SHC2 Gene (Protein Coding)

SHC Adaptor Protein 2

GC19M000715
GIFtS:
40
See more...

Aliases for SHC2 Gene

Aliases for SHC2 Gene

  • SHC Adaptor Protein 2 2 3 5
  • SHCB 2 3 4
  • SCK 2 3 4
  • SHC (Src Homology 2 Domain Containing) Transforming Protein 2 2 3
  • Src Homology 2 Domain-Containing-Transforming Protein C2 3 4
  • Neuronal Shc Adaptor Homolog 2 3
  • SHC-Transforming Protein 2 3 4
  • SHC-Transforming Protein B 3 4
  • SH2 Domain Protein C2 3 4
  • Protein Sck 3 4
  • SLI 2 3
  • SHC2 5

External Ids for SHC2 Gene

Previous GeneCards Identifiers for SHC2 Gene

  • GC19U900043
  • GC19M000369
  • GC19M000186
  • GC19M000420
  • GC19M000428
  • GC19M000502

Summaries for SHC2 Gene

GeneCards Summary for SHC2 Gene

SHC2 (SHC Adaptor Protein 2) is a Protein Coding gene. Diseases associated with SHC2 include Vaginal Discharge and Brachydactyly, Type E1. Among its related pathways are RET signaling and Gastric cancer. Gene Ontology (GO) annotations related to this gene include protein kinase binding and receptor tyrosine kinase binding.

UniProtKB/Swiss-Prot Summary for SHC2 Gene

  • Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity).

Gene Wiki entry for SHC2 Gene

Additional gene information for SHC2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SHC2 Gene

Genomics for SHC2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for SHC2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SHC2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SHC2

Top Transcription factor binding sites by QIAGEN in the SHC2 gene promoter:
  • ATF6
  • COMP1
  • E2F
  • E2F-1
  • p53
  • Pax-4a
  • PPAR-gamma1
  • PPAR-gamma2
  • SRF (504 AA)
  • STAT5A

Genomic Locations for SHC2 Gene

Latest Assembly
chr19:416,583-461,033
(GRCh38/hg38)
Size:
44,451 bases
Orientation:
Minus strand

Previous Assembly
chr19:416,589-461,033
(GRCh37/hg19 by Entrez Gene)
Size:
44,445 bases
Orientation:
Minus strand

chr19:416,583-460,996
(GRCh37/hg19 by Ensembl)
Size:
44,414 bases
Orientation:
Minus strand

Genomic View for SHC2 Gene

Genes around SHC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHC2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SHC2 Gene

Proteins for SHC2 Gene

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  2. Protein products for research
  3. Assay products for research

  • Protein details for SHC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P98077-SHC2_HUMAN
    Recommended name:
    SHC-transforming protein 2
    Protein Accession:
    P98077
    Secondary Accessions:
    • O60230
    • Q9NPL5
    • Q9UCX4

    Protein attributes for SHC2 Gene

    Size:
    582 amino acids
    Molecular mass:
    61916 Da
    Quaternary structure:
    • Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2.
    Miscellaneous:
    • PubMed:15057824 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to PubMed:12006576.

neXtProt entry for SHC2 Gene

Protein Expression for SHC2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SHC2 Gene

Other Protein References for SHC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SHC2 Gene

Domains & Families for SHC2 Gene

Gene Families for SHC2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SHC2 Gene

InterPro:
Blocks:
  • SHC phosphotyrosine interaction domain signature
  • Phosphotyrosine interaction domain

Suggested Antigen Peptide Sequences for SHC2 Gene

GenScript: Design optimal peptide antigens:
  • Src homology 2 domain-containing-transforming protein C2 (SHC2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P98077

UniProtKB/Swiss-Prot:

SHC2_HUMAN :
  • The PID domain mediates binding to the TrkA receptor.
Domain:
  • The PID domain mediates binding to the TrkA receptor.
genes like me logo Genes that share domains with SHC2: view

Function for SHC2 Gene

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  1. Animal Models for research
  2. CRISPR products for research
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  6. Cell Lines for research

Molecular function for SHC2 Gene

UniProtKB/Swiss-Prot Function:
Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity).

Phenotypes From GWAS Catalog for SHC2 Gene

Gene Ontology (GO) - Molecular Function for SHC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16273093
GO:0019901 protein kinase binding IBA 21873635
GO:0030971 receptor tyrosine kinase binding IEA,IBA 21873635
genes like me logo Genes that share ontologies with SHC2: view
genes like me logo Genes that share phenotypes with SHC2: view

Animal Models for SHC2 Gene

MGI Knock Outs for SHC2:

Animal Models for research

miRNA for SHC2 Gene

miRTarBase miRNAs that target SHC2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SHC2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SHC2 Gene

Localization for SHC2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SHC2 gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 3
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SHC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IBA 21873635
genes like me logo Genes that share ontologies with SHC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SHC2 Gene

Pathways & Interactions for SHC2 Gene

PathCards logo

SuperPathways for SHC2 Gene

SuperPathway Contained pathways
1 RET signaling
Frs2-mediated activation
.95
GRB2 events in EGFR signaling
.95
MAPK1/MAPK3 signaling
.95
Prolonged ERK activation events
.95
RAF/MAP kinase cascade
.95
SHC1 events in EGFR signaling
.95
Signaling by Leptin
.95
SOS-mediated signalling
.95
VEGFR2 mediated cell proliferation
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
Interleukin receptor SHC signaling
.95
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Insulin receptor signalling cascade
.92
Signaling by Insulin receptor
.92
IRS-mediated signalling
.91
Signaling by EGFR
.90
FCERI mediated MAPK activation
.90
IGF1R signaling cascade
.90
IRS-related events triggered by IGF1R
.90
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
.90
DAP12 interactions
.89
NCAM signaling for neurite out-growth
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
Gastrin-CREB signalling pathway via PKC and MAPK
.55
2 ErbB signaling pathway
ErbB signaling pathway
.49
ErbB Signaling Pathway
.49
EGFR Inhibitor Pathway, Pharmacodynamics
.49
EGFR tyrosine kinase inhibitor resistance
.39
3 Gastric cancer
Breast cancer
.62
Gastric cancer
.62
Hepatocellular carcinoma
.50
4 Relaxin signaling pathway
Growth hormone synthesis, secretion and action
.35
Relaxin signaling pathway
.35
Estrogen signaling pathway
.30
5 Glioma
Glioma
.47
Endocrine resistance
.31
genes like me logo Genes that share pathways with SHC2: view

Pathways by source for SHC2 Gene

1 Sino Biological pathway for SHC2 Gene
1 PharmGKB pathway for SHC2 Gene
1 GeneGo (Thomson Reuters) pathway for SHC2 Gene
  • Development VEGF signaling via VEGFR2 - generic cascades
1 Qiagen pathway for SHC2 Gene
  • VEGF Pathway

SIGNOR curated interactions for SHC2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SHC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000187 activation of MAPK activity IEA --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA 21873635
GO:0007265 Ras protein signal transduction TAS --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with SHC2: view

Drugs & Compounds for SHC2 Gene

Products:

  1. Drug products for research

(1) Drugs for SHC2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for SHC2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SHC2: view

Transcripts for SHC2 Gene

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  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
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mRNA/cDNA for SHC2 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SHC2

Alternative Splicing Database (ASD) splice patterns (SP) for SHC2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b
SP1: - - - -
SP2: - -
SP3: -
SP4: - - -
SP5: - -
SP6: -
SP7: -
SP8:

Relevant External Links for SHC2 Gene

GeneLoc Exon Structure for
SHC2

Expression for SHC2 Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SHC2 Gene

mRNA expression in normal human tissues for SHC2 Gene
mRNA expression by BioGPS for SHC2 GenemRNA expression by GTEx for SHC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SHC2 Gene

This gene is overexpressed in Pancreas (x5.9).

Protein differential expression in normal tissues from HIPED for SHC2 Gene

This gene is overexpressed in Monocytes (54.8) and Fetal ovary (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SHC2 Gene



Protein tissue co-expression partners for SHC2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SHC2

SOURCE GeneReport for Unigene cluster for SHC2 Gene:

Hs.30965

mRNA Expression by UniProt/SwissProt for SHC2 Gene:

P98077-SHC2_HUMAN
Tissue specificity: Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.

Evidence on tissue expression from TISSUES for SHC2 Gene

  • Nervous system(4.6)
  • Blood(4.4)
  • Skin(2.2)
  • Stomach(2.1)
  • Muscle(2)
  • Liver(2)
genes like me logo Genes that share expression patterns with SHC2: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SHC2 Gene

Orthologs for SHC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SHC2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia SHC2 30
  • 96 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia LOC611955 29
  • 87.74 (n)
Cow
(Bos Taurus)
 Mammalia LOC533455 29
  • 87.11 (n)
SHC2 30
  • 82 (a)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Shc2 29
  • 83.39 (n)
Mouse
(Mus musculus)
 Mammalia Shc2 29 16 30
  • 82.92 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia SHC2 30
  • 73 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves SHC2 29 30
  • 73.39 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia SHC2 30
  • 65 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia shc2 29
  • 64.57 (n)
Zebrafish
(Danio rerio)
 Actinopterygii shc2 29 30
  • 69.12 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta Shc 30
  • 38 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea shc-1 30
  • 28 (a)
 OneToMany
Species where no ortholog for SHC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SHC2 Gene

ENSEMBL:
Gene Tree for SHC2 (if available)
TreeFam:
Gene Tree for SHC2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SHC2: view image
Alliance of Genome Resources:
Additional Orthologs for SHC2

Paralogs for SHC2 Gene

(3) SIMAP similar genes for SHC2 Gene using alignment to 5 proteins:

  • SHC2_HUMAN
  • K7EKS8_HUMAN
  • K7ENB2_HUMAN
  • U3KPV1_HUMAN
  • U3KQU0_HUMAN
genes like me logo Genes that share paralogs with SHC2: view

No data available for Paralogs for SHC2 Gene

Variants for SHC2 Gene

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dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SHC2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SHC2 Gene

Variant ID Type Subtype PubMed ID
dgv1013e212 CNV gain 25503493
dgv1670n106 CNV deletion 24896259
dgv1671n106 CNV deletion 24896259
dgv1966e59 CNV duplication 20981092
dgv213e215 CNV deletion 23714750
dgv6153n54 CNV loss 21841781
dgv6155n54 CNV loss 21841781
dgv6159n54 CNV loss 21841781
esv1499855 CNV insertion 17803354
esv1557758 CNV deletion 17803354
esv1627441 CNV deletion 17803354
esv1994729 CNV deletion 18987734
esv2223344 CNV deletion 18987734
esv2276998 CNV deletion 18987734
esv23197 CNV gain 19812545
esv2323487 CNV deletion 18987734
esv2497793 CNV deletion 19546169
esv25497 CNV gain+loss 19812545
esv26032 CNV loss 19812545
esv2659245 CNV deletion 23128226
esv2659523 CNV deletion 23128226
esv2661854 CNV deletion 23128226
esv2663200 CNV deletion 23128226
esv2669304 CNV deletion 23128226
esv2671474 CNV deletion 23128226
esv2672865 CNV deletion 23128226
esv2676066 CNV deletion 23128226
esv28823 CNV loss 19812545
esv3494 CNV loss 18987735
esv3555816 CNV deletion 23714750
esv3643351 CNV loss 21293372
esv4763 CNV loss 18987735
esv5410 CNV loss 18987735
nsv1065558 CNV gain 25217958
nsv1071880 CNV deletion 25765185
nsv1072289 CNV deletion 25765185
nsv1072830 CNV deletion 25765185
nsv1123205 CNV deletion 24896259
nsv1125665 CNV tandem duplication 24896259
nsv1130724 CNV deletion 24896259
nsv1134738 CNV deletion 24896259
nsv1142924 CNV tandem duplication 24896259
nsv1145825 CNV duplication 26484159
nsv138298 CNV deletion 16902084
nsv2384 CNV insertion 18451855
nsv428360 CNV gain 18775914
nsv433453 CNV gain 18776910
nsv470101 CNV loss 18288195
nsv509712 CNV insertion 20534489
nsv514895 CNV gain 21397061
nsv577978 CNV gain 21841781
nsv578091 CNV gain 21841781
nsv578092 CNV loss 21841781
nsv578093 CNV gain 21841781
nsv578094 CNV gain+loss 21841781
nsv578097 CNV loss 21841781
nsv817810 CNV loss 17921354
nsv820768 CNV deletion 20802225
nsv828348 CNV loss 20364138
nsv953938 CNV deletion 24416366

Variation tolerance for SHC2 Gene

Residual Variation Intolerance Score: 90.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.06; 60.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SHC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SHC2
Leiden Open Variation Database (LOVD)
SHC2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SHC2 Gene

Disorders for SHC2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SHC2 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards
Search SHC2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SHC2

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SHC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SHC2 Gene

Publications for SHC2 Gene

  1. N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling. (PMID: 9507002) Nakamura T … Mori N (The Journal of biological chemistry 1998) 2 3 4
  2. A family of Shc related proteins with conserved PTB, CH1 and SH2 regions. (PMID: 8760305) Pelicci G … Pelicci PG (Oncogene 1996) 3 4 22
  3. An alternative to SH2 domains for binding tyrosine-phosphorylated proteins. (PMID: 7527937) Kavanaugh WM … Williams LT (Science (New York, N.Y.) 1994) 2 3 4
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
  5. ShcB and ShcC activation by the Trk family of receptor tyrosine kinases. (PMID: 12006576) Liu HY … Meakin SO (The Journal of biological chemistry 2002) 3 4

ExternalLinks

View latest publications for SHC2 gene in Mastermind

Products for SHC2 Gene

  • Addgene plasmids for SHC2

Sources for SHC2 Gene