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Aliases for SHISA7 Gene

Aliases for SHISA7 Gene

  • Shisa Family Member 7 2 3 5
  • Shisa Homolog 7 (Xenopus Laevis) 2
  • Protein Shisa-6-Like 4

External Ids for SHISA7 Gene

Previous GeneCards Identifiers for SHISA7 Gene

  • GC19M060639
  • GC19M055940
  • GC19M052263

Summaries for SHISA7 Gene

GeneCards Summary for SHISA7 Gene

SHISA7 (Shisa Family Member 7) is a Protein Coding gene. An important paralog of this gene is SHISA6.

Additional gene information for SHISA7 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHISA7 Gene

Genomics for SHISA7 Gene

GeneHancer (GH) Regulatory Elements for SHISA7 Gene

Promoters and enhancers for SHISA7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I055440 Enhancer 0.9 ENCODE dbSUPER 550.8 +1.9 1928 0.6 HDGF YBX3 MEIS2 PKNOX1 ZBTB40 E4F1 MTA3 POLR2A BRD9 VEZF1 SHISA7 PIR40571
GH19I055442 Enhancer 0.8 ENCODE dbSUPER 550.8 +0.7 734 0.1 ZNF263 KLF1 SP3 RB1 SP2 ZBTB8A ZFHX2 POLR2A PATZ1 EZH2 SHISA7 PIR40571
GH19I055519 Enhancer 1.4 FANTOM5 Ensembl ENCODE 22.2 -77.3 -77346 1 HDGF ATF1 ZNF493 ZNF133 YBX1 GLI4 ZNF416 ZNF548 FOS ATF7 U2AF2 ZNF471 FIZ1 ZNF582 ZNF581 ZNF580 SSC5D ENSG00000267523 NAT14 ZNF667
GH19I055382 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.9 +56.0 55999 8.2 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF213 RPL28 MIR6805 TMEM238 PIR44435 ZNF628 LENG8-AS1 ZNF581 U2AF2 COX6B2 BRSK1
GH19I055431 Enhancer 0.7 dbSUPER 33.4 +10.0 9992 3.2 ATF1 ZBTB21 ZFP64 ZNF266 TSC22D4 CEBPG CDC5L ZNF335 ZFHX2 ZNF791 PIR40571 LENG8 LENG8-AS1 U2AF2 ENSG00000235681 SHISA7 ENSG00000267523 ENSG00000267096 ZNF628 ZNF581
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SHISA7 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SHISA7 Gene

Genomic Locations for SHISA7 Gene
14,126 bases
Minus strand

Genomic View for SHISA7 Gene

Genes around SHISA7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHISA7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHISA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHISA7 Gene

Proteins for SHISA7 Gene

  • Protein details for SHISA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein shisa-7
    Protein Accession:

    Protein attributes for SHISA7 Gene

    538 amino acids
    Molecular mass:
    56214 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SHISA7 Gene

Post-translational modifications for SHISA7 Gene

  • Glycosylation at isoforms=23 and isoforms=59
  • Modification sites at PhosphoSitePlus

Other Protein References for SHISA7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SHISA7 Gene

Domains & Families for SHISA7 Gene

Gene Families for SHISA7 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SHISA7 Gene


Suggested Antigen Peptide Sequences for SHISA7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the shisa family.
  • Belongs to the shisa family.
genes like me logo Genes that share domains with SHISA7: view

Function for SHISA7 Gene

Phenotypes for SHISA7 Gene

GenomeRNAi human phenotypes for SHISA7:
genes like me logo Genes that share phenotypes with SHISA7: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SHISA7 Gene

Localization for SHISA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHISA7 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SHISA7 gene
Compartment Confidence
plasma membrane 4
extracellular 2
mitochondrion 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SHISA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0032281 AMPA glutamate receptor complex IBA --
GO:0045202 synapse IBA --
genes like me logo Genes that share ontologies with SHISA7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SHISA7 Gene

Pathways & Interactions for SHISA7 Gene

SuperPathways for SHISA7 Gene

No Data Available

Interacting Proteins for SHISA7 Gene

Gene Ontology (GO) - Biological Process for SHISA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048172 regulation of short-term neuronal synaptic plasticity IBA --
genes like me logo Genes that share ontologies with SHISA7: view

No data available for Pathways by source and SIGNOR curated interactions for SHISA7 Gene

Drugs & Compounds for SHISA7 Gene

No Compound Related Data Available

Transcripts for SHISA7 Gene

mRNA/cDNA for SHISA7 Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SHISA7 Gene

Shisa homolog 7 (Xenopus laevis):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SHISA7 Gene

No ASD Table

Relevant External Links for SHISA7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SHISA7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SHISA7 Gene

mRNA differential expression in normal tissues according to GTEx for SHISA7 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x6.5), Brain - Cortex (x5.8), Brain - Putamen (basal ganglia) (x5.0), Brain - Caudate (basal ganglia) (x4.8), Brain - Hippocampus (x4.7), Brain - Anterior cingulate cortex (BA24) (x4.4), Brain - Amygdala (x4.2), and Brain - Frontal Cortex (BA9) (x4.1).

Protein differential expression in normal tissues from HIPED for SHISA7 Gene

This gene is overexpressed in Frontal cortex (61.6) and Fetal Liver (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SHISA7 Gene

Protein tissue co-expression partners for SHISA7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SHISA7 Gene:


SOURCE GeneReport for Unigene cluster for SHISA7 Gene:


Evidence on tissue expression from TISSUES for SHISA7 Gene

  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with SHISA7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SHISA7 Gene

Orthologs for SHISA7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SHISA7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SHISA7 33 34
  • 91.35 (n)
(Canis familiaris)
Mammalia SHISA7 33 34
  • 90.11 (n)
(Mus musculus)
Mammalia Shisa7 33 16 34
  • 87.44 (n)
(Rattus norvegicus)
Mammalia Shisa7 33
  • 87.06 (n)
(Ornithorhynchus anatinus)
Mammalia SHISA7 34
  • 55 (a)
(Anolis carolinensis)
Reptilia SHISA7 34
  • 43 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia shisa7 33
  • 58.91 (n)
(Danio rerio)
Actinopterygii LOC101883130 33
  • 56.22 (n)
SHISA7 (1 of 2) 34
  • 33 (a)
shisa7 34
  • 27 (a)
Species where no ortholog for SHISA7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHISA7 Gene

Gene Tree for SHISA7 (if available)
Gene Tree for SHISA7 (if available)

Paralogs for SHISA7 Gene

Paralogs for SHISA7 Gene

genes like me logo Genes that share paralogs with SHISA7: view

Variants for SHISA7 Gene

Sequence variations from dbSNP and Humsavar for SHISA7 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000102308 -- 55,444,775(-) T/C upstream_transcript_variant
rs1000452962 -- 55,444,511(-) A/T upstream_transcript_variant
rs1000500289 -- 55,432,582(-) T/C 3_prime_UTR_variant
rs1000661259 -- 55,440,362(-) C/T intron_variant
rs1000761622 -- 55,432,873(-) G/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for SHISA7 Gene

Variant ID Type Subtype PubMed ID
dgv600n67 CNV loss 20364138
esv3331220 CNV duplication 20981092
nsv1078448 CNV duplication 25765185
nsv1118621 CNV duplication 24896259
nsv953624 CNV deletion 24416366

Variation tolerance for SHISA7 Gene

Gene Damage Index Score: 0.64; 13.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SHISA7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHISA7 Gene

Disorders for SHISA7 Gene

Additional Disease Information for SHISA7

No disorders were found for SHISA7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SHISA7 Gene

Publications for SHISA7 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  4. The sequence of the human genome. (PMID: 11181995) Venter JC … Zhu X (Science (New York, N.Y.) 2001) 3 58

Products for SHISA7 Gene

Sources for SHISA7 Gene

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