Aliases for SHISA7 Gene

Aliases for SHISA7 Gene

  • Shisa Family Member 7 2 3 5
  • Cystine-Knot AMPAR Modulating Protein Of 59 KDa 3 4
  • GABA(A) Receptor Auxiliary Subunit Shisa7 3 4
  • Protein Shisa-7 3 4
  • CKAMP59 3 4
  • Shisa Homolog 7 (Xenopus Laevis) 2
  • Protein Shisa-6-Like 4
  • UPF0626 Protein A 3
  • Shisa Homolog 7 3
  • SHISA7 5

External Ids for SHISA7 Gene

Previous GeneCards Identifiers for SHISA7 Gene

  • GC19M060639
  • GC19M055940
  • GC19M052263

Summaries for SHISA7 Gene

GeneCards Summary for SHISA7 Gene

SHISA7 (Shisa Family Member 7) is a Protein Coding gene. An important paralog of this gene is SHISA6.

UniProtKB/Swiss-Prot Summary for SHISA7 Gene

  • Transmembrane protein that regulates gamma-aminobutyric acid type A receptor (GABA(A)R) trafficking, channel deactivation kinetics and pharmacology, necessary for fast inhibitory transmission in the brain. Enhances the action of benzodiazepine, a primary GABA(A)Rs target drug, in the brain. May affect channel kinetics of AMPA-type glutamate receptors (AMPAR), the brain's main excitatory neurotransmitter, necessary for synaptic hippocampal plasticity, and memory recall. May regulate the induction and maintenance of long-term potentiation at Schaffer collaterals/CA3-CA1 excitatory synapses.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SHISA7 Gene

Genomics for SHISA7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SHISA7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J055440 Enhancer 1.2 Ensembl ENCODE dbSUPER 271.6 +1.1 1090 4 NCOR1 POLR2A NFIC SMAD5 TBP KLF9 SP2 TAL1 ELF1 CTCF SHISA7 HSALNG0127658 EDDM13 UBE2S
GH19J055444 Enhancer 0.6 Ensembl dbSUPER 250.7 -1.4 -1401 0.2 RFX1 EGR2 ZBTB6 BMI1 SHISA7 lnc-ZNF628-1 ISOC2
GH19J055419 Enhancer 0.8 Ensembl ENCODE dbSUPER 39.6 +22.1 22099 2.8 MYC MAX POLR2A ZNF680 TRIM28 SHISA7 ISOC2 ZNF628 RPL28 TMEM238 BRSK1 TMEM190 TNNT1 HSPBP1 PPP6R1
GH19J055519 Enhancer 1.3 FANTOM5 Ensembl ENCODE 22.2 -76.9 -76909 1 ZNF600 ATF2 ZNF10 ZBTB10 ZNF639 ZEB1 ZNF148 MCM3 ZNF513 EP300 HSALNG0127670 ZNF471 U2AF2 ZNF582 SSC5D ZNF581 FIZ1 ENSG00000267523 ZNF580 ZNF542P
GH19J055382 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.9 +56.6 56622 8.6 SP1 ZNF207 MYC ZNF600 SSRP1 ZNF580 ZNF592 POLR2A BRCA1 ZIC2 RPL28 HSALNG0127651 HSALNG0127652 TMEM238 MIR6805 piR-50436 IL11 ZNF628 FIZ1 ZNF542P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SHISA7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SHISA7

Genomic Locations for SHISA7 Gene

Latest Assembly
chr19:55,428,740-55,443,300
(GRCh38/hg38)
Size:
14,561 bases
Orientation:
Minus strand

Previous Assembly
chr19:55,940,105-55,954,230
(GRCh37/hg19 by Entrez Gene)
Size:
14,126 bases
Orientation:
Minus strand

chr19:55,940,107-55,954,230
(GRCh37/hg19 by Ensembl)
Size:
14,124 bases
Orientation:
Minus strand

Genomic View for SHISA7 Gene

Genes around SHISA7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHISA7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHISA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHISA7 Gene

Proteins for SHISA7 Gene

  • Protein details for SHISA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NL88-SHSA7_HUMAN
    Recommended name:
    Protein shisa-7
    Protein Accession:
    A6NL88

    Protein attributes for SHISA7 Gene

    Size:
    538 amino acids
    Molecular mass:
    56214 Da
    Quaternary structure:
    • Interacts with GABA(A)R (GABA type A receptor) subunits GABRA1, GABRA2 and GABRG2; the interaction is direct. Does not interact with GABRB2 and GABRB3 subunits. May interact with AMPAR subunits GRIA1, GRIA2 and GRIA3 and AMPAR auxiliary proteins SHISA6 and SHISA7. May interact (via PDZ-binding motif) with DLG4/PSD-95 (via PDZ domain); the interaction is direct.

neXtProt entry for SHISA7 Gene

Post-translational modifications for SHISA7 Gene

  • Glycosylation at Asn23 and Asn59
  • Modification sites at PhosphoSitePlus

Other Protein References for SHISA7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SHISA7 Gene

Domains & Families for SHISA7 Gene

Gene Families for SHISA7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SHISA7 Gene

InterPro:

Suggested Antigen Peptide Sequences for SHISA7 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ45290 fis, clone BRHIP3002691 (Q6ZSQ7_HUMAN)
  • Protein shisa-6-like (SHSA7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NL88

UniProtKB/Swiss-Prot:

SHSA7_HUMAN :
  • The PDZ-binding motif interacts with PDZ-domain of scaffolding protein DLG4.
  • Belongs to the shisa family.
Domain:
  • The PDZ-binding motif interacts with PDZ-domain of scaffolding protein DLG4.
  • The GRID (GABA(A)R-interacting domain) is critical for its subcellular localization and interaction with GABA(A)R.
Family:
  • Belongs to the shisa family.
genes like me logo Genes that share domains with SHISA7: view

Function for SHISA7 Gene

Molecular function for SHISA7 Gene

UniProtKB/Swiss-Prot Function:
Transmembrane protein that regulates gamma-aminobutyric acid type A receptor (GABA(A)R) trafficking, channel deactivation kinetics and pharmacology, necessary for fast inhibitory transmission in the brain. Enhances the action of benzodiazepine, a primary GABA(A)Rs target drug, in the brain. May affect channel kinetics of AMPA-type glutamate receptors (AMPAR), the brain's main excitatory neurotransmitter, necessary for synaptic hippocampal plasticity, and memory recall. May regulate the induction and maintenance of long-term potentiation at Schaffer collaterals/CA3-CA1 excitatory synapses.

Phenotypes From GWAS Catalog for SHISA7 Gene

Gene Ontology (GO) - Molecular Function for SHISA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035255 NOT ionotropic glutamate receptor binding IEA,ISS --
GO:0050811 GABA receptor binding IEA,ISS --
genes like me logo Genes that share ontologies with SHISA7: view
genes like me logo Genes that share phenotypes with SHISA7: view

Animal Models for SHISA7 Gene

MGI Knock Outs for SHISA7:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SHISA7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SHISA7 Gene

Localization for SHISA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHISA7 Gene

Cell junction, synapse, postsynaptic density membrane. Single-pass type I membrane protein. Note=Localizes at GABAergic inhibitory synapses and colocalizes with gephyrin in hippocampal neurons. {ECO:0000250 UniProtKB:Q8C3Q5}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SHISA7 gene
Compartment Confidence
plasma membrane 3
extracellular 2
mitochondrion 0
lysosome 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SHISA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0014069 postsynaptic density IEA,ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with SHISA7: view

Pathways & Interactions for SHISA7 Gene

PathCards logo

SuperPathways for SHISA7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SHISA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007214 gamma-aminobutyric acid signaling pathway IEA,ISS --
GO:0007613 memory IEA,ISS --
GO:0048172 regulation of short-term neuronal synaptic plasticity IBA 21873635
GO:0097112 gamma-aminobutyric acid receptor clustering IEA,ISS --
GO:0098962 regulation of postsynaptic neurotransmitter receptor activity IEA --
genes like me logo Genes that share ontologies with SHISA7: view

No data available for Pathways by source and SIGNOR curated interactions for SHISA7 Gene

Drugs & Compounds for SHISA7 Gene

No Compound Related Data Available

Transcripts for SHISA7 Gene

mRNA/cDNA for SHISA7 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SHISA7

Alternative Splicing Database (ASD) splice patterns (SP) for SHISA7 Gene

No ASD Table

Relevant External Links for SHISA7 Gene

GeneLoc Exon Structure for
SHISA7

Expression for SHISA7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SHISA7 Gene

mRNA differential expression in normal tissues according to GTEx for SHISA7 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x6.5), Brain - Cortex (x5.8), Brain - Putamen (basal ganglia) (x5.0), Brain - Caudate (basal ganglia) (x4.8), Brain - Hippocampus (x4.7), Brain - Anterior cingulate cortex (BA24) (x4.4), Brain - Amygdala (x4.2), and Brain - Frontal Cortex (BA9) (x4.1).

Protein differential expression in normal tissues from HIPED for SHISA7 Gene

This gene is overexpressed in Frontal cortex (61.6) and Fetal Liver (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SHISA7 Gene



Protein tissue co-expression partners for SHISA7 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SHISA7

SOURCE GeneReport for Unigene cluster for SHISA7 Gene:

Hs.6664

Evidence on tissue expression from TISSUES for SHISA7 Gene

  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with SHISA7: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SHISA7 Gene

Orthologs for SHISA7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SHISA7 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia SHISA7 29 30
  • 91.35 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SHISA7 29 30
  • 90.11 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Shisa7 29 16 30
  • 87.44 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Shisa7 29
  • 87.06 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia SHISA7 30
  • 55 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SHISA7 30
  • 43 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia shisa7 29
  • 58.91 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC101883130 29
  • 56.22 (n)
SHISA7 (1 of 2) 30
  • 33 (a)
OneToMany
shisa7 30
  • 27 (a)
OneToMany
Species where no ortholog for SHISA7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SHISA7 Gene

ENSEMBL:
Gene Tree for SHISA7 (if available)
TreeFam:
Gene Tree for SHISA7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SHISA7: view image
Alliance of Genome Resources:
Additional Orthologs for SHISA7

Paralogs for SHISA7 Gene

Paralogs for SHISA7 Gene

genes like me logo Genes that share paralogs with SHISA7: view

Variants for SHISA7 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SHISA7 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SHISA7 Gene

Variant ID Type Subtype PubMed ID
dgv600n67 CNV loss 20364138
esv3331220 CNV duplication 20981092
nsv1078448 CNV duplication 25765185
nsv1118621 CNV duplication 24896259
nsv953624 CNV deletion 24416366

Variation tolerance for SHISA7 Gene

Gene Damage Index Score: 0.64; 13.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SHISA7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SHISA7
Leiden Open Variation Database (LOVD)
SHISA7

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SHISA7 Gene

Disorders for SHISA7 Gene

Additional Disease Information for SHISA7

No disorders were found for SHISA7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SHISA7 Gene

Publications for SHISA7 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3
  5. The sequence of the human genome. (PMID: 11181995) Venter JC … Zhu X (Science (New York, N.Y.) 2001) 3

Products for SHISA7 Gene

Sources for SHISA7 Gene