This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cel... See more...

Aliases for SIGLEC5 Gene

Aliases for SIGLEC5 Gene

  • Sialic Acid Binding Ig Like Lectin 5 2 3 5
  • OB-BP2 2 3 4
  • Sialic Acid-Binding Ig-Like Lectin 5 3 4
  • Obesity-Binding Protein 2 3 4
  • OB-Binding Protein 2 3 4
  • CD33 Antigen-Like 2 3 4
  • SIGLEC-5 2 3
  • CD33L2 3 4
  • CD170 2 3
  • OBBP2 3 4
  • Sialic Acid-Binding Immunoglobulin-Like Lectin 5 3
  • Sialic Acid Binding Ig-Like Lectin 5 2
  • CD170 Antigen 4
  • Siglec-5 4
  • SIGLEC5 5

External Ids for SIGLEC5 Gene

Previous HGNC Symbols for SIGLEC5 Gene

  • CD33L2

Previous GeneCards Identifiers for SIGLEC5 Gene

  • GC19M052745
  • GC19M052476
  • GC19M056791
  • GC19M056806
  • GC19M052114

Summaries for SIGLEC5 Gene

Entrez Gene Summary for SIGLEC5 Gene

  • This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012]

GeneCards Summary for SIGLEC5 Gene

SIGLEC5 (Sialic Acid Binding Ig Like Lectin 5) is a Protein Coding gene. Diseases associated with SIGLEC5 include Ovarian Cystic Teratoma and Herpetic Whitlow. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is ENSG00000268500.

UniProtKB/Swiss-Prot Summary for SIGLEC5 Gene

  • Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Gene Wiki entry for SIGLEC5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SIGLEC5 Gene

Genomics for SIGLEC5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SIGLEC5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SIGLEC5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SIGLEC5

Top Transcription factor binding sites by QIAGEN in the SIGLEC5 gene promoter:
  • Arnt
  • ARP-1
  • c-Myb
  • CUTL1
  • FOXO4
  • GATA-3
  • POU2F1
  • POU2F1a
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for SIGLEC5 Gene

Genomic Locations for SIGLEC5 Gene
chr19:51,610,967-51,645,545
(GRCh38/hg38)
Size:
34,579 bases
Orientation:
Minus strand
chr19:52,114,781-52,150,151
(GRCh37/hg19)
Size:
35,371 bases
Orientation:
Minus strand

Genomic View for SIGLEC5 Gene

Genes around SIGLEC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIGLEC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIGLEC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLEC5 Gene

Proteins for SIGLEC5 Gene

  • Protein details for SIGLEC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15389-SIGL5_HUMAN
    Recommended name:
    Sialic acid-binding Ig-like lectin 5
    Protein Accession:
    O15389

    Protein attributes for SIGLEC5 Gene

    Size:
    551 amino acids
    Molecular mass:
    60715 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SIGLEC5 Gene

neXtProt entry for SIGLEC5 Gene

Post-translational modifications for SIGLEC5 Gene

  • Glycosylation at Asn100, Asn210, Asn231, Asn253, Asn328, Asn375, Asn384, and Asn393
  • Modification sites at PhosphoSitePlus

Other Protein References for SIGLEC5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Assay Products

  • Boster Bio ELISA Kits for SIGLEC5
  • Signalway ELISA kits for SIGLEC5

No data available for DME Specific Peptides for SIGLEC5 Gene

Domains & Families for SIGLEC5 Gene

Gene Families for SIGLEC5 Gene

Protein Domains for SIGLEC5 Gene

InterPro:
Blocks:
  • Immunoglobulin C-2 type
ProtoNet:

Suggested Antigen Peptide Sequences for SIGLEC5 Gene

GenScript: Design optimal peptide antigens:
  • Obesity-binding protein 2 (SIGL5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O15389

UniProtKB/Swiss-Prot:

SIGL5_HUMAN :
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Domain:
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with SIGLEC5: view

Function for SIGLEC5 Gene

Molecular function for SIGLEC5 Gene

UniProtKB/Swiss-Prot Function:
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
GENATLAS Biochemistry:
sialic acid binding Ig-like lectin 5,expressed in neutrophils,with alternatively spliced transcripts,sialoadhesin family,Ig superfamily

Phenotypes From GWAS Catalog for SIGLEC5 Gene

Gene Ontology (GO) - Molecular Function for SIGLEC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0030246 carbohydrate binding IEA --
GO:0033691 sialic acid binding IBA 21873635
genes like me logo Genes that share ontologies with SIGLEC5: view
genes like me logo Genes that share phenotypes with SIGLEC5: view

Animal Model Products

CRISPR Products

miRNA for SIGLEC5 Gene

miRTarBase miRNAs that target SIGLEC5

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIGLEC5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SIGLEC5 Gene

Localization for SIGLEC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC5 Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIGLEC5 gene
Compartment Confidence
plasma membrane 4
extracellular 2
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SIGLEC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030667 secretory granule membrane TAS --
GO:0070821 tertiary granule membrane TAS --
genes like me logo Genes that share ontologies with SIGLEC5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SIGLEC5 Gene

Pathways & Interactions for SIGLEC5 Gene

genes like me logo Genes that share pathways with SIGLEC5: view

Interacting Proteins for SIGLEC5 Gene

Gene Ontology (GO) - Biological Process for SIGLEC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IBA 21873635
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with SIGLEC5: view

No data available for SIGNOR curated interactions for SIGLEC5 Gene

Drugs & Compounds for SIGLEC5 Gene

(1) Drugs for SIGLEC5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for SIGLEC5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SIGLEC5: view

Transcripts for SIGLEC5 Gene

mRNA/cDNA for SIGLEC5 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIGLEC5

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC5 Gene

No ASD Table

Relevant External Links for SIGLEC5 Gene

GeneLoc Exon Structure for
SIGLEC5

Expression for SIGLEC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SIGLEC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SIGLEC5 Gene

This gene is overexpressed in Whole Blood (x21.3), Testis (x9.2), Spleen (x7.6), and Small Intestine - Terminal Ileum (x5.3).

Protein differential expression in normal tissues from HIPED for SIGLEC5 Gene

This gene is overexpressed in Neutrophil (39.5), Monocytes (13.6), and Peripheral blood mononuclear cells (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SIGLEC5 Gene



Protein tissue co-expression partners for SIGLEC5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SIGLEC5

SOURCE GeneReport for Unigene cluster for SIGLEC5 Gene:

Hs.310333

mRNA Expression by UniProt/SwissProt for SIGLEC5 Gene:

O15389-SIGL5_HUMAN
Tissue specificity: Expressed by monocytic/myeloid lineage cells. Found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. Expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation.

Evidence on tissue expression from TISSUES for SIGLEC5 Gene

  • Nervous system(4.9)
  • Lung(4.2)
  • Blood(3.9)
  • Kidney(3.2)
  • Pancreas(2.9)
  • Bone marrow(2.6)
  • Intestine(2.6)
  • Spleen(2.6)
  • Heart(2.3)
  • Skin(2.2)
  • Eye(2.2)
genes like me logo Genes that share expression patterns with SIGLEC5: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SIGLEC5 Gene

Orthologs for SIGLEC5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SIGLEC5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 95 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia SIGLEC5 30
  • 76.05 (n)
-- 31
  • 63 (a)
ManyToMany
-- 31
  • 57 (a)
ManyToMany
-- 31
  • 55 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia SIGLEC5 30
  • 75.74 (n)
-- 31
  • 62 (a)
ManyToMany
-- 31
  • 57 (a)
ManyToMany
Species where no ortholog for SIGLEC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SIGLEC5 Gene

ENSEMBL:
Gene Tree for SIGLEC5 (if available)
TreeFam:
Gene Tree for SIGLEC5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SIGLEC5: view image

Paralogs for SIGLEC5 Gene

(8) SIMAP similar genes for SIGLEC5 Gene using alignment to 1 proteins:

  • SIGL5_HUMAN
genes like me logo Genes that share paralogs with SIGLEC5: view

Variants for SIGLEC5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SIGLEC5 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
716507 Benign: not provided 51,629,045(-) G/A SYNONYMOUS_VARIANT
785642 Benign: not provided 51,628,043(-) T/C MISSENSE_VARIANT
rs1807124 - p.Met215Val
rs1973019 - p.Val72Ala
rs2278831 - p.Phe322Ser

Additional dbSNP identifiers (rs#s) for SIGLEC5 Gene

Structural Variations from Database of Genomic Variants (DGV) for SIGLEC5 Gene

Variant ID Type Subtype PubMed ID
dgv1061e212 CNV loss 25503493
dgv1062e212 CNV loss 25503493
dgv1063e212 CNV gain 25503493
dgv3623n100 CNV loss 25217958
dgv424n27 CNV loss 19166990
dgv593n67 CNV loss 20364138
dgv6517n54 CNV loss 21841781
dgv6518n54 CNV loss 21841781
dgv6519n54 CNV loss 21841781
dgv6520n54 CNV gain+loss 21841781
dgv6521n54 CNV loss 21841781
dgv656e199 CNV deletion 23128226
esv2516533 CNV deletion 19546169
esv2659920 CNV deletion 23128226
esv27396 CNV loss 19812545
esv2758767 CNV gain+loss 17122850
esv2760513 CNV gain+loss 21179565
esv3644675 CNV loss 21293372
nsv1056611 CNV loss 25217958
nsv1058762 CNV gain 25217958
nsv1072362 CNV deletion 25765185
nsv1140251 OTHER inversion 24896259
nsv1150213 CNV duplication 26484159
nsv1160656 CNV deletion 26073780
nsv181 CNV deletion 15895083
nsv2532 CNV deletion 18451855
nsv2534 CNV insertion 18451855
nsv458725 CNV loss 19166990
nsv469584 CNV loss 16826518
nsv510771 CNV deletion 20534489
nsv579966 CNV loss 21841781
nsv579967 CNV loss 21841781
nsv579968 CNV loss 21841781
nsv9741 CNV loss 18304495

Variation tolerance for SIGLEC5 Gene

Residual Variation Intolerance Score: 63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.71; 83.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SIGLEC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIGLEC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIGLEC5 Gene

Disorders for SIGLEC5 Gene

MalaCards: The human disease database

(73) MalaCards diseases for SIGLEC5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ovarian cystic teratoma
herpetic whitlow
  • herpetic felon
mature teratoma of the ovary
ophthalmia neonatorum
  • gonococcal conjunctivitis
fallopian tube disease
  • fallopian tube diseases
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SIGLEC5

genes like me logo Genes that share disorders with SIGLEC5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SIGLEC5 Gene

Publications for SIGLEC5 Gene

  1. Structural implications of Siglec-5-mediated sialoglycan recognition. (PMID: 18022638) Zhuravleva MA … Sun PD (Journal of molecular biology 2008) 3 4 23
  2. Assignment of the human OB binding protein-2 gene (CD33L2) to chromosome 19q13.3 by radiation hybrid mapping. (PMID: 10343116) Kim HS (Cytogenetics and cell genetics 1999) 2 3 23
  3. Characterization of siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33. (PMID: 9731071) Cornish AL … Crocker PR (Blood 1998) 3 4 23
  4. Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates. (PMID: 17012248) Angata T … Nakamura M (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for SIGLEC5 Gene

  • Signalway ELISA kits for SIGLEC5
  • Signalway Proteins for SIGLEC5

Sources for SIGLEC5 Gene