This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia. [provided by RefSeq, Jul 2008] See more...

Aliases for SIAH2 Gene

Aliases for SIAH2 Gene

  • Siah E3 Ubiquitin Protein Ligase 2 2 3 5
  • RING-Type E3 Ubiquitin Transferase SIAH2 3 4
  • E3 Ubiquitin-Protein Ligase SIAH2 3 4
  • Seven In Absentia Homolog 2 3 4
  • Siah-2 3 4
  • HSiah2 3 4
  • Seven In Absentia (Drosophila) Homolog 2 2
  • Seven In Absentia Homolog 2 (Drosophila) 2
  • EC 2.3.2.27 4
  • EC 6.3.2 52

External Ids for SIAH2 Gene

Previous GeneCards Identifiers for SIAH2 Gene

  • GC03M147291
  • GC03M151291
  • GC03M151740
  • GC03M151779
  • GC03M151941
  • GC03M150458
  • GC03M147832

Summaries for SIAH2 Gene

Entrez Gene Summary for SIAH2 Gene

  • This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia. [provided by RefSeq, Jul 2008]

GeneCards Summary for SIAH2 Gene

SIAH2 (Siah E3 Ubiquitin Protein Ligase 2) is a Protein Coding gene. Diseases associated with SIAH2 include Usher Syndrome. Among its related pathways are Metabolism of proteins and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ligase activity and transcription corepressor activity. An important paralog of this gene is SIAH1.

UniProtKB/Swiss-Prot Summary for SIAH2 Gene

  • E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (GPS2, POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 does not. Promotes monoubiquitination of SNCA. Regulates cellular clock function via ubiquitination of the circadian transcriptional repressors NR1D1 and NR1D2 leading to their proteasomal degradation. Plays an important role in mediating the rhythmic degradation/clearance of NR1D1 and NR1D2 contributing to their circadian profile of protein abundance (PubMed:26392558).

Gene Wiki entry for SIAH2 Gene

Additional gene information for SIAH2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SIAH2 Gene

Genomics for SIAH2 Gene

GeneHancer (GH) Regulatory Elements for SIAH2 Gene

Promoters and enhancers for SIAH2 Gene