SHISA4 Gene (Protein Coding)

Shisa Family Member 4

GC01P201888
GIFtS:
34
See more...

Aliases for SHISA4 Gene

Aliases for SHISA4 Gene

  • Shisa Family Member 4 2 3 5
  • Transmembrane Protein 58 2 3 4
  • Protein Shisa-4 3 4
  • C1orf40 3 4
  • TMEM58 3 4
  • Chromosome 1 Open Reading Frame 40 2
  • Shisa Homolog 4 (Xenopus Laevis) 2
  • Shisa Homolog 4 3
  • HShisa4 2
  • SHISA4 5

External Ids for SHISA4 Gene

Previous HGNC Symbols for SHISA4 Gene

  • C1orf40
  • TMEM58

Previous GeneCards Identifiers for SHISA4 Gene

  • GC01P200126
  • GC01P201857
  • GC01P173023

Summaries for SHISA4 Gene

GeneCards Summary for SHISA4 Gene

SHISA4 (Shisa Family Member 4) is a Protein Coding gene. An important paralog of this gene is SHISA2.

Additional gene information for SHISA4 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SHISA4 Gene

Genomics for SHISA4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for SHISA4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SHISA4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SHISA4

Top Transcription factor binding sites by QIAGEN in the SHISA4 gene promoter:
  • AP-1
  • AP-4
  • GATA-6
  • p53
  • Pax-4a
  • Pax-5
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • TBP

Genomic Locations for SHISA4 Gene

Latest Assembly
chr1:201,888,677-201,892,587
(GRCh38/hg38)
Size:
3,911 bases
Orientation:
Plus strand

Previous Assembly
chr1:201,857,805-201,861,715
(GRCh37/hg19 by Entrez Gene)
Size:
3,911 bases
Orientation:
Plus strand

chr1:201,857,808-201,861,434
(GRCh37/hg19 by Ensembl)
Size:
3,627 bases
Orientation:
Plus strand

Genomic View for SHISA4 Gene

Genes around SHISA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHISA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHISA4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SHISA4 Gene

Proteins for SHISA4 Gene

Products:

  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for SHISA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DD7-SHSA4_HUMAN
    Recommended name:
    Protein shisa-4
    Protein Accession:
    Q96DD7
    Secondary Accessions:
    • B4DFI0
    • B7ZAJ7
    • Q5VUU1
    • Q6P711
    • Q6UWY7

    Protein attributes for SHISA4 Gene

    Size:
    197 amino acids
    Molecular mass:
    21522 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH09558.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

neXtProt entry for SHISA4 Gene

Protein Expression for SHISA4 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SHISA4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SHISA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Boster Bio Antibodies for SHISA4

No data available for DME Specific Peptides for SHISA4 Gene

Domains & Families for SHISA4 Gene

Gene Families for SHISA4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SHISA4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SHISA4 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 58 (SHSA4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96DD7

UniProtKB/Swiss-Prot:

SHSA4_HUMAN :
  • Belongs to the shisa family.
Family:
  • Belongs to the shisa family.
genes like me logo Genes that share domains with SHISA4: view

Function for SHISA4 Gene

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  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Phenotypes From GWAS Catalog for SHISA4 Gene

Gene Ontology (GO) - Molecular Function for SHISA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with SHISA4: view
genes like me logo Genes that share phenotypes with SHISA4: view

Animal Models for SHISA4 Gene

MGI Knock Outs for SHISA4:

Animal Models for research

  • Taconic Biosciences Mouse Models for SHISA4

miRNA for SHISA4 Gene

miRTarBase miRNAs that target SHISA4

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SHISA4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SHISA4 Gene

Localization for SHISA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHISA4 Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SHISA4 gene
Compartment Confidence
plasma membrane 2

Gene Ontology (GO) - Cellular Components for SHISA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SHISA4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SHISA4 Gene

Pathways & Interactions for SHISA4 Gene

PathCards logo

SuperPathways for SHISA4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SHISA4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SHISA4 Gene

Drugs & Compounds for SHISA4 Gene

Products:

  1. Drug products for research
No Compound Related Data Available

Transcripts for SHISA4 Gene

Products:

  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
  4. Clone products for research

mRNA/cDNA for SHISA4 Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SHISA4

Alternative Splicing Database (ASD) splice patterns (SP) for SHISA4 Gene

No ASD Table

Relevant External Links for SHISA4 Gene

GeneLoc Exon Structure for
SHISA4

Expression for SHISA4 Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SHISA4 Gene

mRNA expression in normal human tissues for SHISA4 Gene
mRNA expression by GTEx for SHISA4 GenemRNA expression by BioGPS for SHISA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SHISA4 Gene

This gene is overexpressed in Muscle - Skeletal (x5.6).

Protein differential expression in normal tissues from HIPED for SHISA4 Gene

This gene is overexpressed in Frontal cortex (29.5), Fetal Brain (16.4), Retina (10.7), and Spinal cord (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SHISA4 Gene



Protein tissue co-expression partners for SHISA4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SHISA4

SOURCE GeneReport for Unigene cluster for SHISA4 Gene:

Hs.632471

Evidence on tissue expression from TISSUES for SHISA4 Gene

  • Nervous system(4.8)
  • Muscle(4.6)
  • Kidney(4.2)
  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with SHISA4: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SHISA4 Gene

Orthologs for SHISA4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SHISA4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia SHISA4 30 31
  • 99.15 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Shisa4 30 17 31
  • 90.74 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia SHISA4 30 31
  • 90.08 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Shisa4 30
  • 89.81 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia SHISA4 31
  • 84 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia SHISA4 31
  • 81 (a)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia SHISA4 31
  • 63 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia shisa4 30
  • 60.2 (n)
Zebrafish
(Danio rerio)
 Actinopterygii shisa4 30 31
  • 58.33 (n)
 OneToMany
SHISA4 (3 of 3) 31
  • 24 (a)
 OneToMany
SHISA4 (2 of 3) 31
  • 23 (a)
 OneToMany
Species where no ortholog for SHISA4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SHISA4 Gene

ENSEMBL:
Gene Tree for SHISA4 (if available)
TreeFam:
Gene Tree for SHISA4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SHISA4: view image

Paralogs for SHISA4 Gene

Paralogs for SHISA4 Gene

genes like me logo Genes that share paralogs with SHISA4: view

Variants for SHISA4 Gene

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  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SHISA4 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs2250377 - p.Ile159Met

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SHISA4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SHISA4 Gene

Variant ID Type Subtype PubMed ID
nsv521567 CNV loss 19592680

Variation tolerance for SHISA4 Gene

Residual Variation Intolerance Score: 72.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SHISA4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SHISA4

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHISA4 Gene

Disorders for SHISA4 Gene

Additional Disease Information for SHISA4

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for SHISA4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SHISA4 Gene

Publications for SHISA4 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Systematic protein-protein interaction mapping for clinically relevant human GPCRs. (PMID: 28298427) Sokolina K … Stagljar I (Molecular systems biology 2017) 3

ExternalLinks

View latest publications for SHISA4 gene in Mastermind

Products for SHISA4 Gene

Sources for SHISA4 Gene