 Gene

[Isoform 1]: Cell membrane. Single-pass type I membrane protein.
[Isoform 2]: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIGLEC6 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SIGLEC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IBA 21873635
GO:0005887 integral component of plasma membrane TAS 9465907
GO:0016020 membrane TAS 9465907
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SIGLEC6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SIGLEC6 Gene

Pathways & Interactions for SIGLEC6 Gene

genes like me logo Genes that share pathways with SIGLEC6: view

Pathways by source for SIGLEC6 Gene

Gene Ontology (GO) - Biological Process for SIGLEC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IBA 21873635
GO:0007267 cell-cell signaling TAS 9465907
genes like me logo Genes that share ontologies with SIGLEC6: view

No data available for SIGNOR curated interactions for SIGLEC6 Gene

Drugs & Compounds for SIGLEC6 Gene

No Compound Related Data Available

Transcripts for SIGLEC6 Gene

mRNA/cDNA for SIGLEC6 Gene

6 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIGLEC6

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC6 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: -
SP3: - -
SP4: - -
SP5: -
SP6:

Relevant External Links for SIGLEC6 Gene

GeneLoc Exon Structure for
SIGLEC6

Expression for SIGLEC6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SIGLEC6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SIGLEC6 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x6.0), Esophagus - Muscularis (x4.3), Esophagus - Gastroesophageal Junction (x4.2), and Lung (x4.1).

Protein differential expression in normal tissues from HIPED for SIGLEC6 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SIGLEC6 Gene



Protein tissue co-expression partners for SIGLEC6 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SIGLEC6

SOURCE GeneReport for Unigene cluster for SIGLEC6 Gene:

Hs.720304

mRNA Expression by UniProt/SwissProt for SIGLEC6 Gene:

O43699-SIGL6_HUMAN
Tissue specificity: Expressed at high levels in placenta (cyto- and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine.
genes like me logo Genes that share expression patterns with SIGLEC6: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIGLEC6 Gene

Orthologs for SIGLEC6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SIGLEC6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SIGLEC6 30 31
  • 99.04 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SIGLEC6 31
  • 45 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Siglec5 31
  • 37 (a)
ManyToMany
Species where no ortholog for SIGLEC6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SIGLEC6 Gene

ENSEMBL:
Gene Tree for SIGLEC6 (if available)
TreeFam:
Gene Tree for SIGLEC6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SIGLEC6: view image

Paralogs for SIGLEC6 Gene

(10) SIMAP similar genes for SIGLEC6 Gene using alignment to 1 proteins:

  • SIGL6_HUMAN

Pseudogenes.org Pseudogenes for SIGLEC6 Gene

genes like me logo Genes that share paralogs with SIGLEC6: view

Variants for SIGLEC6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SIGLEC6 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
712817 Benign: not provided 51,531,585(-) C/G MISSENSE_VARIANT
729001 Benign: not provided 51,528,229(-) C/T MISSENSE_VARIANT,INTRON_VARIANT
789352 Benign: not provided 51,531,295(-) C/A MISSENSE_VARIANT
rs370040093 Uncertain Significance: Malignant tumor of prostate 51,529,853(-) C/A MISSENSE_VARIANT
rs2005199 - p.Leu262Phe

Additional dbSNP identifiers (rs#s) for SIGLEC6 Gene

Structural Variations from Database of Genomic Variants (DGV) for SIGLEC6 Gene

Variant ID Type Subtype PubMed ID
esv2758767 CNV gain+loss 17122850
nsv1140251 OTHER inversion 24896259
nsv469584 CNV loss 16826518

Variation tolerance for SIGLEC6 Gene

Residual Variation Intolerance Score: 86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.58; 72.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SIGLEC6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIGLEC6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIGLEC6 Gene

Disorders for SIGLEC6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SIGLEC6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
non-gestational choriocarcinoma
  • choriocarcinoma, non-gestational
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SIGLEC6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SIGLEC6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SIGLEC6 Gene

Publications for SIGLEC6 Gene

  1. Molecular cloning of a novel gene similar to myeloid antigen CD33 and its specific expression in placenta. (PMID: 9465907) Takei Y … Nakamura Y (Cytogenetics and cell genetics 1997) 2 3 4 23
  2. Severe preeclampsia-related changes in gene expression at the maternal-fetal interface include sialic acid-binding immunoglobulin-like lectin-6 and pappalysin-2. (PMID: 18818296) Winn VD … Fisher SJ (Endocrinology 2009) 3 23
  3. OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily. (PMID: 10428856) Patel N … Kastelein RA (The Journal of biological chemistry 1999) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2. (PMID: 30639242) Kovalski JR … Khavari PA (Molecular cell 2019) 3

Products for SIGLEC6 Gene

  • Signalway ELISA kits for SIGLEC6
  • Signalway Proteins for SIGLEC6

Sources for SIGLEC6 Gene