Aliases for SIGLEC15 Gene

Aliases for SIGLEC15 Gene

  • Sialic Acid Binding Ig Like Lectin 15 2 3 5
  • CD33 Antigen-Like 3 2 3 4
  • Sialic Acid-Binding Ig-Like Lectin 15 3 4
  • CD33 Molecule-Like 3 2 3
  • HsT1361 2 3
  • CD33L3 3 4
  • Sialic Acid Binding Ig-Like Lectin 15 2
  • SIGLEC-15 3
  • Siglec-15 4
  • SIGLEC15 5

External Ids for SIGLEC15 Gene

Previous HGNC Symbols for SIGLEC15 Gene

  • CD33L3

Previous GeneCards Identifiers for SIGLEC15 Gene

  • GC18P041660
  • GC18P043405
  • GC18P040262

Summaries for SIGLEC15 Gene

GeneCards Summary for SIGLEC15 Gene

SIGLEC15 (Sialic Acid Binding Ig Like Lectin 15) is a Protein Coding gene. Diseases associated with SIGLEC15 include Osteoporosis, Juvenile. Among its related pathways are Innate Immune System and RET signaling. An important paralog of this gene is SIGLEC5.

UniProtKB/Swiss-Prot Summary for SIGLEC15 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SIGLEC15 Gene

Genomics for SIGLEC15 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SIGLEC15 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J045825 Promoter/Enhancer 0.8 EPDnew dbSUPER 250.7 -0.2 -182 0.1 IKZF1 ZNF366 IKZF2 EP300 HSALNG0121277 SIGLEC15 piR-56341-088 SLC14A1 EPG5
GH18J045827 Promoter/Enhancer 0.7 EPDnew dbSUPER 250.7 +0.0 22 0.1 IKZF1 IKZF2 EP300 HSALNG0121277 SIGLEC15 EPG5
GH18J045828 Enhancer 0.3 ENCODE dbSUPER 250.7 +0.2 216 0.2 HSALNG0121277 SIGLEC15 EPG5
GH18J045801 Enhancer 0.9 ENCODE dbSUPER 13.8 -22.7 -22674 3.6 JUND CEBPB MAX ZNF217 MBD2 ELF1 CTBP1 CUX1 USF2 RAD21 SIGLEC15 SLC14A1 EPG5 HSALNG0121278 piR-37623 HSALNG0121277
GH18J045773 Promoter/Enhancer 1.3 ENCODE CraniofacialAtlas dbSUPER 6.3 -50.8 -50795 2.6 BCLAF1 ZNF580 POLR2A YY1 FEZF1 TBP GABPA HCFC1 EBF1 ZNF843 lnc-SLC14A1-1 SIGLEC15 lnc-SLC14A1-4 ENSG00000288545 HSALNG0121262-003 LOC105372093 SLC14A1 lnc-SLC14A1-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SIGLEC15 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SIGLEC15

Top Transcription factor binding sites by QIAGEN in the SIGLEC15 gene promoter:
  • AML1a
  • ARP-1
  • ATF6
  • c-Ets-1
  • HSF1 (long)
  • HSF1short
  • HSF2

Genomic Locations for SIGLEC15 Gene

Latest Assembly
18,420 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
18,420 bases
Plus strand

(GRCh37/hg19 by Ensembl)
18,569 bases
Plus strand

Genomic View for SIGLEC15 Gene

Genes around SIGLEC15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIGLEC15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIGLEC15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLEC15 Gene

Proteins for SIGLEC15 Gene

  • Protein details for SIGLEC15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sialic acid-binding Ig-like lectin 15
    Protein Accession:
    Secondary Accessions:
    • A8K2Y5
    • B4DVQ9

    Protein attributes for SIGLEC15 Gene

    328 amino acids
    Molecular mass:
    35653 Da
    Quaternary structure:
    • Interacts with TYROBP and HCST.

    Alternative splice isoforms for SIGLEC15 Gene


neXtProt entry for SIGLEC15 Gene

Post-translational modifications for SIGLEC15 Gene

  • Glycosylation at Asn172
  • Modification sites at PhosphoSitePlus

Other Protein References for SIGLEC15 Gene

No data available for DME Specific Peptides for SIGLEC15 Gene

Domains & Families for SIGLEC15 Gene

Gene Families for SIGLEC15 Gene

Protein Domains for SIGLEC15 Gene

  • Immunoglobulin subtype

Suggested Antigen Peptide Sequences for SIGLEC15 Gene

GenScript: Design optimal peptide antigens:
  • SIGLEC-15 (A7E1W7_HUMAN)
  • cDNA FLJ59768 (B4DVQ9_HUMAN)
  • CD33 antigen-like 3 (SIG15_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with SIGLEC15: view

Function for SIGLEC15 Gene

Molecular function for SIGLEC15 Gene

UniProtKB/Swiss-Prot Function:
Binds sialylated glycoproteins.

Phenotypes From GWAS Catalog for SIGLEC15 Gene

genes like me logo Genes that share phenotypes with SIGLEC15: view

Animal Models for SIGLEC15 Gene

MGI Knock Outs for SIGLEC15:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIGLEC15

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIGLEC15 Gene

Localization for SIGLEC15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC15 Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIGLEC15 gene
Compartment Confidence
plasma membrane 4
extracellular 2
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SIGLEC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0032991 protein-containing complex IEA --
genes like me logo Genes that share ontologies with SIGLEC15: view

Pathways & Interactions for SIGLEC15 Gene

PathCards logo

SuperPathways for SIGLEC15 Gene

genes like me logo Genes that share pathways with SIGLEC15: view

Pathways by source for SIGLEC15 Gene

3 Reactome pathways for SIGLEC15 Gene

Interacting Proteins for SIGLEC15 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000374125 Q6ZMC9-SIG15_HUMAN for SIGLEC15 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SIGLEC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032956 regulation of actin cytoskeleton organization IBA 21873635
GO:0045087 innate immune response TAS --
GO:0045124 regulation of bone resorption IBA 21873635
GO:2001204 regulation of osteoclast development IBA 21873635
genes like me logo Genes that share ontologies with SIGLEC15: view

No data available for SIGNOR curated interactions for SIGLEC15 Gene

Drugs & Compounds for SIGLEC15 Gene

No Compound Related Data Available

Transcripts for SIGLEC15 Gene

mRNA/cDNA for SIGLEC15 Gene

9 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIGLEC15

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC15 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: -
SP2: -
SP3: - -

Relevant External Links for SIGLEC15 Gene

GeneLoc Exon Structure for

Expression for SIGLEC15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SIGLEC15 Gene

mRNA differential expression in normal tissues according to GTEx for SIGLEC15 Gene

This gene is overexpressed in Bladder (x10.5), Whole Blood (x4.6), and Spleen (x4.2).

Protein differential expression in normal tissues from HIPED for SIGLEC15 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (61.9) and Breast (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SIGLEC15 Gene

Protein tissue co-expression partners for SIGLEC15 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SIGLEC15

SOURCE GeneReport for Unigene cluster for SIGLEC15 Gene:


mRNA Expression by UniProt/SwissProt for SIGLEC15 Gene:

Tissue specificity: Expressed in macrophage and/or dendritic cells of spleen and lymph nodes.

Evidence on tissue expression from TISSUES for SIGLEC15 Gene

  • Blood(4.3)
  • Spleen(4.3)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with SIGLEC15: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIGLEC15 Gene

Orthologs for SIGLEC15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIGLEC15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SIGLEC15 29 30
  • 98.48 (n)
(Bos Taurus)
Mammalia SIGLEC15 29 30
  • 86.18 (n)
(Mus musculus)
Mammalia Siglec15 29 16 30
  • 85.65 (n)
(Rattus norvegicus)
Mammalia Siglec15 29
  • 83.65 (n)
(Canis familiaris)
Mammalia SIGLEC15 29 30
  • 83.43 (n)
(Monodelphis domestica)
Mammalia SIGLEC15 30
  • 54 (a)
(Gallus gallus)
Aves SIGLEC15 29 30
  • 57.96 (n)
(Anolis carolinensis)
Reptilia SIGLEC15 30
  • 54 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia siglec15 29
  • 53.54 (n)
(Danio rerio)
Actinopterygii si:dkey-11p23.7 29
  • 50.52 (n)
  • 34 (a)
Species where no ortholog for SIGLEC15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SIGLEC15 Gene

Gene Tree for SIGLEC15 (if available)
Gene Tree for SIGLEC15 (if available)
Evolutionary constrained regions (ECRs) for SIGLEC15: view image
Alliance of Genome Resources:
Additional Orthologs for SIGLEC15

Paralogs for SIGLEC15 Gene

genes like me logo Genes that share paralogs with SIGLEC15: view

Variants for SIGLEC15 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SIGLEC15 Gene

SNP ID Clinical significance and condition Chr 18 pos Variation AA Info Type
rs2919643 -- p.Phe273Leu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SIGLEC15 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SIGLEC15 Gene

Variant ID Type Subtype PubMed ID
dgv613e214 CNV gain 21293372
esv3642417 CNV loss 21293372
esv3893100 CNV gain 25118596
nsv525268 CNV gain 19592680

Variation tolerance for SIGLEC15 Gene

Gene Damage Index Score: 9.70; 89.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SIGLEC15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIGLEC15 Gene

Disorders for SIGLEC15 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SIGLEC15 Gene - From: COP

Disorder Aliases PubMed IDs
osteoporosis, juvenile
  • idiopathic juvenile osteoporosis; ijo
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SIGLEC15

genes like me logo Genes that share disorders with SIGLEC15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SIGLEC15 Gene

Publications for SIGLEC15 Gene

  1. Siglec-15: an immune system Siglec conserved throughout vertebrate evolution. (PMID: 17483134) Angata T … Nakamura M (Glycobiology 2007) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. LINC00973 is involved in cancer immune suppression through positive regulation of Siglec-15 in clear-cell renal cell carcinoma. (PMID: 32780490) Liu Y … Huang Y (Cancer science 2020) 3
  4. N-glycosylation of Siglec-15 decreases its lysosome-dependent degradation and promotes its transportation to the cell membrane. (PMID: 32921411) Chen X … Huang Z (Biochemical and biophysical research communications 2020) 3
  5. Siglec-15: a potential regulator of osteoporosis, cancer, and infectious diseases. (PMID: 31900164) Angata T (Journal of biomedical science 2020) 3

Products for SIGLEC15 Gene

Sources for SIGLEC15 Gene