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This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding diff... See more...
Aliases for SIGLEC11 Gene
Aliases for SIGLEC11 Gene
External Ids for SIGLEC11 Gene
- HGNC: 15622
- NCBI Entrez Gene: 114132
- Ensembl: ENSG00000161640
- OMIM®: 607157
- UniProtKB/Swiss-Prot: Q96RL6
Previous GeneCards Identifiers for SIGLEC11 Gene
- GC19M051110
- GC19M050820
- GC19M055128
- GC19M055144
- GC19M055089
- GC19M050412
- GC19M046828
- GC19M050456
- GC19M050457
Summaries for SIGLEC11 Gene
-
This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for SIGLEC11 Gene
SIGLEC11 (Sialic Acid Binding Ig Like Lectin 11) is a Protein Coding gene. Diseases associated with SIGLEC11 include Ovarian Cystic Teratoma. Among its related pathways are Innate Immune System and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is SIGLEC10.
UniProtKB/Swiss-Prot Summary for SIGLEC11 Gene
-
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
Additional gene information for SIGLEC11 Gene
- HGNC (15622)
- NCBI Entrez Gene (114132)
- Ensembl (ENSG00000161640)
- OMIM® (607157)
- UniProtKB/Swiss-Prot (Q96RL6)
- Open Targets Platform(ENSG00000161640)
- Monarch Initiative
- Search for SIGLEC11 at DataMed
- Search for SIGLEC11 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SIGLEC11 Gene
Genomics for SIGLEC11 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SIGLEC11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SIGLEC11 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SIGLEC11
- Top Transcription factor binding sites by QIAGEN in the SIGLEC11 gene promoter:
-
- E2F
- E2F-1
- E2F-2
- E2F-3a
- FOXO1
- FOXO1a
Genomic Locations for SIGLEC11 Gene
Latest Assembly
- chr19:49,948,825-49,961,172
- (GRCh38/hg38)
- Size:
- 12,348 bases
- Orientation:
- Minus strand
Previous Assembly
- chr19:50,452,242-50,464,429
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 12,188 bases
- Orientation:
- Minus strand
- chr19:50,452,242-50,464,429
- (GRCh37/hg19 by Ensembl)
- Size:
- 12,188 bases
- Orientation:
- Minus strand
Genomic View for SIGLEC11 Gene
Genes around SIGLEC11 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.33 by HGNC
- 19q13.33 by Entrez Gene
- 19q13.33 by Ensembl
SIGLEC11 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SIGLEC11 Gene
Proteins for SIGLEC11 Gene
-
Protein details for SIGLEC11 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96RL6-SIG11_HUMAN
- Recommended name:
- Sialic acid-binding Ig-like lectin 11
- Protein Accession:
- Q96RL6
Protein attributes for SIGLEC11 Gene
- Size:
- 698 amino acids
- Molecular mass:
- 75795 Da
- Quaternary structure:
-
- Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation.
- SequenceCaution:
-
- Sequence=AAK72907.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAQ88502.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
Protein Expression for SIGLEC11 Gene
Post-translational modifications for SIGLEC11 Gene
- Phosphorylated on tyrosine residues.
-
Glycosylation at Asn55, Asn90, Asn262, Asn366, Asn375, Asn497, and Asn515
- NX_Q96RL6 (NX_Q96RL6-1)
- Modification sites at PhosphoSitePlus
Other Protein References for SIGLEC11 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- G Biosciences Immunotag™ SIG11 Polyclonal Antibody
- BioLegend Siglec-11 Antibody
- Novus Biologicals Antibodies for SIGLEC11
-
Abcam antibodies for SIGLEC11
- Invitrogen Antibodies for SIGLEC11 (AFLGC-SIGLEC11)
-
Boster Bio Antibodies for SIGLEC11
-
Custom Antibody ServicesProSci Antibodies for SIGLEC11
Protein products for research
-
OriGene Purified Proteins for SIGLEC11
- Search Origene for MassSpec and Protein Over-expression Lysates for SIGLEC11
- Origene Custom Protein Services for SIGLEC11
- antibodies-online: Show 3 available SIGLEC11 Proteins ranked by validation data
- Compare Top SIGLEC11 Proteins
-
Quality Products:
Assay products for research
- RayBiotech Custom Human Siglec-11 ELISA
- antibodies-online: Show 2 available SIGLEC11 Elisa Kits ranked by validation data
- Compare Top SIGLEC11 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for SIGLEC11 Gene
Domains & Families for SIGLEC11 Gene
Gene Families for SIGLEC11 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted membrane proteins
Protein Domains for SIGLEC11 Gene
- InterPro:
- Blocks:
-
- Immunoglobulin C-2 type
- CD80-like C2-set immunoglobulin
- ProtoNet:
Suggested Antigen Peptide Sequences for SIGLEC11 Gene
- GenScript: Design optimal peptide antigens:
-
- Sialic acid-binding Ig-like lectin 11 (SIG11_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q96RL6UniProtKB/Swiss-Prot:
SIG11_HUMAN :- Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
- Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
- Domain:
-
- Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
- Family:
-
- Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Function for SIGLEC11 Gene
Molecular function for SIGLEC11 Gene
- UniProtKB/Swiss-Prot Function:
- Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
Phenotypes From GWAS Catalog for SIGLEC11 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0019902 | phosphatase binding | IPI | 11986327 |
| GO:0030246 | carbohydrate binding | IEA | -- |
| GO:0033691 | sialic acid binding | IDA | 11986327 |
Phenotypes for SIGLEC11 Gene
- GenomeRNAi human phenotypes for SIGLEC11:
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SIGLEC11 - Starting at $85 >
- * SIGLEC11 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SIGLEC11
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SIGLEC11
-
Santa Cruz Biotechnology (SCBT) CRISPR for SIGLEC11
miRNA for SIGLEC11 Gene
- miRTarBase miRNAs that target SIGLEC11
-
- hsa-miR-6807-5p (MIRT514955)
- hsa-miR-7151-3p (MIRT514956)
- hsa-miR-5095 (MIRT514957)
- hsa-miR-5186 (MIRT514958)
- hsa-miR-150-5p (MIRT514959)
- hsa-miR-186-3p (MIRT514960)
- hsa-miR-520h (MIRT514961)
- hsa-miR-520g-3p (MIRT514962)
- hsa-miR-6504-3p (MIRT514963)
- hsa-miR-4438 (MIRT514964)
- hsa-miR-6872-3p (MIRT643398)
- hsa-miR-6849-3p (MIRT643399)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SIGLEC11
- Browse OriGene Inhibitory RNA Products For SIGLEC11
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIGLEC11
Clone products for research
- Applied Biological Materials (abm): Clones for SIGLEC11 - Starting at $45 >
- * SIGLEC11 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
OriGene ORF clones in human for SIGLEC11
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SIGLEC11
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SIGLEC11
Cell Lines for research
-
Horizon Cell Lines for SIGLEC11
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SIGLEC11 Gene
Localization for SIGLEC11 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC11 Gene
- Membrane. Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| extracellular | 2 |
| mitochondrion | 1 |
| nucleus | 1 |
| cytosol | 1 |
| lysosome | 1 |
| peroxisome | 0 |
| endoplasmic reticulum | 0 |
| golgi apparatus | 0 |
- Golgi apparatus (1)
- Nucleoplasm (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IBA | 21873635 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for SIGLEC11 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
| 3 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | ||
Pathways by source for SIGLEC11 Gene
3 Reactome pathways for SIGLEC11 Gene
Interacting Proteins for SIGLEC11 Gene
GPS-Prot Interaction Network for SIGLEC11
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007155 | cell adhesion | IBA | 21873635 |
No data available for SIGNOR curated interactions for SIGLEC11 Gene
Transcripts for SIGLEC11 Gene
mRNA/cDNA for SIGLEC11 Gene
- 2 REFSEQ mRNAs :
- 3 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000426296 825 nts (view in UCSC)
- ENST00000426971 2479 nts (view in UCSC)
- ENST00000447370 3173 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SIGLEC11 - Starting at $85 >
- * SIGLEC11 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SIGLEC11
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SIGLEC11
-
Santa Cruz Biotechnology (SCBT) CRISPR for SIGLEC11
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SIGLEC11
- Browse OriGene Inhibitory RNA Products For SIGLEC11
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIGLEC11
Clone products for research
- Applied Biological Materials (abm): Clones for SIGLEC11 - Starting at $45 >
- * SIGLEC11 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
OriGene ORF clones in human for SIGLEC11
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SIGLEC11
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SIGLEC11
Relevant External Links for SIGLEC11 Gene
- GeneLoc Exon Structure for
- SIGLEC11
Expression for SIGLEC11 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for SIGLEC11 Gene
This gene is overexpressed in Ovary (x23.4), Spleen (x8.6), and Adrenal Gland (x5.3).
This gene is overexpressed in Serum (59.0) and Urine (10.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SIGLEC11 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SIGLEC11
SOURCE GeneReport for Unigene cluster for SIGLEC11 Gene:
Hs.661852mRNA Expression by UniProt/SwissProt for SIGLEC11 Gene:
Q96RL6-SIG11_HUMAN
Tissue specificity:
Expressed by macrophages in various tissues including Kupffer cells. Also found in brain microglia.
Primer products for research
-
OriGene qPCR primer pairs for SIGLEC11
Gene Expression Assays for research
No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIGLEC11 Gene
Orthologs for SIGLEC11 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SIGLEC11 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
| Cow (Bos Taurus) |
Mammalia | -- 31 |
|
OneToMany | |
| Mouse (Mus musculus) |
Mammalia | Siglecg 31 |
|
OneToMany |
- Species where no ortholog for SIGLEC11 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for SIGLEC11 Gene
- ENSEMBL:
- Gene Tree for SIGLEC11 (if available)
- TreeFam:
- Gene Tree for SIGLEC11 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SIGLEC11: view image
Paralogs for SIGLEC11 Gene
Paralogs for SIGLEC11 Gene
(10) SIMAP similar genes for SIGLEC11 Gene using alignment to 2 proteins:
- SIG11_HUMAN
- H7C2S0_HUMAN
Pseudogenes.org Pseudogenes for SIGLEC11 Gene
Variants for SIGLEC11 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SIGLEC11 Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs112796514 | Benign: not provided | 49,951,945(-) |
G/A NM_052884.3(SIGLEC11):c.1776C>T (p.Arg592=) |
SYNONYMOUS | |
| rs199756638 | Benign: not provided | 49,959,787(-) |
T/C NM_052884.3(SIGLEC11):c.779A>G (p.His260Arg) |
MISSENSE | |
| rs200380048 | Likely Benign: not provided | 49,959,777(-) |
C/T NM_052884.3(SIGLEC11):c.789G>A (p.Thr263=) |
SYNONYMOUS | |
| rs201740168 | Benign: not provided | 49,959,773(-) |
C/A NM_052884.3(SIGLEC11):c.793G>T (p.Ala265Ser) |
MISSENSE | |
| rs57682421 | Benign: not provided | 49,958,478(-) |
G/C NM_052884.3(SIGLEC11):c.1456C>G (p.Arg486Gly) |
MISSENSE_VARIANT,INTRON |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv54n68 | CNV | loss | 17160897 |
| esv2762046 | CNV | loss | 21179565 |
| esv3644630 | CNV | gain | 21293372 |
| esv3644632 | CNV | loss | 21293372 |
| esv3644633 | CNV | loss | 21293372 |
| esv3644634 | CNV | loss | 21293372 |
| esv3644635 | CNV | gain | 21293372 |
| nsv1058623 | CNV | gain | 25217958 |
| nsv1065648 | CNV | gain | 25217958 |
| nsv1140251 | OTHER | inversion | 24896259 |
| nsv458720 | CNV | gain | 19166990 |
| nsv579910 | CNV | gain | 21841781 |
| nsv579911 | CNV | gain | 21841781 |
| nsv579912 | CNV | gain | 21841781 |
| nsv7309 | OTHER | inversion | 18451855 |
| nsv9739 | CNV | gain+loss | 18304495 |
Residual Variation Intolerance Score:
95.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.57;
82.50% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SIGLEC11 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIGLEC11 Gene
Disorders for SIGLEC11 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ovarian cystic teratoma |
|
|
Search SIGLEC11 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SIGLEC11
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for SIGLEC11 Gene
Publications for SIGLEC11 Gene
- Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia. (PMID: 11986327) Angata T … Varki A (The Journal of biological chemistry 2002) 2 3 4
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
- Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen. (PMID: 28100677) Schwarz F … Varki A (The EMBO journal 2017) 3
- Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs. (PMID: 25320078) Läubli H … Varki A (The Journal of biological chemistry 2014) 3
- Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
ExternalLinks
Products for SIGLEC11 Gene
- View all 13 R&D Systems SIGLEC11 (Siglec-11) Products
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- Custom Antibody Services
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- Origene Custom Protein Services for SIGLEC11
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SIGLEC11
- Browse OriGene Inhibitory RNA Products For SIGLEC11
- OriGene qPCR primer pairs for SIGLEC11
- OriGene CRISPR knockouts for SIGLEC11
- OriGene ORF clones in human for SIGLEC11
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Sino Biological Human cDNA Clone for SIGLEC11
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- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for SIGLEC11
- Novus Biologicals proteins and lysates for SIGLEC11
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for SIGLEC11
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
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- Invitrogen Antibodies for SIGLEC11 (AFLGC-SIGLEC11)
- VectorBuilder Custom and pre-made DNA vectors for SIGLEC11 (ie. gene expression, shRNA knockdown, CRISPR)
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- VectorBuilder Stable cell line generation for SIGLEC11
- antibodies-online: Show 16 available SIGLEC11 Antibodies ranked by validation data
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- Quality Products:
- antibodies-online: Show 3 available SIGLEC11 Proteins ranked by validation data
- Compare Top SIGLEC11 Proteins
- Quality Products:
- Custom Antibody ServicesProSci Antibodies for SIGLEC11
- Search for SIGLEC11 Proteins at ProSci
- Horizon Cell Lines for SIGLEC11
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SIGLEC11
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SIGLEC11
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SIGLEC11
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIGLEC11
- Boster Bio Antibodies for SIGLEC11
- Browse Boster Bio ELISA Kits
Sources for SIGLEC11 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB