Aliases for SHPRH Gene
External Ids for SHPRH Gene
Previous GeneCards Identifiers for SHPRH Gene
SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006 [PubMed 17108083]).[supplied by OMIM, Mar 2008]
GeneCards Summary for SHPRH Gene
SHPRH (SNF2 Histone Linker PHD RING Helicase) is a Protein Coding gene. Diseases associated with SHPRH include Xeroderma Pigmentosum, Variant Type. Gene Ontology (GO) annotations related to this gene include ligase activity and helicase activity. An important paralog of this gene is CHD7.
UniProtKB/Swiss-Prot Summary for SHPRH Gene
E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'.