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Aliases for SHE Gene

Aliases for SHE Gene

  • Src Homology 2 Domain Containing E 2 3 5

External Ids for SHE Gene

Previous GeneCards Identifiers for SHE Gene

  • GC01M151266
  • GC01M152718
  • GC01M125815

Summaries for SHE Gene

GeneCards Summary for SHE Gene

SHE (Src Homology 2 Domain Containing E) is a Protein Coding gene. Diseases associated with SHE include Blepharoconjunctivitis and Blepharitis. An important paralog of this gene is SHF.

Additional gene information for SHE Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHE Gene

Genomics for SHE Gene

GeneHancer (GH) Regulatory Elements for SHE Gene

Promoters and enhancers for SHE Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I154501 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 562.3 -0.2 -214 2.1 MAZ USF1 SUZ12 CEBPB MAX USF2 CEBPG POLR2A MTA1 CEBPA SHE TDRD10 UBE2Q1-AS1 UBE2Q1 IL6R PIR57366
GH01I154404 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.3 +94.7 94731 5.8 HDGF FOXA2 SMAD1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 LOC101928101 IL6R-AS1 IL6R ATP8B2 RNU7-57P UBE2Q1-AS1 UBE2Q1 SHE TDRD10 SNORA58B
GH01I154384 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +115.9 115938 2.5 HDGF ATF1 FOXA2 SMAD1 ARID4B ZNF48 NCOA2 TCF12 POLR2B GATA2 ATP8B2 IL6R-AS1 RNU7-57P UBE2Q1-AS1 UBE2Q1 SHE TDRD10 C1orf189 SNAPIN UBAP2L
GH01I154479 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.4 +22.1 22112 0.8 RB1 ARNT ARID4B ZNF2 RAD21 RFX5 YY1 CHAMP1 ZNF335 ZNF121 ENSG00000273110 IL6R UBE2Q1-AS1 UBE2Q1 TDRD10 SHE IL6R-AS1 CHRNB2 ILF2 CHTOP
GH01I154492 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.4 +8.9 8917 2 PKNOX1 NR4A1 ZBTB11 MAX EBF1 ATF2 ZBTB40 NR2F2 POLR2A TARDBP TDRD10 UBE2Q1-AS1 UBE2Q1 RNU7-57P ATP8B2 SHE ADAR C1orf189 GBA ENSG00000273110
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SHE on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SHE gene promoter:

Genomic Locations for SHE Gene

Genomic Locations for SHE Gene
chr1:154,469,637-154,502,113
(GRCh38/hg38)
Size:
32,477 bases
Orientation:
Minus strand
chr1:154,442,248-154,474,589
(GRCh37/hg19)

Genomic View for SHE Gene

Genes around SHE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHE Gene

Proteins for SHE Gene

  • Protein details for SHE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VZ18-SHE_HUMAN
    Recommended name:
    SH2 domain-containing adapter protein E
    Protein Accession:
    Q5VZ18
    Secondary Accessions:
    • Q8TEQ5

    Protein attributes for SHE Gene

    Size:
    495 amino acids
    Molecular mass:
    53950 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SHE Gene

Post-translational modifications for SHE Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SHE Gene

No data available for DME Specific Peptides for SHE Gene

Domains & Families for SHE Gene

Gene Families for SHE Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for SHE Gene

Suggested Antigen Peptide Sequences for SHE Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SHE: view

No data available for UniProtKB/Swiss-Prot for SHE Gene

Function for SHE Gene

Gene Ontology (GO) - Molecular Function for SHE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity IBA --
GO:0005515 protein binding IPI 24728074
genes like me logo Genes that share ontologies with SHE: view
genes like me logo Genes that share phenotypes with SHE: view

miRNA for SHE Gene

miRTarBase miRNAs that target SHE

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SHE Gene

Localization for SHE Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SHE gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SHE Gene

Pathways & Interactions for SHE Gene

No Data Available

Gene Ontology (GO) - Biological Process for SHE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0009967 positive regulation of signal transduction IEA --
genes like me logo Genes that share ontologies with SHE: view

No data available for Pathways by source and SIGNOR curated interactions for SHE Gene

Drugs & Compounds for SHE Gene

No Compound Related Data Available

Transcripts for SHE Gene

Unigene Clusters for SHE Gene

Src homology 2 domain containing E:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SHE Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2:

Relevant External Links for SHE Gene

GeneLoc Exon Structure for
SHE
ECgene alternative splicing isoforms for
SHE

Expression for SHE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SHE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SHE Gene

This gene is overexpressed in Brain (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SHE Gene



Protein tissue co-expression partners for SHE Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SHE Gene:

SHE

SOURCE GeneReport for Unigene cluster for SHE Gene:

Hs.591481

Evidence on tissue expression from TISSUES for SHE Gene

  • Spleen(4.3)
  • Intestine(2.5)
genes like me logo Genes that share expression patterns with SHE: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SHE Gene

Orthologs for SHE Gene

This gene was present in the common ancestor of animals.

Orthologs for SHE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SHE 33 34
  • 95.96 (n)
cow
(Bos Taurus)
Mammalia SHE 33 34
  • 87.88 (n)
dog
(Canis familiaris)
Mammalia SHE 33 34
  • 85.42 (n)
mouse
(Mus musculus)
Mammalia She 33 16 34
  • 84.06 (n)
rat
(Rattus norvegicus)
Mammalia She 33
  • 83.44 (n)
oppossum
(Monodelphis domestica)
Mammalia SHE 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SHE 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves SHE 33 34
  • 69.8 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia she 33
  • 64.44 (n)
zebrafish
(Danio rerio)
Actinopterygii she 33 34
  • 58.91 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG43921 34
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3099 34
  • 21 (a)
OneToOne
Species where no ortholog for SHE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHE Gene

ENSEMBL:
Gene Tree for SHE (if available)
TreeFam:
Gene Tree for SHE (if available)

Paralogs for SHE Gene

Paralogs for SHE Gene

(3) SIMAP similar genes for SHE Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SHE: view

Variants for SHE Gene

Sequence variations from dbSNP and Humsavar for SHE Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000081201 -- 154,501,235(-) A/G intron_variant
rs1000304809 -- 154,471,414(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000485114 -- 154,499,520(-) T/C intron_variant
rs1000536320 -- 154,501,400(-) G/A/C/T intron_variant
rs1000551432 -- 154,503,577(-) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SHE Gene

Variant ID Type Subtype PubMed ID
dgv584n54 CNV gain 21841781
dgv585n54 CNV gain 21841781
esv23279 CNV loss 19812545
nsv521887 CNV gain 19592680
nsv547942 CNV gain+loss 21841781
nsv547954 CNV loss 21841781

Variation tolerance for SHE Gene

Residual Variation Intolerance Score: 16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SHE Gene

Human Gene Mutation Database (HGMD)
SHE
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SHE

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHE Gene

Disorders for SHE Gene

MalaCards: The human disease database

(3) MalaCards diseases for SHE Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
blepharoconjunctivitis
blepharitis
strongyloidiasis
  • disseminated strongyloidiasis
- elite association - COSMIC cancer census association via MalaCards
Search SHE in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with SHE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SHE Gene

Publications for SHE Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PMID: 12693554) Jikuya H … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2003) 3 4 58
  4. Identification and characterization of two novel SH2 domain-containing proteins from a yeast two hybrid screen with the ABL tyrosine kinase. (PMID: 9315092) Oda T … Druker BJ (Oncogene 1997) 2 3 58
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 58

Products for SHE Gene

Sources for SHE Gene

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