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SIGLEC14 (Sialic Acid Binding Ig Like Lectin 14) is a Protein Coding gene. Among its related pathways are Innate Immune System and RET signaling. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is SIGLEC5.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0030246 | carbohydrate binding | IEA | -- |
GO:0033691 | sialic acid binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0070821 | tertiary granule membrane | TAS | -- |
GO:0101003 | ficolin-1-rich granule membrane | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
|
|
2 | RET signaling |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007155 | cell adhesion | IBA | 21873635 |
GO:0043312 | neutrophil degranulation | TAS | -- |
GO:0045087 | innate immune response | TAS | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SIGLEC5 30 |
|
||
-- 31 |
|
ManyToMany | |||
Cow (Bos Taurus) |
Mammalia | LOC512863 30 |
|
||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs118075827 | Benign: not provided | 51,644,020(-) |
G/A NM_001098612.2(SIGLEC14):c.771C>T (p.Ser257=) |
SYNONYMOUS |
No disorders were found for SIGLEC14 Gene.