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Aliases for SH3RF2 Gene

Aliases for SH3RF2 Gene

  • SH3 Domain Containing Ring Finger 2 2 3 5
  • Heart Protein Phosphatase 1-Binding Protein 2 3 4
  • Protein Phosphatase 1 Regulatory Subunit 39 3 4
  • SH3 Domain-Containing RING Finger Protein 2 3 4
  • RING-Type E3 Ubiquitin Transferase SH3RF2 3 4
  • POSH-Eliminating RING Protein 2 3
  • RING Finger Protein 158 3 4
  • PPP1R39 3 4
  • RNF158 3 4
  • HEPP1 3 4
  • Protein Phosphatase 1, Regulatory Subunit 39 2
  • Putative E3 Ubiquitin-Protein Ligase SH3RF2 3
  • Phosphatase 1 Binding Protein 3
  • EC 4
  • EC 6.3.2 56
  • POSHER 3

External Ids for SH3RF2 Gene

Previous HGNC Symbols for SH3RF2 Gene

  • PPP1R39

Previous GeneCards Identifiers for SH3RF2 Gene

  • GC05P145345
  • GC05P145296
  • GC05P140462

Summaries for SH3RF2 Gene

GeneCards Summary for SH3RF2 Gene

SH3RF2 (SH3 Domain Containing Ring Finger 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ligase activity and protein phosphatase inhibitor activity. An important paralog of this gene is SH3RF1.

UniProtKB/Swiss-Prot for SH3RF2 Gene

  • Inhibits PPP1CA phosphatase activity. May be a E3 ubiquitin-protein ligase (Potential). May play a role in cardiac function.

Additional gene information for SH3RF2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3RF2 Gene

Genomics for SH3RF2 Gene

GeneHancer (GH) Regulatory Elements for SH3RF2 Gene

Promoters and enhancers for SH3RF2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I145934 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 558.7 +4.5 4517 13.4 PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 SH3RF2 PLAC8L1 GRXCR2 GC05P145976
GH05I145974 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 18.8 +42.7 42682 9.2 PKNOX1 FOXA2 MLX ZFP64 ARID4B NEUROD1 FEZF1 ZNF2 YY1 ZNF213 TCERG1 RBM27 SH3RF2 LARS GRXCR2 GC05P145976 LOC100431175
GH05I145851 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.6 -82.2 -82167 5.2 HDGF PKNOX1 FOXA2 ARNT POLR2B ZNF766 E2F8 ZNF143 FOS ZNF592 GRXCR2 SH3RF2 PRELID2 GC05P145887
GH05I145960 Enhancer 0.5 ENCODE dbSUPER 19.5 +24.3 24331 1.1 ZNF362 SH3RF2 GC05P145976 GRXCR2
GH05I145923 Enhancer 1.2 Ensembl ENCODE dbSUPER 5.2 -11.3 -11329 2.6 ZNF449 JUN INSM2 MZF1 FEZF1 ZIC2 RFX5 ZEB1 HIC1 ZNF664 SH3RF2 GRXCR2 GC05P145887
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SH3RF2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SH3RF2 gene promoter:

Genomic Locations for SH3RF2 Gene

Genomic Locations for SH3RF2 Gene
145,229 bases
Plus strand

Genomic View for SH3RF2 Gene

Genes around SH3RF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH3RF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH3RF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3RF2 Gene

Proteins for SH3RF2 Gene

  • Protein details for SH3RF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative E3 ubiquitin-protein ligase SH3RF2
    Protein Accession:
    Secondary Accessions:
    • A8K961
    • Q08AM9
    • Q6GMR9
    • Q8N5S8
    • Q96LP8

    Protein attributes for SH3RF2 Gene

    729 amino acids
    Molecular mass:
    79320 Da
    Quaternary structure:
    • Interacts with FASLG and PPP1CA.
    • Sequence=AAH31650.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB85025.1; Type=Erroneous termination; Positions=458; Note=Translated as Trp.; Evidence={ECO:0000305};

    Alternative splice isoforms for SH3RF2 Gene


neXtProt entry for SH3RF2 Gene

Selected DME Specific Peptides for SH3RF2 Gene


Post-translational modifications for SH3RF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SH3RF2 Gene

Domains & Families for SH3RF2 Gene

Gene Families for SH3RF2 Gene

Suggested Antigen Peptide Sequences for SH3RF2 Gene

Graphical View of Domain Structure for InterPro Entry



  • The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.
  • Belongs to the SH3RF family.
  • The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.
  • Belongs to the SH3RF family.
genes like me logo Genes that share domains with SH3RF2: view

Function for SH3RF2 Gene

Molecular function for SH3RF2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
Inhibits PPP1CA phosphatase activity. May be a E3 ubiquitin-protein ligase (Potential). May play a role in cardiac function.

Enzyme Numbers (IUBMB) for SH3RF2 Gene

Phenotypes From GWAS Catalog for SH3RF2 Gene

Gene Ontology (GO) - Molecular Function for SH3RF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004864 protein phosphatase inhibitor activity IEA --
GO:0005515 protein binding IPI 19389623
GO:0008157 protein phosphatase 1 binding IDA 19945436
GO:0016740 transferase activity IEA --
GO:0019902 phosphatase binding IDA 19389623
genes like me logo Genes that share ontologies with SH3RF2: view
genes like me logo Genes that share phenotypes with SH3RF2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SH3RF2 Gene

Localization for SH3RF2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SH3RF2 gene
Compartment Confidence
nucleus 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SH3RF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with SH3RF2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SH3RF2 Gene

Pathways & Interactions for SH3RF2 Gene

SuperPathways for SH3RF2 Gene

No Data Available

UniProtKB/Swiss-Prot Q8TEC5-SH3R2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for SH3RF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010923 negative regulation of phosphatase activity IDA 19389623
GO:0016567 protein ubiquitination IEA --
GO:0032515 negative regulation of phosphoprotein phosphatase activity IEA --
genes like me logo Genes that share ontologies with SH3RF2: view

No data available for Pathways by source and SIGNOR curated interactions for SH3RF2 Gene

Drugs & Compounds for SH3RF2 Gene

No Compound Related Data Available

Transcripts for SH3RF2 Gene

Unigene Clusters for SH3RF2 Gene

SH3 domain containing ring finger 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH3RF2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b
SP1: - - - - -
SP3: -
SP4: -

Relevant External Links for SH3RF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SH3RF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SH3RF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SH3RF2 Gene

This gene is overexpressed in Heart - Left Ventricle (x10.2), Testis (x6.9), Skin - Sun Exposed (Lower leg) (x4.7), Skin - Not Sun Exposed (Suprapubic) (x4.3), and Heart - Atrial Appendage (x4.3).

Protein differential expression in normal tissues from HIPED for SH3RF2 Gene

This gene is overexpressed in Urine (59.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SH3RF2 Gene

Protein tissue co-expression partners for SH3RF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SH3RF2 Gene:


SOURCE GeneReport for Unigene cluster for SH3RF2 Gene:


mRNA Expression by UniProt/SwissProt for SH3RF2 Gene:

Tissue specificity: Heart (at protein level). Heart and testis. In the heart, present in the apex, left atrium, right atrium, left ventricle and right ventricle, but not in the aorta.

Evidence on tissue expression from TISSUES for SH3RF2 Gene

  • Intestine(4.2)
  • Nervous system(4.2)
  • Heart(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with SH3RF2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SH3RF2 Gene

Orthologs for SH3RF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SH3RF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SH3RF2 33 34
  • 99.31 (n)
(Canis familiaris)
Mammalia SH3RF2 33 34
  • 89.43 (n)
(Bos Taurus)
Mammalia SH3RF2 34
  • 89 (a)
PPP1R39 33
  • 88.37 (n)
(Rattus norvegicus)
Mammalia Sh3rf2 33
  • 84.31 (n)
(Mus musculus)
Mammalia Sh3rf2 33 16 34
  • 83.98 (n)
(Monodelphis domestica)
Mammalia SH3RF2 34
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia SH3RF2 34
  • 67 (a)
(Gallus gallus)
Aves SH3RF2 33 34
  • 61.4 (n)
(Anolis carolinensis)
Reptilia SH3RF2 34
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sh3rf2 33
  • 56.77 (n)
(Danio rerio)
Actinopterygii SH3RF2 34
  • 33 (a)
fruit fly
(Drosophila melanogaster)
Insecta POSH 34
  • 23 (a)
(Caenorhabditis elegans)
Secernentea sorb-1 34
  • 10 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
Species where no ortholog for SH3RF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SH3RF2 Gene

Gene Tree for SH3RF2 (if available)
Gene Tree for SH3RF2 (if available)

Paralogs for SH3RF2 Gene

Paralogs for SH3RF2 Gene

(5) SIMAP similar genes for SH3RF2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SH3RF2: view

Variants for SH3RF2 Gene

Sequence variations from dbSNP and Humsavar for SH3RF2 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000021056 -- 146,005,769(+) C/G intron_variant
rs1000053412 -- 146,015,095(+) G/A intron_variant
rs1000068927 -- 145,971,424(+) C/A intron_variant
rs1000100329 -- 146,013,680(+) G/T intron_variant
rs1000100447 -- 146,066,081(+) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SH3RF2 Gene

Variant ID Type Subtype PubMed ID
esv2730878 CNV deletion 23290073

Variation tolerance for SH3RF2 Gene

Residual Variation Intolerance Score: 73.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.34; 53.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SH3RF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH3RF2 Gene

Disorders for SH3RF2 Gene

Additional Disease Information for SH3RF2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SH3RF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH3RF2 Gene

Publications for SH3RF2 Gene

  1. Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Plenty of SH3s) protein. (PMID: 22128169) Wilhelm M … Greene LA (The Journal of biological chemistry 2012) 2 3 58
  2. FLJ23654 encodes a heart protein phosphatase 1-binding protein (Hepp1). (PMID: 19945436) Chen CY … Huang HB (Biochemical and biophysical research communications 2010) 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Docking motif-guided mapping of the interactome of protein phosphatase-1. (PMID: 19389623) Hendrickx A … Bollen M (Chemistry & biology 2009) 3 4 58
  5. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PMID: 19807924) Voss M … Janssen O (BMC immunology 2009) 3 4 58

Products for SH3RF2 Gene

Sources for SH3RF2 Gene

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