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Aliases for SIGLEC14 Gene

Aliases for SIGLEC14 Gene

  • Sialic Acid Binding Ig Like Lectin 14 2 3 5
  • Siglec-14 3 4
  • Sialic Acid Binding Ig-Like Lectin 14 2
  • Sialic Acid-Binding Ig-Like Lectin 14 3
  • LLNLR-470E3.1 3

External Ids for SIGLEC14 Gene

Previous GeneCards Identifiers for SIGLEC14 Gene

  • GC19U900740
  • GC19M056837
  • GC19M052115
  • GC19M052145

Summaries for SIGLEC14 Gene

GeneCards Summary for SIGLEC14 Gene

SIGLEC14 (Sialic Acid Binding Ig Like Lectin 14) is a Protein Coding gene. Among its related pathways are Innate Immune System and RET signaling. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is ENSG00000268500.

UniProtKB/Swiss-Prot for SIGLEC14 Gene

  • Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors.

Additional gene information for SIGLEC14 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIGLEC14 Gene

Genomics for SIGLEC14 Gene

GeneHancer (GH) Regulatory Elements for SIGLEC14 Gene

Promoters and enhancers for SIGLEC14 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I051644 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 556.9 +1.0 1004 3.1 BCOR IKZF1 ZFP36 ZMYM3 KDM1A REST SPI1 SIGLEC14 SIGLEC5 ENSG00000268500 IGLON5
GH19I051803 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 28.2 -159.3 -159281 5.7 PKNOX1 ATF1 FOXA2 ARNT ZNF48 TCF12 ZNF766 GATA2 E2F8 ATF7 PIR60089 SIGLEC14 FPR3 SIGLEC8 RPL7P51 SIGLEC5 ZNF577 ENSG00000269483 ZNF766 SIGLEC12
GH19I051687 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 16.1 -43.6 -43612 6.9 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZBTB7B E2F8 ZNF207 ZNF143 ZNF137P ZNF808 ZNF841 ZNF616 ZNF766 ZNF577 ENSG00000268970 ZNF836 ENSG00000269825 ZNF175
GH19I051545 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 16.1 +97.1 97106 8 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A IRF4 POLR2B SIGLEC6 ZNF175 ZNF841 ZNF616 ZNF836 ZNF808 SIGLEC14 SIGLEC8 ZNF350 CEACAM18
GH19I051570 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.9 +74.7 74652 3.6 HDGF PKNOX1 SMAD1 ARNT ARID4B ZNF2 IRF4 YY1 POLR2B ZNF766 ZNF175 ZNF766 ZNF701 ZNF350 ZNF616 ZNF808 ZNF841 SIGLEC14 SIGLEC5 RPL7P51
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SIGLEC14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SIGLEC14 gene promoter:

Genomic Locations for SIGLEC14 Gene

Genomic Locations for SIGLEC14 Gene
4,327 bases
Minus strand

Genomic View for SIGLEC14 Gene

Genes around SIGLEC14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIGLEC14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIGLEC14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLEC14 Gene

Proteins for SIGLEC14 Gene

  • Protein details for SIGLEC14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sialic acid-binding Ig-like lectin 14
    Protein Accession:
    Secondary Accessions:
    • Q6UXG0

    Protein attributes for SIGLEC14 Gene

    396 amino acids
    Molecular mass:
    43970 Da
    Quaternary structure:
    • Interacts with TYROBP.

neXtProt entry for SIGLEC14 Gene

Post-translational modifications for SIGLEC14 Gene

Other Protein References for SIGLEC14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SIGLEC14 Gene

Domains & Families for SIGLEC14 Gene

Gene Families for SIGLEC14 Gene

Suggested Antigen Peptide Sequences for SIGLEC14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with SIGLEC14: view

Function for SIGLEC14 Gene

Molecular function for SIGLEC14 Gene

UniProtKB/Swiss-Prot Function:
Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors.

Phenotypes From GWAS Catalog for SIGLEC14 Gene

Gene Ontology (GO) - Molecular Function for SIGLEC14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with SIGLEC14: view

miRNA for SIGLEC14 Gene

miRTarBase miRNAs that target SIGLEC14

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SIGLEC14 Gene

Localization for SIGLEC14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC14 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIGLEC14 gene
Compartment Confidence
plasma membrane 4
cytosol 1

Gene Ontology (GO) - Cellular Components for SIGLEC14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070821 tertiary granule membrane TAS --
GO:0101003 ficolin-1-rich granule membrane TAS --
genes like me logo Genes that share ontologies with SIGLEC14: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SIGLEC14 Gene

Pathways & Interactions for SIGLEC14 Gene

genes like me logo Genes that share pathways with SIGLEC14: view

Pathways by source for SIGLEC14 Gene

Gene Ontology (GO) - Biological Process for SIGLEC14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0043312 neutrophil degranulation TAS --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with SIGLEC14: view

No data available for SIGNOR curated interactions for SIGLEC14 Gene

Drugs & Compounds for SIGLEC14 Gene

No Compound Related Data Available

Transcripts for SIGLEC14 Gene

mRNA/cDNA for SIGLEC14 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SIGLEC14 Gene

Sialic acid binding Ig-like lectin 14:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC14 Gene

No ASD Table

Relevant External Links for SIGLEC14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SIGLEC14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SIGLEC14 Gene

mRNA differential expression in normal tissues according to GTEx for SIGLEC14 Gene

This gene is overexpressed in Whole Blood (x32.2) and Spleen (x6.3).

Protein differential expression in normal tissues from HIPED for SIGLEC14 Gene

This gene is overexpressed in Serum (33.3), Cervix (17.9), and Cerebrospinal fluid (15.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SIGLEC14 Gene

Protein tissue co-expression partners for SIGLEC14 Gene

NURSA nuclear receptor signaling pathways regulating expression of SIGLEC14 Gene:


SOURCE GeneReport for Unigene cluster for SIGLEC14 Gene:


mRNA Expression by UniProt/SwissProt for SIGLEC14 Gene:

Tissue specificity: Mainly expressed in hematopoietic tissues including bone marrow, spleen and fetal liver. Also detected in lung and testis.
genes like me logo Genes that share expression patterns with SIGLEC14: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIGLEC14 Gene

Orthologs for SIGLEC14 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SIGLEC14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SIGLEC5 33
  • 98.7 (n)
-- 34
  • 31 (a)
(Bos Taurus)
Mammalia LOC512863 33
  • 77.17 (n)
-- 34
  • 58 (a)
-- 34
  • 56 (a)
-- 34
  • 39 (a)
(Canis familiaris)
Mammalia -- 34
  • 62 (a)
-- 34
  • 29 (a)
Species where no ortholog for SIGLEC14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SIGLEC14 Gene

Gene Tree for SIGLEC14 (if available)
Gene Tree for SIGLEC14 (if available)

Paralogs for SIGLEC14 Gene

(11) SIMAP similar genes for SIGLEC14 Gene using alignment to 1 proteins: Pseudogenes for SIGLEC14 Gene

genes like me logo Genes that share paralogs with SIGLEC14: view

Variants for SIGLEC14 Gene

Sequence variations from dbSNP and Humsavar for SIGLEC14 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000272286 -- 51,647,143(-) G/T upstream_transcript_variant
rs1001721362 -- 51,648,752(-) C/T upstream_transcript_variant
rs1002001968 -- 51,647,764(-) G/A upstream_transcript_variant
rs1002223027 -- 51,642,220(-) G/A 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1002572536 -- 51,641,625(-) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SIGLEC14 Gene

Variant ID Type Subtype PubMed ID
dgv1061e212 CNV loss 25503493
dgv1062e212 CNV loss 25503493
dgv1063e212 CNV gain 25503493
dgv1064e212 CNV loss 25503493
dgv1065e212 CNV loss 25503493
dgv1066e212 CNV gain 25503493
dgv30n47 CNV loss 21111241
dgv3623n100 CNV loss 25217958
dgv3624n100 CNV gain 25217958
dgv4e195 OTHER complex 20811451
dgv593n67 CNV loss 20364138
dgv594n67 CNV loss 20364138
dgv595n67 CNV loss 20364138
dgv6517n54 CNV loss 21841781
dgv6518n54 CNV loss 21841781
dgv6520n54 CNV gain+loss 21841781
dgv6521n54 CNV loss 21841781
dgv6522n54 CNV loss 21841781
dgv656e199 CNV deletion 23128226
esv2516533 CNV deletion 19546169
esv2571166 CNV loss 19546169
esv27396 CNV loss 19812545
esv2758767 CNV gain+loss 17122850
esv2760513 CNV gain+loss 21179565
esv2763154 CNV gain+loss 21179565
esv32724 CNV gain 17666407
esv3584741 CNV loss 24956385
esv3584742 CNV loss 24956385
esv3644676 CNV loss 21293372
esv3644677 CNV gain 21293372
nsv1058762 CNV gain 25217958
nsv1066529 CNV loss 25217958
nsv1072362 CNV deletion 25765185
nsv1140251 OTHER inversion 24896259
nsv1160656 CNV deletion 26073780
nsv1160657 OTHER complex 26073780
nsv181 CNV deletion 15895083
nsv2532 CNV deletion 18451855
nsv442771 CNV gain+loss 18776908
nsv458725 CNV loss 19166990
nsv469584 CNV loss 16826518
nsv510771 CNV deletion 20534489
nsv579967 CNV loss 21841781
nsv828611 CNV loss 20364138
nsv828612 CNV loss 20364138
nsv9741 CNV loss 18304495
nsv978899 CNV deletion 23825009

Variation tolerance for SIGLEC14 Gene

Residual Variation Intolerance Score: 83.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.45; 28.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SIGLEC14 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIGLEC14 Gene

Disorders for SIGLEC14 Gene

Additional Disease Information for SIGLEC14

No disorders were found for SIGLEC14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIGLEC14 Gene

Publications for SIGLEC14 Gene

  1. Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates. (PMID: 17012248) Angata T … Nakamura M (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006) 2 3 4 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  3. Human gingiva transcriptome during wound healing. (PMID: 28005267) Wang Y … Tatakis DN (Journal of clinical periodontology 2017) 3 58
  4. Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14. (PMID: 26459514) Fong JJ … Varki A (The EMBO journal 2015) 3 58
  5. Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus. (PMID: 24799499) Ali SR … Varki A (The Journal of experimental medicine 2014) 3 58

Products for SIGLEC14 Gene

Sources for SIGLEC14 Gene

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