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SHC3 (SHC Adaptor Protein 3) is a Protein Coding gene. Diseases associated with SHC3 include Sclerosing Hepatic Carcinoma and Sarcomatous Intrahepatic Cholangiocarcinoma. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include protein kinase binding and receptor tyrosine kinase binding. An important paralog of this gene is SHC1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001784 | phosphotyrosine residue binding | IPI | 20624904 |
GO:0005515 | protein binding | IPI | 11877420 |
GO:0019901 | protein kinase binding | IBA | -- |
GO:0030971 | receptor tyrosine kinase binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005575 | cellular_component | ND | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0005886 | plasma membrane | IBA | 21873635 |
GO:0045202 | synapse | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
.92
|
2 | Gastric cancer |
.62
.62
|
|
3 | ErbB signaling pathway | ||
4 | Relaxin signaling pathway | ||
5 | Focal Adhesion |
.61
.61
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | TAS | -- |
GO:0007165 | signal transduction | IEA | -- |
GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | TAS,IBA | 21873635 |
GO:0007173 | epidermal growth factor receptor signaling pathway | TAS | 8808684 |
GO:0007265 | Ras protein signal transduction | TAS | -- |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||||
SP4: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SHC3 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Shc3 30 |
|
||
Dog (Canis familiaris) |
Mammalia | SHC3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Shc3 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SHC3 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | SHC3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SHC3 30 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | shc3 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | SHC3 31 |
|
OneToOne | |
LOC100332111 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | Shc 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | shc-1 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv4472e59 | CNV | duplication | 20981092 |
dgv4473e59 | CNV | duplication | 20981092 |
esv2554035 | CNV | insertion | 19546169 |
esv26782 | CNV | loss | 19812545 |
esv2738726 | CNV | deletion | 23290073 |
esv29340 | CNV | gain+loss | 19812545 |
esv3310572 | CNV | novel sequence insertion | 20981092 |
esv3446910 | CNV | insertion | 20981092 |
esv3573288 | CNV | loss | 25503493 |
esv3621014 | CNV | gain | 21293372 |
nsv1077559 | CNV | duplication | 25765185 |
nsv1132740 | CNV | duplication | 24896259 |
nsv1147400 | CNV | duplication | 26484159 |
nsv614825 | CNV | gain | 21841781 |
nsv614826 | CNV | loss | 21841781 |
nsv6608 | CNV | deletion | 18451855 |
nsv819886 | CNV | loss | 19587683 |
nsv831651 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
sclerosing hepatic carcinoma |
|
|
sarcomatous intrahepatic cholangiocarcinoma |
|
|
giant hemangioma |
|
|