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Aliases for SHOC2 Gene

Aliases for SHOC2 Gene

  • SHOC2, Leucine Rich Repeat Scaffold Protein 2 3 5
  • Soc-2 (Suppressor Of Clear, C.Elegans) Homolog 2
  • Soc-2 Suppressor Of Clear Homolog (C. Elegans) 2
  • SHOC2 Leucine-Rich Repeat Scaffold Protein 2
  • Leucine-Rich Repeat Protein SHOC-2 3
  • Soc-2 Suppressor Of Clear Homolog 3
  • Protein Soc-2 Homolog 4
  • Protein Sur-8 Homolog 4
  • SIAA0862 3
  • KIAA0862 4
  • SOC2 3
  • SUR8 3

External Ids for SHOC2 Gene

Previous GeneCards Identifiers for SHOC2 Gene

  • GC10P111572
  • GC10P111912
  • GC10P112810
  • GC10P112343
  • GC10P112389
  • GC10P112669
  • GC10P106308
  • GC10P112679

Summaries for SHOC2 Gene

Entrez Gene Summary for SHOC2 Gene

  • This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair. [provided by RefSeq, May 2010]

GeneCards Summary for SHOC2 Gene

SHOC2 (SHOC2, Leucine Rich Repeat Scaffold Protein) is a Protein Coding gene. Diseases associated with SHOC2 include Noonan Syndrome-Like Disorder With Loose Anagen Hair 1 and Noonan Syndrome 3. Among its related pathways are Ras signaling pathway and MAP Kinase Signaling. Gene Ontology (GO) annotations related to this gene include protein phosphatase binding and protein phosphatase regulator activity. An important paralog of this gene is SCRIB.

UniProtKB/Swiss-Prot for SHOC2 Gene

  • Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the Ser-259 inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.

Gene Wiki entry for SHOC2 Gene

Additional gene information for SHOC2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHOC2 Gene

Genomics for SHOC2 Gene

GeneHancer (GH) Regulatory Elements for SHOC2 Gene

Promoters and enhancers for SHOC2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J110915 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 650.7 -0.7 -739 5.9 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF263 SP3 BBIP1 SHOC2 SMC3 SMNDC1 RPL7P35 ENSG00000270589 XPNPEP1 ADRA2A PDCD4
GH10J110943 Promoter 0.7 EPDnew 650.3 +23.7 23674 0.1 SCRT1 ZNF133 SHOC2 RPL13AP6 MIR548E
GH10J110857 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22.1 -53.4 -53373 18 FEZF1 IRF4 YY1 ZNF213 ZNF143 SP3 NFYC MEF2D ZNF610 GLIS1 PDCD4 SHOC2 BBIP1 ADRA2A ENSG00000270589 DUSP5 ENSG00000232470 PDCD4-AS1 RNA5SP327 GC10P110732
GH10J110883 Enhancer 1 Ensembl ENCODE dbSUPER 11.3 -35.5 -35495 0.8 MEIS2 HDAC2 REST MNT MYC RUNX3 CREM ZNF592 BBIP1 SHOC2 PDCD4-AS1 MIR4680 PDCD4 GC10P110732
GH10J110832 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 5.3 -79.2 -79227 15 HDGF PKNOX1 FOXA2 SMAD1 MLX ZFP64 ARID4B NEUROD1 FEZF1 YBX1 RBM20 PDCD4 PDCD4-AS1 ENSG00000232470 SHOC2 SMC3 RNA5SP327 GC10P110732
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SHOC2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SHOC2 gene promoter:
  • Elk-1
  • FOXD1
  • POU2F1a
  • POU2F1
  • AREB6
  • AML1a
  • XBP-1
  • NRF-2
  • Arnt
  • AhR

Genomic Locations for SHOC2 Gene

Genomic Locations for SHOC2 Gene
94,125 bases
Plus strand
94,125 bases
Plus strand

Genomic View for SHOC2 Gene

Genes around SHOC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHOC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHOC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHOC2 Gene

Proteins for SHOC2 Gene

  • Protein details for SHOC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat protein SHOC-2
    Protein Accession:
    Secondary Accessions:
    • A8K9W8
    • B3KR23
    • O76063
    • Q5VZS8
    • Q5VZS9

    Protein attributes for SHOC2 Gene

    582 amino acids
    Molecular mass:
    64888 Da
    Quaternary structure:
    • Interacts with M-Ras/MRAS, and RAF1. Forms a multiprotein complex with Ras (M-Ras/MRAS), Raf (RAF1) and protein phosphatase 1 (PPP1CA, PPP1CB and PPP1CC). Interacts with ERBIN; disrupts the interaction with RAF1 and Ras, leading to prevent activation of the Ras signaling pathway. Specifically binds K-Ras/KRAS, M-Ras/MRAS and N-Ras/NRAS but not H-Ras/HRAS.
    • Sequence=BAA74885.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG52235.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH72813.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SHOC2 Gene


neXtProt entry for SHOC2 Gene

Post-translational modifications for SHOC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SHOC2 Gene

No data available for DME Specific Peptides for SHOC2 Gene

Domains & Families for SHOC2 Gene

Gene Families for SHOC2 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SHOC2 Gene

Suggested Antigen Peptide Sequences for SHOC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SHOC2 family.
  • Belongs to the SHOC2 family.
genes like me logo Genes that share domains with SHOC2: view

Function for SHOC2 Gene

Molecular function for SHOC2 Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the Ser-259 inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.
GENATLAS Biochemistry:
leucine-rich protein,cytoplasmic,ubiquitously expressed,homolog to C elegans soc2,suppressor of clear (clr-1),implicated in fibroblast growth receptor signaling

Phenotypes From GWAS Catalog for SHOC2 Gene

Gene Ontology (GO) - Molecular Function for SHOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16301319
GO:0008157 protein phosphatase 1 binding IDA 25137548
GO:0019888 protein phosphatase regulator activity TAS 16630891
GO:0019903 protein phosphatase binding IDA 16630891
genes like me logo Genes that share ontologies with SHOC2: view
genes like me logo Genes that share phenotypes with SHOC2: view

Human Phenotype Ontology for SHOC2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SHOC2 Gene

MGI Knock Outs for SHOC2:

Animal Model Products

CRISPR Products

miRNA for SHOC2 Gene

miRTarBase miRNAs that target SHOC2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SHOC2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SHOC2 Gene

Localization for SHOC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHOC2 Gene

Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus upon growth factor stimulation.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SHOC2 gene
Compartment Confidence
nucleus 5
cytosol 5
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SHOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000164 protein phosphatase type 1 complex IDA 16630891
GO:0005634 nucleus IEA,IDA 19684605
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm NAS 9618511
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with SHOC2: view

Pathways & Interactions for SHOC2 Gene

genes like me logo Genes that share pathways with SHOC2: view

Pathways by source for SHOC2 Gene

1 KEGG pathway for SHOC2 Gene
1 Cell Signaling Technology pathway for SHOC2 Gene

SIGNOR curated interactions for SHOC2 Gene


Gene Ontology (GO) - Biological Process for SHOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0007265 Ras protein signal transduction NAS 9674433
GO:0008543 fibroblast growth factor receptor signaling pathway NAS 9618511
GO:0043666 regulation of phosphoprotein phosphatase activity IEA --
GO:0046579 positive regulation of Ras protein signal transduction IMP 16630891
genes like me logo Genes that share ontologies with SHOC2: view

Drugs & Compounds for SHOC2 Gene

No Compound Related Data Available

Transcripts for SHOC2 Gene

Unigene Clusters for SHOC2 Gene

Soc-2 suppressor of clear homolog (C. elegans):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SHOC2

Alternative Splicing Database (ASD) splice patterns (SP) for SHOC2 Gene

No ASD Table

Relevant External Links for SHOC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SHOC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SHOC2 Gene

Protein differential expression in normal tissues from HIPED for SHOC2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SHOC2 Gene

Protein tissue co-expression partners for SHOC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SHOC2 Gene:


SOURCE GeneReport for Unigene cluster for SHOC2 Gene:


Evidence on tissue expression from TISSUES for SHOC2 Gene

  • Nervous system(4.7)
  • Skin(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for SHOC2 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • integumentary
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Head and neck:
  • brain
  • cerebellum
  • cerebrospinal fluid
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • meninges
  • mouth
  • neck
  • nose
  • outer ear
  • scalp
  • skull
  • chest wall
  • clavicle
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
  • pelvis
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
  • blood
  • blood vessel
  • hair
  • peripheral nervous system
  • skin
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with SHOC2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SHOC2 Gene

Orthologs for SHOC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SHOC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SHOC2 34 33
  • 99.83 (n)
(Monodelphis domestica)
Mammalia SHOC2 34
  • 97 (a)
(Bos Taurus)
Mammalia SHOC2 34 33
  • 96.05 (n)
(Canis familiaris)
Mammalia SHOC2 34 33
  • 95.93 (n)
(Ornithorhynchus anatinus)
Mammalia SHOC2 34
  • 92 (a)
(Mus musculus)
Mammalia Shoc2 16 34 33
  • 91.92 (n)
(Rattus norvegicus)
Mammalia Shoc2 33
  • 90.55 (n)
(Gallus gallus)
Aves SHOC2 34 33
  • 84.5 (n)
(Anolis carolinensis)
Reptilia SHOC2 34
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia shoc2 33
  • 77.4 (n)
African clawed frog
(Xenopus laevis)
Amphibia shoc2-prov 33
(Danio rerio)
Actinopterygii shoc2 34 33
  • 74.93 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004485 33
  • 59.03 (n)
fruit fly
(Drosophila melanogaster)
Insecta Sur-8 34 35 33
  • 57.21 (n)
(Caenorhabditis elegans)
Secernentea soc-2 34 35 33
  • 56.6 (n)
(Oryza sativa)
Liliopsida Os10g0119200 33
  • 44.32 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 58 (a)
Species where no ortholog for SHOC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SHOC2 Gene

Gene Tree for SHOC2 (if available)
Gene Tree for SHOC2 (if available)
Evolutionary constrained regions (ECRs) for SHOC2: view image

Paralogs for SHOC2 Gene

genes like me logo Genes that share paralogs with SHOC2: view

Variants for SHOC2 Gene

Sequence variations from dbSNP and Humsavar for SHOC2 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1060501926 uncertain-significance, Rasopathy 111,011,669(+) C/G/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1060501927 uncertain-significance, Rasopathy 111,000,523(+) A/G coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1060504382 likely-benign, Rasopathy 111,011,734(+) C/T coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs114628508 likely-benign, Noonan syndrome-like disorder with loose anagen hair 1 111,012,591(+) G/A 3_prime_UTR_variant, non_coding_transcript_variant
rs115713408 likely-benign, Rasopathy 110,964,721(+) G/A coding_sequence_variant, intron_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for SHOC2 Gene

Variant ID Type Subtype PubMed ID
dgv974n100 CNV loss 25217958
dgv975n100 CNV loss 25217958
esv2674974 CNV deletion 23128226
esv3624545 CNV loss 21293372
nsv1035422 CNV loss 25217958
nsv1035602 CNV loss 25217958
nsv1047412 CNV loss 25217958
nsv1143517 CNV deletion 24896259
nsv518667 CNV loss 19592680
nsv7211 OTHER inversion 18451855
nsv7548 CNV insertion 18451855
nsv831985 CNV gain+loss 17160897
nsv948185 CNV duplication 23825009

Variation tolerance for SHOC2 Gene

Residual Variation Intolerance Score: 23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 20.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SHOC2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHOC2 Gene

Disorders for SHOC2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for SHOC2 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search SHOC2 in MalaCards View complete list of genes associated with diseases


  • Noonan syndrome-like disorder with loose anagen hair 1 (NSLH1) [MIM:607721]: A syndrome characterized by Noonan dysmorphic features such as macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck, pectus anomalies, in association with pluckable, sparse, thin and slow-growing hair. {ECO:0000269 PubMed:19684605, ECO:0000269 PubMed:23918763, ECO:0000269 PubMed:25137548}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for SHOC2

genes like me logo Genes that share disorders with SHOC2: view

No data available for Genatlas for SHOC2 Gene

Publications for SHOC2 Gene

  1. soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling. (PMID: 9618511) Selfors LM … Stern MJ (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 22 58
  2. SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans. (PMID: 9674433) Sieburth DS … Han M (Cell 1998) 2 3 4 22 58
  3. Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex. (PMID: 16301319) Dai P … Mei L (The Journal of biological chemistry 2006) 3 4 22 58
  4. A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity. (PMID: 16630891) Rodriguez-Viciana P … McCormick F (Molecular cell 2006) 3 4 22 58
  5. The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf. (PMID: 10783161) Li W … Guan KL (Genes & development 2000) 2 3 4 58

Products for SHOC2 Gene

Sources for SHOC2 Gene

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