External Ids for SHTN1 Gene
Previous HGNC Symbols for SHTN1 Gene
GeneCards Summary for SHTN1 Gene
SHTN1 (Shootin 1) is a Protein Coding gene. Diseases associated with SHTN1 include Epileptic Encephalopathy, Early Infantile, 2 and Hypothyroidism, Thyroidal Or Athyroidal, With Spiky Hair And Cleft Palate. Among its related pathways are Endocytic Trafficking of EGFR and L1CAM interactions. An important paralog of this gene is FHOD3.
UniProtKB/Swiss-Prot Summary for SHTN1 Gene
Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Plays also a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons.