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Aliases for SIGLEC16 Gene
Aliases for SIGLEC16 Gene
External Ids for SIGLEC16 Gene
- HGNC: 24851
- Entrez Gene: 400709
- Ensembl: ENSG00000161643
- UniProtKB: A6NMB1
Previous HGNC Symbols for SIGLEC16 Gene
- SIGLECP16
Previous GeneCards Identifiers for SIGLEC16 Gene
- GC19P055168
- GC19P050473
- GC19P046849
Summaries for SIGLEC16 Gene
GeneCards Summary for SIGLEC16 Gene
SIGLEC16 (Sialic Acid Binding Ig Like Lectin 16) is a Protein Coding gene. Among its related pathways are Innate Immune System and RET signaling. Gene Ontology (GO) annotations related to this gene include carbohydrate binding.
UniProtKB/Swiss-Prot Summary for SIGLEC16 Gene
-
Putative adhesion molecule that mediates sialic-acid dependent binding to cells.
Additional gene information for SIGLEC16 Gene
- HGNC(24851)
- Entrez Gene(400709)
- Ensembl(ENSG00000161643)
- UniProtKB(A6NMB1)
- Open Targets Platform(ENSG00000161643)
- Search for SIGLEC16 at DataMed
- Search for SIGLEC16 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SIGLEC16 Gene
Genomics for SIGLEC16 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SIGLEC16 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SIGLEC16 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SIGLEC16
- Top Transcription factor binding sites by QIAGEN in the SIGLEC16 gene promoter:
-
- E2F
- E2F-1
- E2F-2
- E2F-3a
- FOXO1
- FOXO1a
Genomic Locations for SIGLEC16 Gene
Genomic Locations for SIGLEC16 Gene
- chr19:49,969,664-49,975,814
- (GRCh38/hg38)
- Size:
- 6,151 bases
- Orientation:
- Plus strand
- chr19:50,472,857-50,479,076
- (GRCh37/hg19)
- Size:
- 6,220 bases
- Orientation:
- Plus strand
Genomic View for SIGLEC16 Gene
Genes around SIGLEC16 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.33 by HGNC
- 19q13.33 by Entrez Gene
- 19q13.33 by Ensembl
SIGLEC16 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SIGLEC16 Gene
Proteins for SIGLEC16 Gene
-
Protein details for SIGLEC16 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A6NMB1-SIG16_HUMAN
- Recommended name:
- Sialic acid-binding Ig-like lectin 16
- Protein Accession:
- A6NMB1
Protein attributes for SIGLEC16 Gene
- Size:
- 481 amino acids
- Molecular mass:
- 52992 Da
- Quaternary structure:
- No Data Available
Protein Expression for SIGLEC16 Gene
Post-translational modifications for SIGLEC16 Gene
-
Glycosylation at Asn43, Asn78, Asn338, and Asn347
- NX_A6NMB1 (NX_A6NMB1-1)
Other Protein References for SIGLEC16 Gene
- REFSEQ proteins:
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for SIGLEC16
- Origene Custom Protein Services for SIGLEC16
No data available for DME Specific Peptides for SIGLEC16 Gene
Domains & Families for SIGLEC16 Gene
Gene Families for SIGLEC16 Gene
Protein Domains for SIGLEC16 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SIGLEC16 Gene
- GenScript: Design optimal peptide antigens:
-
- Siglec-P16 (SIG16_HUMAN)
Graphical View of Domain Structure for InterPro Entry
A6NMB1UniProtKB/Swiss-Prot:
SIG16_HUMAN :- Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
- Family:
-
- Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Function for SIGLEC16 Gene
Molecular function for SIGLEC16 Gene
- UniProtKB/Swiss-Prot Function:
- Putative adhesion molecule that mediates sialic-acid dependent binding to cells.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 28100677 |
| GO:0030246 | carbohydrate binding | IEA | -- |
| GO:0033691 | sialic acid binding | IBA | 21873635 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SIGLEC16 - Select products 50% OFF >
- * SIGLEC16 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SIGLEC16
miRNA for SIGLEC16 Gene
- miRTarBase miRNAs that target SIGLEC16
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for SIGLEC16 - Select products 50% OFF >
- * SIGLEC16 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SIGLEC16
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SIGLEC16 Gene
Localization for SIGLEC16 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC16 Gene
- Membrane. Single-pass type I membrane protein.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IBA, TAS | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for SIGLEC16 Gene
Pathways & Interactions for SIGLEC16 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | RET signaling | ||
Pathways by source for SIGLEC16 Gene
3 Reactome pathways for SIGLEC16 Gene
Interacting Proteins for SIGLEC16 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007155 | cell adhesion | IBA | 21873635 |
| GO:0032755 | positive regulation of interleukin-6 production | IDA | 28100677 |
| GO:0045087 | innate immune response | TAS | -- |
| GO:1900426 | positive regulation of defense response to bacterium | IDA | 28100677 |
No data available for SIGNOR curated interactions for SIGLEC16 Gene
Transcripts for SIGLEC16 Gene
mRNA/cDNA for SIGLEC16 Gene
- 1 REFSEQ mRNAs :
- 4 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000599858 1437 nts (view in UCSC)
- ENST00000602139 2510 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SIGLEC16 - Select products 50% OFF >
- * SIGLEC16 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SIGLEC16
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for SIGLEC16 - Select products 50% OFF >
- * SIGLEC16 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SIGLEC16
Relevant External Links for SIGLEC16 Gene
- GeneLoc Exon Structure for
- SIGLEC16
Expression for SIGLEC16 Gene
mRNA differential expression in normal tissues according to GTEx for SIGLEC16 Gene
This gene is overexpressed in Ovary (x20.4), Spleen (x8.2), and Whole Blood (x4.6).
This gene is overexpressed in Synovial fluid (12.5), Placenta (12.4), Platelet (7.6), and Monocytes (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SIGLEC16 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SIGLEC16
SOURCE GeneReport for Unigene cluster for SIGLEC16 Gene:
Hs.568076mRNA Expression by UniProt/SwissProt for SIGLEC16 Gene:
A6NMB1-SIG16_HUMAN
Tissue specificity:
Expressed in bone marrow, fetal brain, fetal liver, lung and salivary gland. Detected in brain, macrophage, cancerous esophagus and lung at protein level.
Primer Products
-
OriGene qPCR primer pairs for SIGLEC16
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIGLEC16 Gene
Orthologs for SIGLEC16 Gene
No data available for Orthologs for SIGLEC16 Gene
Paralogs for SIGLEC16 Gene
(10) SIMAP similar genes for SIGLEC16 Gene using alignment to 2 proteins:
- SIG16_HUMAN
- I1VSB5_HUMAN
No data available for Paralogs for SIGLEC16 Gene
Variants for SIGLEC16 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv54n68 | CNV | loss | 17160897 |
| esv3644630 | CNV | gain | 21293372 |
| esv3644635 | CNV | gain | 21293372 |
| nsv1065648 | CNV | gain | 25217958 |
| nsv1065753 | CNV | gain | 25217958 |
| nsv1140251 | OTHER | inversion | 24896259 |
| nsv579912 | CNV | gain | 21841781 |
| nsv7309 | OTHER | inversion | 18451855 |
| nsv9739 | CNV | gain+loss | 18304495 |
Additional Variant Information for SIGLEC16 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for SIGLEC16 Gene
Disorders for SIGLEC16 Gene
Additional Disease Information for SIGLEC16
No disorders were found for SIGLEC16 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIGLEC16 Gene
Publications for SIGLEC16 Gene
- SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans. (PMID: 18629938) Cao H … Barrow AD (European journal of immunology 2008) 2 3 4
- Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia. (PMID: 11986327) Angata T … Varki A (The Journal of biological chemistry 2002) 2 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
ExternalLinks
Products for SIGLEC16 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for SIGLEC16
- Origene Custom Protein Services for SIGLEC16
- Browse OriGene Inhibitory RNA Products For SIGLEC16
- OriGene qPCR primer pairs for SIGLEC16
- OriGene CRISPR knockouts for SIGLEC16
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SIGLEC16
- Sino Biological Human cDNA Clone for SIGLEC16
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- VectorBuilder Custom and pre-made DNA vectors for SIGLEC16 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for SIGLEC16 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for SIGLEC16 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for SIGLEC16 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for SIGLEC16
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for SIGLEC16
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for SIGLEC16
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SIGLEC16
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for SIGLEC16
Sources for SIGLEC16 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB