Aliases for SHB Gene
External Ids for SHB Gene
Previous GeneCards Identifiers for SHB Gene
GeneCards Summary for SHB Gene
SHB (SH2 Domain Containing Adaptor Protein B) is a Protein Coding gene. Diseases associated with SHB include Sulfhemoglobinemia. Among its related pathways are Development FGFR signaling pathway and Developmental Biology. Gene Ontology (GO) annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is ENSG00000255872.
UniProtKB/Swiss-Prot Summary for SHB Gene
Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.