Aliases for SIGLEC10 Gene
Aliases for SIGLEC10 Gene
External Ids for SIGLEC10 Gene
- HGNC: 15620
- Entrez Gene: 89790
- Ensembl: ENSG00000142512
- OMIM: 606091
- UniProtKB: Q96LC7
Previous GeneCards Identifiers for SIGLEC10 Gene
- GC19M052544
- GC19M052275
- GC19M056589
- GC19M056606
- GC19M056607
- GC19M056608
- GC19M051915
- GC19M051916
Summaries for SIGLEC10 Gene
-
SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002]
GeneCards Summary for SIGLEC10 Gene
SIGLEC10 (Sialic Acid Binding Ig Like Lectin 10) is a Protein Coding gene. Diseases associated with SIGLEC10 include Stargardt Disease. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is SIGLEC11.
UniProtKB/Swiss-Prot for SIGLEC10 Gene
-
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid (By similarity). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules (PubMed:11284738, PubMed:12163025). Involved in negative regulation of B-cell antigen receptor signaling. The inhibition of B cell activation is dependent on PTPN6/SHP-1 (By similarity). In association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (By similarity). In association with CD24 may regulate the immune repsonse of natural killer (NK) cells (PubMed:25450598). Plays a role in the control of autoimmunity (By similarity). During initiation of adaptive immune responses by CD8-alpha(+) dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification (By similarity).
Additional gene information for SIGLEC10 Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIGLEC10 Gene
Genomics for SIGLEC10 Gene
GeneHancer (GH) Regulatory Elements for SIGLEC10 Gene
Promoters and enhancers for SIGLEC10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around SIGLEC10 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the SIGLEC10 gene promoter:
Regulatory Element Products
Genomic Locations for SIGLEC10 Gene
Genomic Locations for SIGLEC10 Gene
- chr19:51,410,021-51,417,803
- (GRCh38/hg38)
- Size:
- 7,783 bases
- Orientation:
- Minus strand
- chr19:51,913,275-51,921,057
- (GRCh37/hg19)
Genomic View for SIGLEC10 Gene
Genes around SIGLEC10 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.41 by Ensembl
- 19q13.41 by Entrez Gene
- 19q13.41 by HGNC
SIGLEC10 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SIGLEC10 Gene
Proteins for SIGLEC10 Gene
-
Protein details for SIGLEC10 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96LC7-SIG10_HUMAN
- Recommended name:
- Sialic acid-binding Ig-like lectin 10
- Protein Accession:
- Q96LC7
- A8K1I5
- A8K3C7
- C9JJ33
- C9JM10
- F8W917
- Q3MIR5
- Q6UXI8
- Q96G54
- Q96LC8
Protein attributes for SIGLEC10 Gene
- Size:
- 697 amino acids
- Molecular mass:
- 76592 Da
- Quaternary structure:
-
- Interacts with PTPN6/SHP-1 upon phosphorylation (PubMed:12163025). Interacts with NCF1 (By similarity). Interacts with CD24; the probable CD24:SIGLEC10 complex is proposed to inhibit HGMB1-mediated tissue damage immune response. Interacts with HMGB1; the interaction is dependent on CD24 (PubMed:19264983). Interacts with DDX58, CBL and PTPN11 (By similarity).
Protein Expression for SIGLEC10 Gene
Post-translational modifications for SIGLEC10 Gene
- Phosphorylation of Tyr-667 is involved in binding to PTPN6.
- Glycosylation at isoforms=2, 3, 4, 5, 6, 7, 8, 9100, posLast=355355, posLast=364364, posLast=486486, and posLast=504504
- Modification sites at PhosphoSitePlus
Other Protein References for SIGLEC10 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for SIGLEC10 (Siglec-10)
-
Custom Antibody ServicesOriGene Antibodies for SIGLEC10
- Novus Biologicals Antibodies for SIGLEC10
-
Abcam antibodies for SIGLEC10
-
Cloud-Clone Corp. Antibodies for SIGLEC10
- Invitrogen Antibodies for SIGLEC10
- GeneTex SIGLEC10 antibody for SIGLEC10
-
Santa Cruz Biotechnology (SCBT) Antibodies for SIGLEC10
Protein Products
- R&D Systems Proteins and Enzymes for SIGLEC10 (Siglec-10)
-
OriGene Purified Proteins for SIGLEC10
- Search Origene for MassSpec and Protein Over-expression Lysates for SIGLEC10
- Origene Custom Protein Services for SIGLEC10
-
Cloud-Clone Corp. Proteins for SIGLEC10
- antibodies-online: Search results for 7 available SIGLEC10 Proteins ranked by validation data
- Compare Top SIGLEC10 Proteins
-
Quality Products:
- Search GeneTex for Proteins for SIGLEC10
-
Abcam proteins for SIGLEC10
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for SIGLEC10 (Siglec-10)
-
Cloud-Clone Corp. Assay Kits for SIGLEC10
No data available for DME Specific Peptides for SIGLEC10 Gene
Domains & Families for SIGLEC10 Gene
Gene Families for SIGLEC10 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for SIGLEC10 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SIGLEC10 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96LC7UniProtKB/Swiss-Prot:
SIG10_HUMAN :- Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
- Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
- Domain:
-
- Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
- Family:
-
- Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Function for SIGLEC10 Gene
Molecular function for SIGLEC10 Gene
- UniProtKB/Swiss-Prot Function:
- Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid (By similarity). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules (PubMed:11284738, PubMed:12163025). Involved in negative regulation of B-cell antigen receptor signaling. The inhibition of B cell activation is dependent on PTPN6/SHP-1 (By similarity). In association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (By similarity). In association with CD24 may regulate the immune repsonse of natural killer (NK) cells (PubMed:25450598). Plays a role in the control of autoimmunity (By similarity). During initiation of adaptive immune responses by CD8-alpha(+) dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification (By similarity).
Phenotypes From GWAS Catalog for SIGLEC10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 19264983 |
| GO:0019902 | phosphatase binding | IPI | 12163025 |
| GO:0030246 | carbohydrate binding | IEA | -- |
| GO:0042169 | SH2 domain binding | IMP | 12163025 |
Phenotypes for SIGLEC10 Gene
- MGI mutant phenotypes for SIGLEC10:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for SIGLEC10:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SIGLEC10
-
- Search ViGene Biosciences for SIGLEC10
CRISPR Products
-
OriGene CRISPR knockouts for SIGLEC10
- genomics-online: gRNA clones - Search results for 114 available SIGLEC10 gene related products
- Overview of 114 available SIGLEC10 gene related products
-
Recommended
- Applied Biological Materials CRISPR for SIGLEC10
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SIGLEC10
- GenScript: Design CRISPR guide RNA sequences for SIGLEC10
miRNA for SIGLEC10 Gene
- miRTarBase miRNAs that target SIGLEC10
-
- hsa-mir-142-3p (MIRT021581)
- hsa-mir-7151-3p (MIRT526705)
- hsa-mir-5095 (MIRT526706)
- hsa-mir-6715b-5p (MIRT526707)
- hsa-mir-4269 (MIRT526708)
- hsa-mir-5582-5p (MIRT526709)
- hsa-mir-4438 (MIRT526710)
- hsa-mir-362-3p (MIRT526711)
- hsa-mir-329-3p (MIRT526712)
- hsa-mir-6513-5p (MIRT617823)
- hsa-mir-887-5p (MIRT617825)
- hsa-mir-3913-5p (MIRT617826)
- hsa-mir-3122 (MIRT617827)
- hsa-mir-450a-1-3p (MIRT617828)
- hsa-mir-4298 (MIRT617829)
- hsa-mir-1302 (MIRT617830)
- hsa-mir-6749-3p (MIRT617831)
- hsa-mir-6792-3p (MIRT617832)
- hsa-mir-4691-5p (MIRT617833)
- hsa-mir-1298-5p (MIRT617834)
- hsa-mir-6832-3p (MIRT617835)
- hsa-mir-664a-3p (MIRT617836)
- hsa-mir-4788 (MIRT716316)
- hsa-mir-6861-3p (MIRT716317)
- hsa-mir-643 (MIRT716318)
- hsa-mir-6870-3p (MIRT716319)
- hsa-mir-5699-3p (MIRT716320)
- hsa-mir-4421 (MIRT716321)
- hsa-mir-6748-3p (MIRT716322)
- hsa-mir-660-3p (MIRT716323)
- hsa-mir-185-5p (MIRT763184)
- hsa-mir-4306 (MIRT768525)
- hsa-mir-4311 (MIRT768558)
- hsa-mir-4419a (MIRT768747)
- hsa-mir-4510 (MIRT769888)
- hsa-mir-4644 (MIRT770572)
- hsa-mir-6127 (MIRT775807)
- hsa-mir-6129 (MIRT775827)
- hsa-mir-6130 (MIRT775886)
- hsa-mir-6133 (MIRT775919)
- hsa-mir-6731-5p (MIRT777985)
- hsa-mir-6758-5p (MIRT778434)
- hsa-mir-6760-5p (MIRT778458)
- hsa-mir-6770-5p (MIRT778600)
- hsa-mir-6856-5p (MIRT780496)
- hsa-mir-6873-5p (MIRT780721)
- hsa-mir-8085 (MIRT782428)
miRNA Products
- Search ViGene Biosciences for SIGLEC10
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SIGLEC10
- Browse OriGene Inhibitory RNA Products For SIGLEC10
- genomics-online: shRNA clones - Search results for 114 available SIGLEC10 gene related products
- Overview of 114 available SIGLEC10 gene related products
-
Recommended
Clone Products
-
OriGene ORF clones in human for SIGLEC10
- RG210995
- RC210995L2
- RC210995L1
- RC210995
- RG230111
- RC230111L2
- RC230111L1
- RC230111
- RG230217
- RC230217L2
- RC230217L1
- RC230217
- RG230254
- RC230254L2
- RC230254L1
- RC230254
- RG230263
- RC230263L2
- RC230263L1
- RC230263
- RG230331
- RC230331L2
- RC230331L1
- RC230331
- RG230382
- RC230382L2
- RC230382L1
- RC230382
- RC210995L2V
- RC210995L1V
- RC230111L2V
- RC230111L1V
- RC230217L2V
- RC230217L1V
- RC230254L2V
- RC230254L1V
- RC230263L2V
- RC230263L1V
- RC230331L2V
- RC230331L1V
- RC230382L2V
- RC230382L1V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SIGLEC10
- VectorBuilder custom plasmid, inducible vectors for SIGLEC10
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SIGLEC10
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 114 available SIGLEC10 gene related products
- Overview of 114 available SIGLEC10 gene related products
-
Recommended
- orf clones - Search results for 114 available SIGLEC10 gene related products
- Overview of 114 available SIGLEC10 gene related products
-
Recommended
- Applied Biological Materials Clones for SIGLEC10
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for SIGLEC10 (Siglec-10)
Cell Line Products
-
Horizon Cell Lines for SIGLEC10
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIGLEC10 Gene
Localization for SIGLEC10 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC10 Gene
- Isoform 1: Cell membrane; Single-pass type I membrane protein.
- Isoform 2: Cell membrane; Single-pass type I membrane protein.
- Isoform 3: Cell membrane; Single-pass type I membrane protein.
- Isoform 4: Cell membrane; Single-pass type I membrane protein.
- Isoform 5: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytosol | 3 |
| cytoskeleton | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Actin filaments (3)
- Cytosol (3)
- Plasma membrane (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005886 | plasma membrane | IDA,IEA | 11284738 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for SIGLEC10 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
| 3 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | ||
Pathways by source for SIGLEC10 Gene
3 Reactome pathways for SIGLEC10 Gene
Interacting Proteins for SIGLEC10 Gene
Selected Interacting proteins:
Q96LC7-SIG10_HUMAN
ENSP00000345243
for SIGLEC10 Gene via
IID
MINT
STRING
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002250 | adaptive immune response | IEA | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0007155 | cell adhesion | IEA | -- |
| GO:0045087 | innate immune response | IEA | -- |
| GO:0106015 | negative regulation of inflammatory response to wounding | IPI | 19264983 |
Transcripts for SIGLEC10 Gene
mRNA/cDNA for SIGLEC10 Gene
- (11) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (21) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SIGLEC10 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SIGLEC10
- genomics-online: gRNA clones - Search results for 114 available SIGLEC10 gene related products
- Overview of 114 available SIGLEC10 gene related products
-
Recommended
- Applied Biological Materials CRISPR for SIGLEC10
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SIGLEC10
- GenScript: Design CRISPR guide RNA sequences for SIGLEC10
miRNA Products
- Search ViGene Biosciences for SIGLEC10
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SIGLEC10
- Browse OriGene Inhibitory RNA Products For SIGLEC10
- genomics-online: shRNA clones - Search results for 114 available SIGLEC10 gene related products
- Overview of 114 available SIGLEC10 gene related products
-
Recommended
Clone Products
-
OriGene ORF clones in human for SIGLEC10
- RG210995
- RC210995L2
- RC210995L1
- RC210995
- RG230111
- RC230111L2
- RC230111L1
- RC230111
- RG230217
- RC230217L2
- RC230217L1
- RC230217
- RG230254
- RC230254L2
- RC230254L1
- RC230254
- RG230263
- RC230263L2
- RC230263L1
- RC230263
- RG230331
- RC230331L2
- RC230331L1
- RC230331
- RG230382
- RC230382L2
- RC230382L1
- RC230382
- RC210995L2V
- RC210995L1V
- RC230111L2V
- RC230111L1V
- RC230217L2V
- RC230217L1V
- RC230254L2V
- RC230254L1V
- RC230263L2V
- RC230263L1V
- RC230331L2V
- RC230331L1V
- RC230382L2V
- RC230382L1V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SIGLEC10
- VectorBuilder custom plasmid, inducible vectors for SIGLEC10
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SIGLEC10
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 114 available SIGLEC10 gene related products
- Overview of 114 available SIGLEC10 gene related products
-
Recommended
- orf clones - Search results for 114 available SIGLEC10 gene related products
- Overview of 114 available SIGLEC10 gene related products
-
Recommended
- Applied Biological Materials Clones for SIGLEC10
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for SIGLEC10 (Siglec-10)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||||||||||||
| SP7: |
Expression for SIGLEC10 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Thymus (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for SIGLEC10 Gene
This gene is overexpressed in Whole Blood (x21.9) and Spleen (x8.0).
This gene is overexpressed in Peripheral blood mononuclear cells (37.7), Monocytes (20.7), and Blymphocyte (10.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SIGLEC10 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of SIGLEC10 Gene:
SIGLEC10SOURCE GeneReport for Unigene cluster for SIGLEC10 Gene:
Hs.284813mRNA Expression by UniProt/SwissProt for SIGLEC10 Gene:
Q96LC7-SIG10_HUMAN
Tissue specificity:
Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation). Isoform 5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow, spleen and spinal chord. Isoform 2 is also found in brain. Isoform 4 is specifically found in natural killer cells.
Evidence on tissue expression from TISSUES for SIGLEC10 Gene
- Lymph node(4.4)
- Spleen(4.4)
- Blood(4.3)
- Liver(4.1)
- Nervous system(4.1)
Primer Products
-
OriGene qPCR primer pairs for SIGLEC10
- genomics-online: primer clones - Search results for 114 available SIGLEC10 gene related products
- Overview of 114 available SIGLEC10 gene related products
-
Recommended
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SIGLEC10 Gene
Orthologs for SIGLEC10 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SIGLEC10 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | SIGLEC10 33 |
|
||
| -- 34 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | SIGLEC10 33 |
|
||
| -- 34 |
|
OneToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Siglec10 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Siglecg 33 16 34 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC101732062 33 |
|
- Species where no ortholog for SIGLEC10 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for SIGLEC10 Gene
Paralogs for SIGLEC10 Gene
(13) SIMAP similar genes for SIGLEC10 Gene using alignment to 6 proteins:
Pseudogenes.org Pseudogenes for SIGLEC10 Gene
Variants for SIGLEC10 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000801667 | -- | 51,416,022(-) | G/A | coding_sequence_variant, intron_variant, synonymous_variant | |
| rs1001670861 | -- | 51,412,510(-) | G/A | intron_variant | |
| rs1001698039 | -- | 51,412,132(-) | A/C | intron_variant | |
| rs1001757913 | -- | 51,417,140(-) | C/T | coding_sequence_variant, synonymous_variant | |
| rs1001789132 | -- | 51,416,953(-) | G/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1140251 | OTHER | inversion | 24896259 |
Residual Variation Intolerance Score:
83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
10.87;
91.81% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SIGLEC10 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SIGLEC10
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIGLEC10 Gene
Disorders for SIGLEC10 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| stargardt disease |
|
|
Search SIGLEC10 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SIGLEC10
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for SIGLEC10 Gene
Publications for SIGLEC10 Gene
- Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor. (PMID: 11284738) Munday J … Crocker PR (The Biochemical journal 2001) 2 3 4 58
- Molecular characterization, tissue expression, and mapping of a novel Siglec-like gene (SLG2) with three splice variants. (PMID: 11409878) Yousef GM … Diamandis EP (Biochemical and biophysical research communications 2001) 3 4 22 58
- Siglec-10 is associated with survival and natural killer cell dysfunction in hepatocellular carcinoma. (PMID: 25450598) Zhang P … Wu K (The Journal of surgical research 2015) 3 4 58
- CD24 and Siglec-10 selectively repress tissue damage-induced immune responses. (PMID: 19264983) Chen GY … Liu Y (Science (New York, N.Y.) 2009) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
Products for SIGLEC10 Gene
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Sources for SIGLEC10 Gene
- (1) GeneCards
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- (68) Cloud-Clone Corp.
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