Aliases for SHISA8 Gene

Aliases for SHISA8 Gene

  • Shisa Family Member 8 2 3 4 5
  • Protein Shisa-8 3 4
  • C22orf17 3 4
  • Chromosome 22 Open Reading Frame 17 2
  • Shisa Homolog 8 (Xenopus Laevis) 2
  • Putative Protein Shisa-8 3
  • Shisa Homolog 8 3
  • CTA-250D10.17 3
  • Orf26 3

External Ids for SHISA8 Gene

Previous HGNC Symbols for SHISA8 Gene

  • C22orf17

Previous GeneCards Identifiers for SHISA8 Gene

  • GC22M040636
  • GC22M042305

Summaries for SHISA8 Gene

GeneCards Summary for SHISA8 Gene

SHISA8 (Shisa Family Member 8) is a Protein Coding gene. An important paralog of this gene is SHISA9.

UniProtKB/Swiss-Prot Summary for SHISA8 Gene

  • May regulate trafficking and current kinetics of AMPA-type glutamate receptor (AMPAR) at synapses.

Additional gene information for SHISA8 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SHISA8 Gene

Genomics for SHISA8 Gene

GeneHancer (GH) Regulatory Elements for SHISA8 Gene

Promoters and enhancers for SHISA8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SHISA8 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SHISA8

Genomic Locations for SHISA8 Gene

Genomic Locations for SHISA8 Gene
chr22:41,909,533-41,915,093
(GRCh38/hg38)
Size:
5,561 bases
Orientation:
Minus strand
chr22:42,305,558-42,310,671
(GRCh37/hg19)
Size:
5,114 bases
Orientation:
Minus strand

Genomic View for SHISA8 Gene

Genes around SHISA8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHISA8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHISA8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHISA8 Gene

Proteins for SHISA8 Gene

  • Protein details for SHISA8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B8ZZ34-SHSA8_HUMAN
    Recommended name:
    Protein shisa-8
    Protein Accession:
    B8ZZ34
    Secondary Accessions:
    • A0A087WXQ4

    Protein attributes for SHISA8 Gene

    Size:
    397 amino acids
    Molecular mass:
    41995 Da
    Quaternary structure:
    • Interacts with AMPAR subunits GRIA1 and GRIA2.

    Alternative splice isoforms for SHISA8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SHISA8 Gene

Post-translational modifications for SHISA8 Gene

  • Glycosylation at Asn75
  • Modification sites at PhosphoSitePlus

Other Protein References for SHISA8 Gene

No data available for DME Specific Peptides for SHISA8 Gene

Domains & Families for SHISA8 Gene

Gene Families for SHISA8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SHISA8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SHISA8 Gene

GenScript: Design optimal peptide antigens:
  • Putative protein shisa-8 (SHSA8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

B8ZZ34

UniProtKB/Swiss-Prot:

SHSA8_HUMAN :
  • Belongs to the shisa family.
Family:
  • Belongs to the shisa family.
genes like me logo Genes that share domains with SHISA8: view

Function for SHISA8 Gene

Molecular function for SHISA8 Gene

UniProtKB/Swiss-Prot Function:
May regulate trafficking and current kinetics of AMPA-type glutamate receptor (AMPAR) at synapses.

Phenotypes From GWAS Catalog for SHISA8 Gene

genes like me logo Genes that share phenotypes with SHISA8: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SHISA8 Gene

Localization for SHISA8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHISA8 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SHISA8 gene
Compartment Confidence
plasma membrane 3
extracellular 1
peroxisome 1
cytosol 1
mitochondrion 0
nucleus 0

Gene Ontology (GO) - Cellular Components for SHISA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014069 postsynaptic density IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0032281 AMPA glutamate receptor complex IBA 21873635
GO:0032591 dendritic spine membrane IBA 21873635
genes like me logo Genes that share ontologies with SHISA8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SHISA8 Gene

Pathways & Interactions for SHISA8 Gene

PathCards logo

SuperPathways for SHISA8 Gene

No Data Available

Interacting Proteins for SHISA8 Gene

;

Gene Ontology (GO) - Biological Process for SHISA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048172 regulation of short-term neuronal synaptic plasticity IBA 21873635
GO:2000311 regulation of AMPA receptor activity IBA 21873635
genes like me logo Genes that share ontologies with SHISA8: view

No data available for Pathways by source and SIGNOR curated interactions for SHISA8 Gene

Drugs & Compounds for SHISA8 Gene

No Compound Related Data Available

Transcripts for SHISA8 Gene

mRNA/cDNA for SHISA8 Gene

3 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SHISA8 Gene

No ASD Table

Relevant External Links for SHISA8 Gene

GeneLoc Exon Structure for
SHISA8

Expression for SHISA8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SHISA8 Gene

mRNA differential expression in normal tissues according to GTEx for SHISA8 Gene

This gene is overexpressed in Brain - Cerebellum (x18.5), Brain - Cerebellar Hemisphere (x18.3), and Adrenal Gland (x5.0).

Protein differential expression in normal tissues from HIPED for SHISA8 Gene

This gene is overexpressed in Heart (40.4) and Brain (28.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SHISA8 Gene



Protein tissue co-expression partners for SHISA8 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SHISA8

SOURCE GeneReport for Unigene cluster for SHISA8 Gene:

Hs.526704
genes like me logo Genes that share expression patterns with SHISA8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SHISA8 Gene

Orthologs for SHISA8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SHISA8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SHISA8 31 30
  • 95.87 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SHISA8 30
  • 85.8 (n)
rat
(Rattus norvegicus)
Mammalia Shisa8 30
  • 79.58 (n)
mouse
(Mus musculus)
Mammalia AI848285 30
  • 79.49 (n)
Shisa8 17
platypus
(Ornithorhynchus anatinus)
Mammalia SHISA8 31
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves SHISA8 30
  • 67.74 (n)
lizard
(Anolis carolinensis)
Reptilia SHISA8 31
  • 22 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489046 30
  • 50.66 (n)
zebrafish
(Danio rerio)
Actinopterygii SHISA8 (2 of 2) 31
  • 35 (a)
OneToMany
SHISA8 (1 of 2) 31
  • 17 (a)
OneToMany
Species where no ortholog for SHISA8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHISA8 Gene

ENSEMBL:
Gene Tree for SHISA8 (if available)
TreeFam:
Gene Tree for SHISA8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SHISA8: view image

Paralogs for SHISA8 Gene

Paralogs for SHISA8 Gene

(1) SIMAP similar genes for SHISA8 Gene using alignment to 1 proteins:

  • SHSA8_HUMAN
genes like me logo Genes that share paralogs with SHISA8: view

Variants for SHISA8 Gene

Additional dbSNP identifiers (rs#s) for SHISA8 Gene

Structural Variations from Database of Genomic Variants (DGV) for SHISA8 Gene

Variant ID Type Subtype PubMed ID
nsv1057208 CNV gain 25217958
nsv1118954 CNV deletion 24896259
nsv508736 CNV insertion 20534489
nsv589053 CNV loss 21841781
nsv955162 CNV deletion 24416366

Additional Variant Information for SHISA8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SHISA8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for SHISA8 Gene

Disorders for SHISA8 Gene

Additional Disease Information for SHISA8

No disorders were found for SHISA8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SHISA8 Gene

Publications for SHISA8 Gene

  1. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) Schizophrenia Working Group of the Psychiatric Genomics Consortium (Nature 2014) 3 54
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 4 54

Products for SHISA8 Gene

Sources for SHISA8 Gene