Aliases for SHC3 Gene

Aliases for SHC3 Gene

  • SHC Adaptor Protein 3 2 3 5
  • N-Shc 2 3 4
  • NSHC 2 3 4
  • SHCC 2 3 4
  • SHC (Src Homology 2 Domain Containing) Transforming Protein 3 2 3
  • SHC-Transforming Protein 3 3 4
  • SHC-Transforming Protein C 3 4
  • SH2 Domain Protein C3 3 4
  • Neuronal Shc 3 4
  • Protein Rai 3 4
  • Src Homology 2 Domain Containing Transforming Protein C3 2
  • Src Homology 2 Domain-Containing Transforming Protein C3 3
  • Src Homology 2 Domain-Containing-Transforming Protein C3 4
  • Shc3 P51 3
  • SHC3 5
  • RAI 3

External Ids for SHC3 Gene

Previous GeneCards Identifiers for SHC3 Gene

  • GC09M082643
  • GC09M083496
  • GC09M085215
  • GC09M087117
  • GC09M088857
  • GC09M090817
  • GC09M091628
  • GC09M061453

Summaries for SHC3 Gene

GeneCards Summary for SHC3 Gene

SHC3 (SHC Adaptor Protein 3) is a Protein Coding gene. Diseases associated with SHC3 include Sclerosing Hepatic Carcinoma and Sarcomatous Intrahepatic Cholangiocarcinoma. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include protein kinase binding and receptor tyrosine kinase binding. An important paralog of this gene is SHC1.

UniProtKB/Swiss-Prot Summary for SHC3 Gene

  • Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.

Gene Wiki entry for SHC3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SHC3 Gene

Genomics for SHC3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SHC3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J089175 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 626.6 +4.0 4029 5.9 CEBPG ATF7 PRDM10 ZNF629 ZNF7 JUND FOXA1 RBFOX2 POLR2A PATZ1 SHC3 C9orf47 piR-31292-213 S1PR3
GH09J089309 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.1 -129.9 -129905 6.4 SP1 HNRNPL CREB1 ATF7 PRDM10 ZNF629 TFE3 IKZF1 RFX5 POLR2A CKS2 LOC105376136 MIR3153 NONHSAG052777.2 lnc-SEMA4D-4 SHC3 SECISBP2 SEMA4D lnc-SEMA4D-9 MN298114-298
GH09J089136 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 27.2 +44.1 44137 4.5 JUND CEBPB ESR1 FOS ZNF592 MAX EP300 STAT1 ZNF687 POLR2A SHC3 ENSG00000224945 CKS2 piR-47402-043 lnc-CKS2-3 C9orf47 S1PR3
GH09J089152 Enhancer 0.8 ENCODE dbSUPER 22.9 +27.9 27870 3.2 PKNOX1 HDAC1 ETV6 JUND CEBPB BRCA1 JUN FOS FOSL1 EP300 SHC3 ENSG00000224945 CKS2 lnc-CKS2-3 piR-47402-043 C9orf47 S1PR3
GH09J089149 Enhancer 0.4 Ensembl 25.7 +32.5 32501 0.6 CEBPB FOS JUND SPI1 SHC3 lnc-CKS2-3 piR-47402-043 C9orf47 S1PR3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SHC3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SHC3

Top Transcription factor binding sites by QIAGEN in the SHC3 gene promoter:
  • C/EBPalpha
  • C/EBPbeta
  • HSF1 (long)
  • HSF1short
  • Lmo2
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for SHC3 Gene

Genomic Locations for SHC3 Gene
176,632 bases
Minus strand
172,997 bases
Minus strand

Genomic View for SHC3 Gene

Genes around SHC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHC3 Gene

Proteins for SHC3 Gene

  • Protein details for SHC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SHC-transforming protein 3
    Protein Accession:
    Secondary Accessions:
    • Q5T7I7
    • Q8TAP2
    • Q9UCX5

    Protein attributes for SHC3 Gene

    594 amino acids
    Molecular mass:
    64056 Da
    Quaternary structure:
    • Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors.

    Alternative splice isoforms for SHC3 Gene


neXtProt entry for SHC3 Gene

Post-translational modifications for SHC3 Gene

Other Protein References for SHC3 Gene

No data available for DME Specific Peptides for SHC3 Gene

Domains & Families for SHC3 Gene

Gene Families for SHC3 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SHC3 Gene

  • SHC phosphotyrosine interaction domain signature
  • Phosphotyrosine interaction domain

Suggested Antigen Peptide Sequences for SHC3 Gene

GenScript: Design optimal peptide antigens:
  • Src homology 2 domain-containing-transforming protein C3 (SHC3_HUMAN)
genes like me logo Genes that share domains with SHC3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SHC3 Gene

Function for SHC3 Gene

Molecular function for SHC3 Gene

UniProtKB/Swiss-Prot Function:
Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.

Phenotypes From GWAS Catalog for SHC3 Gene

Gene Ontology (GO) - Molecular Function for SHC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001784 phosphotyrosine residue binding IPI 20624904
GO:0005515 protein binding IPI 11877420
GO:0019901 protein kinase binding IBA --
GO:0030971 receptor tyrosine kinase binding IBA 21873635
genes like me logo Genes that share ontologies with SHC3: view
genes like me logo Genes that share phenotypes with SHC3: view

Animal Models for SHC3 Gene

MGI Knock Outs for SHC3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SHC3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SHC3 Gene

Localization for SHC3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SHC3 gene
Compartment Confidence
cytosol 5
plasma membrane 4
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SHC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IBA 21873635
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with SHC3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SHC3 Gene

Pathways & Interactions for SHC3 Gene

PathCards logo

SuperPathways for SHC3 Gene

SuperPathway Contained pathways
1 RET signaling
2 Gastric cancer
3 ErbB signaling pathway
4 Relaxin signaling pathway
5 Focal Adhesion
genes like me logo Genes that share pathways with SHC3: view

SIGNOR curated interactions for SHC3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SHC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0007165 signal transduction IEA --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS,IBA 21873635
GO:0007173 epidermal growth factor receptor signaling pathway TAS 8808684
GO:0007265 Ras protein signal transduction TAS --
genes like me logo Genes that share ontologies with SHC3: view

Drugs & Compounds for SHC3 Gene

(1) Drugs for SHC3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for SHC3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SHC3: view

Transcripts for SHC3 Gene

mRNA/cDNA for SHC3 Gene

7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SHC3

Alternative Splicing Database (ASD) splice patterns (SP) for SHC3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16a · 16b
SP1: - - - - -
SP2: - -

Relevant External Links for SHC3 Gene

GeneLoc Exon Structure for

Expression for SHC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SHC3 Gene

mRNA differential expression in normal tissues according to GTEx for SHC3 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x6.2), Brain - Frontal Cortex (BA9) (x5.8), and Brain - Cortex (x4.8).

Protein differential expression in normal tissues from HIPED for SHC3 Gene

This gene is overexpressed in Frontal cortex (45.1) and Ovary (23.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SHC3 Gene

Protein tissue co-expression partners for SHC3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SHC3

SOURCE GeneReport for Unigene cluster for SHC3 Gene:


mRNA Expression by UniProt/SwissProt for SHC3 Gene:

Tissue specificity: Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord.

Evidence on tissue expression from TISSUES for SHC3 Gene

  • Nervous system(4.9)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with SHC3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SHC3 Gene

Orthologs for SHC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SHC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SHC3 30 31
  • 99.38 (n)
(Rattus norvegicus)
Mammalia Shc3 30
  • 88.14 (n)
(Canis familiaris)
Mammalia SHC3 30 31
  • 87.61 (n)
(Mus musculus)
Mammalia Shc3 30 17 31
  • 87.24 (n)
(Bos Taurus)
Mammalia SHC3 30 31
  • 86.09 (n)
(Monodelphis domestica)
Mammalia SHC3 31
  • 64 (a)
(Gallus gallus)
Aves SHC3 30 31
  • 69.83 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia shc3 30
  • 66.04 (n)
(Danio rerio)
Actinopterygii SHC3 31
  • 66 (a)
LOC100332111 30
  • 64.83 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Shc 31 32
  • 38 (a)
(Caenorhabditis elegans)
Secernentea shc-1 31
  • 29 (a)
Species where no ortholog for SHC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SHC3 Gene

Gene Tree for SHC3 (if available)
Gene Tree for SHC3 (if available)
Evolutionary constrained regions (ECRs) for SHC3: view image

Paralogs for SHC3 Gene

Paralogs for SHC3 Gene

(9) SIMAP similar genes for SHC3 Gene using alignment to 2 proteins:

  • Q5T7I8_HUMAN
genes like me logo Genes that share paralogs with SHC3: view

Variants for SHC3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SHC3 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
710663 Likely Benign: not provided 89,038,160(-) C/T MISSENSE_VARIANT
754759 Likely Benign: not provided 89,178,224(-) C/G SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for SHC3 Gene

Structural Variations from Database of Genomic Variants (DGV) for SHC3 Gene

Variant ID Type Subtype PubMed ID
dgv4472e59 CNV duplication 20981092
dgv4473e59 CNV duplication 20981092
esv2554035 CNV insertion 19546169
esv26782 CNV loss 19812545
esv2738726 CNV deletion 23290073
esv29340 CNV gain+loss 19812545
esv3310572 CNV novel sequence insertion 20981092
esv3446910 CNV insertion 20981092
esv3573288 CNV loss 25503493
esv3621014 CNV gain 21293372
nsv1077559 CNV duplication 25765185
nsv1132740 CNV duplication 24896259
nsv1147400 CNV duplication 26484159
nsv614825 CNV gain 21841781
nsv614826 CNV loss 21841781
nsv6608 CNV deletion 18451855
nsv819886 CNV loss 19587683
nsv831651 CNV gain 17160897

Variation tolerance for SHC3 Gene

Residual Variation Intolerance Score: 13.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.28; 40.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SHC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHC3 Gene

Disorders for SHC3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SHC3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
sclerosing hepatic carcinoma
  • sclerosing hepatocellular carcinoma
sarcomatous intrahepatic cholangiocarcinoma
  • sarcomatoid intrahepatic cholangiocarcinoma
giant hemangioma
- elite association - COSMIC cancer census association via MalaCards
Search SHC3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SHC3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SHC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SHC3 Gene

Publications for SHC3 Gene

  1. N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway. (PMID: 8808684) Nakamura T … Mori N (Oncogene 1996) 2 3 4 23
  2. A family of Shc related proteins with conserved PTB, CH1 and SH2 regions. (PMID: 8760305) Pelicci G … Pelicci PG (Oncogene 1996) 3 4 23
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  4. Brain-derived neurotrophic factor modulation of Kv1.3 channel is disregulated by adaptor proteins Grb10 and nShc. (PMID: 19166614) Colley BS … Fadool DA (BMC neuroscience 2009) 3 23
  5. Linkage and association studies in African- and Caucasian-American populations demonstrate that SHC3 is a novel susceptibility locus for nicotine dependence. (PMID: 17179996) Li MD … Ma JZ (Molecular psychiatry 2007) 3 41

Products for SHC3 Gene

  • Signalway Proteins for SHC3

Sources for SHC3 Gene