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Aliases for SHISAL1 Gene

Aliases for SHISAL1 Gene

  • Shisa Like 1 2 3 5
  • KIAA1644 2 3 4
  • Protein Shisa-Like-1 3

External Ids for SHISAL1 Gene

Previous HGNC Symbols for SHISAL1 Gene

  • KIAA1644

Summaries for SHISAL1 Gene

GeneCards Summary for SHISAL1 Gene

SHISAL1 (Shisa Like 1) is a Protein Coding gene.

Additional gene information for SHISAL1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHISAL1 Gene

Genomics for SHISAL1 Gene

GeneHancer (GH) Regulatory Elements for SHISAL1 Gene

Promoters and enhancers for SHISAL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J044330 Enhancer 0.9 Ensembl 661.4 +0.1 73 2.6 ZNF133 GLI4 ZNF2 GLIS2 KLF7 YY2 TSHZ1 GLIS1 ZNF624 WT1 SHISAL1 ENSG00000273243 RTL6 PHF21B ENSG00000236079 RPS10P31 NUP50 ENSG00000273287 FAM118A LOC101927499
GH22J044684 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -354.3 -354291 3.4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF207 ZNF143 ZNF263 SP3 ARHGAP8 ENSG00000273243 SHISAL1 PRR5 PRR5-ARHGAP8
GH22J044020 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +310.0 309984 2.2 ZNF473 ZSCAN4 INSM2 GLI4 ZEB1 ZNF335 ZNF366 FOS YY2 ZNF662 ENSG00000261251 LOC100506679 SAMM50 RPL35AP36 RTL6 SHISAL1 PHF21B TTLL1 PARVB GC22M044040
GH22J044357 Enhancer 1.2 FANTOM5 Ensembl ENCODE 11.3 -29.8 -29814 7.6 CTCF ZNF768 MXI1 MAX SIN3A ZKSCAN1 POLR2A SMC3 RCOR1 FOSL2 SHISAL1 FAM118A GC22P044366 GC22M044364
GH22J044454 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 11 -124.0 -124031 2.6 NCOA3 ESRRA EBF1 BATF ZIC2 CTBP1 GATA3 EED RCOR1 FOS RTL6 SHISAL1 GC22P044453 GC22P044472
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SHISAL1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SHISAL1 Gene

Genomic Locations for SHISAL1 Gene
chr22:44,243,665-44,331,695
(GRCh38/hg38)
Size:
88,031 bases
Orientation:
Minus strand
chr22:44,639,547-44,708,731
(GRCh37/hg19)
Size:
69,185 bases
Orientation:
Minus strand

Genomic View for SHISAL1 Gene

Genes around SHISAL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHISAL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHISAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHISAL1 Gene

Proteins for SHISAL1 Gene

  • Protein details for SHISAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3SXP7-SHSL1_HUMAN
    Recommended name:
    Protein shisa-like-1
    Protein Accession:
    Q3SXP7
    Secondary Accessions:
    • A6NHP0
    • A9Z1Z0
    • Q3SXP8
    • Q5JZ71
    • Q9BYB5

    Protein attributes for SHISAL1 Gene

    Size:
    199 amino acids
    Molecular mass:
    22573 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SHISAL1 Gene

Post-translational modifications for SHISAL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SHISAL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SHISAL1 Gene

Domains & Families for SHISAL1 Gene

Gene Families for SHISAL1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SHISAL1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q3SXP7

UniProtKB/Swiss-Prot:

SHSL1_HUMAN :
  • Belongs to the shisa family.
Family:
  • Belongs to the shisa family.
genes like me logo Genes that share domains with SHISAL1: view

No data available for Suggested Antigen Peptide Sequences for SHISAL1 Gene

Function for SHISAL1 Gene

Phenotypes From GWAS Catalog for SHISAL1 Gene

Phenotypes for SHISAL1 Gene

genes like me logo Genes that share phenotypes with SHISAL1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SHISAL1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SHISAL1 Gene

Localization for SHISAL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHISAL1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SHISAL1 gene
Compartment Confidence
plasma membrane 3
extracellular 3
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SHISAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SHISAL1: view

Pathways & Interactions for SHISAL1 Gene

SuperPathways for SHISAL1 Gene

No Data Available

Interacting Proteins for SHISAL1 Gene

Gene Ontology (GO) - Biological Process for SHISAL1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SHISAL1 Gene

Drugs & Compounds for SHISAL1 Gene

No Compound Related Data Available

Transcripts for SHISAL1 Gene

mRNA/cDNA for SHISAL1 Gene

(2) REFSEQ mRNAs :
(70) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SHISAL1

Alternative Splicing Database (ASD) splice patterns (SP) for SHISAL1 Gene

No ASD Table

Relevant External Links for SHISAL1 Gene

GeneLoc Exon Structure for
SHISAL1
ECgene alternative splicing isoforms for
SHISAL1

Expression for SHISAL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of SHISAL1 Gene:

SHISAL1

Evidence on tissue expression from TISSUES for SHISAL1 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with SHISAL1: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SHISAL1 Gene

Orthologs for SHISAL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SHISAL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1644 34 33
  • 99.33 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KIAA1644 34 33
  • 91.58 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA1644 34 33
  • 90.07 (n)
OneToOne
mouse
(Mus musculus)
Mammalia 1810041L15Rik 34 33
  • 87.54 (n)
OneToOne
Shisal1 16
rat
(Rattus norvegicus)
Mammalia RGD1566029 33
  • 86.36 (n)
oppossum
(Monodelphis domestica)
Mammalia KIAA1644 34
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1644 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA1644 34 33
  • 73.37 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA1644 34
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733025 33
  • 72.04 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-14k9.2 34 33
  • 65.16 (n)
OneToMany
si:ch73-66d24.2 34
  • 55 (a)
OneToMany
Species where no ortholog for SHISAL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHISAL1 Gene

ENSEMBL:
Gene Tree for SHISAL1 (if available)
TreeFam:
Gene Tree for SHISAL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SHISAL1: view image

Paralogs for SHISAL1 Gene

No data available for Paralogs for SHISAL1 Gene

Variants for SHISAL1 Gene

Sequence variations from dbSNP and Humsavar for SHISAL1 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000022620 -- 44,283,144(-) G/A intron_variant
rs1000023444 -- 44,314,127(-) C/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000045153 -- 44,299,288(-) C/T intron_variant
rs1000143667 -- 44,281,750(-) T/A intron_variant
rs1000197417 -- 44,280,678(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SHISAL1 Gene

Variant ID Type Subtype PubMed ID
dgv737e201 CNV deletion 23290073
esv2554291 CNV deletion 19546169
esv25690 CNV gain 19812545
esv2657182 CNV deletion 23128226
esv2677488 CNV deletion 23128226
esv2724346 CNV deletion 23290073
esv2724347 CNV deletion 23290073
esv2724348 CNV deletion 23290073
esv2724351 CNV deletion 23290073
esv2724353 CNV deletion 23290073
esv2742673 CNV deletion 23290073
esv2758841 CNV gain+loss 17122850
esv3558214 CNV deletion 23714750
esv3558216 CNV deletion 23714750
esv3558217 CNV deletion 23714750
esv3647892 CNV gain 21293372
esv3647894 CNV loss 21293372
nsv1071796 CNV deletion 25765185
nsv1117939 CNV deletion 24896259
nsv438347 CNV loss 16468122
nsv474011 CNV novel sequence insertion 20440878
nsv474076 CNV novel sequence insertion 20440878
nsv474078 CNV novel sequence insertion 20440878
nsv474543 CNV novel sequence insertion 20440878
nsv475318 CNV novel sequence insertion 20440878
nsv477880 CNV novel sequence insertion 20440878
nsv478151 CNV novel sequence insertion 20440878
nsv478728 CNV novel sequence insertion 20440878
nsv479260 CNV novel sequence insertion 20440878
nsv479469 CNV novel sequence insertion 20440878
nsv479502 CNV novel sequence insertion 20440878
nsv479666 CNV novel sequence insertion 20440878
nsv479708 CNV novel sequence insertion 20440878
nsv480150 CNV novel sequence insertion 20440878
nsv480179 CNV novel sequence insertion 20440878
nsv480881 CNV novel sequence insertion 20440878
nsv481033 CNV novel sequence insertion 20440878
nsv481543 CNV novel sequence insertion 20440878
nsv519623 CNV loss 19592680
nsv589103 CNV loss 21841781
nsv829266 CNV gain 20364138

Variation tolerance for SHISAL1 Gene

Residual Variation Intolerance Score: 27.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.61; 45.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SHISAL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SHISAL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHISAL1 Gene

Disorders for SHISAL1 Gene

Additional Disease Information for SHISAL1

No disorders were found for SHISAL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SHISAL1 Gene

Publications for SHISAL1 Gene

  1. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. (PMID: 11258795) Hirosawa M … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 58
  2. Unexpected diversity in Shisa-like proteins suggests the importance of their roles as transmembrane adaptors. (PMID: 22120523) Pei J … Grishin NV (Cellular signalling 2012) 2 3 58
  3. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for SHISAL1 Gene

Sources for SHISAL1 Gene

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