Aliases for SHPRH Gene
External Ids for SHPRH Gene
Previous GeneCards Identifiers for SHPRH Gene
SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006 [PubMed 17108083]).[supplied by OMIM, Mar 2008]
GeneCards Summary for SHPRH Gene
SHPRH (SNF2 Histone Linker PHD RING Helicase) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ligase activity and helicase activity. An important paralog of this gene is CHD7.
UniProtKB/Swiss-Prot Summary for SHPRH Gene
E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'.