Aliases for SHB Gene
External Ids for SHB Gene
Previous GeneCards Identifiers for SHB Gene
GeneCards Summary for SHB Gene
SHB (SH2 Domain Containing Adaptor Protein B) is a Protein Coding gene. Diseases associated with SHB include Sulfhemoglobinemia and Acute Dacryocystitis. Among its related pathways are RET signaling and Development VEGF signaling via VEGFR2 - generic cascades. Gene Ontology (GO) annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is ENSG00000255872.
UniProtKB/Swiss-Prot Summary for SHB Gene
Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.