Aliases for SHBG Gene
External Ids for SHBG Gene
Previous GeneCards Identifiers for SHBG Gene
This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers. Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
GeneCards Summary for SHBG Gene
SHBG (Sex Hormone Binding Globulin) is a Protein Coding gene. Diseases associated with SHBG include Ovarian Disease and Anovulation. Among its related pathways are Nongenotropic Androgen signaling and CCR5 Pathway in Macrophages. Gene Ontology (GO) annotations related to this gene include androgen binding. An important paralog of this gene is PROS1.
UniProtKB/Swiss-Prot Summary for SHBG Gene
Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.