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Aliases for SIDT2 Gene
Aliases for SIDT2 Gene
External Ids for SIDT2 Gene
- HGNC: 24272
- Entrez Gene: 51092
- Ensembl: ENSG00000149577
- OMIM: 617551
- UniProtKB: Q8NBJ9
Previous GeneCards Identifiers for SIDT2 Gene
- GC11P116554
- GC11P117049
- GC11P112982
Summaries for SIDT2 Gene
GeneCards Summary for SIDT2 Gene
SIDT2 (SID1 Transmembrane Family Member 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include RNA transmembrane transporter activity. An important paralog of this gene is SIDT1.
UniProtKB/Swiss-Prot Summary for SIDT2 Gene
-
Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA or DNA is directly imported into lysosomes in an ATP-dependent manner, and degraded (PubMed:27046251, PubMed:27846365). Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis (PubMed:28277980). In vitro, mediates the uptake of linear DNA more efficiently than that of circular DNA, but exhibits similar uptake efficacy toward RNA and DNA. Binds long double-stranded RNA (dsRNA) (500 - 700 base pairs), but not dsRNA shorter than 100 bp (By similarity).
Additional gene information for SIDT2 Gene
- HGNC(24272)
- Entrez Gene(51092)
- Ensembl(ENSG00000149577)
- OMIM(617551)
- UniProtKB(Q8NBJ9)
- Open Targets Platform(ENSG00000149577)
- Search for SIDT2 at DataMed
- Search for SIDT2 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SIDT2 Gene
Genomics for SIDT2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SIDT2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SIDT2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SIDT2
- Top Transcription factor binding sites by QIAGEN in the SIDT2 gene promoter:
-
- AML1a
- AP-1
- CUTL1
- HFH-1
- Sp1
- STAT5B
- TBP
Genomic Locations for SIDT2 Gene
Genomic Locations for SIDT2 Gene
- chr11:117,178,736-117,197,445
- (GRCh38/hg38)
- Size:
- 18,710 bases
- Orientation:
- Plus strand
- chr11:117,049,449-117,068,161
- (GRCh37/hg19)
- Size:
- 18,713 bases
- Orientation:
- Plus strand
Genomic View for SIDT2 Gene
Genes around SIDT2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q23.3 by HGNC
- 11q23.3 by Entrez Gene
- 11q23.3 by Ensembl
SIDT2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SIDT2 Gene
Proteins for SIDT2 Gene
-
Protein details for SIDT2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NBJ9-SIDT2_HUMAN
- Recommended name:
- SID1 transmembrane family member 2
- Protein Accession:
- Q8NBJ9
- Q8NBY7
- Q9Y357
Protein attributes for SIDT2 Gene
- Size:
- 832 amino acids
- Molecular mass:
- 94454 Da
- Quaternary structure:
-
- Interacts with adapter protein complex 1 (AP-1) and AP-2, but not AP-3 and AP-4 (By similarity). Interacts with LAMP2 (PubMed:27046251).
- SequenceCaution:
-
- Sequence=BAC11427.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAC11641.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
Protein Expression for SIDT2 Gene
Post-translational modifications for SIDT2 Gene
- Glycosylated.
-
Glycosylation at Asn27, Asn54, Asn60, Asn123, Asn141, Asn165, Asn476, Asn496, Asn572, and Asn603
- NX_Q8NBJ9 (NX_Q8NBJ9-1)
- Modification sites at PhosphoSitePlus
Other Protein References for SIDT2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences SIDT2 Antibody (LS-B10067) and SIDT2 Antibody (LS-B11312)
- Novus Biologicals Antibodies for SIDT2
-
Abcam antibodies for SIDT2
- Invitrogen Antibodies for SIDT2 (AFLGC-SIDT2)
- antibodies-online: Show 11 available SIDT2 Antibodies ranked by validation data
-
Boster Bio Antibodies for SIDT2
-
Custom Antibody ServicesProSci Antibodies for SIDT2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for SIDT2
- Origene Custom Protein Services for SIDT2
- Novus Biologicals proteins for SIDT2
No data available for DME Specific Peptides for SIDT2 Gene
Domains & Families for SIDT2 Gene
Gene Families for SIDT2 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
- Transporters
Protein Domains for SIDT2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SIDT2 Gene
- GenScript: Design optimal peptide antigens:
-
- SIDT2 protein (Q24JR2_HUMAN)
- SID1 transmembrane family member 2 (SIDT2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8NBJ9- Family:
-
- Belongs to the SID1 family.
Function for SIDT2 Gene
Molecular function for SIDT2 Gene
- UniProtKB/Swiss-Prot Function:
- Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA or DNA is directly imported into lysosomes in an ATP-dependent manner, and degraded (PubMed:27046251, PubMed:27846365). Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis (PubMed:28277980). In vitro, mediates the uptake of linear DNA more efficiently than that of circular DNA, but exhibits similar uptake efficacy toward RNA and DNA. Binds long double-stranded RNA (dsRNA) (500 - 700 base pairs), but not dsRNA shorter than 100 bp (By similarity).
Phenotypes From GWAS Catalog for SIDT2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003723 | RNA binding | IEA | -- |
| GO:0003725 | double-stranded RNA binding | IBA | 21873635 |
| GO:0035612 | AP-2 adaptor complex binding | ISS | -- |
| GO:0035650 | AP-1 adaptor complex binding | ISS | -- |
Phenotypes for SIDT2 Gene
- MGI mutant phenotypes for SIDT2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for SIDT2:
Animal Models for SIDT2 Gene
- MGI Knock Outs for SIDT2:
-
- Sidt2 Sidt2<tm1.1Hzha>
Animal Model Products
-
Taconic Biosciences Mouse Models for SIDT2
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SIDT2 - Select products 50% OFF >
- * SIDT2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SIDT2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SIDT2
-
Santa Cruz Biotechnology (SCBT) CRISPR for SIDT2
miRNA for SIDT2 Gene
- miRTarBase miRNAs that target SIDT2
-
- mmu-miR-451a (MIRT008414)
- mmu-miR-9-5p (MIRT015150)
- hsa-miR-3187-3p (MIRT443802)
- hsa-miR-4435 (MIRT443803)
- hsa-miR-588 (MIRT443804)
- hsa-miR-4701-5p (MIRT443805)
- hsa-miR-548s (MIRT443806)
- hsa-miR-3926 (MIRT443807)
- hsa-miR-16-5p (MIRT443808)
- hsa-miR-15a-5p (MIRT443809)
- hsa-miR-497-5p (MIRT443810)
- hsa-miR-424-5p (MIRT443811)
- hsa-miR-15b-5p (MIRT443812)
- hsa-miR-6838-5p (MIRT443813)
- hsa-miR-195-5p (MIRT443814)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SIDT2
- Browse OriGene Inhibitory RNA Products For SIDT2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIDT2
Clone Products
- Applied Biological Materials (abm): Clones for SIDT2 - Select products 50% OFF >
- * SIDT2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SIDT2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SIDT2
Cell Line Products
-
Horizon Cell Lines for SIDT2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIDT2 Gene
Localization for SIDT2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SIDT2 Gene
- Lysosome membrane. Multi-pass membrane protein. Cell membrane. Note=Mainly localizes to lysosomes and only partly to the plasma membrane (PubMed:28277980). Lysosomal localization is required for SIDT2-mediated intracellular degradation of endogenous RNA (By similarity). {ECO:0000250 UniProtKB:Q8CIF6, ECO:0000269 PubMed:28277980}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| lysosome | 5 |
| extracellular | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005764 | lysosome | IBA,IDA | 28277980 |
| GO:0005765 | lysosomal membrane | IEA,IDA | 17897319 |
| GO:0005886 | plasma membrane | IBA,IDA | 28277980 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for SIDT2 Gene
Pathways & Interactions for SIDT2 Gene
Interacting Proteins for SIDT2 Gene
GPS-Prot Interaction Network for SIDT2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000902 | cell morphogenesis | IEA | -- |
| GO:0003323 | type B pancreatic cell development | IEA | -- |
| GO:0006401 | RNA catabolic process | ISS | -- |
| GO:0009749 | response to glucose | IEA | -- |
| GO:0033227 | dsRNA transport | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for SIDT2 Gene
Transcripts for SIDT2 Gene
mRNA/cDNA for SIDT2 Gene
- 2 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 20 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000278951 3135 nts (view in UCSC)
- ENST00000324225 4396 nts (view in UCSC)
- ENST00000431081 3910 nts (view in UCSC)
- ENST00000524842 834 nts (view in UCSC)
- ENST00000524988 476 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SIDT2 - Select products 50% OFF >
- * SIDT2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SIDT2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SIDT2
-
Santa Cruz Biotechnology (SCBT) CRISPR for SIDT2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SIDT2
- Browse OriGene Inhibitory RNA Products For SIDT2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIDT2
Clone Products
- Applied Biological Materials (abm): Clones for SIDT2 - Select products 50% OFF >
- * SIDT2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SIDT2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SIDT2
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | · | 16c | · | 16d | ^ | 17a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: |
| ExUns: | 17b | ^ | 18a | · | 18b | ^ | 19a | · | 19b | ^ | 20a | · | 20b | ^ | 21a | · | 21b | · | 21c | ^ | 22 | ^ | 23 | ^ | 24a | · | 24b | ^ | 25 | ^ | 26a | · | 26b | ^ | 27 | ^ | 28a | · | 28b | · | 28c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||||||||||||||||
| SP13: |
Relevant External Links for SIDT2 Gene
- GeneLoc Exon Structure for
- SIDT2
Expression for SIDT2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Pancreas (Endocrine System)
This gene is overexpressed in Pancreas (24.7), Placenta (15.2), Testis (15.0), and Ovary (9.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SIDT2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SIDT2
SOURCE GeneReport for Unigene cluster for SIDT2 Gene:
Hs.712144Evidence on tissue expression from TISSUES for SIDT2 Gene
- Nervous system(4.1)
- Liver(2.3)
- Muscle(2.2)
- Pancreas(2)
Primer Products
-
OriGene qPCR primer pairs for SIDT2
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIDT2 Gene
Orthologs for SIDT2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SIDT2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SIDT2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SIDT2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Sidt2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Sidt2 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | SIDT2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | SIDT2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | SIDT2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | sidt2 30 |
|
||
| Str.18477 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.14690 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | sidt2 31 |
|
OneToOne | |
| wufc73a07 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6494 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | tag-130 30 |
|
||
| chup-1 31 |
|
ManyToMany | |||
| sid-1 31 |
|
ManyToMany |
- Species where no ortholog for SIDT2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for SIDT2 Gene
- ENSEMBL:
- Gene Tree for SIDT2 (if available)
- TreeFam:
- Gene Tree for SIDT2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SIDT2: view image
Paralogs for SIDT2 Gene
Variants for SIDT2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SIDT2 Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 779316 | Benign: not provided | 117,192,273(+) | C/T | MISSENSE_VARIANT | |
| 779317 | Benign: not provided | 117,192,304(+) | C/T | SYNONYMOUS_VARIANT | |
| 789211 | Benign: not provided | 117,186,578(+) | A/G | INTRON_VARIANT | |
| rs12285035 | - | p.Thr631Met | |||
| rs17120425 | - | p.Val636Ile |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2186n54 | CNV | loss | 21841781 |
| dgv730n106 | OTHER | inversion | 24896259 |
| nsv1078301 | OTHER | inversion | 25765185 |
| nsv518908 | CNV | loss | 19592680 |
| nsv524270 | CNV | loss | 19592680 |
| nsv7223 | OTHER | inversion | 18451855 |
Residual Variation Intolerance Score:
41.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.09;
60.97% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SIDT2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SIDT2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIDT2 Gene
Disorders for SIDT2 Gene
Additional Disease Information for SIDT2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for SIDT2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIDT2 Gene
Publications for SIDT2 Gene
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4
- Lysosomal membrane protein SIDT2 mediates the direct uptake of DNA by lysosomes. (PMID: 27846365) Aizawa S … Kabuta T (Autophagy 2017) 3 4
- SIDT2 mediates gymnosis, the uptake of naked single-stranded oligonucleotides into living cells. (PMID: 28277980) Takahashi M … Kabuta T (RNA biology 2017) 3 4
- Lysosomal putative RNA transporter SIDT2 mediates direct uptake of RNA by lysosomes. (PMID: 27046251) Aizawa S … Kabuta T (Autophagy 2016) 3 4
ExternalLinks
Products for SIDT2 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for SIDT2
- Origene Custom Protein Services for SIDT2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SIDT2
- Browse OriGene Inhibitory RNA Products For SIDT2
- OriGene qPCR primer pairs for SIDT2
- OriGene CRISPR knockouts for SIDT2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SIDT2
- Sino Biological Human cDNA Clone for SIDT2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for SIDT2
- Novus Biologicals proteins for SIDT2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for SIDT2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for SIDT2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for SIDT2 (AFLGC-SIDT2)
- VectorBuilder Custom and pre-made DNA vectors for SIDT2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for SIDT2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for SIDT2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for SIDT2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for SIDT2
- antibodies-online: Show 11 available SIDT2 Antibodies ranked by validation data
- antibodies-online: Search results for available SIDT2 related products ranked by validation data
- antibodies-online: Search results for available SIDT2 related products ranked by validation data
- Custom Antibody ServicesProSci Antibodies for SIDT2
- Search for SIDT2 Proteins at ProSci
- Horizon Cell Lines for SIDT2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SIDT2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SIDT2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SIDT2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIDT2
- Boster Bio Antibodies for SIDT2
- Browse Boster Bio ELISA Kits
Sources for SIDT2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB