Aliases for SIDT2 Gene
External Ids for SIDT2 Gene
Previous GeneCards Identifiers for SIDT2 Gene
GeneCards Summary for SIDT2 Gene
SIDT2 (SID1 Transmembrane Family Member 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include RNA transmembrane transporter activity. An important paralog of this gene is SIDT1.
UniProtKB/Swiss-Prot Summary for SIDT2 Gene
Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA or DNA is directly imported into lysosomes in an ATP-dependent manner, and degraded (PubMed:27046251, PubMed:27846365). Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis (PubMed:28277980). In vitro, mediates the uptake of linear DNA more efficiently than that of circular DNA, but exhibits similar uptake efficacy toward RNA and DNA. Binds long double-stranded RNA (dsRNA) (500 - 700 base pairs), but not dsRNA shorter than 100 bp (By similarity).