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SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002]
SIGLEC10 (Sialic Acid Binding Ig Like Lectin 10) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is SIGLEC11.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 19264983 |
GO:0019902 | phosphatase binding | IPI | 12163025 |
GO:0030246 | carbohydrate binding | IEA | -- |
GO:0033691 | sialic acid binding | IBA | 21873635 |
GO:0042169 | SH2 domain binding | IMP | 12163025 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005886 | plasma membrane | IBA,IDA | 11284738 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Class I MHC mediated antigen processing and presentation | ||
2 | Innate Immune System |
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|
|
3 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002250 | adaptive immune response | IEA | -- |
GO:0002376 | immune system process | IEA | -- |
GO:0007155 | cell adhesion | IBA | 21873635 |
GO:0045087 | innate immune response | IEA | -- |
GO:0106015 | negative regulation of inflammatory response to wounding | IPI | 19264983 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||||||
SP6: | - | - | - | ||||||||||||||||||||||||||||||
SP7: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SIGLEC10 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SIGLEC10 30 |
|
||
-- 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | SIGLEC10 30 |
|
||
-- 31 |
|
OneToMany | |||
Rat (Rattus norvegicus) |
Mammalia | Siglec10 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Siglecg 30 17 31 |
|
OneToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC101732062 30 |
|
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
710149 | Benign: not provided | 51,415,221(-) | T/A | SYNONYMOUS_VARIANT | |
723714 | Benign: not provided | 51,416,811(-) | G/A | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
769046 | Benign: not provided | 51,417,359(-) | C/. | NON_CODING_TRANSCRIPT_VARIANT,NO_SEQUENCE_ALTERATION | |
770811 | Benign: not provided | 51,414,834(-) | C/G | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
773360 | Benign: not provided | 51,416,744(-) | T/C | MISSENSE_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1140251 | OTHER | inversion | 24896259 |
No disorders were found for SIGLEC10 Gene.