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Aliases for SIGLEC10 Gene

Aliases for SIGLEC10 Gene

  • Sialic Acid Binding Ig Like Lectin 10 2 3 5
  • Sialic Acid Binding Ig-Like Lectin 10 Ig-Like Lectin 7 2 3
  • Siglec-Like Protein 2 3 4
  • Siglec-Like Gene 2 2 3
  • SIGLEC-10 3 4
  • SLG2 3 4
  • Sialic Acid Binding Ig-Like Lectin 10 2
  • Sialic Acid-Binding Ig-Like Lectin 10 3
  • PRO940 3

External Ids for SIGLEC10 Gene

Previous GeneCards Identifiers for SIGLEC10 Gene

  • GC19M052544
  • GC19M052275
  • GC19M056589
  • GC19M056606
  • GC19M056607
  • GC19M056608
  • GC19M051915
  • GC19M051916

Summaries for SIGLEC10 Gene

Entrez Gene Summary for SIGLEC10 Gene

  • SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002]

GeneCards Summary for SIGLEC10 Gene

SIGLEC10 (Sialic Acid Binding Ig Like Lectin 10) is a Protein Coding gene. Diseases associated with SIGLEC10 include Stargardt Disease. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is SIGLEC11.

UniProtKB/Swiss-Prot for SIGLEC10 Gene

  • Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid (By similarity). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules (PubMed:11284738, PubMed:12163025). Involved in negative regulation of B-cell antigen receptor signaling. The inhibition of B cell activation is dependent on PTPN6/SHP-1 (By similarity). In association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (By similarity). In association with CD24 may regulate the immune repsonse of natural killer (NK) cells (PubMed:25450598). Plays a role in the control of autoimmunity (By similarity). During initiation of adaptive immune responses by CD8-alpha(+) dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification (By similarity).

Gene Wiki entry for SIGLEC10 Gene

Additional gene information for SIGLEC10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIGLEC10 Gene

Genomics for SIGLEC10 Gene

GeneHancer (GH) Regulatory Elements for SIGLEC10 Gene

Promoters and enhancers for SIGLEC10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I051416 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 556.2 +0.4 403 2.8 HDGF PKNOX1 EBF1 BATF KLF5 IRF4 FOSL1 POLR2A VEZF1 ETV6 SIGLEC10 LOC100129083
GH19I051760 Promoter/Enhancer 1.6 EPDnew FANTOM5 Ensembl ENCODE 9 -345.6 -345641 5.7 CTCF L3MBTL2 CEBPB ZMYM3 REST CEBPG GABPA IRF9 ATF4 POLR2A FPR2 FPR1 SIGLEC10 ZNF350 FPR3 LOC105372448
GH19I051748 Promoter/Enhancer 1.3 EPDnew FANTOM5 Ensembl ENCODE 11 -332.7 -332698 5 CEBPB FPR1 FPR2 SIGLEC10 FPR3 MIR125A MIR99B MIRLET7E SPACA6 ZNF350 HAS1
GH19I051735 Enhancer 1.2 FANTOM5 Ensembl ENCODE 11.7 -318.4 -318398 1.2 CTCF KLF1 ATF1 TEAD4 TAL1 ZMYM3 CEBPG ZBTB40 FOSL1 TCF12 FPR1 FPR2 SIGLEC10 ZNF350 SIGLEC14 HAS1
GH19I051771 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 9 -354.0 -354030 1.1 CTCF POLR2A GABPB1 GABPA FPR2 FPR1 SIGLEC10 ZNF350 SIGLEC14 LOC105372448
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SIGLEC10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SIGLEC10 gene promoter:

Genomic Locations for SIGLEC10 Gene

Genomic Locations for SIGLEC10 Gene
chr19:51,410,021-51,417,803
(GRCh38/hg38)
Size:
7,783 bases
Orientation:
Minus strand
chr19:51,913,275-51,921,057
(GRCh37/hg19)

Genomic View for SIGLEC10 Gene

Genes around SIGLEC10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIGLEC10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIGLEC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLEC10 Gene

Proteins for SIGLEC10 Gene

  • Protein details for SIGLEC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LC7-SIG10_HUMAN
    Recommended name:
    Sialic acid-binding Ig-like lectin 10
    Protein Accession:
    Q96LC7
    Secondary Accessions:
    • A8K1I5
    • A8K3C7
    • C9JJ33
    • C9JM10
    • F8W917
    • Q3MIR5
    • Q6UXI8
    • Q96G54
    • Q96LC8

    Protein attributes for SIGLEC10 Gene

    Size:
    697 amino acids
    Molecular mass:
    76592 Da
    Quaternary structure:
    • Interacts with PTPN6/SHP-1 upon phosphorylation (PubMed:12163025). Interacts with NCF1 (By similarity). Interacts with CD24; the probable CD24:SIGLEC10 complex is proposed to inhibit HGMB1-mediated tissue damage immune response. Interacts with HMGB1; the interaction is dependent on CD24 (PubMed:19264983). Interacts with DDX58, CBL and PTPN11 (By similarity).

    Alternative splice isoforms for SIGLEC10 Gene

neXtProt entry for SIGLEC10 Gene

Post-translational modifications for SIGLEC10 Gene

  • Phosphorylation of Tyr-667 is involved in binding to PTPN6.
  • Glycosylation at isoforms=2, 3, 4, 5, 6, 7, 8, 9100, posLast=355355, posLast=364364, posLast=486486, and posLast=504504
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for SIGLEC10 Gene

Domains & Families for SIGLEC10 Gene

Gene Families for SIGLEC10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for SIGLEC10 Gene

Graphical View of Domain Structure for InterPro Entry

Q96LC7

UniProtKB/Swiss-Prot:

SIG10_HUMAN :
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Domain:
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with SIGLEC10: view

Function for SIGLEC10 Gene

Molecular function for SIGLEC10 Gene

UniProtKB/Swiss-Prot Function:
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid (By similarity). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules (PubMed:11284738, PubMed:12163025). Involved in negative regulation of B-cell antigen receptor signaling. The inhibition of B cell activation is dependent on PTPN6/SHP-1 (By similarity). In association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (By similarity). In association with CD24 may regulate the immune repsonse of natural killer (NK) cells (PubMed:25450598). Plays a role in the control of autoimmunity (By similarity). During initiation of adaptive immune responses by CD8-alpha(+) dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification (By similarity).

Phenotypes From GWAS Catalog for SIGLEC10 Gene

Gene Ontology (GO) - Molecular Function for SIGLEC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19264983
GO:0019902 phosphatase binding IPI 12163025
GO:0030246 carbohydrate binding IEA --
GO:0042169 SH2 domain binding IMP 12163025
genes like me logo Genes that share ontologies with SIGLEC10: view
genes like me logo Genes that share phenotypes with SIGLEC10: view

Animal Models for SIGLEC10 Gene

MGI Knock Outs for SIGLEC10:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIGLEC10 Gene

Localization for SIGLEC10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC10 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Cell membrane; Single-pass type I membrane protein.
Isoform 3: Cell membrane; Single-pass type I membrane protein.
Isoform 4: Cell membrane; Single-pass type I membrane protein.
Isoform 5: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIGLEC10 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 3
cytoskeleton 2
mitochondrion 1
peroxisome 1
nucleus 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (3)
  • Cytosol (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SIGLEC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IDA,IEA 11284738
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SIGLEC10: view

Pathways & Interactions for SIGLEC10 Gene

genes like me logo Genes that share pathways with SIGLEC10: view

Pathways by source for SIGLEC10 Gene

SIGNOR curated interactions for SIGLEC10 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for SIGLEC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0007155 cell adhesion IEA --
GO:0045087 innate immune response IEA --
GO:0106015 negative regulation of inflammatory response to wounding IPI 19264983
genes like me logo Genes that share ontologies with SIGLEC10: view

Drugs & Compounds for SIGLEC10 Gene

No Compound Related Data Available

Transcripts for SIGLEC10 Gene

Unigene Clusters for SIGLEC10 Gene

Sialic acid binding Ig-like lectin 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC10 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7
SP1: - - - -
SP2: - -
SP3: - - - - -
SP4: - -
SP5: -
SP6: - - -
SP7:

Relevant External Links for SIGLEC10 Gene

GeneLoc Exon Structure for
SIGLEC10
ECgene alternative splicing isoforms for
SIGLEC10

Expression for SIGLEC10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SIGLEC10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SIGLEC10 Gene

This gene is overexpressed in Whole Blood (x21.9) and Spleen (x8.0).

Protein differential expression in normal tissues from HIPED for SIGLEC10 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (37.7), Monocytes (20.7), and Blymphocyte (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SIGLEC10 Gene



Protein tissue co-expression partners for SIGLEC10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SIGLEC10 Gene:

SIGLEC10

SOURCE GeneReport for Unigene cluster for SIGLEC10 Gene:

Hs.284813

mRNA Expression by UniProt/SwissProt for SIGLEC10 Gene:

Q96LC7-SIG10_HUMAN
Tissue specificity: Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation). Isoform 5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow, spleen and spinal chord. Isoform 2 is also found in brain. Isoform 4 is specifically found in natural killer cells.

Evidence on tissue expression from TISSUES for SIGLEC10 Gene

  • Lymph node(4.4)
  • Spleen(4.4)
  • Blood(4.3)
  • Liver(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with SIGLEC10: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SIGLEC10 Gene

Orthologs for SIGLEC10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIGLEC10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIGLEC10 33 34
  • 98.76 (n)
dog
(Canis familiaris)
Mammalia SIGLEC10 33
  • 76.38 (n)
-- 34
  • 58 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SIGLEC10 33
  • 75.71 (n)
-- 34
  • 63 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Siglec10 33
  • 74.5 (n)
mouse
(Mus musculus)
Mammalia Siglecg 33 16 34
  • 72.44 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732062 33
  • 47.09 (n)
Species where no ortholog for SIGLEC10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SIGLEC10 Gene

ENSEMBL:
Gene Tree for SIGLEC10 (if available)
TreeFam:
Gene Tree for SIGLEC10 (if available)

Paralogs for SIGLEC10 Gene

Pseudogenes.org Pseudogenes for SIGLEC10 Gene

genes like me logo Genes that share paralogs with SIGLEC10: view

Variants for SIGLEC10 Gene

Sequence variations from dbSNP and Humsavar for SIGLEC10 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000801667 -- 51,416,022(-) G/A coding_sequence_variant, intron_variant, synonymous_variant
rs1001670861 -- 51,412,510(-) G/A intron_variant
rs1001698039 -- 51,412,132(-) A/C intron_variant
rs1001757913 -- 51,417,140(-) C/T coding_sequence_variant, synonymous_variant
rs1001789132 -- 51,416,953(-) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SIGLEC10 Gene

Variant ID Type Subtype PubMed ID
nsv1140251 OTHER inversion 24896259

Variation tolerance for SIGLEC10 Gene

Residual Variation Intolerance Score: 83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.87; 91.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SIGLEC10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIGLEC10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIGLEC10 Gene

Disorders for SIGLEC10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SIGLEC10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
stargardt disease
  • stargardt disease-1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SIGLEC10

genes like me logo Genes that share disorders with SIGLEC10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SIGLEC10 Gene

Publications for SIGLEC10 Gene

  1. Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor. (PMID: 11284738) Munday J … Crocker PR (The Biochemical journal 2001) 2 3 4 58
  2. Molecular characterization, tissue expression, and mapping of a novel Siglec-like gene (SLG2) with three splice variants. (PMID: 11409878) Yousef GM … Diamandis EP (Biochemical and biophysical research communications 2001) 3 4 22 58
  3. Siglec-10 is associated with survival and natural killer cell dysfunction in hepatocellular carcinoma. (PMID: 25450598) Zhang P … Wu K (The Journal of surgical research 2015) 3 4 58
  4. CD24 and Siglec-10 selectively repress tissue damage-induced immune responses. (PMID: 19264983) Chen GY … Liu Y (Science (New York, N.Y.) 2009) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for SIGLEC10 Gene

Sources for SIGLEC10 Gene

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