This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair. [provided by RefSeq, ... See more...

Aliases for SHOC2 Gene

Aliases for SHOC2 Gene

  • SHOC2 Leucine Rich Repeat Scaffold Protein 2 3 5
  • Leucine-Rich Repeat Protein SHOC-2 3 4
  • Soc-2 (Suppressor Of Clear, C.Elegans) Homolog 2
  • Soc-2 Suppressor Of Clear Homolog (C. Elegans) 2
  • SHOC2, Leucine Rich Repeat Scaffold Protein 2
  • SHOC2 Leucine-Rich Repeat Scaffold Protein 2
  • Soc-2 Suppressor Of Clear Homolog 3
  • Protein Soc-2 Homolog 4
  • Protein Sur-8 Homolog 4
  • SIAA0862 3
  • KIAA0862 4
  • SOC2 3
  • SUR8 3

External Ids for SHOC2 Gene

Previous GeneCards Identifiers for SHOC2 Gene

  • GC10P111572
  • GC10P111912
  • GC10P112810
  • GC10P112343
  • GC10P112389
  • GC10P112669
  • GC10P106308
  • GC10P112679

Summaries for SHOC2 Gene

Entrez Gene Summary for SHOC2 Gene

  • This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair. [provided by RefSeq, May 2010]

GeneCards Summary for SHOC2 Gene

SHOC2 (SHOC2 Leucine Rich Repeat Scaffold Protein) is a Protein Coding gene. Diseases associated with SHOC2 include Noonan Syndrome-Like Disorder With Loose Anagen Hair 1 and Noonan Syndrome 3. Among its related pathways are Ras signaling pathway and MAP Kinase Signaling. Gene Ontology (GO) annotations related to this gene include protein phosphatase binding and protein phosphatase regulator activity. An important paralog of this gene is LRRD1.

UniProtKB/Swiss-Prot Summary for SHOC2 Gene

  • Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.

Gene Wiki entry for SHOC2 Gene

Additional gene information for SHOC2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SHOC2 Gene

Genomics for SHOC2 Gene

GeneHancer (GH) Regulatory Elements for SHOC2 Gene

Promoters and enhancers for SHOC2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J110915 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 506.7 -0.2 -215 6.9 ZBTB40 ZNF217 EP300 ZSCAN5C SIN3A NRF1 TCF12 POLR2G SP1 PHF8 BBIP1 SHOC2 lnc-SMNDC1-8 ENSG00000270589 SMC3 SMNDC1 XPNPEP1 ADRA2A PDCD4
GH10J110943 Promoter/Enhancer 0.8 EPDnew Ensembl 518.4 +25.7 25658 5.2 POLR2A FOS SCRT1 ZNF133 MYC FOXA1 STAT3 SHOC2 BBIP1 ADRA2A ENSG00000270589 RPL13AP6 MIR548E
GH10J110855 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 22.1 -53.7 -53742 19.2 FOXK2 ZBTB40 EP300 ZSCAN5C SIN3A TCF12 NRF1 MYC POLR2G USF1 PDCD4 SMNDC1 SHOC2 SMC3 BBIP1 ADRA2A ENSG00000270589 DUSP5 ENSG00000232470 lnc-BBIP1-4
GH10J110965 Enhancer 0.7 Ensembl 17.7 +45.4 45358 9 RBM25 ZNF316 ZKSCAN1 BCOR BATF ADNP ZNF146 PRDM6 FEZF1 RXRA SHOC2 ADRA2A BBIP1 ENSG00000270589 MIR548E RPL13AP6
GH10J110883 Promoter/Enhancer 1.1 Ensembl ENCODE dbSUPER 11.3 -35.5 -35495 0.8 MAX IRF1 ZNF592 MYC MNT HDAC2 MEIS2 REST CREM USF1 BBIP1 SHOC2 PDCD4-AS1 NONHSAG006867.2 PDCD4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SHOC2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SHOC2

Top Transcription factor binding sites by QIAGEN in the SHOC2 gene promoter:
  • AhR
  • AML1a
  • AREB6
  • Arnt
  • Elk-1
  • FOXD1
  • NRF-2
  • POU2F1
  • POU2F1a
  • XBP-1

Genomic Locations for SHOC2 Gene

Genomic Locations for SHOC2 Gene
chr10:110,919,543-111,013,667
(GRCh38/hg38)
Size:
94,125 bases
Orientation:
Plus strand
chr10:112,679,301-112,773,425
(GRCh37/hg19)
Size:
94,125 bases
Orientation:
Plus strand

Genomic View for SHOC2 Gene

Genes around SHOC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHOC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHOC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHOC2 Gene

Proteins for SHOC2 Gene

  • Protein details for SHOC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQ13-SHOC2_HUMAN
    Recommended name:
    Leucine-rich repeat protein SHOC-2
    Protein Accession:
    Q9UQ13
    Secondary Accessions:
    • A8K9W8
    • B3KR23
    • O76063
    • Q5VZS8
    • Q5VZS9

    Protein attributes for SHOC2 Gene

    Size:
    582 amino acids
    Molecular mass:
    64888 Da
    Quaternary structure:
    • Interacts with M-Ras/MRAS, and RAF1 (PubMed:16630891, PubMed:25137548). Forms a multiprotein complex with Ras (M-Ras/MRAS), Raf (RAF1) and protein phosphatase 1 (PPP1CA, PPP1CB and PPP1CC) (PubMed:16630891, PubMed:25137548). Interacts with ERBIN; disrupts the interaction with RAF1 and Ras, leading to prevent activation of the Ras signaling pathway (PubMed:16301319). Specifically binds K-Ras/KRAS, M-Ras/MRAS and N-Ras/NRAS but not H-Ras/HRAS (PubMed:9674433). Interacts with LZTR1 (PubMed:30368668).
    SequenceCaution:
    • Sequence=BAA74885.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAG52235.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for SHOC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SHOC2 Gene

Post-translational modifications for SHOC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SHOC2 Gene

No data available for DME Specific Peptides for SHOC2 Gene

Domains & Families for SHOC2 Gene

Gene Families for SHOC2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SHOC2 Gene

Blocks:
  • Leucine-rich repeat signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SHOC2 Gene

GenScript: Design optimal peptide antigens:
  • Protein sur-8 homolog (SHOC2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UQ13

UniProtKB/Swiss-Prot:

SHOC2_HUMAN :
  • Belongs to the SHOC2 family.
Family:
  • Belongs to the SHOC2 family.
genes like me logo Genes that share domains with SHOC2: view

Function for SHOC2 Gene

Molecular function for SHOC2 Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.
GENATLAS Biochemistry:
leucine-rich protein,cytoplasmic,ubiquitously expressed,homolog to C elegans soc2,suppressor of clear (clr-1),implicated in fibroblast growth receptor signaling

Phenotypes From GWAS Catalog for SHOC2 Gene

Gene Ontology (GO) - Molecular Function for SHOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 25137548
GO:0008157 protein phosphatase 1 binding IDA 25137548
GO:0019888 protein phosphatase regulator activity TAS 16630891
GO:0019903 protein phosphatase binding IDA 16630891
genes like me logo Genes that share ontologies with SHOC2: view
genes like me logo Genes that share phenotypes with SHOC2: view

Human Phenotype Ontology for SHOC2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SHOC2 Gene

MGI Knock Outs for SHOC2:

Animal Model Products

CRISPR Products

miRNA for SHOC2 Gene

miRTarBase miRNAs that target SHOC2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SHOC2

Clone Products

  • Addgene plasmids for SHOC2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SHOC2 Gene

Localization for SHOC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHOC2 Gene

Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus upon growth factor stimulation. {ECO:0000269 PubMed:19684605}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SHOC2 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SHOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000164 protein phosphatase type 1 complex IDA 16630891
GO:0005634 nucleus IDA,IEA 19684605
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm NAS 9618511
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with SHOC2: view

Pathways & Interactions for SHOC2 Gene

PathCards logo

SuperPathways for SHOC2 Gene

genes like me logo Genes that share pathways with SHOC2: view

Pathways by source for SHOC2 Gene

1 KEGG pathway for SHOC2 Gene
1 Cell Signaling Technology pathway for SHOC2 Gene

SIGNOR curated interactions for SHOC2 Gene

Activates:

Gene Ontology (GO) - Biological Process for SHOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007265 Ras protein signal transduction NAS 9674433
GO:0008543 fibroblast growth factor receptor signaling pathway NAS 9618511
GO:0043666 regulation of phosphoprotein phosphatase activity IEA --
GO:0046579 positive regulation of Ras protein signal transduction IMP 16630891
genes like me logo Genes that share ontologies with SHOC2: view

Drugs & Compounds for SHOC2 Gene

No Compound Related Data Available

Transcripts for SHOC2 Gene

mRNA/cDNA for SHOC2 Gene

4 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SHOC2

Clone Products

  • Addgene plasmids for SHOC2

Alternative Splicing Database (ASD) splice patterns (SP) for SHOC2 Gene

No ASD Table

Relevant External Links for SHOC2 Gene

GeneLoc Exon Structure for
SHOC2

Expression for SHOC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SHOC2 Gene

Protein differential expression in normal tissues from HIPED for SHOC2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SHOC2 Gene



Protein tissue co-expression partners for SHOC2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SHOC2

SOURCE GeneReport for Unigene cluster for SHOC2 Gene:

Hs.104315

Evidence on tissue expression from TISSUES for SHOC2 Gene

  • Nervous system(4.7)
  • Skin(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for SHOC2 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • integumentary
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cerebellum
  • cerebrospinal fluid
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • meninges
  • mouth
  • neck
  • nose
  • outer ear
  • scalp
  • skull
Thorax:
  • chest wall
  • clavicle
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Pelvis:
  • pelvis
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • hair
  • peripheral nervous system
  • skin
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with SHOC2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SHOC2 Gene

Orthologs for SHOC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SHOC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SHOC2 31 30
  • 99.83 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SHOC2 31
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SHOC2 31 30
  • 96.05 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SHOC2 31 30
  • 95.93 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SHOC2 31
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Shoc2 17 31 30
  • 91.92 (n)
rat
(Rattus norvegicus)
Mammalia Shoc2 30
  • 90.55 (n)
chicken
(Gallus gallus)
Aves SHOC2 31 30
  • 84.5 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SHOC2 31
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia shoc2 30
  • 77.4 (n)
African clawed frog
(Xenopus laevis)
Amphibia shoc2-prov 30
zebrafish
(Danio rerio)
Actinopterygii shoc2 31 30
  • 74.93 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004485 30
  • 59.03 (n)
fruit fly
(Drosophila melanogaster)
Insecta Sur-8 31 32 30
  • 57.21 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea soc-2 31 32 30
  • 56.6 (n)
OneToMany
rice
(Oryza sativa)
Liliopsida Os10g0119200 30
  • 44.32 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 58 (a)
OneToOne
Species where no ortholog for SHOC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SHOC2 Gene

ENSEMBL:
Gene Tree for SHOC2 (if available)
TreeFam:
Gene Tree for SHOC2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SHOC2: view image

Paralogs for SHOC2 Gene

Variants for SHOC2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SHOC2 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
640623 Uncertain Significance: Rasopathy 111,004,637(+) G/A MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
652343 Uncertain Significance: Rasopathy 110,964,410(+) G/A MISSENSE_VARIANT
703416 Likely Benign: not provided 110,964,712(+) A/G SYNONYMOUS_VARIANT
723509 Likely Benign: not provided 110,965,070(+) C/A INTRON_VARIANT
739517 Likely Benign: not provided 110,985,618(+) C/T INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for SHOC2 Gene

Structural Variations from Database of Genomic Variants (DGV) for SHOC2 Gene

Variant ID Type Subtype PubMed ID
dgv974n100 CNV loss 25217958
dgv975n100 CNV loss 25217958
esv2674974 CNV deletion 23128226
esv3624545 CNV loss 21293372
nsv1035422 CNV loss 25217958
nsv1035602 CNV loss 25217958
nsv1047412 CNV loss 25217958
nsv1143517 CNV deletion 24896259
nsv518667 CNV loss 19592680
nsv7211 OTHER inversion 18451855
nsv7548 CNV insertion 18451855
nsv831985 CNV gain+loss 17160897
nsv948185 CNV duplication 23825009

Variation tolerance for SHOC2 Gene

Residual Variation Intolerance Score: 23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 20.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SHOC2 Gene

Human Gene Mutation Database (HGMD)
SHOC2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SHOC2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHOC2 Gene

Disorders for SHOC2 Gene

MalaCards: The human disease database

(18) MalaCards diseases for SHOC2 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search SHOC2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

SHOC2_HUMAN
  • Noonan syndrome-like disorder with loose anagen hair 1 (NSLH1) [MIM:607721]: A syndrome characterized by Noonan dysmorphic features such as macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck, pectus anomalies, in association with pluckable, sparse, thin and slow-growing hair. {ECO:0000269 PubMed:19684605, ECO:0000269 PubMed:23918763, ECO:0000269 PubMed:25137548}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for SHOC2

genes like me logo Genes that share disorders with SHOC2: view

No data available for Genatlas for SHOC2 Gene

Publications for SHOC2 Gene

  1. SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans. (PMID: 9674433) Sieburth DS … Han M (Cell 1998) 2 3 4 23 54
  2. soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling. (PMID: 9618511) Selfors LM … Stern MJ (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 23 54
  3. Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex. (PMID: 16301319) Dai P … Mei L (The Journal of biological chemistry 2006) 3 4 23 54
  4. A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity. (PMID: 16630891) Rodriguez-Viciana P … McCormick F (Molecular cell 2006) 3 4 23 54
  5. The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf. (PMID: 10783161) Li W … Guan KL (Genes & development 2000) 2 3 4 54

Products for SHOC2 Gene

Sources for SHOC2 Gene