Aliases for SHC3 Gene
Aliases for SHC3 Gene
External Ids for SHC3 Gene
- HGNC: 18181
- Entrez Gene: 53358
- Ensembl: ENSG00000148082
- OMIM: 605263
- UniProtKB: Q92529
Previous GeneCards Identifiers for SHC3 Gene
- GC09M082643
- GC09M083496
- GC09M085215
- GC09M087117
- GC09M088857
- GC09M090817
- GC09M091628
- GC09M061453
Summaries for SHC3 Gene
GeneCards Summary for SHC3 Gene
SHC3 (SHC Adaptor Protein 3) is a Protein Coding gene. Diseases associated with SHC3 include Sarcomatous Intrahepatic Cholangiocarcinoma and Sclerosing Hepatic Carcinoma. Among its related pathways are RET signaling and Chronic myeloid leukemia. Gene Ontology (GO) annotations related to this gene include protein kinase binding and receptor tyrosine kinase binding. An important paralog of this gene is SHC1.
UniProtKB/Swiss-Prot for SHC3 Gene
-
Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHC3 Gene
Genomics for SHC3 Gene
GeneHancer (GH) Regulatory Elements for SHC3 Gene
Promoters and enhancers for SHC3 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH09I089175 | Promoter/Enhancer | 2.5 | EPDnew FANTOM5 Ensembl ENCODE | 567.8 | +3.4 | 3445 | 5.4 | PKNOX1 FOXA2 ARID4B SIN3A FEZF1 ZNF2 YY1 GLIS2 ATF7 FOS | SHC3 SECISBP2 C9orf47 ENSG00000224945 | |
| GH09I089136 | Enhancer | 1.2 | FANTOM5 Ensembl ENCODE dbSUPER | 27.2 | +43.7 | 43729 | 4.4 | STAT1 ZNF687 JUND POLR2A MAX CEBPB FOS EP300 ZNF592 | SHC3 ENSG00000224945 CKS2 | |
| GH09I089152 | Enhancer | 1.1 | Ensembl ENCODE dbSUPER | 22.9 | +27.5 | 27540 | 3.2 | HDAC1 MEIS2 PKNOX1 JUN BRCA1 FOSL1 POLR2A FOSL2 ETV6 FOS | SHC3 ENSG00000224945 CKS2 | |
| GH09I089020 | Enhancer | 0.9 | Ensembl ENCODE | 5.3 | +160.0 | 159977 | 4 | ESRRA JUN RFX5 FOSL1 CTBP1 ZNF316 GATA3 NFE2 FOSL2 FOS | SHC3 GC09M089006 ENSG00000224945 | |
| GH09I089140 | Enhancer | 0.4 | ENCODE dbSUPER | 11.1 | +41.0 | 40974 | 1.1 | ENSG00000224945 SHC3 PA2G4P6 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around SHC3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the SHC3 gene promoter:
Regulatory Element Products
Genomic Locations for SHC3 Gene
Genomic Locations for SHC3 Gene
- chr9:89,005,771-89,182,072
- (GRCh38/hg38)
- Size:
- 176,302 bases
- Orientation:
- Minus strand
- chr9:91,620,686-91,793,682
- (GRCh37/hg19)
Genomic View for SHC3 Gene
Genes around SHC3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q22.1 by Ensembl
- 9q22.1 by Entrez Gene
- 9q22.1 by HGNC
SHC3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SHC3 Gene
Proteins for SHC3 Gene
-
Protein details for SHC3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q92529-SHC3_HUMAN
- Recommended name:
- SHC-transforming protein 3
- Protein Accession:
- Q92529
- Q5T7I7
- Q8TAP2
- Q9UCX5
Protein attributes for SHC3 Gene
- Size:
- 594 amino acids
- Molecular mass:
- 64056 Da
- Quaternary structure:
-
- Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors.
Protein Expression for SHC3 Gene
Post-translational modifications for SHC3 Gene
- Tyrosine phosphorylated.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for SHC3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
Abcam antibodies for SHC3
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Cloud-Clone Corp. Antibodies for SHC3
- Invitrogen Antibodies for SHC3
- antibodies-online: Search results for 57 available SHC3 Antibodies ranked by validation data
- Compare Top SHC3 Antibodies
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Recommended
- 1 IHC (p) Antibody (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 18 WB Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-rat)
- 1 IHC Antibody (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 13 WB Antibodies (anti-rat)
- 1 IHC Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 32 WB Antibodies (anti-human)
- Search GeneTex for Antibodies for SHC3
-
Santa Cruz Biotechnology (SCBT) Antibodies for SHC3
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for SHC3
- Origene Custom Protein Services for SHC3
-
Cloud-Clone Corp. Proteins for SHC3
- Search GeneTex for Proteins for SHC3
-
Abcam proteins for SHC3
Assay Products
- antibodies-online: Search results for available SHC3 related products ranked by validation data
No data available for DME Specific Peptides for SHC3 Gene
Domains & Families for SHC3 Gene
Gene Families for SHC3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for SHC3 Gene
Suggested Antigen Peptide Sequences for SHC3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for SHC3 Gene
Function for SHC3 Gene
Molecular function for SHC3 Gene
- UniProtKB/Swiss-Prot Function:
- Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
Phenotypes From GWAS Catalog for SHC3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001784 | phosphotyrosine residue binding | IPI | 20624904 |
| GO:0004871 | signal transducer activity | TAS | 8808684 |
| GO:0005088 | Ras guanyl-nucleotide exchange factor activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 11877420 |
| GO:0030971 | receptor tyrosine kinase binding | IBA | -- |
Phenotypes for SHC3 Gene
- MGI mutant phenotypes for SHC3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SHC3:
Animal Models for SHC3 Gene
- MGI Knock Outs for SHC3:
-
- Shc3 tm1Paw
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SHC3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SHC3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SHC3 gene
- Search ViGene Biosciences for SHC3
CRISPR Products
-
OriGene CRISPR knockouts for SHC3
- genomics-online: gRNA clones - Search results for 88 available SHC3 gene related products
- Overview of 88 available SHC3 gene related products
- Applied Biological Materials CRISPR for SHC3
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Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SHC3
- GenScript: Design CRISPR guide RNA sequences for SHC3
miRNA for SHC3 Gene
- miRTarBase miRNAs that target SHC3
-
- hsa-mir-124-3p (MIRT002724)
- hsa-mir-335-5p (MIRT018309)
- hsa-mir-92a-3p (MIRT049052)
- hsa-mir-2355-3p (MIRT528184)
- hsa-mir-4646-3p (MIRT528185)
- hsa-mir-3912-5p (MIRT528186)
- hsa-mir-376b-3p (MIRT528187)
- hsa-mir-376a-3p (MIRT528188)
- hsa-mir-885-5p (MIRT528189)
- hsa-mir-4733-5p (MIRT528190)
- hsa-mir-155-3p (MIRT569208)
- hsa-mir-3619-3p (MIRT569209)
- hsa-mir-342-3p (MIRT569210)
- hsa-mir-665 (MIRT569211)
- hsa-mir-1285-5p (MIRT569212)
- hsa-mir-3120-3p (MIRT569213)
miRNA Products
- Search ViGene Biosciences for SHC3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SHC3
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- genomics-online: shRNA clones - Search results for 88 available SHC3 gene related products
- Overview of 88 available SHC3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SHC3 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for SHC3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SHC3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SHC3
- Applied Biological Materials Clones for SHC3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for SHC3
-
ViGene Biosciences adenoviral particle packaged cDNA for SHC3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SHC3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SHC3 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SHC3 Gene
Localization for SHC3 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| plasma membrane | 3 |
| endoplasmic reticulum | 1 |
- Cytosol (4)
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | IBA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for SHC3 Gene
Pathways & Interactions for SHC3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Gastric cancer |
.62
.62
|
|
| 3 | Relaxin signaling pathway | ||
| 4 | Focal Adhesion |
.62
.62
|
|
| 5 | Endometrial cancer |
.52
|
|
Pathways by source for SHC3 Gene
6 BioSystems pathways for SHC3 Gene
46 Reactome pathways for SHC3 Gene
1 PharmGKB pathway for SHC3 Gene
20 KEGG pathways for SHC3 Gene
Interacting Proteins for SHC3 Gene
Selected Interacting proteins:
Q92529-SHC3_HUMAN
ENSP00000364995
for SHC3 Gene via
IID
STRING
UniProtKB
MINT
SIGNOR curated interactions for SHC3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | TAS | 8808684 |
| GO:0007173 | epidermal growth factor receptor signaling pathway | TAS | 8808684 |
| GO:0007265 | Ras protein signal transduction | TAS | -- |
Transcripts for SHC3 Gene
mRNA/cDNA for SHC3 Gene
- (5) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (41) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SHC3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SHC3
- genomics-online: gRNA clones - Search results for 88 available SHC3 gene related products
- Overview of 88 available SHC3 gene related products
- Applied Biological Materials CRISPR for SHC3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SHC3
- GenScript: Design CRISPR guide RNA sequences for SHC3
miRNA Products
- Search ViGene Biosciences for SHC3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SHC3
- Browse OriGene Inhibitory RNA Products For SHC3
- genomics-online: shRNA clones - Search results for 88 available SHC3 gene related products
- Overview of 88 available SHC3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SHC3 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for SHC3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SHC3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SHC3
- Applied Biological Materials Clones for SHC3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||
| SP4: |
Expression for SHC3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
- Inner Cell Mass (Early Embryonic Tissues)
- Brain (Nervous System)
- Umbilical Cord (Extraembryonic Tissues)
- Mesenchymal Stem Cells (Uncategorized)
- Spinal Cord (Nervous System)
- Oligodendrocytes (Nervous System)
mRNA differential expression in normal tissues according to GTEx for SHC3 Gene
This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x6.2), Brain - Frontal Cortex (BA9) (x5.8), and Brain - Cortex (x4.8).
This gene is overexpressed in Frontal cortex (45.1) and Ovary (23.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SHC3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of SHC3 Gene:
SHC3SOURCE GeneReport for Unigene cluster for SHC3 Gene:
Hs.292737mRNA Expression by UniProt/SwissProt for SHC3 Gene:
Q92529-SHC3_HUMAN
Tissue specificity:
Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord.
Evidence on tissue expression from TISSUES for SHC3 Gene
- Nervous system(4.9)
Primer Products
-
OriGene qPCR primer pairs for SHC3
-
OriGene qPCR primer pairs and template standards for SHC3
- genomics-online: primer clones - Search results for 88 available SHC3 gene related products
- Overview of 88 available SHC3 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SHC3 Gene
Orthologs for SHC3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SHC3 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Shc3 33 |
|
||
| dog (Canis familiaris) |
Mammalia | SHC3 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Shc3 33 16 34 |
|
||
| cow (Bos Taurus) |
Mammalia | SHC3 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | SHC3 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SHC3 33 34 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | shc3 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | SHC3 34 |
|
OneToOne | |
| LOC100332111 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Shc 35 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | shc-1 34 |
|
OneToMany |
- Species where no ortholog for SHC3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for SHC3 Gene
Variants for SHC3 Gene
| SNP ID | Clin | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000034630 | -- | 89,056,285(-) | C/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000066862 | -- | 89,166,970(-) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000090307 | -- | 89,048,119(-) | C/G/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000096116 | -- | 89,031,874(-) | C/G | genic_downstream_transcript_variant, intron_variant | |
| rs1000113545 | -- | 89,133,589(-) | G/T | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4472e59 | CNV | duplication | 20981092 |
| dgv4473e59 | CNV | duplication | 20981092 |
| esv2554035 | CNV | insertion | 19546169 |
| esv26782 | CNV | loss | 19812545 |
| esv2738726 | CNV | deletion | 23290073 |
| esv29340 | CNV | gain+loss | 19812545 |
| esv3310572 | CNV | novel sequence insertion | 20981092 |
| esv3446910 | CNV | insertion | 20981092 |
| esv3573288 | CNV | loss | 25503493 |
| esv3621014 | CNV | gain | 21293372 |
| nsv1077559 | CNV | duplication | 25765185 |
| nsv1132740 | CNV | duplication | 24896259 |
| nsv1147400 | CNV | duplication | 26484159 |
| nsv614825 | CNV | gain | 21841781 |
| nsv614826 | CNV | loss | 21841781 |
| nsv6608 | CNV | deletion | 18451855 |
| nsv819886 | CNV | loss | 19587683 |
| nsv831651 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
13.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.28;
40.86% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SHC3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SHC3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHC3 Gene
Disorders for SHC3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| sarcomatous intrahepatic cholangiocarcinoma |
|
|
| sclerosing hepatic carcinoma |
|
|
Search SHC3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SHC3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for SHC3 Gene
Publications for SHC3 Gene
- N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway. (PMID: 8808684) Nakamura T … Mori N (Oncogene 1996) 2 3 4 22 58
- A family of Shc related proteins with conserved PTB, CH1 and SH2 regions. (PMID: 8760305) Pelicci G … Pelicci PG (Oncogene 1996) 3 4 22 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- Linkage and association studies in African- and Caucasian-American populations demonstrate that SHC3 is a novel susceptibility locus for nicotine dependence. (PMID: 17179996) Li MD … Ma JZ (Molecular psychiatry 2007) 3 44 58
- Domain-specific function of ShcC docking protein in neuroblastoma cells. (PMID: 15735675) Miyake I … Sakai R (Oncogene 2005) 3 22 58
Products for SHC3 Gene
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- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cloud-Clone Corp. Antibodies for SHC3
- Cloud-Clone Corp. Proteins for SHC3
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for SHC3
- VectorBuilder custom plasmid, inducible vectors for SHC3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SHC3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SHC3
- antibodies-online: Search results for 57 available SHC3 Antibodies ranked by validation data
- Compare Top SHC3 Antibodies
- Recommended
- 32 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 13 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 18 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- antibodies-online: Search results for available SHC3 related products ranked by validation data
- antibodies-online: Search results for 6 available SHC3 Proteins ranked by validation data
- Compare Top SHC3 Proteins
- Search GeneTex for Antibodies for SHC3
- Search GeneTex for Proteins for SHC3
- ViGene Biosciences adenoviral particle packaged cDNA for SHC3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for SHC3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SHC3 gene
- Search ViGene Biosciences for SHC3
- Santa Cruz Biotechnology (SCBT) Antibodies for SHC3
- Search Santa Cruz Biotechnology (SCBT) for SHC3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SHC3
- Horizon Cell Lines for SHC3
- genomics-online: cdna clones - Search results for 88 available SHC3 gene related products
- Overview of 88 available SHC3 gene related products
- orf clones - Search results for 88 available SHC3 gene related products
- Overview of 88 available SHC3 gene related products
- genomics-online: gRNA clones - Search results for 88 available SHC3 gene related products
- Overview of 88 available SHC3 gene related products
- genomics-online: primer clones - Search results for 88 available SHC3 gene related products
- Overview of 88 available SHC3 gene related products
- genomics-online: shRNA clones - Search results for 88 available SHC3 gene related products
- Overview of 88 available SHC3 gene related products
Sources for SHC3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems