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SHC2 (SHC Adaptor Protein 2) is a Protein Coding gene. Diseases associated with SHC2 include Vaginal Discharge and Brachydactyly, Type E1. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include protein kinase binding and receptor tyrosine kinase binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 16273093 |
GO:0019901 | protein kinase binding | IBA | -- |
GO:0030971 | receptor tyrosine kinase binding | IEA,IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005575 | cellular_component | ND | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0005886 | plasma membrane | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
.92
|
2 | ErbB signaling pathway | ||
3 | Gastric cancer |
.62
.62
|
|
4 | Relaxin signaling pathway | ||
5 | Glioma |
.49
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | TAS | -- |
GO:0000187 | activation of MAPK activity | IEA | -- |
GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | IBA | 21873635 |
GO:0007265 | Ras protein signal transduction | TAS | -- |
GO:0035556 | intracellular signal transduction | IEA | -- |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15a | · | 15b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP8: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SHC2 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | LOC611955 30 |
|
||
Cow (Bos Taurus) |
Mammalia | LOC533455 30 |
|
||
SHC2 31 |
|
OneToOne | |||
Rat (Rattus norvegicus) |
Mammalia | Shc2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Shc2 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SHC2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SHC2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SHC2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | shc2 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | shc2 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Shc 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | shc-1 31 |
|
OneToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
vaginal discharge |
|
|
brachydactyly, type e1 |
|
|
isolated elevated serum creatine phosphokinase levels |
|
|