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This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase sign... See more...
Aliases for SH3RF1 Gene
Aliases for SH3RF1 Gene
- SH3 Domain Containing Ring Finger 1 2 3 5
- RNF142 2 3 4
- POSH 2 3 4
- SH3 Domain-Containing RING Finger Protein 1 3 4
- RING-Type E3 Ubiquitin Transferase SH3RF1 3 4
- E3 Ubiquitin-Protein Ligase SH3RF1 3 4
- SH3 Multiple Domains Protein 2 3 4
- SH3 Multiple Domains 2 2 3
- Plenty Of SH3 Domains 2 3
- Plenty Of SH3s 3 4
External Ids for SH3RF1 Gene
- HGNC: 17650
- Entrez Gene: 57630
- Ensembl: ENSG00000154447
- OMIM: 618642
- UniProtKB: Q7Z6J0
Previous HGNC Symbols for SH3RF1 Gene
- SH3MD2
Previous GeneCards Identifiers for SH3RF1 Gene
- GC04M170251
- GC04M170015
- GC04M165769
Summaries for SH3RF1 Gene
-
This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module. [provided by RefSeq, Jul 2008]
GeneCards Summary for SH3RF1 Gene
SH3RF1 (SH3 Domain Containing Ring Finger 1) is a Protein Coding gene. Among its related pathways are G13 Signaling Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is SH3RF3.
UniProtKB/Swiss-Prot Summary for SH3RF1 Gene
-
Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination (PubMed:15659549, PubMed:20696164). Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis (PubMed:19710010). Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation. Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells. Plays a crucial role in the migration of neocortical neurons in the developing brain. Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly (By similarity).
-
(Microbial infection) Plays an essential role in the targeting of HIV-1 Gag to the plasma membrane, this function is dependent on it's RING domain, and hence it's E3 ligase activity.
Additional gene information for SH3RF1 Gene
- HGNC(17650)
- Entrez Gene(57630)
- Ensembl(ENSG00000154447)
- OMIM(618642)
- UniProtKB(Q7Z6J0)
- Open Targets Platform(ENSG00000154447)
- Monarch Initiative
- Search for SH3RF1 at DataMed
- Search for SH3RF1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SH3RF1 Gene
Genomics for SH3RF1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SH3RF1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SH3RF1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SH3RF1
- Top Transcription factor binding sites by QIAGEN in the SH3RF1 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- Egr-1
- Egr-4
- FOXJ2 (long isoform)
- NF-1
- NF-1/L
- TBP
Genomic Locations for SH3RF1 Gene
Genomic Locations for SH3RF1 Gene
- chr4:169,094,259-169,270,956
- (GRCh38/hg38)
- Size:
- 176,698 bases
- Orientation:
- Minus strand
- chr4:170,015,407-170,192,256
- (GRCh37/hg19)
- Size:
- 176,850 bases
- Orientation:
- Minus strand
Genomic View for SH3RF1 Gene
Genes around SH3RF1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q32.3-q33 by HGNC
- 4q32.3-q33 by Entrez Gene
- 4q33 by Ensembl
SH3RF1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SH3RF1 Gene
Proteins for SH3RF1 Gene
-
Protein details for SH3RF1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7Z6J0-SH3R1_HUMAN
- Recommended name:
- E3 ubiquitin-protein ligase SH3RF1
- Protein Accession:
- Q7Z6J0
- Q05BT2
- Q8IW46
- Q9HAM2
- Q9P234
Protein attributes for SH3RF1 Gene
- Size:
- 888 amino acids
- Molecular mass:
- 93129 Da
- Quaternary structure:
-
- Interacts with RAC1; in a GTP-dependent manner (PubMed:20696164). Interacts with MAP3K10/MLK2 and MAP3K11/MLK3. Interacts with MAPK8IP; this interaction leads to the PJAC complex (POSH-JIP or SH3RF1/MAPK8IP apoptotic complex) with a 1:1 ratio. Interacts with SIAH1. Interacts with HERP1. Probably part of a signaling complex that may contain SH3RF1, MAPK8IP, DLK1, MAP2K4/MKK4, MAP2K7/MKK7, MAPK8/JNK1, MAPK9/JNK2, AKT1 and AKT2 (PubMed:12514131, PubMed:14504284, PubMed:16230351, PubMed:16571722, PubMed:17420289, PubMed:17535800). Found in a complex with RAC2, MAP3K7/TAK1, MAP2K7/MKK7, MAPK8IP1/JIP1, MAPK8/JNK1 and MAPK9/JNK2. Found in a complex with RAC1, MAP3K11/MLK3, MAP2K7/MKK7, MAPK8IP1/JIP1 and MAPK8/JNK1. Interacts with SH3RF2 (By similarity).
- SequenceCaution:
-
- Sequence=AAH33203.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAH33203.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH53671.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the middle of the protein.; Evidence={ECO:0000305};
Protein Expression for SH3RF1 Gene
Selected DME Specific Peptides for SH3RF1 Gene
- Q7Z6J0:
-
- HGFFPTNFVQ
- RVDENWAEG
- AKVLPCQHTFC
- DKIGIFPISYVEFNSAA
- TGLFPGSFV
- HIQTSPQ
- PVLISSSNP
- KKNTKKRHSFTSL
- LLECPVC
- IKPLPQPPPQCKALYDFE
- PRKEDELELRKGEMFLV
- LPSNILLVRLLDGIKQRPWKPGP
- LRRQVDENWYHGE
- KIGVFPGNY
- GLSCSAPSQ
- PQLPCAKALYNY
- KDKEADKDCLPF
- EKKGLLKLLS
- RPTAAVTPIQ
Post-translational modifications for SH3RF1 Gene
- Phosphorylated at Ser-304 by AKT1 and AKT2. When phosphorylated, it has reduced ability to bind Rac.
- Autoubiquitinated (PubMed:20696164). Ubiquitinated by SH3RF2, leading to proteasome-mediated degradation (By similarity).
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for SH3RF1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-SH3RF1 (aa 790-888) polyclonal antibody
- Creative Biolabs Recombinant Mouse Anti-Human SH3RF1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for SH3RF1
- Novus Biologicals Antibodies for SH3RF1
- Invitrogen Antibodies for SH3RF1 (AFLGC-SH3RF1)
-
Santa Cruz Biotechnology (SCBT) Antibodies for SH3RF1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for SH3RF1
- Origene Custom Protein Services for SH3RF1
- antibodies-online: Show 4 available SH3RF1 Proteins ranked by validation data
- Compare Top SH3RF1 Proteins
-
Quality Products:
-
Abcam proteins for SH3RF1
Domains & Families for SH3RF1 Gene
Gene Families for SH3RF1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for SH3RF1 Gene
- InterPro:
- Blocks:
-
- Zn-finger, RING
- ProtoNet:
Suggested Antigen Peptide Sequences for SH3RF1 Gene
- GenScript: Design optimal peptide antigens:
-
- SH3 multiple domains protein 2 (SH3R1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q7Z6J0UniProtKB/Swiss-Prot:
SH3R1_HUMAN :- The RING finger domain is required for ubiquitin ligase activity and autoubiquitination.
- Belongs to the SH3RF family.
- Domain:
-
- The RING finger domain is required for ubiquitin ligase activity and autoubiquitination.
- Family:
-
- Belongs to the SH3RF family.
Function for SH3RF1 Gene
Molecular function for SH3RF1 Gene
- UniProtKB/Swiss-Prot Function:
- Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination (PubMed:15659549, PubMed:20696164). Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis (PubMed:19710010). Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation. Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells. Plays a crucial role in the migration of neocortical neurons in the developing brain. Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly (By similarity).
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Plays an essential role in the targeting of HIV-1 Gag to the plasma membrane, this function is dependent on it's RING domain, and hence it's E3 ligase activity.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence={ECO:0000269|PubMed:15659549, ECO:0000269|PubMed:19710010, ECO:0000269|PubMed:20696164};.
Enzyme Numbers (IUBMB) for SH3RF1 Gene
Phenotypes From GWAS Catalog for SH3RF1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005078 | MAP-kinase scaffold activity | ISS | -- |
| GO:0005515 | protein binding | IPI | 20696164 |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
| GO:0061630 | ubiquitin protein ligase activity | IMP | 20696164 |
Phenotypes for SH3RF1 Gene
- MGI mutant phenotypes for SH3RF1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SH3RF1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SH3RF1 - Select products 50% OFF >
- * SH3RF1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SH3RF1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SH3RF1
-
Santa Cruz Biotechnology (SCBT) CRISPR for SH3RF1
miRNA for SH3RF1 Gene
- miRTarBase miRNAs that target SH3RF1
-
- mmu-miR-30e-5p (MIRT013508)
- hsa-miR-128-3p (MIRT021985)
- hsa-miR-296-3p (MIRT038416)
- hsa-miR-7106-5p (MIRT460313)
- hsa-miR-4668-5p (MIRT460314)
- hsa-miR-765 (MIRT460315)
- hsa-miR-4784 (MIRT460316)
- hsa-miR-3150b-3p (MIRT460317)
- hsa-miR-6754-5p (MIRT460318)
- hsa-miR-4270 (MIRT460319)
- hsa-miR-4441 (MIRT460320)
- hsa-miR-586 (MIRT460321)
- hsa-miR-6783-5p (MIRT460322)
- hsa-miR-4756-5p (MIRT460323)
- hsa-miR-4739 (MIRT460324)
- hsa-miR-1321 (MIRT460325)
- hsa-miR-6510-5p (MIRT460326)
- hsa-miR-4690-5p (MIRT460327)
- hsa-miR-6165 (MIRT460328)
- hsa-miR-5700 (MIRT460329)
- mmu-miR-421-3p (MIRT581059)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SH3RF1
- Browse OriGene Inhibitory RNA Products For SH3RF1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SH3RF1
Clone Products
- Applied Biological Materials (abm): Clones for SH3RF1 - Select products 50% OFF >
- * SH3RF1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SH3RF1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SH3RF1
Cell Line Products
-
Horizon Cell Lines for SH3RF1
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SH3RF1 Gene
Localization for SH3RF1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SH3RF1 Gene
- Cytoplasm, perinuclear region. Cell projection, lamellipodium. Golgi apparatus, trans-Golgi network. Note=Colocalizes, with AKT2, in lamellipodia (By similarity). Colocalizes, with HERP1, in trans-Golgi network. {ECO:0000250 UniProtKB:Q69ZI1, ECO:0000269 PubMed:17420289}.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 4 |
| golgi apparatus | 4 |
| plasma membrane | 2 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
- Vesicles (3)
- Intermediate filaments (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0005829 | cytosol | IDA | 21586138 |
| GO:0030027 | lamellipodium | ISS | -- |
| GO:0042995 | cell projection | IEA | -- |
Pathways & Interactions for SH3RF1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | TGF-Beta Pathway |
JNK Pathway
.51
|
|
| 3 | ERK Signaling |
MAPK Signaling
.58
|
|
| 4 | Apoptotic Pathways in Synovial Fibroblasts |
Rac1 Pathway
.65
|
|
| 5 | Innate Immune System |
.61
|
|
Pathways by source for SH3RF1 Gene
1 BioSystems pathway for SH3RF1 Gene
4 Reactome pathways for SH3RF1 Gene
3 Qiagen pathways for SH3RF1 Gene
- JNK Pathway
- MAPK Signaling
- Rac1 Pathway
UniProtKB/Swiss-Prot Q7Z6J0-SH3R1_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for SH3RF1 Gene
Selected Interacting proteins:
Q7Z6J0-SH3R1_HUMAN
ENSP00000284637
for SH3RF1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for SH3RF1
SIGNOR curated interactions for SH3RF1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001764 | neuron migration | ISS | -- |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0016032 | viral process | IEA | -- |
| GO:0016567 | protein ubiquitination | IEA | -- |
| GO:0043066 | negative regulation of apoptotic process | IMP | 21586138 |
Drugs & Compounds for SH3RF1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Guanosine triphosphate | Experimental | Pharma | 0 |
Transcripts for SH3RF1 Gene
mRNA/cDNA for SH3RF1 Gene
- 1 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000284637 5120 nts (view in UCSC)
- ENST00000502315 487 nts (view in UCSC)
- ENST00000508685 2020 nts (view in UCSC)
- ENST00000510806 591 nts (view in UCSC)
- ENST00000511421 1657 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SH3RF1 - Select products 50% OFF >
- * SH3RF1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SH3RF1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SH3RF1
-
Santa Cruz Biotechnology (SCBT) CRISPR for SH3RF1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SH3RF1
- Browse OriGene Inhibitory RNA Products For SH3RF1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SH3RF1
Clone Products
- Applied Biological Materials (abm): Clones for SH3RF1 - Select products 50% OFF >
- * SH3RF1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SH3RF1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SH3RF1
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ | 15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP7: |
Relevant External Links for SH3RF1 Gene
- GeneLoc Exon Structure for
- SH3RF1
Expression for SH3RF1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Mandibular Arch Muscles
- Muscle Progenitor Cells Hyoid Arch Muscles
-
Limb (Muscoskeletal System)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Ectoderm (Gastrulation Derivatives)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Peripheral Nervous System (Nervous System)
- Schwann Precursor Cells Peripheral Nerve Domain
-
Stomach (Gastrointestinal Tract)
This gene is overexpressed in Platelet (58.6) and Placenta (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SH3RF1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SH3RF1
SOURCE GeneReport for Unigene cluster for SH3RF1 Gene:
Hs.301804Evidence on tissue expression from TISSUES for SH3RF1 Gene
- Nervous system(4.6)
- Liver(4.3)
- Eye(4.2)
- Kidney(2.1)
Primer Products
-
OriGene qPCR primer pairs for SH3RF1
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SH3RF1 Gene
Orthologs for SH3RF1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SH3RF1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SH3RF1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Sh3rf1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Sh3rf1 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SH3RF1 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | SH3RF1 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SH3RF1 30 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | SH3RF1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | SH3RF1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | sh3rf1 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | sh3rf1 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | POSH 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | sorb-1 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | NBP2 33 |
|
|
|
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for SH3RF1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for SH3RF1 Gene
- ENSEMBL:
- Gene Tree for SH3RF1 (if available)
- TreeFam:
- Gene Tree for SH3RF1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SH3RF1: view image
Paralogs for SH3RF1 Gene
Paralogs for SH3RF1 Gene
(16) SIMAP similar genes for SH3RF1 Gene using alignment to 4 proteins:
- SH3R1_HUMAN
- D6RAL3_HUMAN
- D6RHX5_HUMAN
- H0YA90_HUMAN
Variants for SH3RF1 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1236515 | CNV | deletion | 17803354 |
| esv1943131 | CNV | deletion | 18987734 |
| esv2728720 | CNV | deletion | 23290073 |
| esv2728721 | CNV | deletion | 23290073 |
| esv2728722 | CNV | deletion | 23290073 |
| esv2728723 | CNV | deletion | 23290073 |
| esv3564979 | CNV | deletion | 23714750 |
| esv3564980 | CNV | deletion | 23714750 |
| esv3603115 | CNV | loss | 21293372 |
| nsv1112082 | CNV | deletion | 24896259 |
| nsv1120843 | CNV | deletion | 24896259 |
| nsv1128109 | CNV | deletion | 24896259 |
| nsv290567 | CNV | insertion | 16902084 |
| nsv4599 | CNV | insertion | 18451855 |
| nsv964112 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
15.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.94;
59.61% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SH3RF1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SH3RF1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH3RF1 Gene
Disorders for SH3RF1 Gene
Additional Disease Information for SH3RF1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for SH3RF1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH3RF1 Gene
Publications for SH3RF1 Gene
- Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex. (PMID: 14504284) Figueroa C … Vojtek AB (The Journal of biological chemistry 2003) 3 4 23
- POSH2 is a RING finger E3 ligase with Rac1 binding activity through a partial CRIB domain. (PMID: 20696164) Kärkkäinen S … Renkema GH (FEBS letters 2010) 3 4
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
- POSH stimulates the ubiquitination and the clathrin-independent endocytosis of ROMK1 channels. (PMID: 19710010) Lin DH … Wang WH (The Journal of biological chemistry 2009) 3 4
- Regulation of the Pro-apoptotic scaffolding protein POSH by Akt. (PMID: 17535800) Lyons TR … Kassenbrock CK (The Journal of biological chemistry 2007) 3 4
ExternalLinks
Products for SH3RF1 Gene
- Custom Antibody ServicesOriGene Antibodies for SH3RF1
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- Sino Biological Human cDNA Clone for SH3RF1
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- Novus Biologicals proteins and lysates for SH3RF1
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- VectorBuilder Virus packaging for SH3RF1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for SH3RF1
- antibodies-online: Show 14 available SH3RF1 Antibodies ranked by validation data
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- antibodies-online: Show 4 available SH3RF1 Proteins ranked by validation data
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- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for SH3RF1
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Sources for SH3RF1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
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- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB