Aliases for SIGLEC16 Gene

Aliases for SIGLEC16 Gene

  • Sialic Acid Binding Ig Like Lectin 16 2 3 5
  • Siglec-P16 2 3 4
  • Sialic Acid Binding Ig-Like Lectin, Pseudogene 16 2 3
  • Sialic Acid-Binding Ig-Like Lectin 16 3 4
  • SIGLECP16 3 4
  • Siglec-16 3 4
  • Sialic Acid Binding Ig-Like Lectin 16 (Gene/Pseudogene) 2
  • Sialic Acid Binding Ig Like Lectin 16 (Gene/Pseudogene) 2
  • Sialic Acid-Binding Immunoglobulin-Like Lectin 16 3
  • SIGLEC16 5

External Ids for SIGLEC16 Gene

Previous HGNC Symbols for SIGLEC16 Gene


Previous GeneCards Identifiers for SIGLEC16 Gene

  • GC19P055168
  • GC19P050473
  • GC19P046849

Summaries for SIGLEC16 Gene

GeneCards Summary for SIGLEC16 Gene

SIGLEC16 (Sialic Acid Binding Ig Like Lectin 16) is a Protein Coding gene. Among its related pathways are Innate Immune System and RET signaling. Gene Ontology (GO) annotations related to this gene include carbohydrate binding.

UniProtKB/Swiss-Prot Summary for SIGLEC16 Gene

  • Putative adhesion molecule that mediates sialic-acid dependent binding to cells.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SIGLEC16 Gene

Genomics for SIGLEC16 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SIGLEC16 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J049969 Promoter 0.4 Ensembl 250.7 +0.2 201 0.4 PRDM10 HSALNG0127061 HSALNG0127062 SIGLEC16 lnc-ATF5-2 MN297603 ZNF473
GH19J050022 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 41.9 +55.4 55375 4.9 BCLAF1 SP1 ZNF207 NCOR1 MYC IKZF1 SIX5 ZNF580 ZNF592 ATF2 ZNF473 VRK3 lnc-SIGLEC11-2 NUP62 POLD1 PTOV1-AS2 SIGLEC16 SNORD35A SNORD35B ALDH16A1
GH19J049983 Enhancer 0.8 ENCODE 31.9 +14.2 14219 0.2 BCLAF1 ZNF207 ZNF654 CTCF REST TRIM22 FOXA2 SAP130 RAD21 SMC3 lnc-ZNF473-4 SIGLEC16 ENSG00000221125 IL4I1 NUP62 ATF5 lnc-SIGLEC11-1 VRK3 ZNF473
GH19J049976 Enhancer 0.4 ENCODE 30.2 +7.5 7523 1.4 ZNF384 TEAD4 CBFA2T3 HSALNG0127064 HSALNG0127065 SIGLEC16 VRK3 ENSG00000221125 SIGLEC11 ZNF473
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SIGLEC16 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SIGLEC16

Top Transcription factor binding sites by QIAGEN in the SIGLEC16 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • FOXO1
  • FOXO1a

Genomic Locations for SIGLEC16 Gene

Latest Assembly
6,220 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
6,151 bases
Plus strand

(GRCh37/hg19 by Ensembl)
6,215 bases
Plus strand

Genomic View for SIGLEC16 Gene

Genes around SIGLEC16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIGLEC16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIGLEC16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLEC16 Gene

Proteins for SIGLEC16 Gene

  • Protein details for SIGLEC16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sialic acid-binding Ig-like lectin 16
    Protein Accession:

    Protein attributes for SIGLEC16 Gene

    481 amino acids
    Molecular mass:
    52992 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SIGLEC16 Gene

Post-translational modifications for SIGLEC16 Gene

  • Glycosylation at Asn43, Asn78, Asn338, and Asn347

Other Protein References for SIGLEC16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SIGLEC16 Gene

Domains & Families for SIGLEC16 Gene

Protein Domains for SIGLEC16 Gene

Suggested Antigen Peptide Sequences for SIGLEC16 Gene

GenScript: Design optimal peptide antigens:
  • Siglec-P16 (SIG16_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with SIGLEC16: view

Function for SIGLEC16 Gene

Molecular function for SIGLEC16 Gene

UniProtKB/Swiss-Prot Function:
Putative adhesion molecule that mediates sialic-acid dependent binding to cells.

Gene Ontology (GO) - Molecular Function for SIGLEC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 28100677
GO:0030246 carbohydrate binding IEA --
GO:0033691 sialic acid binding IBA 21873635
genes like me logo Genes that share ontologies with SIGLEC16: view

miRNA for SIGLEC16 Gene

miRTarBase miRNAs that target SIGLEC16

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SIGLEC16 Gene

Localization for SIGLEC16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC16 Gene

Membrane. Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for SIGLEC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA, TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SIGLEC16: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for SIGLEC16 Gene

Pathways & Interactions for SIGLEC16 Gene

PathCards logo

SuperPathways for SIGLEC16 Gene

genes like me logo Genes that share pathways with SIGLEC16: view

Pathways by source for SIGLEC16 Gene

3 Reactome pathways for SIGLEC16 Gene

Interacting Proteins for SIGLEC16 Gene

Selected Interacting proteins: A6NMB1-SIG16_HUMAN for SIGLEC16 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for SIGLEC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IBA 21873635
GO:0032755 positive regulation of interleukin-6 production IDA 28100677
GO:0045087 innate immune response TAS --
GO:1900426 positive regulation of defense response to bacterium IDA 28100677
genes like me logo Genes that share ontologies with SIGLEC16: view

No data available for SIGNOR curated interactions for SIGLEC16 Gene

Drugs & Compounds for SIGLEC16 Gene

No Compound Related Data Available

Transcripts for SIGLEC16 Gene

mRNA/cDNA for SIGLEC16 Gene

4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC16 Gene

No ASD Table

Relevant External Links for SIGLEC16 Gene

GeneLoc Exon Structure for

Expression for SIGLEC16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SIGLEC16 Gene

mRNA differential expression in normal tissues according to GTEx for SIGLEC16 Gene

This gene is overexpressed in Ovary (x20.4), Spleen (x8.2), and Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for SIGLEC16 Gene

This gene is overexpressed in Synovial fluid (12.5), Placenta (12.4), Platelet (7.6), and Monocytes (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SIGLEC16 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SIGLEC16

SOURCE GeneReport for Unigene cluster for SIGLEC16 Gene:


mRNA Expression by UniProt/SwissProt for SIGLEC16 Gene:

Tissue specificity: Expressed in bone marrow, fetal brain, fetal liver, lung and salivary gland. Detected in brain, macrophage, cancerous esophagus and lung at protein level.
genes like me logo Genes that share expression patterns with SIGLEC16: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIGLEC16 Gene

Orthologs for SIGLEC16 Gene

Evolution for SIGLEC16 Gene

Gene Tree for SIGLEC16 (if available)
Gene Tree for SIGLEC16 (if available)
Alliance of Genome Resources:
Additional Orthologs for SIGLEC16

No data available for Orthologs for SIGLEC16 Gene

Paralogs for SIGLEC16 Gene

(10) SIMAP similar genes for SIGLEC16 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SIGLEC16: view

No data available for Paralogs for SIGLEC16 Gene

Variants for SIGLEC16 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SIGLEC16 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SIGLEC16 Gene

Variant ID Type Subtype PubMed ID
dgv54n68 CNV loss 17160897
esv3644630 CNV gain 21293372
esv3644635 CNV gain 21293372
nsv1065648 CNV gain 25217958
nsv1065753 CNV gain 25217958
nsv1140251 OTHER inversion 24896259
nsv579912 CNV gain 21841781
nsv7309 OTHER inversion 18451855
nsv9739 CNV gain+loss 18304495

Additional Variant Information for SIGLEC16 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for SIGLEC16 Gene

Disorders for SIGLEC16 Gene

Additional Disease Information for SIGLEC16

No disorders were found for SIGLEC16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIGLEC16 Gene

Publications for SIGLEC16 Gene

  1. SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans. (PMID: 18629938) Cao H … Barrow AD (European journal of immunology 2008) 2 3 4
  2. Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia. (PMID: 11986327) Angata T … Varki A (The Journal of biological chemistry 2002) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
  5. Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen. (PMID: 28100677) Schwarz F … Varki A (The EMBO journal 2017) 3

Products for SIGLEC16 Gene

Sources for SIGLEC16 Gene