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Aliases for SH3YL1 Gene

Aliases for SH3YL1 Gene

  • SH3 And SYLF Domain Containing 1 2 3 5
  • SH3 Domain Containing, Ysc84-Like 1 (S. Cerevisiae) 2
  • SH3 Domain-Containing YSC84-Like Protein 1 3
  • SH3 Domain Containing, Ysc84-Like 1 3
  • RAY 3

External Ids for SH3YL1 Gene

Previous GeneCards Identifiers for SH3YL1 Gene

  • GC02M000212

Summaries for SH3YL1 Gene

GeneCards Summary for SH3YL1 Gene

SH3YL1 (SH3 And SYLF Domain Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol binding and phosphatase binding.

Additional gene information for SH3YL1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3YL1 Gene

Genomics for SH3YL1 Gene

GeneHancer (GH) Regulatory Elements for SH3YL1 Gene

Promoters and enhancers for SH3YL1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I000260 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 624 +3.0 3005 6.6 PKNOX1 SMAD1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SH3YL1 ACP1 ALKAL2 TMEM18 LOC101927262 ENSG00000227061 GC02M000255
GH02I000249 Promoter 1.2 EPDnew 550.4 +16.6 16581 0.1 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 TCF12 SLC30A9 SP5 MXD4 SH3YL1 LOC101927262 ALKAL2 TMEM18 LOC105373354 GC02M000255 GC02M000239
GH02I000043 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 23.7 +220.9 220895 5 ELF3 RAD21 RARA ETS1 SLC30A9 ZNF335 GLIS2 SCRT2 ELK4 SP3 FAM110C SH3YL1
GH02I000289 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE 32.8 -23.4 -23395 1.3 ARID4B DNMT3B RAD21 YY1 NCOA2 ZNF143 MXD4 REST MIER2 KAT8 ALKAL2 SH3YL1 LOC101927262 ENSG00000277997
GH02I000174 Enhancer 1.1 Ensembl ENCODE 31.1 +90.0 90008 3.3 FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 TCF12 FOS SP5 ZHX2 SH3YL1 ENSG00000227061 LOC105373324 GC02P000127
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SH3YL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SH3YL1 gene promoter:

Genomic Locations for SH3YL1 Gene

Genomic Locations for SH3YL1 Gene
48,669 bases
Minus strand

Genomic View for SH3YL1 Gene

Genes around SH3YL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH3YL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH3YL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3YL1 Gene

Proteins for SH3YL1 Gene

  • Protein details for SH3YL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH3 domain-containing YSC84-like protein 1
    Protein Accession:
    Secondary Accessions:
    • A8K8E7
    • B7WNJ4
    • B7WPL6
    • Q8NEL2
    • Q9H5X4
    • Q9Y3V5

    Protein attributes for SH3YL1 Gene

    342 amino acids
    Molecular mass:
    37148 Da
    Quaternary structure:
    • Interacts with SH3D19.

    Three dimensional structures from OCA and Proteopedia for SH3YL1 Gene

    Alternative splice isoforms for SH3YL1 Gene


neXtProt entry for SH3YL1 Gene

Post-translational modifications for SH3YL1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SH3YL1 Gene

Domains & Families for SH3YL1 Gene

Gene Families for SH3YL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for SH3YL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SH3YL1 family.
  • Belongs to the SH3YL1 family.
genes like me logo Genes that share domains with SH3YL1: view

Function for SH3YL1 Gene

Phenotypes From GWAS Catalog for SH3YL1 Gene

Gene Ontology (GO) - Molecular Function for SH3YL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0019902 phosphatase binding IDA 21624956
GO:0035091 phosphatidylinositol binding IDA 21624956
genes like me logo Genes that share ontologies with SH3YL1: view
genes like me logo Genes that share phenotypes with SH3YL1: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SH3YL1 Gene

Localization for SH3YL1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SH3YL1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 3
cytosol 3
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SH3YL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032587 ruffle membrane IDA 21624956
genes like me logo Genes that share ontologies with SH3YL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SH3YL1 Gene

Pathways & Interactions for SH3YL1 Gene

SuperPathways for SH3YL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SH3YL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006661 phosphatidylinositol biosynthetic process IEA --
GO:1900027 regulation of ruffle assembly IBA --
genes like me logo Genes that share ontologies with SH3YL1: view

No data available for Pathways by source and SIGNOR curated interactions for SH3YL1 Gene

Drugs & Compounds for SH3YL1 Gene

No Compound Related Data Available

Transcripts for SH3YL1 Gene

Unigene Clusters for SH3YL1 Gene

SH3 domain containing, Ysc84-like 1 (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH3YL1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b · 15c · 15d · 15e ^ 16 ^
SP1: - - - - - - - - -
SP2: - - - - - - -
SP3: - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - -
SP7: - - - - - - - -
SP8: - - - -
SP9: - - -
SP11: -

ExUns: 17 ^ 18 ^ 19a · 19b · 19c
SP1: -
SP2: - -
SP3: - -
SP4: -
SP5: - -
SP8: - -

Relevant External Links for SH3YL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SH3YL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SH3YL1 Gene

Protein differential expression in normal tissues from HIPED for SH3YL1 Gene

This gene is overexpressed in Salivary gland (59.4) and Placenta (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SH3YL1 Gene

Protein tissue co-expression partners for SH3YL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SH3YL1 Gene:


SOURCE GeneReport for Unigene cluster for SH3YL1 Gene:


Evidence on tissue expression from TISSUES for SH3YL1 Gene

  • Nervous system(3.4)
  • Skin(2.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with SH3YL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SH3YL1 Gene

Orthologs for SH3YL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SH3YL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SH3YL1 33 34
  • 99.28 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 91 (a)
-- 34
  • 82 (a)
(Bos Taurus)
Mammalia SH3YL1 33 34
  • 87.1 (n)
(Canis familiaris)
Mammalia SH3YL1 33 34
  • 86.94 (n)
(Mus musculus)
Mammalia Sh3yl1 33 16 34
  • 86.37 (n)
(Monodelphis domestica)
Mammalia SH3YL1 34
  • 86 (a)
(Rattus norvegicus)
Mammalia Sh3yl1 33
  • 85.88 (n)
(Gallus gallus)
Aves SH3YL1 33 34
  • 74.92 (n)
(Anolis carolinensis)
Reptilia SH3YL1 34
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sh3yl1 33
  • 75.29 (n)
(Danio rerio)
Actinopterygii sh3yl1 33 34
  • 62.66 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A08360g 33
  • 55.28 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LSB3 33 34
  • 54.28 (n)
YSC84 34
  • 34 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL017W 33
  • 48.93 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03888 33
  • 57.2 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAPJ696.02 33
  • 56.55 (n)
Species where no ortholog for SH3YL1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SH3YL1 Gene

Gene Tree for SH3YL1 (if available)
Gene Tree for SH3YL1 (if available)

Paralogs for SH3YL1 Gene

(4) SIMAP similar genes for SH3YL1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SH3YL1: view

No data available for Paralogs for SH3YL1 Gene

Variants for SH3YL1 Gene

Sequence variations from dbSNP and Humsavar for SH3YL1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000048078 -- 257,193(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000163180 -- 231,611(-) A/C genic_downstream_transcript_variant, intron_variant
rs1000213604 -- 242,597(-) G/A intron_variant
rs1000250784 -- 231,954(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000313151 -- 235,126(-) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SH3YL1 Gene

Variant ID Type Subtype PubMed ID
dgv3694n100 CNV loss 25217958
dgv3695n100 CNV gain 25217958
esv1237216 CNV deletion 17803354
esv1550511 CNV deletion 17803354
esv2751887 CNV loss 17911159
esv2759016 CNV gain 17122850
esv2760594 CNV loss 21179565
esv3589595 CNV loss 21293372
esv3589598 CNV gain 21293372
esv3589599 CNV gain 21293372
esv994728 CNV deletion 20482838
nsv1006547 CNV gain 25217958
nsv1007793 CNV gain 25217958
nsv2561 CNV insertion 18451855
nsv508735 CNV insertion 20534489
nsv519763 CNV loss 19592680
nsv580421 CNV loss 21841781
nsv833148 CNV loss 17160897
nsv833159 CNV loss 17160897

Variation tolerance for SH3YL1 Gene

Residual Variation Intolerance Score: 81.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.58; 30.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SH3YL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH3YL1 Gene

Disorders for SH3YL1 Gene

Additional Disease Information for SH3YL1

No disorders were found for SH3YL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH3YL1 Gene

Publications for SH3YL1 Gene

  1. SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain. (PMID: 21624956) Hasegawa J … Itoh T (The Journal of cell biology 2011) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Identification of a Novel Coregulator, SH3YL1, That Interacts With the Androgen Receptor N-Terminus. (PMID: 26305679) Blessing AM … Frigo DE (Molecular endocrinology (Baltimore, Md.) 2015) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for SH3YL1 Gene

Sources for SH3YL1 Gene

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