This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers. Polymorphisms in this gene have b... See more...

Aliases for SHBG Gene

Aliases for SHBG Gene

  • Sex Hormone Binding Globulin 2 3 5
  • Sex Hormone-Binding Globulin 2 3 4
  • ABP 2 3 4
  • Testis-Specific Androgen-Binding Protein 3 4
  • Testosterone-Estradiol-Binding Globulin 3 4
  • Testosterone-Estrogen-Binding Globulin 3 4
  • Sex Steroid-Binding Protein 3 4
  • TEBG 2 3
  • SBP 3 4
  • Testosterone-Binding Beta-Globulin 3
  • Androgen Binding Protein 2
  • MGC126834 2
  • MGC138391 2
  • SHBG 5
  • TeBG 4

External Ids for SHBG Gene

Previous GeneCards Identifiers for SHBG Gene

  • GC17P007947
  • GC17P008273
  • GC17P007474
  • GC17P007734
  • GC17P007731
  • GC17P007472
  • GC17P007535
  • GC17P007413
  • GC17P007519
  • GC17P007523

Summaries for SHBG Gene

Entrez Gene Summary for SHBG Gene

  • This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers. Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for SHBG Gene

SHBG (Sex Hormone Binding Globulin) is a Protein Coding gene. Diseases associated with SHBG include Ovarian Disease and Anovulation. Among its related pathways are Nongenotropic Androgen signaling and CCR5 Pathway in Macrophages. Gene Ontology (GO) annotations related to this gene include androgen binding. An important paralog of this gene is PROS1.

UniProtKB/Swiss-Prot Summary for SHBG Gene

  • Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.

Gene Wiki entry for SHBG Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SHBG Gene

Genomics for SHBG Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SHBG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J007625 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 250.4 +14.3 14277 5.8 SP1 POLR2A ZIC2 YY1 KLF11 HES1 BHLHE40 ZNF341 HOMEZ SIN3A SAT2 lnc-SAT2-2 SHBG CHRNB1 DVL2 TP53 WRAP53 CYB5D1 EFNB3 SENP3
GH17J007612 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 +0.1 59 4 SP1 ZNF207 MYC IKZF1 ZNF600 ATF3 ZIC2 ZBTB10 YY1 CTCF FXR2 SHBG SNORD10 SNORA48 WRAP53 PFAS DVL2 POLR2A CTC1 TP53
GH17J007632 Enhancer 0.9 Ensembl ENCODE 0.4 +18.9 18854 0.8 ZNF654 ZNF600 YY1 REST TRIM22 CTCF RXRA RAD21 SMC3 SMARCA5 HSALNG0114332 SAT2 piR-57133-245 ATP1B2 SHBG
GH17J007368 Enhancer 0.2 FANTOM5 1.3 -245.9 -245860 0.1 piR-39663-001 SLC35G6 WRAP53 SHBG TMEM95 TNK1 piR-35674-206 L13712-011
GH17J007634 Enhancer 0.6 ENCODE 0.4 +18.3 18290 0.3 TRIM22 RXRA CTCF STAT5A ZNF362 HNF4A SP1 ZNF384 HNF1A MBD1 HSALNG0114332 SAT2 piR-57133-245 ATP1B2 SHBG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SHBG on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SHBG

Top Transcription factor binding sites by QIAGEN in the SHBG gene promoter:
  • COUP
  • COUP-TF
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for SHBG Gene

Latest Assembly
chr17:7,613,946-7,633,382
(GRCh38/hg38)
Size:
19,437 bases
Orientation:
Plus strand

Previous Assembly
chr17:7,517,382-7,536,690
(GRCh37/hg19 by Entrez Gene)
Size:
19,309 bases
Orientation:
Plus strand

chr17:7,517,382-7,536,700
(GRCh37/hg19 by Ensembl)
Size:
19,319 bases
Orientation:
Plus strand

Genomic View for SHBG Gene

Genes around SHBG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHBG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHBG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHBG Gene

Proteins for SHBG Gene

  • Protein details for SHBG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04278-SHBG_HUMAN
    Recommended name:
    Sex hormone-binding globulin
    Protein Accession:
    P04278
    Secondary Accessions:
    • B0FWH4
    • E9PGW1
    • F5H5Z8
    • I3L1N7
    • P14689
    • Q16616
    • Q3MIL0
    • Q6ISD2

    Protein attributes for SHBG Gene

    Size:
    402 amino acids
    Molecular mass:
    43779 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=CAA29309.1; Type=Frameshift; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 2]: Incomplete sequence.

    Three dimensional structures from OCA and Proteopedia for SHBG Gene

    Alternative splice isoforms for SHBG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SHBG Gene

Post-translational modifications for SHBG Gene

  • Variant Asn-356 contains one N-linked (GlcNAc...) at position 356.
  • Glycosylation at Thr36, Asn380, and Asn396
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • SHBG_HUMAN (562)

No data available for DME Specific Peptides for SHBG Gene

Domains & Families for SHBG Gene

Gene Families for SHBG Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for SHBG Gene

InterPro:
Blocks:
  • Laminin G
  • Laminin G, subdomain 1

Suggested Antigen Peptide Sequences for SHBG Gene

GenScript: Design optimal peptide antigens:
  • Sex hormone binding globulin (B0FWH2_HUMAN)
  • Sex hormone binding globulin (B0FWH4_HUMAN)
  • Sex hormone binding globulin (B0FWH5_HUMAN)
  • Sex hormone binding globulin (B0FWH6_HUMAN)
  • Sex hormone binding globulin (B0FWH7_HUMAN)
genes like me logo Genes that share domains with SHBG: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SHBG Gene

Function for SHBG Gene

Molecular function for SHBG Gene

UniProtKB/Swiss-Prot Function:
Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.
GENATLAS Biochemistry:
sex hormone-binding globulin gene

Phenotypes From GWAS Catalog for SHBG Gene

Gene Ontology (GO) - Molecular Function for SHBG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005496 steroid binding IBA 21873635
GO:0005497 androgen binding TAS 2587256
GO:0005515 protein binding IPI 16143106
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with SHBG: view
genes like me logo Genes that share phenotypes with SHBG: view

miRNA for SHBG Gene

miRTarBase miRNAs that target SHBG

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SHBG

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SHBG Gene

Localization for SHBG Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHBG Gene

Secreted. Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SHBG gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 3
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SHBG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 14718574
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with SHBG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SHBG Gene

Pathways & Interactions for SHBG Gene

PathCards logo

SuperPathways for SHBG Gene

SuperPathway Contained pathways
1 CCR5 Pathway in Macrophages
.52
2 Nongenotropic Androgen signaling
genes like me logo Genes that share pathways with SHBG: view

Pathways by source for SHBG Gene

1 BioSystems pathway for SHBG Gene
1 Qiagen pathway for SHBG Gene
  • Androgen Signaling

Gene Ontology (GO) - Biological Process for SHBG Gene

None

No data available for SIGNOR curated interactions for SHBG Gene

Drugs & Compounds for SHBG Gene

(145) Drugs for SHBG Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Danazol Approved Pharma Carrier, antagonist 32
Estradiol Approved, Investigational, Vet_approved Pharma Carrier, binder Sex hormone 1160
Estrone Approved Pharma Target Estrogenic hormone 24
Testosterone Approved, Investigational Pharma Carrier, binder Endogenous androgen receptor agonist 711
Desogestrel Approved Pharma Carrier, binder 62

(29) Additional Compounds for SHBG Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Methoxyestrone
  • 2-(8S,9S,13S,14S)-3-Hydroxy-2-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one
  • 2-Hydroxyestrone 2-methyl ether
  • 2-Methoxy-17-oxoestra-1,3,5(10)-trien-3-ol
  • 2-Methoxy-3-hydroxyestra-1,3,5(10)-trien-17-one
  • 3-Hydroxy-2-methoxy-estra-1,3,5(10)-trien-17-one
362-08-3
genes like me logo Genes that share compounds with SHBG: view

Transcripts for SHBG Gene

mRNA/cDNA for SHBG Gene

8 REFSEQ mRNAs :
32 NCBI additional mRNA sequence :
21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SHBG

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for SHBG Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1:
SP2: - -
SP3: -
SP4: - - -
SP5: -
SP6:

Relevant External Links for SHBG Gene

GeneLoc Exon Structure for
SHBG

Expression for SHBG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SHBG Gene

mRNA differential expression in normal tissues according to GTEx for SHBG Gene

This gene is overexpressed in Liver (x26.3) and Testis (x6.1).

Protein differential expression in normal tissues from HIPED for SHBG Gene

This gene is overexpressed in Serum (33.4), Plasma (12.0), Skin (8.7), and Synovial fluid (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SHBG Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SHBG

SOURCE GeneReport for Unigene cluster for SHBG Gene:

Hs.632235

mRNA Expression by UniProt/SwissProt for SHBG Gene:

P04278-SHBG_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are present in liver and testis.

Evidence on tissue expression from TISSUES for SHBG Gene

  • Liver(4.6)
  • Bone marrow(4.2)
  • Blood(3.2)
  • Adrenal gland(2.6)
  • Thyroid gland(2.5)
  • Nervous system(2.4)
  • Heart(2.3)
  • Skin(2.2)
  • Urine(2.2)
  • Muscle(2.2)
  • Kidney(2.1)
  • Intestine(2)
genes like me logo Genes that share expression patterns with SHBG: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SHBG Gene

Orthologs for SHBG Gene

This gene was present in the common ancestor of chordates.

Orthologs for SHBG Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SHBG 29 30
  • 99.42 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SHBG 29 30
  • 82.29 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SHBG 29 30
  • 81.51 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Shbg 29
  • 77.4 (n)
Mouse
(Mus musculus)
Mammalia Shbg 29 16 30
  • 77.04 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SHBG 30
  • 53 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SHBG 30
  • 34 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SHBG 30
  • 37 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100498622 29
  • 46.77 (n)
Zebrafish
(Danio rerio)
Actinopterygii shbg 29 30
  • 43.96 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 11 (a)
ManyToMany
-- 30
  • 5 (a)
ManyToMany
Species where no ortholog for SHBG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SHBG Gene

ENSEMBL:
Gene Tree for SHBG (if available)
TreeFam:
Gene Tree for SHBG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SHBG: view image
Alliance of Genome Resources:
Additional Orthologs for SHBG

Paralogs for SHBG Gene

Paralogs for SHBG Gene

(2) SIMAP similar genes for SHBG Gene using alignment to 16 proteins:

  • SHBG_HUMAN
  • B0FWH2_HUMAN
  • B0FWH5_HUMAN
  • B0FWH6_HUMAN
  • B0FWH7_HUMAN
  • B0FWH8_HUMAN
  • B4DYU0_HUMAN
  • I3L0M1_HUMAN
  • I3L145_HUMAN
  • I3L1C1_HUMAN
  • I3L1G4_HUMAN
  • I3L1J1_HUMAN
  • I3L2F1_HUMAN
  • I3L2X4_HUMAN
  • I3L4B9_HUMAN
  • I3L4D0_HUMAN
genes like me logo Genes that share paralogs with SHBG: view

Variants for SHBG Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SHBG Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
917853 Uncertain Significance: Sex Hormone-Binding Globulin Deficiency 7,633,269(+) G/A
NM_001040.5(SHBG):c.1126G>A (p.Asp376Asn)
MISSENSE_VARIANT,THREE_PRIME_UTR
rs115336700 Benign: not provided 7,631,341(+) G/C
NM_001040.5(SHBG):c.535G>C (p.Ala179Pro)
MISSENSE
rs1597921295 Likely Benign: not provided 7,631,690(+) A/G
NM_001040.5(SHBG):c.657A>G (p.Val219=)
SYNONYMOUS
rs4987212 Benign: not provided 7,632,841(+) G/A
NM_001040.5(SHBG):c.942G>A (p.Arg314=)
SYNONYMOUS_VARIANT,INTRON
rs6260 Benign: not provided 7,630,246(+) G/Ap.Arg25His
NM_001040.5(SHBG):c.74G>A (p.Arg25His)
MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SHBG Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SHBG Gene

Variant ID Type Subtype PubMed ID
dgv531e199 CNV deletion 23128226
esv2422288 CNV deletion 17116639
esv2715601 CNV deletion 23290073
esv3554089 CNV deletion 23714750
nsv1152811 CNV deletion 26484159
nsv457659 CNV loss 19166990
nsv574322 CNV loss 21841781

Variation tolerance for SHBG Gene

Residual Variation Intolerance Score: 47.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.31; 53.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SHBG Gene

Human Gene Mutation Database (HGMD)
SHBG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SHBG
Leiden Open Variation Database (LOVD)
SHBG

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHBG Gene

Disorders for SHBG Gene

MalaCards: The human disease database

(99) MalaCards diseases for SHBG Gene - From: COP and GCD

Disorder Aliases PubMed IDs
ovarian disease
  • ovarian dysfunction
anovulation
polycystic ovary syndrome
  • multicystic ovaries
androgenic alopecia
  • alopecia androgenetica, male pattern baldness
hyperandrogenism
  • hyperandrogenization syndrome
- elite association - COSMIC cancer census association via MalaCards
Search SHBG in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SHBG

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SHBG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SHBG Gene

Publications for SHBG Gene

  1. Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians. (PMID: 20432167) Iwasaki M … Tsugane S (Nutrition and cancer 2010) 3 22 40
  2. Polymorphisms of estrogen-related genes jointly confer susceptibility to human spermatogenic defect. (PMID: 18980759) Su MT … Kuo PL (Fertility and sterility 2010) 3 22 40
  3. Polymorphisms in the BRCA1 and ABCB1 genes modulate menopausal hormone therapy associated breast cancer risk in postmenopausal women. (PMID: 19672706) MARIE-GENICA Consortium on Genetic Susceptibility for Menopausal Hormone Therapy Related Breast Cancer Risk (Breast cancer research and treatment 2010) 3 22 40
  4. Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes. (PMID: 19933169) Perry JR … Frayling TM (Human molecular genetics 2010) 3 22 40
  5. Polymorphisms of the SHBG gene contribute to the interindividual variation of sex steroid hormone blood levels in young, middle-aged and elderly men. (PMID: 18681858) Vanbillemont G … Kaufman JM (Clinical endocrinology 2009) 3 22 40

Products for SHBG Gene

Sources for SHBG Gene