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Aliases for SIGLEC15 Gene

Aliases for SIGLEC15 Gene

  • Sialic Acid Binding Ig Like Lectin 15 2 3 5
  • CD33 Antigen-Like 3 2 3 4
  • CD33 Molecule-Like 3 2 3
  • SIGLEC-15 3 4
  • CD33L3 3 4
  • Sialic Acid Binding Ig-Like Lectin 15 2
  • Sialic Acid-Binding Ig-Like Lectin 15 3
  • HsT1361 3

External Ids for SIGLEC15 Gene

Previous HGNC Symbols for SIGLEC15 Gene

  • CD33L3

Previous GeneCards Identifiers for SIGLEC15 Gene

  • GC18P041660
  • GC18P043405
  • GC18P040262

Summaries for SIGLEC15 Gene

GeneCards Summary for SIGLEC15 Gene

SIGLEC15 (Sialic Acid Binding Ig Like Lectin 15) is a Protein Coding gene. Among its related pathways are Innate Immune System and RET signaling.

UniProtKB/Swiss-Prot for SIGLEC15 Gene

  • Binds sialylated glycoproteins.

Additional gene information for SIGLEC15 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIGLEC15 Gene

Genomics for SIGLEC15 Gene

GeneHancer (GH) Regulatory Elements for SIGLEC15 Gene

Promoters and enhancers for SIGLEC15 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18I045825 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.3 289 0.8 ZFHX2 ZNF366 IKZF1 IKZF2 EGR2 SIGLEC15 GC18P045827 EPG5
GH18I045801 Enhancer 1.2 Ensembl ENCODE dbSUPER 13.8 -22.5 -22511 3.6 PKNOX1 CLOCK NFIB ZNF133 NEUROD1 NFXL1 FOS RCOR1 USF2 CEBPB SIGLEC15 SLC14A1 EPG5 GC18P045808 ENSG00000267558
GH18I045773 Enhancer 1.2 Ensembl ENCODE dbSUPER 6.3 -50.6 -50616 2.6 RB1 FEZF1 ZBTB40 RAD21 YY1 ZNF143 BCLAF1 IKZF2 SP3 HCFC1 SIGLEC15 LOC105372093 GC18M045733
GH18I045833 Enhancer 0.9 Ensembl ENCODE 7.5 +10.5 10523 4.7 CTCF MEIS2 PKNOX1 USF1 SUZ12 MAX SIN3A USF2 REST RAD21 SIGLEC15 EPG5 GC18P045827 GC18M045898
GH18I045771 Enhancer 0.7 FANTOM5 ENCODE 7.3 -53.6 -53585 1 ZFHX2 SOX6 SIGLEC15 SLC14A1 LOC105372093 GC18M045733
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SIGLEC15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SIGLEC15 gene promoter:

Genomic Locations for SIGLEC15 Gene

Genomic Locations for SIGLEC15 Gene
18,569 bases
Plus strand

Genomic View for SIGLEC15 Gene

Genes around SIGLEC15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIGLEC15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIGLEC15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLEC15 Gene

Proteins for SIGLEC15 Gene

  • Protein details for SIGLEC15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sialic acid-binding Ig-like lectin 15
    Protein Accession:
    Secondary Accessions:
    • A8K2Y5
    • B4DVQ9

    Protein attributes for SIGLEC15 Gene

    328 amino acids
    Molecular mass:
    35653 Da
    Quaternary structure:
    • Interacts with TYROBP and HCST.

    Alternative splice isoforms for SIGLEC15 Gene


neXtProt entry for SIGLEC15 Gene

Post-translational modifications for SIGLEC15 Gene

  • Glycosylation at posLast=172172
  • Modification sites at PhosphoSitePlus

Other Protein References for SIGLEC15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SIGLEC15 Gene

Domains & Families for SIGLEC15 Gene

Gene Families for SIGLEC15 Gene

Protein Domains for SIGLEC15 Gene

Suggested Antigen Peptide Sequences for SIGLEC15 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with SIGLEC15: view

Function for SIGLEC15 Gene

Molecular function for SIGLEC15 Gene

UniProtKB/Swiss-Prot Function:
Binds sialylated glycoproteins.
genes like me logo Genes that share phenotypes with SIGLEC15: view

Animal Models for SIGLEC15 Gene

MGI Knock Outs for SIGLEC15:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIGLEC15 Gene

Localization for SIGLEC15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC15 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIGLEC15 gene
Compartment Confidence
plasma membrane 5
extracellular 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SIGLEC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043234 protein complex IEA --
genes like me logo Genes that share ontologies with SIGLEC15: view

Pathways & Interactions for SIGLEC15 Gene

genes like me logo Genes that share pathways with SIGLEC15: view

Pathways by source for SIGLEC15 Gene

3 Reactome pathways for SIGLEC15 Gene

Gene Ontology (GO) - Biological Process for SIGLEC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032956 regulation of actin cytoskeleton organization IEA --
GO:0045087 innate immune response TAS --
GO:0045124 regulation of bone resorption IEA --
GO:2001204 regulation of osteoclast development IEA --
genes like me logo Genes that share ontologies with SIGLEC15: view

No data available for SIGNOR curated interactions for SIGLEC15 Gene

Drugs & Compounds for SIGLEC15 Gene

No Compound Related Data Available

Transcripts for SIGLEC15 Gene

mRNA/cDNA for SIGLEC15 Gene

Unigene Clusters for SIGLEC15 Gene

Sialic acid binding Ig-like lectin 15:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC15 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: -
SP2: -
SP3: - -

Relevant External Links for SIGLEC15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SIGLEC15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SIGLEC15 Gene

mRNA differential expression in normal tissues according to GTEx for SIGLEC15 Gene

This gene is overexpressed in Bladder (x10.5), Whole Blood (x4.6), and Spleen (x4.2).

Protein differential expression in normal tissues from HIPED for SIGLEC15 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (61.9) and Breast (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SIGLEC15 Gene

Protein tissue co-expression partners for SIGLEC15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SIGLEC15 Gene:


SOURCE GeneReport for Unigene cluster for SIGLEC15 Gene:


mRNA Expression by UniProt/SwissProt for SIGLEC15 Gene:

Tissue specificity: Expressed in macrophage and/or dendritic cells of spleen and lymph nodes.

Evidence on tissue expression from TISSUES for SIGLEC15 Gene

  • Blood(4)
  • Liver(4)
  • Spleen(4)
genes like me logo Genes that share expression patterns with SIGLEC15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIGLEC15 Gene

Orthologs for SIGLEC15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIGLEC15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SIGLEC15 33 34
  • 98.48 (n)
(Bos Taurus)
Mammalia SIGLEC15 33 34
  • 86.18 (n)
(Mus musculus)
Mammalia Siglec15 33 16 34
  • 85.65 (n)
(Rattus norvegicus)
Mammalia Siglec15 33
  • 83.65 (n)
(Canis familiaris)
Mammalia SIGLEC15 33 34
  • 83.43 (n)
(Monodelphis domestica)
Mammalia SIGLEC15 34
  • 54 (a)
(Gallus gallus)
Aves SIGLEC15 33 34
  • 57.96 (n)
(Anolis carolinensis)
Reptilia SIGLEC15 34
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia siglec15 33
  • 53.54 (n)
(Danio rerio)
Actinopterygii si:dkey-11p23.7 33
  • 50.52 (n)
  • 34 (a)
Species where no ortholog for SIGLEC15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SIGLEC15 Gene

Gene Tree for SIGLEC15 (if available)
Gene Tree for SIGLEC15 (if available)

Paralogs for SIGLEC15 Gene

No data available for Paralogs for SIGLEC15 Gene

Variants for SIGLEC15 Gene

Sequence variations from dbSNP and Humsavar for SIGLEC15 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000135281 -- 45,829,618(+) CCCCC/CCCCCC intron_variant
rs1000146526 -- 45,828,474(+) G/A intron_variant
rs1000192772 -- 45,841,457(+) G/C intron_variant
rs1000679785 -- 45,834,381(+) C/T intron_variant
rs1000846482 -- 45,833,184(+) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SIGLEC15 Gene

Variant ID Type Subtype PubMed ID
dgv613e214 CNV gain 21293372
esv3642417 CNV loss 21293372
esv3893100 CNV gain 25118596
nsv525268 CNV gain 19592680

Variation tolerance for SIGLEC15 Gene

Gene Damage Index Score: 9.70; 89.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SIGLEC15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIGLEC15 Gene

Disorders for SIGLEC15 Gene

Additional Disease Information for SIGLEC15

No disorders were found for SIGLEC15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIGLEC15 Gene

Publications for SIGLEC15 Gene

  1. Siglec-15: an immune system Siglec conserved throughout vertebrate evolution. (PMID: 17483134) Angata T … Nakamura M (Glycobiology 2007) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 58
  4. The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-β secretion from monocytes/macrophages through the DAP12-Syk pathway. (PMID: 23035012) Takamiya R … Angata T (Glycobiology 2013) 3 58
  5. DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C … Lander ES (Nature 2005) 4 58

Products for SIGLEC15 Gene

Sources for SIGLEC15 Gene

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