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This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
SIGLEC11 (Sialic Acid Binding Ig Like Lectin 11) is a Protein Coding gene. Diseases associated with SIGLEC11 include Ovarian Cystic Teratoma. Among its related pathways are Innate Immune System and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is SIGLEC10.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0019902 | phosphatase binding | IPI | 11986327 |
GO:0030246 | carbohydrate binding | IEA | -- |
GO:0033691 | sialic acid binding | IDA | 11986327 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | IBA | 21873635 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Class I MHC mediated antigen processing and presentation | ||
2 | Innate Immune System |
.61
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|
3 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007155 | cell adhesion | IBA | 21873635 |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SIGLEC11 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
Cow (Bos Taurus) |
Mammalia | -- 31 |
|
OneToMany | |
Mouse (Mus musculus) |
Mammalia | Siglecg 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs112796514 | Benign: not provided | 49,951,945(-) |
G/A NM_052884.3(SIGLEC11):c.1776C>T (p.Arg592=) |
SYNONYMOUS | |
rs199756638 | Benign: not provided | 49,959,787(-) |
T/C NM_052884.3(SIGLEC11):c.779A>G (p.His260Arg) |
MISSENSE | |
rs200380048 | Likely Benign: not provided | 49,959,777(-) |
C/T NM_052884.3(SIGLEC11):c.789G>A (p.Thr263=) |
SYNONYMOUS | |
rs201740168 | Benign: not provided | 49,959,773(-) |
C/A NM_052884.3(SIGLEC11):c.793G>T (p.Ala265Ser) |
MISSENSE | |
rs57682421 | Benign: not provided | 49,958,478(-) |
G/C NM_052884.3(SIGLEC11):c.1456C>G (p.Arg486Gly) |
MISSENSE_VARIANT,INTRON |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv54n68 | CNV | loss | 17160897 |
esv2762046 | CNV | loss | 21179565 |
esv3644630 | CNV | gain | 21293372 |
esv3644632 | CNV | loss | 21293372 |
esv3644633 | CNV | loss | 21293372 |
esv3644634 | CNV | loss | 21293372 |
esv3644635 | CNV | gain | 21293372 |
nsv1058623 | CNV | gain | 25217958 |
nsv1065648 | CNV | gain | 25217958 |
nsv1140251 | OTHER | inversion | 24896259 |
nsv458720 | CNV | gain | 19166990 |
nsv579910 | CNV | gain | 21841781 |
nsv579911 | CNV | gain | 21841781 |
nsv579912 | CNV | gain | 21841781 |
nsv7309 | OTHER | inversion | 18451855 |
nsv9739 | CNV | gain+loss | 18304495 |
Disorder | Aliases | PubMed IDs |
---|---|---|
ovarian cystic teratoma |
|
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