Aliases for SIGIRR Gene

Aliases for SIGIRR Gene

  • Single Ig And TIR Domain Containing 2 3 5
  • TIR8 2 3 4
  • Single Immunoglobulin And Toll-Interleukin 1 Receptor (TIR) Domain 2 3
  • Single Immunoglobulin Domain-Containing IL1R-Related Protein 3 4
  • Single Immunoglobulin Domain IL1R1 Related 2 3
  • Single Ig IL-1R-Related Molecule 3 4
  • Single Ig IL-1-Related Receptor 3 4
  • Toll/Interleukin-1 Receptor 8 3 4
  • IL-1R8 2 3
  • Interleukin-1 Receptor 8 Long Isoform 3
  • SIGIRR 5

External Ids for SIGIRR Gene

Previous GeneCards Identifiers for SIGIRR Gene

  • GC11U990281
  • GC11P000782
  • GC11M000395
  • GC11M000220
  • GC11M000456

Summaries for SIGIRR Gene

GeneCards Summary for SIGIRR Gene

SIGIRR (Single Ig And TIR Domain Containing) is a Protein Coding gene. Diseases associated with SIGIRR include Central Nervous System Tuberculosis and Progressive Myoclonus Epilepsy 8. Among its related pathways are Activated TLR4 signalling and Innate Immune System. An important paralog of this gene is IL1RAPL2.

UniProtKB/Swiss-Prot Summary for SIGIRR Gene

  • Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.

Gene Wiki entry for SIGIRR Gene

Additional gene information for SIGIRR Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SIGIRR Gene

Genomics for SIGIRR Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SIGIRR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J000413 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 621.7 +1.9 1875 5.2 PRDM1 ZIC2 ZSCAN4 RXRB MTA1 NR2C1 SP1 EZH2 ZNF600 ZFX SIGIRR MN309219 lnc-SIGIRR-1 RNH1 PKP3 ANO9
GH11J000405 Promoter/Enhancer 1.9 Ensembl ENCODE CraniofacialAtlas dbSUPER 39.6 +10.4 10449 2.2 SP1 HNRNPL IKZF1 CTCF ZNF692 LARP7 ZNF143 MTA2 ZIC2 RBFOX2 SIGIRR LMNTD2-AS1 MN309219 PKP3 lnc-SIGIRR-1
GH11J000391 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 22 +22.6 22565 5.8 HNRNPL IKZF1 CTCF TARDBP JUND LARP7 MTA2 RBFOX2 PKNOX1 ZNF24 PKP3 SIGIRR TSPAN4 TMEM80 SNORA52 PHRF1 BET1L ENSG00000255237 PIDD1 PTDSS2
GH11J000304 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.7 +103.8 103839 18.4 GATAD2A CTCF HNRNPL TEAD4 PRDM10 REST IKZF1 POLR2A BACH1 LARP7 IFITM2 IFITM3 IFITM1 HSALNG0081954 ENSG00000254910 PGGHG PIDD1 TMEM80 ENSG00000270030 ENSG00000251661
GH11J000408 Enhancer 0.7 dbSUPER 36.8 +8.2 8202 1.3 HNRNPL GATAD2A ZIC2 SP1 SCRT2 ESR1 YY1 GABPA ZBTB25 NR2F2 SIGIRR PTDSS2 MN309219 lnc-SIGIRR-1 PKP3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SIGIRR on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SIGIRR

Top Transcription factor binding sites by QIAGEN in the SIGIRR gene promoter:
  • PPAR-gamma1
  • PPAR-gamma2
  • STAT3

Genomic Locations for SIGIRR Gene

Genomic Locations for SIGIRR Gene
chr11:405,716-417,455
(GRCh38/hg38)
Size:
11,740 bases
Orientation:
Minus strand
chr11:405,716-417,455
(GRCh37/hg19)
Size:
11,740 bases
Orientation:
Minus strand

Genomic View for SIGIRR Gene

Genes around SIGIRR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIGIRR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIGIRR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGIRR Gene

Proteins for SIGIRR Gene

  • Protein details for SIGIRR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IA17-SIGIR_HUMAN
    Recommended name:
    Single Ig IL-1-related receptor
    Protein Accession:
    Q6IA17
    Secondary Accessions:
    • Q3KQY2
    • Q6UXI3
    • Q9H733

    Protein attributes for SIGIRR Gene

    Size:
    410 amino acids
    Molecular mass:
    45679 Da
    Quaternary structure:
    • Interacts with IL1R1, IRAK1, TLR4, TLR5, TLR9 and TRAF6. Upon IL-1 stimulation found in a complex at least composed of IL1R1, SIGIRR, MYD88, IRAK1 and TRAF6. Upon stimulation with LPC found in a complex at least composed of TLR4, SIG1IR, MYD88, IRAK1 and TRAF6. Interacts with PALM3.

    Alternative splice isoforms for SIGIRR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIGIRR Gene

Post-translational modifications for SIGIRR Gene

  • Glycosylation at Asn31, Asn73, Asn86, and Asn102
  • Ubiquitination at Lys196
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SIGIRR Gene

Domains & Families for SIGIRR Gene

Gene Families for SIGIRR Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SIGIRR Gene

Suggested Antigen Peptide Sequences for SIGIRR Gene

GenScript: Design optimal peptide antigens:
  • Toll/interleukin-1 receptor 8 (SIGIR_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6IA17

UniProtKB/Swiss-Prot:

SIGIR_HUMAN :
  • Belongs to the interleukin-1 receptor family.
Family:
  • Belongs to the interleukin-1 receptor family.
genes like me logo Genes that share domains with SIGIRR: view

Function for SIGIRR Gene

Molecular function for SIGIRR Gene

UniProtKB/Swiss-Prot Function:
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
UniProtKB/Swiss-Prot Induction:
Down-regulated during inflammation by inhibition of an SP1-mediated pathway.

Phenotypes From GWAS Catalog for SIGIRR Gene

Gene Ontology (GO) - Molecular Function for SIGIRR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 12925853
genes like me logo Genes that share ontologies with SIGIRR: view
genes like me logo Genes that share phenotypes with SIGIRR: view

Animal Models for SIGIRR Gene

MGI Knock Outs for SIGIRR:

Animal Model Products

  • Taconic Biosciences Mouse Models for SIGIRR

CRISPR Products

miRNA for SIGIRR Gene

miRTarBase miRNAs that target SIGIRR

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIGIRR

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIGIRR Gene

Localization for SIGIRR Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGIRR Gene

Membrane. Single-pass type III membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIGIRR gene
Compartment Confidence
plasma membrane 5
extracellular 3
nucleus 3
cytosol 3
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SIGIRR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA,IMP 10346978
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SIGIRR: view

Pathways & Interactions for SIGIRR Gene

genes like me logo Genes that share pathways with SIGIRR: view

Pathways by source for SIGIRR Gene

1 R&D Systems pathway for SIGIRR Gene
1 Qiagen pathway for SIGIRR Gene
  • Toll-Like Receptors Pathway

Gene Ontology (GO) - Biological Process for SIGIRR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001960 negative regulation of cytokine-mediated signaling pathway ISS --
GO:0006953 acute-phase response ISS --
GO:0007165 signal transduction IEA --
GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway TAS 15866876
GO:0043433 negative regulation of DNA-binding transcription factor activity IMP 12925853
genes like me logo Genes that share ontologies with SIGIRR: view

No data available for SIGNOR curated interactions for SIGIRR Gene

Drugs & Compounds for SIGIRR Gene

No Compound Related Data Available

Transcripts for SIGIRR Gene

mRNA/cDNA for SIGIRR Gene

3 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIGIRR

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIGIRR Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - - -
SP5: - - - - - - - - - - -
SP6: -
SP7: - - - - -
SP8: - - - - - - -
SP9: - - - - -
SP10: - - - - - -
SP11: - - -
SP12: - - - - - - -
SP13: - - - - - -
SP14: - - - - -
SP15: - - -
SP16: - - - - - - - - -
SP17: - - - - - - - - - -
SP18: -
SP19:
SP20:
SP21:

ExUns: 14a · 14b · 14c · 14d ^ 15a · 15b
SP1: -
SP2: -
SP3: -
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: -
SP19:
SP20:
SP21:

Relevant External Links for SIGIRR Gene

GeneLoc Exon Structure for
SIGIRR

Expression for SIGIRR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SIGIRR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SIGIRR Gene

This gene is overexpressed in Whole Blood (x5.1).

Protein differential expression in normal tissues from HIPED for SIGIRR Gene

This gene is overexpressed in Peripheral blood mononuclear cells (33.3) and NK cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SIGIRR Gene



Protein tissue co-expression partners for SIGIRR Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SIGIRR

SOURCE GeneReport for Unigene cluster for SIGIRR Gene:

Hs.501624

mRNA Expression by UniProt/SwissProt for SIGIRR Gene:

Q6IA17-SIGIR_HUMAN
Tissue specificity: Mainly expressed in epithelial tissues such as kidney, lung and gut.

Evidence on tissue expression from TISSUES for SIGIRR Gene

  • Intestine(4.6)
  • Lung(4.5)
  • Liver(4.5)
  • Pancreas(4.3)
  • Spleen(3)
  • Lymph node(3)
  • Kidney(2.7)
  • Bone marrow(2.5)
  • Blood(2.5)
  • Heart(2.2)
  • Stomach(2.1)
  • Nervous system(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with SIGIRR: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SIGIRR Gene

Orthologs for SIGIRR Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIGIRR Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SIGIRR 30 31
  • 97.96 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SIGIRR 30 31
  • 85.53 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SIGIRR 30 31
  • 82.44 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Sigirr 30 17 31
  • 81.83 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Sigirr 30
  • 80.85 (n)
Chicken
(Gallus gallus)
Aves SIGIRR 30 31
  • 64.82 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SIGIRR 31
  • 54 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia sigirr 30
  • 56.24 (n)
Zebrafish
(Danio rerio)
Actinopterygii sigirr 30 31
  • 53.16 (n)
OneToOne
Species where no ortholog for SIGIRR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SIGIRR Gene

ENSEMBL:
Gene Tree for SIGIRR (if available)
TreeFam:
Gene Tree for SIGIRR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SIGIRR: view image

Paralogs for SIGIRR Gene

genes like me logo Genes that share paralogs with SIGIRR: view

Variants for SIGIRR Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SIGIRR Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
746264 Likely Benign: not provided 405,980(-) G/A SYNONYMOUS_VARIANT
756397 Likely Benign: not provided 406,921(-) G/A SYNONYMOUS_VARIANT
768408 Benign: not provided 408,745(-) G/A SYNONYMOUS_VARIANT
776555 Benign: not provided 408,191(-) C/G SYNONYMOUS_VARIANT
rs111819059 - p.Pro115Arg

Additional dbSNP identifiers (rs#s) for SIGIRR Gene

Structural Variations from Database of Genomic Variants (DGV) for SIGIRR Gene

Variant ID Type Subtype PubMed ID
dgv1012n100 CNV gain 25217958
dgv1505n54 CNV gain 21841781
dgv182e199 CNV deletion 23128226
dgv564n106 OTHER inversion 24896259
esv2759794 CNV loss 17122850
esv27645 CNV gain+loss 19812545
esv3891907 CNV loss 25118596
nsv1070918 CNV deletion 25765185
nsv1077764 OTHER inversion 25765185
nsv1143663 CNV deletion 24896259
nsv1143665 CNV deletion 24896259
nsv1151392 CNV insertion 26484159
nsv1159790 CNV deletion 26073780
nsv467633 CNV loss 19166990
nsv469923 CNV loss 18288195
nsv527327 CNV loss 19592680
nsv552770 CNV gain 21841781
nsv552776 CNV loss 21841781
nsv552822 CNV loss 21841781
nsv552823 CNV loss 21841781
nsv552824 CNV loss 21841781
nsv552825 CNV gain+loss 21841781
nsv552826 CNV gain 21841781
nsv951268 CNV deletion 24416366

Variation tolerance for SIGIRR Gene

Residual Variation Intolerance Score: 85.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.44; 42.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SIGIRR Gene

Human Gene Mutation Database (HGMD)
SIGIRR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIGIRR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIGIRR Gene

Disorders for SIGIRR Gene

MalaCards: The human disease database

(4) MalaCards diseases for SIGIRR Gene - From: DISEASES

Disorder Aliases PubMed IDs
central nervous system tuberculosis
  • intracranial tuberculoma
progressive myoclonus epilepsy 8
  • emp8
loeffler syndrome
  • loeffler's pneumonia
perinatal necrotizing enterocolitis
  • enterocolitis necrotizing
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SIGIRR

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SIGIRR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SIGIRR Gene

Publications for SIGIRR Gene

  1. Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily. (PMID: 10346978) Thomassen E … Sims JE (Cytokine 1999) 2 3 4 23
  2. SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms. (PMID: 15866876) Qin J … Li X (The Journal of biological chemistry 2005) 3 4 23
  3. Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR. (PMID: 14715412) Polentarutti N … Mantovani A (European cytokine network 2003) 3 4 23
  4. SIGIRR genetic variants in premature infants with necrotizing enterocolitis. (PMID: 25963006) Sampath V … Dimmock DP (Pediatrics 2015) 3 4
  5. A novel binding protein of single immunoglobulin IL-1 receptor-related molecule: Paralemmin-3. (PMID: 21187075) Chen X … Qian G (Biochemical and biophysical research communications 2011) 3 4

Products for SIGIRR Gene

Sources for SIGIRR Gene