This gene encodes a single-transmembrane protein which is one of nine members of a family of transmembrane adaptors that modulate both WNT and FGF signaling by blocking the maturation and transport of their receptors to the cell surface. Members of this family contain an N-terminal cysteine-rich domain with a distinct cysteine pattern, a single transmembrane domain, and a C-ter... See more...

Aliases for SHISA3 Gene

Aliases for SHISA3 Gene

  • Shisa Family Member 3 2 3 5
  • Protein Shisa-3 Homolog 3 4
  • Shisa Homolog 3 (Xenopus Laevis) 2
  • Shisa Homolog 3 3
  • HShisa3 3

External Ids for SHISA3 Gene

Previous GeneCards Identifiers for SHISA3 Gene

  • GC04P042095
  • GC04P041721

Summaries for SHISA3 Gene

Entrez Gene Summary for SHISA3 Gene

  • This gene encodes a single-transmembrane protein which is one of nine members of a family of transmembrane adaptors that modulate both WNT and FGF signaling by blocking the maturation and transport of their receptors to the cell surface. Members of this family contain an N-terminal cysteine-rich domain with a distinct cysteine pattern, a single transmembrane domain, and a C-terminal proline-rich, low complexity region. The encoded protein acts as a tumor suppressor by accelerating beta-catenin degradation. [provided by RefSeq, Jul 2017]

GeneCards Summary for SHISA3 Gene

SHISA3 (Shisa Family Member 3) is a Protein Coding gene. An important paralog of this gene is SHISA2.

UniProtKB/Swiss-Prot Summary for SHISA3 Gene

  • Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling.

Additional gene information for SHISA3 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SHISA3 Gene

Genomics for SHISA3 Gene

GeneHancer (GH) Regulatory Elements for SHISA3 Gene

Promoters and enhancers for SHISA3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J042397 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas 505.9 +0.9 912 3.6 CTCF ZIC2 ZBTB26 EZH2 POLR2A HDAC2 MXI1 WT1 SMC3 ZBTB17 SHISA3 ATP8A1 lnc-BEND4-4
GH04J042425 Enhancer 0.8 UCNEbase Ensembl ENCODE 12.8 +28.2 28213 1.8 POU5F1 NANOG SHISA3 ENSG00000250781 ATP8A1 lnc-BEND4-4 piR-31937-152
GH04J042626 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 4.6 +237.6 237613 19.8 EP300 SIN3A USF1 SP1 RELA MEF2C RCOR1 REST TRIM22 POLR2A ATP8A1 SHISA3 GRXCR1 piR-35674-391
GH04J042452 Enhancer 0.4 Ensembl 16.8 +55.4 55413 1.8 PRDM6 ZNF687 EBF1 SHISA3 ENSG00000250781 ATP8A1 piR-31937-152 lnc-BEND4-4
GH04J042482 Enhancer 0.9 Ensembl ENCODE 5.1 +89.0 89012 8.2 EP300 RELA POLR2A MXI1 BCL11A CBFB ZNF384 GATA3 REST CEBPG ATP8A1 SHISA3 RF00017-4299 piR-45963-002
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SHISA3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SHISA3

Top Transcription factor binding sites by QIAGEN in the SHISA3 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • FOXJ2
  • FOXJ2 (long isoform)
  • S8
  • SRY

Genomic Locations for SHISA3 Gene

Genomic Locations for SHISA3 Gene
chr4:42,397,488-42,402,487
(GRCh38/hg38)
Size:
5,000 bases
Orientation:
Plus strand
chr4:42,399,856-42,404,504
(GRCh37/hg19)
Size:
4,649 bases
Orientation:
Plus strand

Genomic View for SHISA3 Gene

Genes around SHISA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHISA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHISA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHISA3 Gene

Proteins for SHISA3 Gene

  • Protein details for SHISA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0PJX4-SHSA3_HUMAN
    Recommended name:
    Protein shisa-3 homolog
    Protein Accession:
    A0PJX4
    Secondary Accessions:
    • A0PJX3
    • Q96EQ5

    Protein attributes for SHISA3 Gene

    Size:
    238 amino acids
    Molecular mass:
    25832 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SHISA3 Gene

Post-translational modifications for SHISA3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SHISA3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SHISA3 Gene

Domains & Families for SHISA3 Gene

Gene Families for SHISA3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SHISA3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SHISA3 Gene

GenScript: Design optimal peptide antigens:
  • Protein shisa-3 homolog (SHSA3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A0PJX4

UniProtKB/Swiss-Prot:

SHSA3_HUMAN :
  • Belongs to the shisa family.
Family:
  • Belongs to the shisa family.
genes like me logo Genes that share domains with SHISA3: view

Function for SHISA3 Gene

Molecular function for SHISA3 Gene

UniProtKB/Swiss-Prot Function:
Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling.

Phenotypes From GWAS Catalog for SHISA3 Gene

Gene Ontology (GO) - Molecular Function for SHISA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SHISA3: view

Phenotypes for SHISA3 Gene

genes like me logo Genes that share phenotypes with SHISA3: view

Animal Models for SHISA3 Gene

MGI Knock Outs for SHISA3:

Animal Model Products

  • Taconic Biosciences Mouse Models for SHISA3

CRISPR Products

miRNA for SHISA3 Gene

miRTarBase miRNAs that target SHISA3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SHISA3 Gene

Localization for SHISA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHISA3 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SHISA3 gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 3
plasma membrane 2
cytosol 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Lipid droplets (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SHISA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SHISA3: view

Pathways & Interactions for SHISA3 Gene

PathCards logo

SuperPathways for SHISA3 Gene

No Data Available

Interacting Proteins for SHISA3 Gene

Selected Interacting proteins: A0PJX4-SHSA3_HUMAN for SHISA3 Gene via UniProtKB IID

Symbol External ID(s) Details
PNMA1
;

Gene Ontology (GO) - Biological Process for SHISA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with SHISA3: view

No data available for Pathways by source and SIGNOR curated interactions for SHISA3 Gene

Drugs & Compounds for SHISA3 Gene

No Compound Related Data Available

Transcripts for SHISA3 Gene

mRNA/cDNA for SHISA3 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SHISA3 Gene

No ASD Table

Relevant External Links for SHISA3 Gene

GeneLoc Exon Structure for
SHISA3

Expression for SHISA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SHISA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SHISA3 Gene

This gene is overexpressed in Kidney - Cortex (x5.5), Nerve - Tibial (x4.9), and Heart - Atrial Appendage (x4.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SHISA3

SOURCE GeneReport for Unigene cluster for SHISA3 Gene:

Hs.370904
genes like me logo Genes that share expression patterns with SHISA3: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SHISA3 Gene

Orthologs for SHISA3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SHISA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SHISA3 31 30
  • 99.58 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SHISA3 31 30
  • 91.22 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SHISA3 31
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Shisa3 17 31 30
  • 87.8 (n)
rat
(Rattus norvegicus)
Mammalia Shisa3 30
  • 87.05 (n)
dog
(Canis familiaris)
Mammalia SHISA3 31 30
  • 79.77 (n)
OneToOne
chicken
(Gallus gallus)
Aves SHISA3 31 30
  • 73.73 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SHISA3 31
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia shisa3 30
  • 71.39 (n)
zebrafish
(Danio rerio)
Actinopterygii shisa3 31 30
  • 64.71 (n)
OneToOne
Species where no ortholog for SHISA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHISA3 Gene

ENSEMBL:
Gene Tree for SHISA3 (if available)
TreeFam:
Gene Tree for SHISA3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SHISA3: view image

Paralogs for SHISA3 Gene

Paralogs for SHISA3 Gene

(1) SIMAP similar genes for SHISA3 Gene using alignment to 1 proteins:

  • SHSA3_HUMAN

Pseudogenes.org Pseudogenes for SHISA3 Gene

genes like me logo Genes that share paralogs with SHISA3: view

Variants for SHISA3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SHISA3 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs11733156 - p.Trp13Cys

Additional dbSNP identifiers (rs#s) for SHISA3 Gene

Variation tolerance for SHISA3 Gene

Residual Variation Intolerance Score: 41.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.36; 81.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SHISA3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SHISA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SHISA3 Gene

Disorders for SHISA3 Gene

Additional Disease Information for SHISA3

No disorders were found for SHISA3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SHISA3 Gene

Publications for SHISA3 Gene

  1. Hypermethylation of SHISA3 Promotes Nasopharyngeal Carcinoma Metastasis by Reducing SGSM1 Stability. (PMID: 30573520) Zhang J … Liu N (Cancer research 2019) 3 54
  2. Increased SHISA3 expression characterizes chronic lymphocytic leukemia patients sensitive to lenalidomide. (PMID: 28639485) Maffei R … Marasca R (Leukemia & lymphoma 2018) 3 54
  3. SHISA3 Promoter Methylation Is a Potential Diagnostic and Prognostic Biomarker for Laryngeal Squamous Cell Carcinoma. (PMID: 28299336) Shen Z … Zhang Y (BioMed research international 2017) 3 54
  4. DNA Hypermethylation of SHISA3 in Colorectal Cancer: An Independent Predictor of Poor Prognosis. (PMID: 25968618) Tsai MH … Yang YC (Annals of surgical oncology 2015) 3 54
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 54

Products for SHISA3 Gene

Sources for SHISA3 Gene