Aliases for SHROOM3 Gene
External Ids for SHROOM3 Gene
Previous GeneCards Identifiers for SHROOM3 Gene
This gene encodes a PDZ-domain-containing protein that belongs to a family of Shroom-related proteins. This protein may be involved in regulating cell shape in certain tissues. A similar protein in mice is required for proper neurulation. [provided by RefSeq, Jan 2011]
GeneCards Summary for SHROOM3 Gene
SHROOM3 (Shroom Family Member 3) is a Protein Coding gene. Diseases associated with SHROOM3 include Neutrophil Actin Dysfunction and Brachyolmia Type 4 With Mild Epiphyseal And Metaphyseal Changes. Gene Ontology (GO) annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is SHROOM2.
UniProtKB/Swiss-Prot Summary for SHROOM3 Gene
Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity).