Aliases for SH3RF2 Gene

Aliases for SH3RF2 Gene

  • SH3 Domain Containing Ring Finger 2 2 3 5
  • Heart Protein Phosphatase 1-Binding Protein 2 3 4
  • POSH-Eliminating RING Protein 2 3 4
  • Protein Phosphatase 1 Regulatory Subunit 39 3 4
  • SH3 Domain-Containing RING Finger Protein 2 3 4
  • RING-Type E3 Ubiquitin Transferase SH3RF2 3 4
  • E3 Ubiquitin-Protein Ligase SH3RF2 3 4
  • RING Finger Protein 158 3 4
  • PPP1R39 3 4
  • POSHER 3 4
  • RNF158 3 4
  • HEPP1 3 4
  • Protein Phosphatase 1, Regulatory Subunit 39 2
  • Putative E3 Ubiquitin-Protein Ligase SH3RF2 3
  • Phosphatase 1 Binding Protein 3
  • EC 2.3.2.27 4
  • EC 6.3.2 52
  • POSH3 4

External Ids for SH3RF2 Gene

Previous HGNC Symbols for SH3RF2 Gene

  • PPP1R39

Previous GeneCards Identifiers for SH3RF2 Gene

  • GC05P145345
  • GC05P145296
  • GC05P140462

Summaries for SH3RF2 Gene

GeneCards Summary for SH3RF2 Gene

SH3RF2 (SH3 Domain Containing Ring Finger 2) is a Protein Coding gene. Diseases associated with SH3RF2 include Ureter Transitional Cell Carcinoma and Ureter, Cancer Of. Gene Ontology (GO) annotations related to this gene include ligase activity and protein phosphatase inhibitor activity. An important paralog of this gene is SH3RF3.

UniProtKB/Swiss-Prot Summary for SH3RF2 Gene

  • Has E3 ubiquitin-protein ligase activity (PubMed:24130170). Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation (PubMed:22128169). Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation (PubMed:24130170). Inhibits PPP1CA phosphatase activity (PubMed:19945436, PubMed:19389623).

Additional gene information for SH3RF2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SH3RF2 Gene

Genomics for SH3RF2 Gene

GeneHancer (GH) Regulatory Elements for SH3RF2 Gene

Promoters and enhancers for SH3RF2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J145934 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 508.6 +4.6 4630 13.6 ZNF217 ZSCAN5C TCF12 POLR2G JUND ZNF639 ZNF10 ZIC2 REST TCF7 SH3RF2 PLAC8L1 GRXCR2 piR-31210-036
GH05J146050 Promoter 0.4 EPDnew 500.1 +113.5 113509 0.1 CTCF SH3RF2 RF00017-4983 lnc-PLAC8L1-1
GH05J145974 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 18.8 +43.6 43638 11.2 ZNF217 ZSCAN5C TCF12 ZNF300 NCOR1 ZNF639 ZNF10 ZIC2 KDM6A TCF7 TCERG1 RBM27 SH3RF2 LARS1 GRXCR2 piR-32023-200 piR-31210-036
GH05J145851 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 9.6 -82.2 -82168 5.2 POLR2G GTF2E2 JUND PHB2 FOS ZIC2 ZBTB11 TCF7 AFF1 TRIM28 GRXCR2 SH3RF2 PRELID2 piR-56037-015
GH05J145960 Enhancer 0.6 Ensembl ENCODE dbSUPER 19.5 +24.6 24607 1.7 ZNF362 SH3RF2 piR-31210-036 piR-32023-200
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SH3RF2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SH3RF2

Top Transcription factor binding sites by QIAGEN in the SH3RF2 gene promoter:
  • AML1a
  • Arnt
  • Cdc5
  • E47
  • Gfi-1
  • HSF2
  • Lmo2
  • POU6F1 (c2)
  • Tal-1beta

Genomic Locations for SH3RF2 Gene

Genomic Locations for SH3RF2 Gene
chr5:145,936,563-146,081,791
(GRCh38/hg38)
Size:
145,229 bases
Orientation:
Plus strand
chr5:145,316,126-145,461,354
(GRCh37/hg19)
Size:
145,229 bases
Orientation:
Plus strand

Genomic View for SH3RF2 Gene

Genes around SH3RF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH3RF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH3RF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3RF2 Gene

Proteins for SH3RF2 Gene

  • Protein details for SH3RF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TEC5-SH3R2_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase SH3RF2
    Protein Accession:
    Q8TEC5
    Secondary Accessions:
    • A8K961
    • Q08AM9
    • Q6GMR9
    • Q8N5S8
    • Q96LP8

    Protein attributes for SH3RF2 Gene

    Size:
    729 amino acids
    Molecular mass:
    79320 Da
    Quaternary structure:
    • Interacts with FASLG and PPP1CA (PubMed:19389623, PubMed:19807924, PubMed:19945436). Interacts with PAK4 and TNFRSF1A (PubMed:24130170). Interacts with DLK1, MAP3K10/MLK2, MAPK8IP1/JIP1, MAPK8IP2/JIP2 and MAPK8IP3/JIP3. Interacts with RAC1 (both active GTP- or inactive GDP-bound forms) (By similarity).
    SequenceCaution:
    • Sequence=AAH31650.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAB85025.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for SH3RF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SH3RF2 Gene

Selected DME Specific Peptides for SH3RF2 Gene

Q8TEC5:
  • RVDENWAEG
  • HTFCKPC
  • AKVLPCQHTFC
  • PVLISSSNP
  • LLECPVC

Post-translational modifications for SH3RF2 Gene

Other Protein References for SH3RF2 Gene

Domains & Families for SH3RF2 Gene

Gene Families for SH3RF2 Gene

Protein Domains for SH3RF2 Gene

Blocks:
  • SH3 domain signature
  • Variant SH3
  • Zn-finger, RING
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SH3RF2 Gene

GenScript: Design optimal peptide antigens:
  • SH3 domain containing ring finger 2 (Q08AM8_HUMAN)
  • SH3 domain-containing RING finger protein 2 (SH3R2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TEC5

UniProtKB/Swiss-Prot:

SH3R2_HUMAN :
  • The RING finger domain is required for ubiquitin ligase activity and autoubiquitination.
  • Belongs to the SH3RF family.
Domain:
  • The RING finger domain is required for ubiquitin ligase activity and autoubiquitination.
Family:
  • Belongs to the SH3RF family.
genes like me logo Genes that share domains with SH3RF2: view

Function for SH3RF2 Gene

Molecular function for SH3RF2 Gene

UniProtKB/Swiss-Prot Function:
Has E3 ubiquitin-protein ligase activity (PubMed:24130170). Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation (PubMed:22128169). Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation (PubMed:24130170). Inhibits PPP1CA phosphatase activity (PubMed:19945436, PubMed:19389623).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=. ;.

Enzyme Numbers (IUBMB) for SH3RF2 Gene

Phenotypes From GWAS Catalog for SH3RF2 Gene

Gene Ontology (GO) - Molecular Function for SH3RF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004864 protein phosphatase inhibitor activity IEA --
GO:0005515 protein binding IPI,IEA 19389623
GO:0008157 protein phosphatase 1 binding IDA 19945436
GO:0016740 transferase activity IEA --
GO:0019902 phosphatase binding IDA 19389623
genes like me logo Genes that share ontologies with SH3RF2: view
genes like me logo Genes that share phenotypes with SH3RF2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SH3RF2

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SH3RF2 Gene

Localization for SH3RF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SH3RF2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SH3RF2 gene
Compartment Confidence
nucleus 5
cytoskeleton 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SH3RF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 24130170
GO:0005654 nucleoplasm IDA,IBA --
genes like me logo Genes that share ontologies with SH3RF2: view

Pathways & Interactions for SH3RF2 Gene

PathCards logo

SuperPathways for SH3RF2 Gene

No Data Available

UniProtKB/Swiss-Prot Q8TEC5-SH3R2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for SH3RF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010923 negative regulation of phosphatase activity IDA,IBA 19389623
GO:0016567 protein ubiquitination IEA --
GO:0030335 positive regulation of cell migration IMP 24130170
GO:0031397 negative regulation of protein ubiquitination IMP 24130170
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA,IMP 22128169
genes like me logo Genes that share ontologies with SH3RF2: view

No data available for Pathways by source and SIGNOR curated interactions for SH3RF2 Gene

Drugs & Compounds for SH3RF2 Gene

No Compound Related Data Available

Transcripts for SH3RF2 Gene

mRNA/cDNA for SH3RF2 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SH3RF2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH3RF2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b
SP1: - - - - -
SP2:
SP3: -
SP4: -
SP5:

Relevant External Links for SH3RF2 Gene

GeneLoc Exon Structure for
SH3RF2

Expression for SH3RF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SH3RF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SH3RF2 Gene

This gene is overexpressed in Heart - Left Ventricle (x10.2), Testis (x6.9), Skin - Sun Exposed (Lower leg) (x4.7), Skin - Not Sun Exposed (Suprapubic) (x4.3), and Heart - Atrial Appendage (x4.3).

Protein differential expression in normal tissues from HIPED for SH3RF2 Gene

This gene is overexpressed in Urine (59.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SH3RF2 Gene



Protein tissue co-expression partners for SH3RF2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SH3RF2

SOURCE GeneReport for Unigene cluster for SH3RF2 Gene:

Hs.443728

mRNA Expression by UniProt/SwissProt for SH3RF2 Gene:

Q8TEC5-SH3R2_HUMAN
Tissue specificity: Heart (at protein level). Up-regulated in colon cancer tissues as compared to normal colon tissues (at protein level). Testis. In the heart, present in the apex, left atrium, right atrium, left ventricle and right ventricle, but not in the aorta.

Evidence on tissue expression from TISSUES for SH3RF2 Gene

  • Intestine(4.2)
  • Nervous system(4.2)
  • Heart(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with SH3RF2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SH3RF2 Gene

Orthologs for SH3RF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SH3RF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SH3RF2 31 30
  • 99.31 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SH3RF2 31 30
  • 89.43 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SH3RF2 31
  • 89 (a)
OneToOne
PPP1R39 30
  • 88.37 (n)
rat
(Rattus norvegicus)
Mammalia Sh3rf2 30
  • 84.31 (n)
mouse
(Mus musculus)
Mammalia Sh3rf2 17 31 30
  • 83.98 (n)
oppossum
(Monodelphis domestica)
Mammalia SH3RF2 31
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SH3RF2 31
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves SH3RF2 31 30
  • 61.4 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SH3RF2 31
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sh3rf2 30
  • 56.77 (n)
zebrafish
(Danio rerio)
Actinopterygii SH3RF2 31
  • 33 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta POSH 31
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sorb-1 31
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 35 (a)
OneToMany
Species where no ortholog for SH3RF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SH3RF2 Gene

ENSEMBL:
Gene Tree for SH3RF2 (if available)
TreeFam:
Gene Tree for SH3RF2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SH3RF2: view image

Paralogs for SH3RF2 Gene

(5) SIMAP similar genes for SH3RF2 Gene using alignment to 2 proteins:

  • SH3R2_HUMAN
  • Q08AM8_HUMAN
genes like me logo Genes that share paralogs with SH3RF2: view

Variants for SH3RF2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SH3RF2 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs1056149 - p.Gly710Ala
rs11435 - p.Val687Ile
rs2962525 - p.Trp592Arg
rs34739859 - p.Phe16Ser
rs34942619 - p.Phe174Val

Additional dbSNP identifiers (rs#s) for SH3RF2 Gene

Structural Variations from Database of Genomic Variants (DGV) for SH3RF2 Gene

Variant ID Type Subtype PubMed ID
esv2730878 CNV deletion 23290073

Variation tolerance for SH3RF2 Gene

Residual Variation Intolerance Score: 73.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.34; 53.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SH3RF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SH3RF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH3RF2 Gene

Disorders for SH3RF2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SH3RF2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ureter transitional cell carcinoma
  • transitional cell carcinoma of ureter
ureter, cancer of
  • ureter cancer
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SH3RF2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SH3RF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SH3RF2 Gene

Publications for SH3RF2 Gene

  1. Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Plenty of SH3s) protein. (PMID: 22128169) Wilhelm M … Greene LA (The Journal of biological chemistry 2012) 2 3 4 54
  2. SH3RF2 functions as an oncogene by mediating PAK4 protein stability. (PMID: 24130170) Kim TW … Park KC (Carcinogenesis 2014) 3 4 54
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  4. FLJ23654 encodes a heart protein phosphatase 1-binding protein (Hepp1). (PMID: 19945436) Chen CY … Huang HB (Biochemical and biophysical research communications 2010) 3 4 54
  5. Docking motif-guided mapping of the interactome of protein phosphatase-1. (PMID: 19389623) Hendrickx A … Bollen M (Chemistry & biology 2009) 3 4 54

Products for SH3RF2 Gene

Sources for SH3RF2 Gene