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Aliases for SHC3 Gene
Aliases for SHC3 Gene
External Ids for SHC3 Gene
- HGNC: 18181
- NCBI Entrez Gene: 53358
- Ensembl: ENSG00000148082
- OMIM®: 605263
- UniProtKB/Swiss-Prot: Q92529
Previous GeneCards Identifiers for SHC3 Gene
- GC09M082643
- GC09M083496
- GC09M085215
- GC09M087117
- GC09M088857
- GC09M090817
- GC09M091628
- GC09M061453
Summaries for SHC3 Gene
GeneCards Summary for SHC3 Gene
SHC3 (SHC Adaptor Protein 3) is a Protein Coding gene. Among its related pathways are RET signaling and Gastric cancer. Gene Ontology (GO) annotations related to this gene include protein kinase binding and receptor tyrosine kinase binding. An important paralog of this gene is SHC1.
UniProtKB/Swiss-Prot Summary for SHC3 Gene
-
Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
Additional gene information for SHC3 Gene
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SHC3 Gene
Genomics for SHC3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SHC3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SHC3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SHC3
- Top Transcription factor binding sites by QIAGEN in the SHC3 gene promoter:
-
- C/EBPalpha
- C/EBPbeta
- HSF1 (long)
- HSF1short
- Lmo2
- POU3F2
- POU3F2 (N-Oct-5a)
- POU3F2 (N-Oct-5b)
- PPAR-gamma1
- PPAR-gamma2
Genomic Locations for SHC3 Gene
Latest Assembly
- chr9:89,005,771-89,182,402
- (GRCh38/hg38)
- Size:
- 176,632 bases
- Orientation:
- Minus strand
Previous Assembly
- chr9:91,620,686-91,793,733
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 173,048 bases
- Orientation:
- Minus strand
Genomic View for SHC3 Gene
Genes around SHC3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q22.1 by HGNC
- 9q22.1 by Entrez Gene
- 9q22.1 by Ensembl
SHC3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SHC3 Gene
Proteins for SHC3 Gene
-
Protein details for SHC3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q92529-SHC3_HUMAN
- Recommended name:
- SHC-transforming protein 3
- Protein Accession:
- Q92529
- Q5T7I7
- Q8TAP2
- Q9UCX5
Protein attributes for SHC3 Gene
- Size:
- 594 amino acids
- Molecular mass:
- 64056 Da
- Quaternary structure:
-
- Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors.
Protein Expression for SHC3 Gene
Post-translational modifications for SHC3 Gene
- Tyrosine phosphorylated.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for SHC3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences SHC3 / SHCC Antibody
- G Biosciences Immunotag™ Shc3 Antibody
-
Custom Antibody ServicesOriGene Antibodies for SHC3
- Novus Biologicals Antibodies for SHC3
-
Abcam antibodies for SHC3
- Invitrogen Antibodies for SHC3 (AFLGC-SHC3)
- antibodies-online: Show 8 available SHC3 Antibodies ranked by validation data
- Compare Top SHC3 Antibodies
-
Recommended
- 32 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 15 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- 21 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
-
Boster Bio Antibodies for SHC3
-
Santa Cruz Biotechnology (SCBT) Antibodies for SHC3
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for SHC3
- Origene Custom Protein Services for SHC3
-
Abcam proteins for SHC3
Assay products for research
- antibodies-online: Search results for available SHC3 related products ranked by validation data
No data available for DME Specific Peptides for SHC3 Gene
Domains & Families for SHC3 Gene
Gene Families for SHC3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for SHC3 Gene
- InterPro:
- Blocks:
-
- SHC phosphotyrosine interaction domain signature
- Phosphotyrosine interaction domain
Suggested Antigen Peptide Sequences for SHC3 Gene
- GenScript: Design optimal peptide antigens:
-
- Src homology 2 domain-containing-transforming protein C3 (SHC3_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SHC3 Gene
Function for SHC3 Gene
Molecular function for SHC3 Gene
- UniProtKB/Swiss-Prot Function:
- Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
Phenotypes From GWAS Catalog for SHC3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001784 | phosphotyrosine residue binding | IPI | 20624904 |
| GO:0005515 | protein binding | IPI | 11877420 |
| GO:0019901 | protein kinase binding | IBA | 21873635 |
| GO:0030971 | receptor tyrosine kinase binding | IBA | 21873635 |
Phenotypes for SHC3 Gene
- MGI mutant phenotypes for SHC3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SHC3:
-
- Increased vaccinia virus (VACV) infection
- Increased G1 DNA content
- no effect
- Decreased vaccinia virus (VACV) infection
- Decreased viability in esophageal squamous lineage
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Synthetic lethal with vaccinia virus (VACV) infection
- G0/1 arrest
- Increased endosome-nucleus distance (endosomes dispersed in the cell periphery)
Animal Models for SHC3 Gene
- MGI Knock Outs for SHC3:
-
- Shc3 Shc3<tm1Paw>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SHC3 - Starting at $85 >
- * SHC3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SHC3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SHC3
-
Santa Cruz Biotechnology (SCBT) CRISPR for SHC3
miRNA for SHC3 Gene
- miRTarBase miRNAs that target SHC3
-
- hsa-miR-124-3p (MIRT002724)
- hsa-miR-335-5p (MIRT018309)
- hsa-miR-92a-3p (MIRT049052)
- hsa-miR-2355-3p (MIRT528184)
- hsa-miR-4646-3p (MIRT528185)
- hsa-miR-3912-5p (MIRT528186)
- hsa-miR-376b-3p (MIRT528187)
- hsa-miR-376a-3p (MIRT528188)
- hsa-miR-885-5p (MIRT528189)
- hsa-miR-4733-5p (MIRT528190)
- hsa-miR-155-3p (MIRT569208)
- hsa-miR-3619-3p (MIRT569209)
- hsa-miR-342-3p (MIRT569210)
- hsa-miR-665 (MIRT569211)
- hsa-miR-1285-5p (MIRT569212)
- hsa-miR-3120-3p (MIRT569213)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SHC3
- Browse OriGene Inhibitory RNA Products For SHC3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SHC3
Clone products for research
- Applied Biological Materials (abm): Clones for SHC3 - Starting at $45 >
- * SHC3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for SHC3
- Addgene plasmids for SHC3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SHC3
Cell Lines for research
-
Horizon Cell Lines for SHC3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SHC3 Gene
Localization for SHC3 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| plasma membrane | 4 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | IBA | 21873635 |
| GO:0045202 | synapse | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for SHC3 Gene
Pathways & Interactions for SHC3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Gastric cancer |
.62
.62
|
|
| 3 | ErbB signaling pathway | ||
| 4 | Relaxin signaling pathway | ||
| 5 | Focal Adhesion |
.61
.61
|
|
Pathways by source for SHC3 Gene
1 Sino Biological pathway for SHC3 Gene
6 BioSystems pathways for SHC3 Gene
46 Reactome pathways for SHC3 Gene
1 PharmGKB pathway for SHC3 Gene
21 KEGG pathways for SHC3 Gene
Interacting Proteins for SHC3 Gene
Selected Interacting proteins:
Q92529-SHC3_HUMAN
ENSP00000364995
for SHC3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for SHC3
SIGNOR curated interactions for SHC3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | IBA | 21873635 |
| GO:0007173 | epidermal growth factor receptor signaling pathway | TAS | 8808684 |
| GO:0007265 | Ras protein signal transduction | TAS | -- |
Transcripts for SHC3 Gene
mRNA/cDNA for SHC3 Gene
- 1 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000375831 569 nts (view in UCSC)
- ENST00000375835 9819 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SHC3 - Starting at $85 >
- * SHC3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SHC3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SHC3
-
Santa Cruz Biotechnology (SCBT) CRISPR for SHC3
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SHC3
- Browse OriGene Inhibitory RNA Products For SHC3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SHC3
Clone products for research
- Applied Biological Materials (abm): Clones for SHC3 - Starting at $45 >
- * SHC3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for SHC3
- Addgene plasmids for SHC3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SHC3
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||
| SP4: |
Relevant External Links for SHC3 Gene
- GeneLoc Exon Structure for
- SHC3
Expression for SHC3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
- Inner Cell Mass (Early Embryonic Tissues)
- Brain (Nervous System)
- Mesenchymal Stem Cells (Uncategorized)
- Umbilical Cord (Extraembryonic Tissues)
- Oligodendrocytes (Nervous System)
- Spinal Cord (Nervous System)
mRNA differential expression in normal tissues according to GTEx for SHC3 Gene
This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x6.2), Brain - Frontal Cortex (BA9) (x5.8), and Brain - Cortex (x4.8).
This gene is overexpressed in Frontal cortex (45.1) and Ovary (23.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SHC3 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SHC3
SOURCE GeneReport for Unigene cluster for SHC3 Gene:
Hs.292737mRNA Expression by UniProt/SwissProt for SHC3 Gene:
Q92529-SHC3_HUMAN
Tissue specificity:
Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord.
Evidence on tissue expression from TISSUES for SHC3 Gene
- Nervous system(4.9)
Primer products for research
-
OriGene qPCR primer pairs for SHC3
-
OriGene qPCR primer pairs and template standards for SHC3
Gene Expression Assays for research
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SHC3 Gene
Orthologs for SHC3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SHC3 29 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Shc3 29 |
|
||
| Dog (Canis familiaris) |
Mammalia | SHC3 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Shc3 29 16 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SHC3 29 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | SHC3 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | SHC3 29 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | shc3 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | SHC3 30 |
|
OneToOne | |
| LOC100332111 29 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Shc 30 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | shc-1 30 |
|
OneToMany |
- Species where no ortholog for SHC3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for SHC3 Gene
- ENSEMBL:
- Gene Tree for SHC3 (if available)
- TreeFam:
- Gene Tree for SHC3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SHC3: view image
- Alliance of Genome Resources:
- Additional Orthologs for SHC3
Paralogs for SHC3 Gene
Variants for SHC3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SHC3 Gene
| SNP ID | Clinical significance and condition | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs149700558 | Likely Benign: not provided | 89,038,160(-) |
C/T NM_016848.6(SHC3):c.1489G>A (p.Glu497Lys) |
MISSENSE | |
| rs1587773727 | Likely Benign: not provided | 89,178,224(-) |
C/G NM_016848.6(SHC3):c.237G>C (p.Ser79=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4472e59 | CNV | duplication | 20981092 |
| dgv4473e59 | CNV | duplication | 20981092 |
| esv2554035 | CNV | insertion | 19546169 |
| esv26782 | CNV | loss | 19812545 |
| esv2738726 | CNV | deletion | 23290073 |
| esv29340 | CNV | gain+loss | 19812545 |
| esv3310572 | CNV | novel sequence insertion | 20981092 |
| esv3446910 | CNV | insertion | 20981092 |
| esv3573288 | CNV | loss | 25503493 |
| esv3621014 | CNV | gain | 21293372 |
| nsv1077559 | CNV | duplication | 25765185 |
| nsv1132740 | CNV | duplication | 24896259 |
| nsv1147400 | CNV | duplication | 26484159 |
| nsv614825 | CNV | gain | 21841781 |
| nsv614826 | CNV | loss | 21841781 |
| nsv6608 | CNV | deletion | 18451855 |
| nsv819886 | CNV | loss | 19587683 |
| nsv831651 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
13.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.28;
40.86% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SHC3 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHC3 Gene
Disorders for SHC3 Gene
Additional Disease Information for SHC3
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No disorders were found for SHC3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SHC3 Gene
Publications for SHC3 Gene
- N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway. (PMID: 8808684) Nakamura T … Mori N (Oncogene 1996) 2 3 4 22
- A family of Shc related proteins with conserved PTB, CH1 and SH2 regions. (PMID: 8760305) Pelicci G … Pelicci PG (Oncogene 1996) 3 4 22
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
- Brain-derived neurotrophic factor modulation of Kv1.3 channel is disregulated by adaptor proteins Grb10 and nShc. (PMID: 19166614) Colley BS … Fadool DA (BMC neuroscience 2009) 3 22
- Linkage and association studies in African- and Caucasian-American populations demonstrate that SHC3 is a novel susceptibility locus for nicotine dependence. (PMID: 17179996) Li MD … Ma JZ (Molecular psychiatry 2007) 3 40
ExternalLinks
Products for SHC3 Gene
- Custom Antibody ServicesOriGene Antibodies for SHC3
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for SHC3
- Origene Custom Protein Services for SHC3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SHC3
- Browse OriGene Inhibitory RNA Products For SHC3
- OriGene qPCR primer pairs for SHC3
- OriGene qPCR primer pairs and template standards for SHC3
- OriGene CRISPR knockouts for SHC3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SHC3
- Sino Biological Human cDNA Clone for SHC3
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for SHC3
- Novus Biologicals proteins and lysates for SHC3
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for SHC3
- Abcam proteins for SHC3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for SHC3 (AFLGC-SHC3)
- VectorBuilder Custom and pre-made DNA vectors for SHC3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for SHC3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for SHC3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for SHC3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for SHC3
- Addgene plasmids for SHC3
- antibodies-online: Show 8 available SHC3 Antibodies ranked by validation data
- Compare Top SHC3 Antibodies
- Recommended
- 32 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 15 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- 21 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- antibodies-online: Search results for available SHC3 related products ranked by validation data
- antibodies-online: Show 6 available SHC3 Proteins ranked by validation data
- Compare Top SHC3 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for SHC3
- Search Santa Cruz Biotechnology (SCBT) for SHC3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SHC3
- Horizon Cell Lines for SHC3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SHC3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SHC3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SHC3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SHC3
- Boster Bio Antibodies for SHC3
- Browse Boster Bio ELISA Kits
Sources for SHC3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
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- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
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- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
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- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
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- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources