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SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002] See more...
Aliases for SIGLEC10 Gene
Aliases for SIGLEC10 Gene
External Ids for SIGLEC10 Gene
- HGNC: 15620
- NCBI Entrez Gene: 89790
- Ensembl: ENSG00000142512
- OMIM®: 606091
- UniProtKB/Swiss-Prot: Q96LC7
Previous GeneCards Identifiers for SIGLEC10 Gene
- GC19M052544
- GC19M052275
- GC19M056589
- GC19M056606
- GC19M056607
- GC19M056608
- GC19M051915
- GC19M051916
Summaries for SIGLEC10 Gene
-
SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002]
GeneCards Summary for SIGLEC10 Gene
SIGLEC10 (Sialic Acid Binding Ig Like Lectin 10) is a Protein Coding gene. Among its related pathways are Innate Immune System and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is SIGLEC11.
UniProtKB/Swiss-Prot Summary for SIGLEC10 Gene
-
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid (By similarity). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules (PubMed:11284738, PubMed:12163025). Involved in negative regulation of B-cell antigen receptor signaling. The inhibition of B cell activation is dependent on PTPN6/SHP-1 (By similarity). In association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (By similarity). In association with CD24 may regulate the immune repsonse of natural killer (NK) cells (PubMed:25450598). Plays a role in the control of autoimmunity (By similarity). During initiation of adaptive immune responses by CD8-alpha(+) dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification (By similarity).
Additional gene information for SIGLEC10 Gene
- HGNC (15620)
- NCBI Entrez Gene (89790)
- Ensembl (ENSG00000142512)
- OMIM® (606091)
- UniProtKB/Swiss-Prot (Q96LC7)
- Open Targets Platform(ENSG00000142512)
- Search for SIGLEC10 at DataMed
- Search for SIGLEC10 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SIGLEC10 Gene
Genomics for SIGLEC10 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SIGLEC10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SIGLEC10 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SIGLEC10
- Top Transcription factor binding sites by QIAGEN in the SIGLEC10 gene promoter:
-
- E2F
- E2F-1
- E2F-2
- E2F-3a
- E2F-4
- E2F-5
- FOXO1
- HEN1
- NRSF form 1
- NRSF form 2
Genomic Locations for SIGLEC10 Gene
Latest Assembly
- chr19:51,410,020-51,417,803
- (GRCh38/hg38)
- Size:
- 7,784 bases
- Orientation:
- Minus strand
Previous Assembly
- chr19:51,913,274-51,920,896
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 7,623 bases
- Orientation:
- Minus strand
- chr19:51,913,275-51,921,057
- (GRCh37/hg19 by Ensembl)
- Size:
- 7,783 bases
- Orientation:
- Minus strand
Genomic View for SIGLEC10 Gene
Genes around SIGLEC10 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.41 by HGNC
- 19q13.41 by Entrez Gene
- 19q13.41 by Ensembl
SIGLEC10 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SIGLEC10 Gene
Proteins for SIGLEC10 Gene
-
Protein details for SIGLEC10 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96LC7-SIG10_HUMAN
- Recommended name:
- Sialic acid-binding Ig-like lectin 10
- Protein Accession:
- Q96LC7
- A8K1I5
- A8K3C7
- C9JJ33
- C9JM10
- F8W917
- Q3MIR5
- Q6UXI8
- Q96G54
- Q96LC8
Protein attributes for SIGLEC10 Gene
- Size:
- 697 amino acids
- Molecular mass:
- 76592 Da
- Quaternary structure:
-
- Interacts with PTPN6/SHP-1 upon phosphorylation (PubMed:12163025). Interacts with NCF1 (By similarity). Interacts with CD24; the probable CD24:SIGLEC10 complex is proposed to inhibit HGMB1-mediated tissue damage immune response. Interacts with HMGB1; the interaction is dependent on CD24 (PubMed:19264983). Interacts with DDX58, CBL and PTPN11 (By similarity).
Protein Expression for SIGLEC10 Gene
Post-translational modifications for SIGLEC10 Gene
- Phosphorylation of Tyr-667 is involved in binding to PTPN6.
-
Glycosylation at Asn100, Asn355, Asn364, Asn486, and Asn504
- NX_Q96LC7 (NX_Q96LC7-1)
- Modification sites at PhosphoSitePlus
Other Protein References for SIGLEC10 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- G Biosciences Immunotag™ SIG10 Polyclonal Antibody
-
Custom Antibody ServicesOriGene Antibodies for SIGLEC10
- Novus Biologicals Antibodies for SIGLEC10
-
Abcam antibodies for SIGLEC10
- Invitrogen Antibodies for SIGLEC10 (AFLGC-SIGLEC10)
-
Biorbyt antibodies for SIGLEC10
-
Boster Bio Antibodies for SIGLEC10
-
Custom Antibody ServicesProSci Antibodies for SIGLEC10
-
Santa Cruz Biotechnology (SCBT) Antibodies for SIGLEC10
Protein products for research
-
OriGene Purified Proteins for SIGLEC10
- Search Origene for MassSpec and Protein Over-expression Lysates for SIGLEC10
- Origene Custom Protein Services for SIGLEC10
- Sino Biological Cell Lysates for SIGLEC10
- Sino Biological Recombinant Proteins for SIGLEC10
- antibodies-online: Show 8 available SIGLEC10 Proteins ranked by validation data
- Compare Top SIGLEC10 Proteins
-
Quality Products:
-
Abcam proteins for SIGLEC10
No data available for DME Specific Peptides for SIGLEC10 Gene
Domains & Families for SIGLEC10 Gene
Gene Families for SIGLEC10 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for SIGLEC10 Gene
- InterPro:
- Blocks:
-
- Immunoglobulin C-2 type
- Immunoglobulin subtype
- CD80-like C2-set immunoglobulin
- ProtoNet:
Suggested Antigen Peptide Sequences for SIGLEC10 Gene
- GenScript: Design optimal peptide antigens:
-
- SIGLEC10 protein (B7ZL04_HUMAN)
- SIGLEC10 protein (B7ZL06_HUMAN)
- Siglec-like protein 2 (SIG10_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q96LC7UniProtKB/Swiss-Prot:
SIG10_HUMAN :- Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
- Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
- Domain:
-
- Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
- Family:
-
- Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Function for SIGLEC10 Gene
Molecular function for SIGLEC10 Gene
- UniProtKB/Swiss-Prot Function:
- Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid (By similarity). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules (PubMed:11284738, PubMed:12163025). Involved in negative regulation of B-cell antigen receptor signaling. The inhibition of B cell activation is dependent on PTPN6/SHP-1 (By similarity). In association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (By similarity). In association with CD24 may regulate the immune repsonse of natural killer (NK) cells (PubMed:25450598). Plays a role in the control of autoimmunity (By similarity). During initiation of adaptive immune responses by CD8-alpha(+) dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification (By similarity).
Phenotypes From GWAS Catalog for SIGLEC10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 19264983 |
| GO:0019902 | phosphatase binding | IPI | 12163025 |
| GO:0030246 | carbohydrate binding | IEA | -- |
| GO:0033691 | sialic acid binding | IBA | 21873635 |
| GO:0042169 | SH2 domain binding | IMP | 12163025 |
Phenotypes for SIGLEC10 Gene
- MGI mutant phenotypes for SIGLEC10:
- inferred from 7 alleles
- GenomeRNAi human phenotypes for SIGLEC10:
Animal Models for SIGLEC10 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SIGLEC10 - Starting at $85 >
- * SIGLEC10 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SIGLEC10
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SIGLEC10
-
Santa Cruz Biotechnology (SCBT) CRISPR for SIGLEC10
miRNA for SIGLEC10 Gene
- miRTarBase miRNAs that target SIGLEC10
-
- hsa-miR-142-3p (MIRT021581)
- hsa-miR-7151-3p (MIRT526705)
- hsa-miR-5095 (MIRT526706)
- hsa-miR-6715b-5p (MIRT526707)
- hsa-miR-4269 (MIRT526708)
- hsa-miR-5582-5p (MIRT526709)
- hsa-miR-4438 (MIRT526710)
- hsa-miR-362-3p (MIRT526711)
- hsa-miR-329-3p (MIRT526712)
- hsa-miR-6513-5p (MIRT617823)
- hsa-miR-887-5p (MIRT617825)
- hsa-miR-3913-5p (MIRT617826)
- hsa-miR-3122 (MIRT617827)
- hsa-miR-450a-1-3p (MIRT617828)
- hsa-miR-4298 (MIRT617829)
- hsa-miR-1302 (MIRT617830)
- hsa-miR-6749-3p (MIRT617831)
- hsa-miR-6792-3p (MIRT617832)
- hsa-miR-4691-5p (MIRT617833)
- hsa-miR-1298-5p (MIRT617834)
- hsa-miR-6832-3p (MIRT617835)
- hsa-miR-664a-3p (MIRT617836)
- hsa-miR-4788 (MIRT716316)
- hsa-miR-6861-3p (MIRT716317)
- hsa-miR-643 (MIRT716318)
- hsa-miR-6870-3p (MIRT716319)
- hsa-miR-5699-3p (MIRT716320)
- hsa-miR-4421 (MIRT716321)
- hsa-miR-6748-3p (MIRT716322)
- hsa-miR-660-3p (MIRT716323)
- hsa-miR-185-5p (MIRT763184)
- hsa-miR-4306 (MIRT768525)
- hsa-miR-4311 (MIRT768558)
- hsa-miR-4419a (MIRT768747)
- hsa-miR-4510 (MIRT769888)
- hsa-miR-4644 (MIRT770572)
- hsa-miR-6127 (MIRT775807)
- hsa-miR-6129 (MIRT775827)
- hsa-miR-6130 (MIRT775886)
- hsa-miR-6133 (MIRT775919)
- hsa-miR-6731-5p (MIRT777985)
- hsa-miR-6758-5p (MIRT778434)
- hsa-miR-6760-5p (MIRT778458)
- hsa-miR-6770-5p (MIRT778600)
- hsa-miR-6856-5p (MIRT780496)
- hsa-miR-6873-5p (MIRT780721)
- hsa-miR-8085 (MIRT782428)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SIGLEC10
- Browse OriGene Inhibitory RNA Products For SIGLEC10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIGLEC10
Clone products for research
- Applied Biological Materials (abm): Clones for SIGLEC10 - Starting at $45 >
- * SIGLEC10 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- RC210995
- RC210995L1
- RC210995L2
- RC210995L3
- RC210995L4
- RC230111
- RC230111L3
- RC230111L4
- RC230217
- RC230217L3
- RC230217L4
- RC230254
- RC230254L3
- RC230254L4
- RC230263
- RC230263L3
- RC230263L4
- RC230331
- RC230331L3
- RC230331L4
- RC230382
- RC230382L3
- RC230382L4
- RG210995
- RG230111
- RG230217
- RG230254
- RG230263
- RG230331
- RG230382
- RR215606
- RR215606L3
- RR215606L4
- RC210995L1V
- RC210995L2V
- RC210995L3V
- RC210995L4V
- RC230111L3V
- RC230111L4V
- RC230217L3V
- RC230217L4V
- RC230254L3V
- RC230254L4V
- RC230263L3V
- RC230263L4V
- RC230331L3V
- RC230331L4V
- RC230382L3V
- RC230382L4V
- RR215606L3V
- RR215606L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SIGLEC10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SIGLEC10
Cell Lines for research
-
Horizon Cell Lines for SIGLEC10
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIGLEC10 Gene
Localization for SIGLEC10 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC10 Gene
- [Isoform 1]: Cell membrane. Single-pass type I membrane protein.
- [Isoform 2]: Cell membrane. Single-pass type I membrane protein.
- [Isoform 3]: Cell membrane. Single-pass type I membrane protein.
- [Isoform 4]: Cell membrane. Single-pass type I membrane protein.
- [Isoform 5]: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytosol | 3 |
| cytoskeleton | 2 |
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| peroxisome | 0 |
| golgi apparatus | 0 |
- Actin filaments (3)
- Cytosol (3)
- Plasma membrane (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005886 | plasma membrane | IBA,IDA | 11284738 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for SIGLEC10 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
| 3 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | ||
Pathways by source for SIGLEC10 Gene
3 Reactome pathways for SIGLEC10 Gene
Interacting Proteins for SIGLEC10 Gene
Selected Interacting proteins:
Q96LC7-SIG10_HUMAN
ENSP00000345243
for SIGLEC10 Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for SIGLEC10
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002250 | adaptive immune response | IEA | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0007155 | cell adhesion | IBA | 21873635 |
| GO:0045087 | innate immune response | IEA | -- |
| GO:0106015 | negative regulation of inflammatory response to wounding | IPI | 19264983 |
Transcripts for SIGLEC10 Gene
mRNA/cDNA for SIGLEC10 Gene
- 8 REFSEQ mRNAs :
- 17 NCBI additional mRNA sequence :
- 11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000339313 3234 nts (view in UCSC)
- ENST00000353836 3109 nts (view in UCSC)
- ENST00000357375 3059 nts (view in UCSC)
- ENST00000436984 1776 nts (view in UCSC)
- ENST00000439889 2126 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SIGLEC10 - Starting at $85 >
- * SIGLEC10 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SIGLEC10
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SIGLEC10
-
Santa Cruz Biotechnology (SCBT) CRISPR for SIGLEC10
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SIGLEC10
- Browse OriGene Inhibitory RNA Products For SIGLEC10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIGLEC10
Clone products for research
- Applied Biological Materials (abm): Clones for SIGLEC10 - Starting at $45 >
- * SIGLEC10 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- RC210995
- RC210995L1
- RC210995L2
- RC210995L3
- RC210995L4
- RC230111
- RC230111L3
- RC230111L4
- RC230217
- RC230217L3
- RC230217L4
- RC230254
- RC230254L3
- RC230254L4
- RC230263
- RC230263L3
- RC230263L4
- RC230331
- RC230331L3
- RC230331L4
- RC230382
- RC230382L3
- RC230382L4
- RG210995
- RG230111
- RG230217
- RG230254
- RG230263
- RG230331
- RG230382
- RR215606
- RR215606L3
- RR215606L4
- RC210995L1V
- RC210995L2V
- RC210995L3V
- RC210995L4V
- RC230111L3V
- RC230111L4V
- RC230217L3V
- RC230217L4V
- RC230254L3V
- RC230254L4V
- RC230263L3V
- RC230263L4V
- RC230331L3V
- RC230331L4V
- RC230382L3V
- RC230382L4V
- RR215606L3V
- RR215606L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SIGLEC10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SIGLEC10
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||||||||||||
| SP7: |
Relevant External Links for SIGLEC10 Gene
- GeneLoc Exon Structure for
- SIGLEC10
Expression for SIGLEC10 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Thymus (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for SIGLEC10 Gene
This gene is overexpressed in Whole Blood (x21.9) and Spleen (x8.0).
This gene is overexpressed in Peripheral blood mononuclear cells (37.7), Monocytes (20.7), and Blymphocyte (10.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SIGLEC10 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SIGLEC10
SOURCE GeneReport for Unigene cluster for SIGLEC10 Gene:
Hs.284813mRNA Expression by UniProt/SwissProt for SIGLEC10 Gene:
Q96LC7-SIG10_HUMAN
Tissue specificity:
Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation). Isoform 5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow, spleen and spinal chord. Isoform 2 is also found in brain. Isoform 4 is specifically found in natural killer cells.
Evidence on tissue expression from TISSUES for SIGLEC10 Gene
- Spleen(4.5)
- Lymph node(4.5)
- Blood(4.4)
- Liver(4.3)
- Nervous system(4.3)
- Intestine(2.2)
Primer products for research
-
OriGene qPCR primer pairs for SIGLEC10
Gene Expression Assays for research
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SIGLEC10 Gene
Orthologs for SIGLEC10 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SIGLEC10 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SIGLEC10 30 |
|
||
| -- 31 |
|
OneToMany | |||
| Cow (Bos Taurus) |
Mammalia | SIGLEC10 30 |
|
||
| -- 31 |
|
OneToMany | |||
| Rat (Rattus norvegicus) |
Mammalia | Siglec10 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Siglecg 30 17 31 |
|
OneToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC101732062 30 |
|
- Species where no ortholog for SIGLEC10 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for SIGLEC10 Gene
- ENSEMBL:
- Gene Tree for SIGLEC10 (if available)
- TreeFam:
- Gene Tree for SIGLEC10 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SIGLEC10: view image
Paralogs for SIGLEC10 Gene
Paralogs for SIGLEC10 Gene
(13) SIMAP similar genes for SIGLEC10 Gene using alignment to 6 proteins:
- SIG10_HUMAN
- B7ZL04_HUMAN
- B7ZL06_HUMAN
- E9PJA1_HUMAN
- E9PKV9_HUMAN
- E9PL79_HUMAN
Pseudogenes.org Pseudogenes for SIGLEC10 Gene
Variants for SIGLEC10 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SIGLEC10 Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 769046 | Benign: not provided | 51,417,359(-) |
C/. NM_033130.5(SIGLEC10):c.144= (p.Gln48=) |
NON_CODING_TRANSCRIPT_VARIANT,NO_SEQUENCE_ALTERATION | |
| rs11882566 | Benign: not provided | 51,415,221(-) |
T/A NM_033130.5(SIGLEC10):c.1290A>T (p.Pro430=) |
SYNONYMOUS | |
| rs142651280 | Benign: not provided | 51,416,811(-) |
G/A NM_033130.5(SIGLEC10):c.561C>T (p.Ser187=) |
SYNONYMOUS_VARIANT,INTRON | |
| rs145650287 | Benign: not provided | 51,414,834(-) |
C/G NM_033130.5(SIGLEC10):c.1605G>C (p.Leu535=) |
SYNONYMOUS_VARIANT,INTRON | |
| rs202177835 | Benign: not provided | 51,416,956(-) |
A/G NM_033130.5(SIGLEC10):c.422-6T>C |
INTRON |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1140251 | OTHER | inversion | 24896259 |
Residual Variation Intolerance Score:
83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
10.87;
91.81% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SIGLEC10 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SIGLEC10
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIGLEC10 Gene
Disorders for SIGLEC10 Gene
Additional Disease Information for SIGLEC10
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No disorders were found for SIGLEC10 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIGLEC10 Gene
Publications for SIGLEC10 Gene
- Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor. (PMID: 11284738) Munday J … Crocker PR (The Biochemical journal 2001) 2 3 4
- Molecular characterization, tissue expression, and mapping of a novel Siglec-like gene (SLG2) with three splice variants. (PMID: 11409878) Yousef GM … Diamandis EP (Biochemical and biophysical research communications 2001) 3 4 23
- Siglec-10 is associated with survival and natural killer cell dysfunction in hepatocellular carcinoma. (PMID: 25450598) Zhang P … Wu K (The Journal of surgical research 2015) 3 4
- CD24 and Siglec-10 selectively repress tissue damage-induced immune responses. (PMID: 19264983) Chen GY … Liu Y (Science (New York, N.Y.) 2009) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
ExternalLinks
Products for SIGLEC10 Gene
- View all 6 R&D Systems SIGLEC10 (Siglec-10) Products
- View all R&D Systems SIGLEC10 (Siglec-10) Proteins and Enzymes
- View all 3 R&D Systems SIGLEC10 (Siglec-10) Primary Antibodies
- View all R&D Systems SIGLEC10 (Siglec-10) Proteome Profiler Antibody Arrays
- View all R&D Systems SIGLEC10 (Siglec-10) cDNA Clones
- Learn more about R&D Systems custom SIGLEC10 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for SIGLEC10
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for SIGLEC10
- Search Origene for MassSpec and Protein Over-expression Lysates for SIGLEC10
- Origene Custom Protein Services for SIGLEC10
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SIGLEC10
- Browse OriGene Inhibitory RNA Products For SIGLEC10
- OriGene qPCR primer pairs for SIGLEC10
- OriGene CRISPR knockouts for SIGLEC10
- RC210995
- RC210995L1
- RC210995L2
- RC210995L3
- RC210995L4
- RC230111
- RC230111L3
- RC230111L4
- RC230217
- RC230217L3
- RC230217L4
- RC230254
- RC230254L3
- RC230254L4
- RC230263
- RC230263L3
- RC230263L4
- RC230331
- RC230331L3
- RC230331L4
- RC230382
- RC230382L3
- RC230382L4
- RG210995
- RG230111
- RG230217
- RG230254
- RG230263
- RG230331
- RG230382
- RR215606
- RR215606L3
- RR215606L4
- RC210995L1V
- RC210995L2V
- RC210995L3V
- RC210995L4V
- RC230111L3V
- RC230111L4V
- RC230217L3V
- RC230217L4V
- RC230254L3V
- RC230254L4V
- RC230263L3V
- RC230263L4V
- RC230331L3V
- RC230331L4V
- RC230382L3V
- RC230382L4V
- RR215606L3V
- RR215606L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SIGLEC10
- Sino Biological Human cDNA Clone for SIGLEC10
- Sino Biological Cell Lysates for SIGLEC10
- Sino Biological Recombinant Proteins for SIGLEC10
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for SIGLEC10
- Novus Biologicals proteins and lysates for SIGLEC10
- Browse Antibodies
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- Abcam antibodies for SIGLEC10
- Abcam proteins for SIGLEC10
- Find your target
- Browse Primary Antibodies
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- Invitrogen Antibodies for SIGLEC10 (AFLGC-SIGLEC10)
- VectorBuilder Custom and pre-made DNA vectors for SIGLEC10 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for SIGLEC10 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for SIGLEC10 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for SIGLEC10 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for SIGLEC10
- antibodies-online: Show 25 available SIGLEC10 Antibodies ranked by validation data
- Compare Top SIGLEC10 Antibodies
- antibodies-online: Search results for available SIGLEC10 related products ranked by validation data
- antibodies-online: Show 8 available SIGLEC10 Proteins ranked by validation data
- Compare Top SIGLEC10 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for SIGLEC10
- Search Santa Cruz Biotechnology (SCBT) for SIGLEC10 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SIGLEC10
- Horizon Cell Lines for SIGLEC10
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SIGLEC10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SIGLEC10
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SIGLEC10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIGLEC10
- Boster Bio Antibodies for SIGLEC10
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for SIGLEC10
Sources for SIGLEC10 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB