This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding diff... See more...

Aliases for SIGLEC11 Gene

Aliases for SIGLEC11 Gene

  • Sialic Acid Binding Ig Like Lectin 11 2 3 5
  • Sialic Acid-Binding Ig-Like Lectin 11 3 4
  • Siglec-11 3 4
  • Sialic Acid Binding Ig-Like Lectin 11 2
  • Sialic Acid-Binding Lectin 11 4
  • SIGLEC11 5

External Ids for SIGLEC11 Gene

Previous GeneCards Identifiers for SIGLEC11 Gene

  • GC19M051110
  • GC19M050820
  • GC19M055128
  • GC19M055144
  • GC19M055089
  • GC19M050412
  • GC19M046828
  • GC19M050456
  • GC19M050457

Summaries for SIGLEC11 Gene

Entrez Gene Summary for SIGLEC11 Gene

  • This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for SIGLEC11 Gene

SIGLEC11 (Sialic Acid Binding Ig Like Lectin 11) is a Protein Coding gene. Diseases associated with SIGLEC11 include Ovarian Cystic Teratoma. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is SIGLEC10.

UniProtKB/Swiss-Prot Summary for SIGLEC11 Gene

  • Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SIGLEC11 Gene

Genomics for SIGLEC11 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SIGLEC11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J049950 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas 615.7 +6.3 6303 9.5 CREB1 RFX1 IKZF1 ZNF24 SP1 ZNF341 CEBPA SCRT2 CEBPB ZNF316 SIGLEC11 piR-45616-001 piR-53204 VRK3 ENSG00000204666 NUP62 ENSG00000269179 piR-45036
GH19J049959 Promoter 0.3 Ensembl 618.8 +0.6 571 0.8 SIGLEC11 HSALNG0127060 SIGLEC16 ENSG00000269179
GH19J049961 Promoter 0.3 EPDnew 600.7 +0.1 69 0.1 HSALNG0127060 SIGLEC11 ENSG00000269179
GH19J050022 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 11.9 -63.8 -63803 4.9 ZNF221 RNF2 SP1 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 TFE3 RFX1 ZNF473 VRK3 lnc-SIGLEC11-2 POLD1 PTOV1-AS2 SIGLEC16 SNORD35A NUP62 SNORD35B ALDH16A1
GH19J050050 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas 11.3 -89.7 -89675 1.7 CREB1 PRDM10 ZNF629 RFX1 RFX5 ZNF692 TARDBP ZHX2 FOXA1 ZNF143 ENSG00000204666 ENSG00000269091 ENSG00000267890 LOC400710 VRK3 SIGLEC11 ZNF473 IZUMO2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SIGLEC11 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SIGLEC11

Top Transcription factor binding sites by QIAGEN in the SIGLEC11 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • FOXO1
  • FOXO1a

Genomic Locations for SIGLEC11 Gene

Genomic Locations for SIGLEC11 Gene
chr19:49,948,825-49,961,172
(GRCh38/hg38)
Size:
12,348 bases
Orientation:
Minus strand
chr19:50,452,242-50,464,429
(GRCh37/hg19)
Size:
12,188 bases
Orientation:
Minus strand

Genomic View for SIGLEC11 Gene

Genes around SIGLEC11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIGLEC11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIGLEC11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLEC11 Gene

Proteins for SIGLEC11 Gene

  • Protein details for SIGLEC11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RL6-SIG11_HUMAN
    Recommended name:
    Sialic acid-binding Ig-like lectin 11
    Protein Accession:
    Q96RL6

    Protein attributes for SIGLEC11 Gene

    Size:
    698 amino acids
    Molecular mass:
    75795 Da
    Quaternary structure:
    • Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation.
    SequenceCaution:
    • Sequence=AAK72907.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAQ88502.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for SIGLEC11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIGLEC11 Gene

Post-translational modifications for SIGLEC11 Gene

  • Phosphorylated on tyrosine residues.
  • Glycosylation at Asn55, Asn90, Asn262, Asn366, Asn375, Asn497, and Asn515
  • Modification sites at PhosphoSitePlus

Other Protein References for SIGLEC11 Gene

No data available for DME Specific Peptides for SIGLEC11 Gene

Domains & Families for SIGLEC11 Gene

Gene Families for SIGLEC11 Gene

Protein Domains for SIGLEC11 Gene

InterPro:
Blocks:
  • Immunoglobulin C-2 type
  • CD80-like C2-set immunoglobulin
ProtoNet:

Suggested Antigen Peptide Sequences for SIGLEC11 Gene

GenScript: Design optimal peptide antigens:
  • Sialic acid-binding Ig-like lectin 11 (SIG11_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96RL6

UniProtKB/Swiss-Prot:

SIG11_HUMAN :
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Domain:
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with SIGLEC11: view

Function for SIGLEC11 Gene

Molecular function for SIGLEC11 Gene

UniProtKB/Swiss-Prot Function:
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.

Phenotypes From GWAS Catalog for SIGLEC11 Gene

Gene Ontology (GO) - Molecular Function for SIGLEC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019902 phosphatase binding IPI 11986327
GO:0030246 carbohydrate binding IEA --
GO:0033691 sialic acid binding IBA,IDA 11986327
genes like me logo Genes that share ontologies with SIGLEC11: view
genes like me logo Genes that share phenotypes with SIGLEC11: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIGLEC11

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SIGLEC11 Gene

Localization for SIGLEC11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC11 Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIGLEC11 gene
Compartment Confidence
plasma membrane 4
extracellular 2
mitochondrion 1
nucleus 1
cytosol 1
lysosome 1
peroxisome 0
endoplasmic reticulum 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SIGLEC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SIGLEC11: view

Pathways & Interactions for SIGLEC11 Gene

genes like me logo Genes that share pathways with SIGLEC11: view

Pathways by source for SIGLEC11 Gene

Gene Ontology (GO) - Biological Process for SIGLEC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IBA 21873635
genes like me logo Genes that share ontologies with SIGLEC11: view

No data available for SIGNOR curated interactions for SIGLEC11 Gene

Drugs & Compounds for SIGLEC11 Gene

No Compound Related Data Available

Transcripts for SIGLEC11 Gene

mRNA/cDNA for SIGLEC11 Gene

2 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIGLEC11

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC11 Gene

No ASD Table

Relevant External Links for SIGLEC11 Gene

GeneLoc Exon Structure for
SIGLEC11

Expression for SIGLEC11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SIGLEC11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Spleen (Hematopoietic System)
  • Ovary (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for SIGLEC11 Gene

This gene is overexpressed in Ovary (x23.4), Spleen (x8.6), and Adrenal Gland (x5.3).

Protein differential expression in normal tissues from HIPED for SIGLEC11 Gene

This gene is overexpressed in Serum (59.0) and Urine (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SIGLEC11 Gene



Protein tissue co-expression partners for SIGLEC11 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SIGLEC11

SOURCE GeneReport for Unigene cluster for SIGLEC11 Gene:

Hs.661852

mRNA Expression by UniProt/SwissProt for SIGLEC11 Gene:

Q96RL6-SIG11_HUMAN
Tissue specificity: Expressed by macrophages in various tissues including Kupffer cells. Also found in brain microglia.

Evidence on tissue expression from TISSUES for SIGLEC11 Gene

  • Nervous system(2)
genes like me logo Genes that share expression patterns with SIGLEC11: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SIGLEC11 Gene

Orthologs for SIGLEC11 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SIGLEC11 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SIGLEC11 30 31
  • 97.71 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 55 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 54 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Siglecg 31
  • 54 (a)
OneToMany
Species where no ortholog for SIGLEC11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SIGLEC11 Gene

ENSEMBL:
Gene Tree for SIGLEC11 (if available)
TreeFam:
Gene Tree for SIGLEC11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SIGLEC11: view image

Paralogs for SIGLEC11 Gene

(10) SIMAP similar genes for SIGLEC11 Gene using alignment to 2 proteins:

  • SIG11_HUMAN
  • H7C2S0_HUMAN

Pseudogenes.org Pseudogenes for SIGLEC11 Gene

genes like me logo Genes that share paralogs with SIGLEC11: view

Variants for SIGLEC11 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SIGLEC11 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
730463 Likely Benign: not provided 49,951,927(-) C/T SYNONYMOUS_VARIANT
730516 Likely Benign: not provided 49,959,085(-) G/A INTRON_VARIANT
769039 Likely Benign: not provided 49,959,777(-) C/T SYNONYMOUS_VARIANT
769040 Benign: not provided 49,959,787(-) T/C MISSENSE_VARIANT
769041 Benign: not provided 49,960,413(-) T/G MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for SIGLEC11 Gene

Structural Variations from Database of Genomic Variants (DGV) for SIGLEC11 Gene

Variant ID Type Subtype PubMed ID
dgv54n68 CNV loss 17160897
esv2762046 CNV loss 21179565
esv3644630 CNV gain 21293372
esv3644632 CNV loss 21293372
esv3644633 CNV loss 21293372
esv3644634 CNV loss 21293372
esv3644635 CNV gain 21293372
nsv1058623 CNV gain 25217958
nsv1065648 CNV gain 25217958
nsv1140251 OTHER inversion 24896259
nsv458720 CNV gain 19166990
nsv579910 CNV gain 21841781
nsv579911 CNV gain 21841781
nsv579912 CNV gain 21841781
nsv7309 OTHER inversion 18451855
nsv9739 CNV gain+loss 18304495

Variation tolerance for SIGLEC11 Gene

Residual Variation Intolerance Score: 95.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.57; 82.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SIGLEC11 Gene

Human Gene Mutation Database (HGMD)
SIGLEC11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIGLEC11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIGLEC11 Gene

Disorders for SIGLEC11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SIGLEC11 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ovarian cystic teratoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SIGLEC11

genes like me logo Genes that share disorders with SIGLEC11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SIGLEC11 Gene

Publications for SIGLEC11 Gene

  1. Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia. (PMID: 11986327) Angata T … Varki A (The Journal of biological chemistry 2002) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
  3. Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen. (PMID: 28100677) Schwarz F … Varki A (The EMBO journal 2017) 3
  4. Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs. (PMID: 25320078) Läubli H … Varki A (The Journal of biological chemistry 2014) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for SIGLEC11 Gene

Sources for SIGLEC11 Gene