Aliases for SIGIRR Gene
External Ids for SIGIRR Gene
Previous GeneCards Identifiers for SIGIRR Gene
GeneCards Summary for SIGIRR Gene
SIGIRR (Single Ig And TIR Domain Containing) is a Protein Coding gene. Diseases associated with SIGIRR include Central Nervous System Tuberculosis and Progressive Myoclonus Epilepsy 8. Among its related pathways are Activated TLR4 signalling and Innate Immune System. An important paralog of this gene is IL1RAPL2.
UniProtKB/Swiss-Prot Summary for SIGIRR Gene
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.