SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002] See more...

Aliases for SIGLEC10 Gene

Aliases for SIGLEC10 Gene

  • Sialic Acid Binding Ig Like Lectin 10 2 3 5
  • SLG2 2 3 4
  • Sialic Acid Binding Ig-Like Lectin 10 Ig-Like Lectin 7 2 3
  • Sialic Acid-Binding Ig-Like Lectin 10 3 4
  • Siglec-Like Protein 2 3 4
  • Siglec-Like Gene 2 2 3
  • SIGLEC-10 2 3
  • PRO940 2 3
  • Sialic Acid Binding Ig-Like Lectin 10 2
  • MGC126774 2
  • Siglec-10 4
  • SIGLEC10 5

External Ids for SIGLEC10 Gene

Previous GeneCards Identifiers for SIGLEC10 Gene

  • GC19M052544
  • GC19M052275
  • GC19M056589
  • GC19M056606
  • GC19M056607
  • GC19M056608
  • GC19M051915
  • GC19M051916

Summaries for SIGLEC10 Gene

Entrez Gene Summary for SIGLEC10 Gene

  • SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002]

GeneCards Summary for SIGLEC10 Gene

SIGLEC10 (Sialic Acid Binding Ig Like Lectin 10) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is SIGLEC11.

UniProtKB/Swiss-Prot Summary for SIGLEC10 Gene

  • Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid (By similarity). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules (PubMed:11284738, PubMed:12163025). Involved in negative regulation of B-cell antigen receptor signaling. The inhibition of B cell activation is dependent on PTPN6/SHP-1 (By similarity). In association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (By similarity). In association with CD24 may regulate the immune repsonse of natural killer (NK) cells (PubMed:25450598). Plays a role in the control of autoimmunity (By similarity). During initiation of adaptive immune responses by CD8-alpha(+) dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification (By similarity).

Gene Wiki entry for SIGLEC10 Gene

Additional gene information for SIGLEC10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SIGLEC10 Gene

Genomics for SIGLEC10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SIGLEC10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J051416 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 606.1 +0.2 203 2.4 JUND LARP7 IKZF2 POLR2A RCOR1 PKNOX1 EED NRF1 UBTF DPF2 SIGLEC10 ENSG00000255441 SIGLEC10-AS1 C19orf84
GH19J051749 Promoter/Enhancer 1.4 EPDnew FANTOM5 Ensembl ENCODE 11 -332.8 -332798 4 SPI1 CEBPB ATF3 JUND FPR1 FPR2 piR-38580-149 SIGLEC10 ZNF350 HAS1
GH19J051731 Enhancer 1.2 FANTOM5 Ensembl ENCODE 11.7 -320.8 -320798 16.8 JUND PKNOX1 MNT CREB1 TRIM24 NCOR1 FOSL1 CTCF BCOR ZNF395 FPR1 FPR2 HAS1 FPR3 SIGLEC10 SIGLEC14 MIR125A MIR99B MIRLET7E SPACA6
GH19J051621 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 9.2 -203.0 -202998 2.8 TCF12 IKZF2 EED DPF2 RUNX3 GATAD2B BCLAF1 CBFB BCL11A CTCF RPL9P33 lnc-ZNF175-4 FPR2 FPR1 SIGLEC14 SIGLEC10 ZNF350 SIGLEC5 HSALNG0127238 ENSG00000268500
GH19J051123 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.8 +291.3 291322 9.6 LEF1 IKZF1 JUND ETV6 PKNOX1 MTA1 DPF2 HDAC1 SOX6 EP300 SIGLEC9 MN297605 ZNF613 ZNF841 ZNF577 POLD1 SIGLEC18P KLK11 C19orf81 SIGLEC10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SIGLEC10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SIGLEC10

Top Transcription factor binding sites by QIAGEN in the SIGLEC10 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • FOXO1
  • HEN1
  • NRSF form 1
  • NRSF form 2

Genomic Locations for SIGLEC10 Gene

Genomic Locations for SIGLEC10 Gene
chr19:51,410,020-51,417,803
(GRCh38/hg38)
Size:
7,784 bases
Orientation:
Minus strand
chr19:51,913,275-51,921,057
(GRCh37/hg19)
Size:
7,783 bases
Orientation:
Minus strand

Genomic View for SIGLEC10 Gene

Genes around SIGLEC10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIGLEC10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIGLEC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLEC10 Gene

Proteins for SIGLEC10 Gene

  • Protein details for SIGLEC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LC7-SIG10_HUMAN
    Recommended name:
    Sialic acid-binding Ig-like lectin 10
    Protein Accession:
    Q96LC7
    Secondary Accessions:
    • A8K1I5
    • A8K3C7
    • C9JJ33
    • C9JM10
    • F8W917
    • Q3MIR5
    • Q6UXI8
    • Q96G54
    • Q96LC8

    Protein attributes for SIGLEC10 Gene

    Size:
    697 amino acids
    Molecular mass:
    76592 Da
    Quaternary structure:
    • Interacts with PTPN6/SHP-1 upon phosphorylation (PubMed:12163025). Interacts with NCF1 (By similarity). Interacts with CD24; the probable CD24:SIGLEC10 complex is proposed to inhibit HGMB1-mediated tissue damage immune response. Interacts with HMGB1; the interaction is dependent on CD24 (PubMed:19264983). Interacts with DDX58, CBL and PTPN11 (By similarity).

    Alternative splice isoforms for SIGLEC10 Gene

neXtProt entry for SIGLEC10 Gene

Post-translational modifications for SIGLEC10 Gene

  • Phosphorylation of Tyr-667 is involved in binding to PTPN6.
  • Glycosylation at Asn100, Asn355, Asn364, Asn486, and Asn504
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SIGLEC10 Gene

Domains & Families for SIGLEC10 Gene

Gene Families for SIGLEC10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SIGLEC10 Gene

InterPro:
Blocks:
  • Immunoglobulin C-2 type
  • Immunoglobulin subtype
  • CD80-like C2-set immunoglobulin
ProtoNet:

Suggested Antigen Peptide Sequences for SIGLEC10 Gene

GenScript: Design optimal peptide antigens:
  • SIGLEC10 protein (B7ZL04_HUMAN)
  • SIGLEC10 protein (B7ZL06_HUMAN)
  • Siglec-like protein 2 (SIG10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96LC7

UniProtKB/Swiss-Prot:

SIG10_HUMAN :
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Domain:
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with SIGLEC10: view

Function for SIGLEC10 Gene

Molecular function for SIGLEC10 Gene

UniProtKB/Swiss-Prot Function:
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid (By similarity). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules (PubMed:11284738, PubMed:12163025). Involved in negative regulation of B-cell antigen receptor signaling. The inhibition of B cell activation is dependent on PTPN6/SHP-1 (By similarity). In association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (By similarity). In association with CD24 may regulate the immune repsonse of natural killer (NK) cells (PubMed:25450598). Plays a role in the control of autoimmunity (By similarity). During initiation of adaptive immune responses by CD8-alpha(+) dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification (By similarity).

Phenotypes From GWAS Catalog for SIGLEC10 Gene

Gene Ontology (GO) - Molecular Function for SIGLEC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19264983
GO:0019902 phosphatase binding IPI 12163025
GO:0030246 carbohydrate binding IEA --
GO:0033691 sialic acid binding IBA 21873635
GO:0042169 SH2 domain binding IMP 12163025
genes like me logo Genes that share ontologies with SIGLEC10: view
genes like me logo Genes that share phenotypes with SIGLEC10: view

Animal Models for SIGLEC10 Gene

MGI Knock Outs for SIGLEC10:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIGLEC10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIGLEC10 Gene

Localization for SIGLEC10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC10 Gene

[Isoform 1]: Cell membrane. Single-pass type I membrane protein.
[Isoform 2]: Cell membrane. Single-pass type I membrane protein.
[Isoform 3]: Cell membrane. Single-pass type I membrane protein.
[Isoform 4]: Cell membrane. Single-pass type I membrane protein.
[Isoform 5]: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIGLEC10 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 3
cytoskeleton 2
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
lysosome 1
peroxisome 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (3)
  • Cytosol (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SIGLEC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IBA,IDA 11284738
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SIGLEC10: view

Pathways & Interactions for SIGLEC10 Gene

genes like me logo Genes that share pathways with SIGLEC10: view

Pathways by source for SIGLEC10 Gene

SIGNOR curated interactions for SIGLEC10 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for SIGLEC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0007155 cell adhesion IBA 21873635
GO:0045087 innate immune response IEA --
GO:0106015 negative regulation of inflammatory response to wounding IPI 19264983
genes like me logo Genes that share ontologies with SIGLEC10: view

Drugs & Compounds for SIGLEC10 Gene

No Compound Related Data Available

Transcripts for SIGLEC10 Gene

mRNA/cDNA for SIGLEC10 Gene

8 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIGLEC10

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC10 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7
SP1: - - - -
SP2: - -
SP3: - - - - -
SP4: - -
SP5: -
SP6: - - -
SP7:

Relevant External Links for SIGLEC10 Gene

GeneLoc Exon Structure for
SIGLEC10

Expression for SIGLEC10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SIGLEC10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SIGLEC10 Gene

This gene is overexpressed in Whole Blood (x21.9) and Spleen (x8.0).

Protein differential expression in normal tissues from HIPED for SIGLEC10 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (37.7), Monocytes (20.7), and Blymphocyte (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SIGLEC10 Gene



Protein tissue co-expression partners for SIGLEC10 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SIGLEC10

SOURCE GeneReport for Unigene cluster for SIGLEC10 Gene:

Hs.284813

mRNA Expression by UniProt/SwissProt for SIGLEC10 Gene:

Q96LC7-SIG10_HUMAN
Tissue specificity: Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation). Isoform 5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow, spleen and spinal chord. Isoform 2 is also found in brain. Isoform 4 is specifically found in natural killer cells.

Evidence on tissue expression from TISSUES for SIGLEC10 Gene

  • Spleen(4.5)
  • Lymph node(4.5)
  • Blood(4.5)
  • Liver(4.3)
  • Nervous system(4.3)
  • Intestine(2.3)
genes like me logo Genes that share expression patterns with SIGLEC10: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SIGLEC10 Gene

Orthologs for SIGLEC10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIGLEC10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SIGLEC10 30 31
  • 98.76 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SIGLEC10 30
  • 76.38 (n)
-- 31
  • 58 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia SIGLEC10 30
  • 75.71 (n)
-- 31
  • 63 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Siglec10 30
  • 74.5 (n)
Mouse
(Mus musculus)
Mammalia Siglecg 30 17 31
  • 72.44 (n)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC101732062 30
  • 47.09 (n)
Species where no ortholog for SIGLEC10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SIGLEC10 Gene

ENSEMBL:
Gene Tree for SIGLEC10 (if available)
TreeFam:
Gene Tree for SIGLEC10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SIGLEC10: view image

Paralogs for SIGLEC10 Gene

(13) SIMAP similar genes for SIGLEC10 Gene using alignment to 6 proteins:

  • SIG10_HUMAN
  • B7ZL04_HUMAN
  • B7ZL06_HUMAN
  • E9PJA1_HUMAN
  • E9PKV9_HUMAN
  • E9PL79_HUMAN

Pseudogenes.org Pseudogenes for SIGLEC10 Gene

genes like me logo Genes that share paralogs with SIGLEC10: view

Variants for SIGLEC10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SIGLEC10 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
710149 Benign: not provided 51,415,221(-) T/A SYNONYMOUS_VARIANT
723714 Benign: not provided 51,416,811(-) G/A SYNONYMOUS_VARIANT,INTRON_VARIANT
769046 Benign: not provided 51,417,359(-) C/. NON_CODING_TRANSCRIPT_VARIANT,NO_SEQUENCE_ALTERATION
770811 Benign: not provided 51,414,834(-) C/G SYNONYMOUS_VARIANT,INTRON_VARIANT
773360 Benign: not provided 51,416,744(-) T/C MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for SIGLEC10 Gene

Structural Variations from Database of Genomic Variants (DGV) for SIGLEC10 Gene

Variant ID Type Subtype PubMed ID
nsv1140251 OTHER inversion 24896259

Variation tolerance for SIGLEC10 Gene

Residual Variation Intolerance Score: 83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.87; 91.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SIGLEC10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIGLEC10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIGLEC10 Gene

Disorders for SIGLEC10 Gene

Additional Disease Information for SIGLEC10

No disorders were found for SIGLEC10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIGLEC10 Gene

Publications for SIGLEC10 Gene

  1. Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor. (PMID: 11284738) Munday J … Crocker PR (The Biochemical journal 2001) 2 3 4
  2. Molecular characterization, tissue expression, and mapping of a novel Siglec-like gene (SLG2) with three splice variants. (PMID: 11409878) Yousef GM … Diamandis EP (Biochemical and biophysical research communications 2001) 3 4 23
  3. Siglec-10 is associated with survival and natural killer cell dysfunction in hepatocellular carcinoma. (PMID: 25450598) Zhang P … Wu K (The Journal of surgical research 2015) 3 4
  4. CD24 and Siglec-10 selectively repress tissue damage-induced immune responses. (PMID: 19264983) Chen GY … Liu Y (Science (New York, N.Y.) 2009) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for SIGLEC10 Gene

Sources for SIGLEC10 Gene