Aliases for SIGLEC14 Gene

Aliases for SIGLEC14 Gene

  • Sialic Acid Binding Ig Like Lectin 14 2 3 5
  • Sialic Acid-Binding Ig-Like Lectin 14 3 4
  • Siglec-14 3 4
  • Sialic Acid Binding Ig-Like Lectin 14 2
  • LLNLR-470E3.1 3
  • SIGLEC14 5

External Ids for SIGLEC14 Gene

Previous GeneCards Identifiers for SIGLEC14 Gene

  • GC19U900740
  • GC19M056837
  • GC19M052115
  • GC19M052145

Summaries for SIGLEC14 Gene

GeneCards Summary for SIGLEC14 Gene

SIGLEC14 (Sialic Acid Binding Ig Like Lectin 14) is a Protein Coding gene. Among its related pathways are Innate Immune System and RET signaling. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is ENSG00000268500.

UniProtKB/Swiss-Prot Summary for SIGLEC14 Gene

  • Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors.

Additional gene information for SIGLEC14 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SIGLEC14 Gene

Genomics for SIGLEC14 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SIGLEC14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J051644 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 606.8 +1.0 977 3.1 BCOR SPI1 REST BHLHE40 ZMYM3 KDM1A IKZF1 RAD51 SIGLEC14 ENSG00000268500 SIGLEC5 lnc-SIGLEC5-1 IGLON5
GH19J051643 Promoter 0.3 EPDnew 600.7 +3.8 3810 0.1 SIGLEC14 ENSG00000273837 ENSG00000268500 SIGLEC5 lnc-SIGLEC5-1 ZNF175
GH19J051803 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 28.2 -159.2 -159247 5.6 CREB1 GATAD2A TFE3 LEF1 SOX13 IKZF1 FOXA1 MTA2 PKNOX1 RXRB FPR1 piR-37044 SIGLEC14 FPR3 SIGLEC8 RPL7P51 SIGLEC5 ZNF577 ENSG00000269483 ZNF766
GH19J051687 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 16.1 -43.6 -43639 6.9 RNF2 ARHGAP35 GATAD2A ZBTB33 TEAD4 PRDM10 ZNF512 RFX1 LEF1 IKZF1 SPACA6 ZNF137P ZNF808 ZNF841 ZNF577 ZNF616 ZNF766 ZNF175 ENSG00000268970 ENSG00000269825
GH19J051701 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas 17.4 -56.8 -56795 4.3 SP1 CREB1 CTCF TFE3 IKZF1 ZNF692 POLR2A BACH1 JUND LARP7 lnc-HAS1-2 SIGLEC14 HAS1 FPR1 FPR3 CEACAM18 RPL7P51 SIGLEC5 SPACA6 NONHSAG026381.2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SIGLEC14 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SIGLEC14

Top Transcription factor binding sites by QIAGEN in the SIGLEC14 gene promoter:
  • Arnt
  • ARP-1
  • FOXO4
  • GATA-3
  • POU2F1
  • POU2F1a
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for SIGLEC14 Gene

Genomic Locations for SIGLEC14 Gene
chr19:51,639,478-51,646,852
(GRCh38/hg38)
Size:
7,375 bases
Orientation:
Minus strand
chr19:52,145,806-52,150,132
(GRCh37/hg19)
Size:
4,327 bases
Orientation:
Minus strand

Genomic View for SIGLEC14 Gene

Genes around SIGLEC14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIGLEC14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIGLEC14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLEC14 Gene

Proteins for SIGLEC14 Gene

  • Protein details for SIGLEC14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08ET2-SIG14_HUMAN
    Recommended name:
    Sialic acid-binding Ig-like lectin 14
    Protein Accession:
    Q08ET2
    Secondary Accessions:
    • Q6UXG0

    Protein attributes for SIGLEC14 Gene

    Size:
    396 amino acids
    Molecular mass:
    43970 Da
    Quaternary structure:
    • Interacts with TYROBP.

neXtProt entry for SIGLEC14 Gene

Post-translational modifications for SIGLEC14 Gene

  • Glycosylation at Asn100, Asn210, Asn231, and Asn247
  • Glycosylation from GlyConnect
    • SIG14_HUMAN (1978)

Other Protein References for SIGLEC14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SIGLEC14 Gene

Domains & Families for SIGLEC14 Gene

Gene Families for SIGLEC14 Gene

Protein Domains for SIGLEC14 Gene

InterPro:
Blocks:
  • Immunoglobulin C-2 type
ProtoNet:

Suggested Antigen Peptide Sequences for SIGLEC14 Gene

GenScript: Design optimal peptide antigens:
  • Sialic acid-binding Ig-like lectin 14 (SIG14_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q08ET2

UniProtKB/Swiss-Prot:

SIG14_HUMAN :
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with SIGLEC14: view

Function for SIGLEC14 Gene

Molecular function for SIGLEC14 Gene

UniProtKB/Swiss-Prot Function:
Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors.

Phenotypes From GWAS Catalog for SIGLEC14 Gene

Gene Ontology (GO) - Molecular Function for SIGLEC14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
GO:0033691 sialic acid binding IBA 21873635
genes like me logo Genes that share ontologies with SIGLEC14: view

Animal Model Products

CRISPR Products

miRNA for SIGLEC14 Gene

miRTarBase miRNAs that target SIGLEC14

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIGLEC14

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SIGLEC14 Gene

Localization for SIGLEC14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC14 Gene

Cell membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIGLEC14 gene
Compartment Confidence
plasma membrane 3
extracellular 1
nucleus 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SIGLEC14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070821 tertiary granule membrane TAS --
GO:0101003 ficolin-1-rich granule membrane TAS --
genes like me logo Genes that share ontologies with SIGLEC14: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SIGLEC14 Gene

Pathways & Interactions for SIGLEC14 Gene

PathCards logo

SuperPathways for SIGLEC14 Gene

genes like me logo Genes that share pathways with SIGLEC14: view

Pathways by source for SIGLEC14 Gene

Gene Ontology (GO) - Biological Process for SIGLEC14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IBA 21873635
GO:0043312 neutrophil degranulation TAS --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with SIGLEC14: view

No data available for SIGNOR curated interactions for SIGLEC14 Gene

Drugs & Compounds for SIGLEC14 Gene

No Compound Related Data Available

Transcripts for SIGLEC14 Gene

mRNA/cDNA for SIGLEC14 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIGLEC14

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC14 Gene

No ASD Table

Relevant External Links for SIGLEC14 Gene

GeneLoc Exon Structure for
SIGLEC14

Expression for SIGLEC14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SIGLEC14 Gene

mRNA differential expression in normal tissues according to GTEx for SIGLEC14 Gene

This gene is overexpressed in Whole Blood (x32.2) and Spleen (x6.3).

Protein differential expression in normal tissues from HIPED for SIGLEC14 Gene

This gene is overexpressed in Serum (33.3), Cervix (17.9), and Cerebrospinal fluid (15.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SIGLEC14 Gene



Protein tissue co-expression partners for SIGLEC14 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SIGLEC14

SOURCE GeneReport for Unigene cluster for SIGLEC14 Gene:

Hs.707374

mRNA Expression by UniProt/SwissProt for SIGLEC14 Gene:

Q08ET2-SIG14_HUMAN
Tissue specificity: Mainly expressed in hematopoietic tissues including bone marrow, spleen and fetal liver. Also detected in lung and testis.
genes like me logo Genes that share expression patterns with SIGLEC14: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIGLEC14 Gene

Orthologs for SIGLEC14 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SIGLEC14 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SIGLEC5 30
  • 98.7 (n)
-- 31
  • 31 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia LOC512863 30
  • 77.17 (n)
-- 31
  • 58 (a)
ManyToMany
-- 31
  • 56 (a)
ManyToMany
-- 31
  • 39 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 62 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
Species where no ortholog for SIGLEC14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SIGLEC14 Gene

ENSEMBL:
Gene Tree for SIGLEC14 (if available)
TreeFam:
Gene Tree for SIGLEC14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SIGLEC14: view image

Paralogs for SIGLEC14 Gene

(11) SIMAP similar genes for SIGLEC14 Gene using alignment to 1 proteins:

  • SIG14_HUMAN

Pseudogenes.org Pseudogenes for SIGLEC14 Gene

genes like me logo Genes that share paralogs with SIGLEC14: view

Variants for SIGLEC14 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SIGLEC14 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
719833 Benign: not provided 51,644,020(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for SIGLEC14 Gene

Structural Variations from Database of Genomic Variants (DGV) for SIGLEC14 Gene

Variant ID Type Subtype PubMed ID
dgv1061e212 CNV loss 25503493
dgv1062e212 CNV loss 25503493
dgv1063e212 CNV gain 25503493
dgv1064e212 CNV loss 25503493
dgv1065e212 CNV loss 25503493
dgv1066e212 CNV gain 25503493
dgv30n47 CNV loss 21111241
dgv3623n100 CNV loss 25217958
dgv3624n100 CNV gain 25217958
dgv4e195 OTHER complex 20811451
dgv593n67 CNV loss 20364138
dgv594n67 CNV loss 20364138
dgv595n67 CNV loss 20364138
dgv6517n54 CNV loss 21841781
dgv6518n54 CNV loss 21841781
dgv6520n54 CNV gain+loss 21841781
dgv6521n54 CNV loss 21841781
dgv6522n54 CNV loss 21841781
dgv656e199 CNV deletion 23128226
esv2516533 CNV deletion 19546169
esv2571166 CNV loss 19546169
esv27396 CNV loss 19812545
esv2758767 CNV gain+loss 17122850
esv2760513 CNV gain+loss 21179565
esv2763154 CNV gain+loss 21179565
esv32724 CNV gain 17666407
esv3584741 CNV loss 24956385
esv3584742 CNV loss 24956385
esv3644676 CNV loss 21293372
esv3644677 CNV gain 21293372
nsv1058762 CNV gain 25217958
nsv1066529 CNV loss 25217958
nsv1072362 CNV deletion 25765185
nsv1140251 OTHER inversion 24896259
nsv1160656 CNV deletion 26073780
nsv1160657 OTHER complex 26073780
nsv181 CNV deletion 15895083
nsv2532 CNV deletion 18451855
nsv442771 CNV gain+loss 18776908
nsv458725 CNV loss 19166990
nsv469584 CNV loss 16826518
nsv510771 CNV deletion 20534489
nsv579967 CNV loss 21841781
nsv828611 CNV loss 20364138
nsv828612 CNV loss 20364138
nsv9741 CNV loss 18304495
nsv978899 CNV deletion 23825009

Variation tolerance for SIGLEC14 Gene

Residual Variation Intolerance Score: 83.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.45; 28.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SIGLEC14 Gene

Human Gene Mutation Database (HGMD)
SIGLEC14
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIGLEC14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIGLEC14 Gene

Disorders for SIGLEC14 Gene

No disorders were found for SIGLEC14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIGLEC14 Gene

Publications for SIGLEC14 Gene

  1. Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates. (PMID: 17012248) Angata T … Nakamura M (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
  3. Soluble Siglec-14 glycan-recognition protein is generated by alternative splicing and suppresses myeloid inflammatory responses. (PMID: 30377253) Huang PJ … Angata T (The Journal of biological chemistry 2018) 3
  4. Human gingiva transcriptome during wound healing. (PMID: 28005267) Wang Y … Tatakis DN (Journal of clinical periodontology 2017) 3
  5. The SIGLEC14 null allele is associated with Mycobacterium tuberculosis- and BCG-induced clinical and immunologic outcomes. (PMID: 28454648) Graustein AD … Hawn TR (Tuberculosis (Edinburgh, Scotland) 2017) 3

Products for SIGLEC14 Gene

Sources for SIGLEC14 Gene