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This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module. [provided by RefSeq, Jul 2008]
SH3RF1 (SH3 Domain Containing Ring Finger 1) is a Protein Coding gene. Among its related pathways are G13 Signaling Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is SH3RF3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005078 | MAP-kinase scaffold activity | ISS | -- |
GO:0005515 | protein binding | IPI | 20696164 |
GO:0016740 | transferase activity | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO:0061630 | ubiquitin protein ligase activity | IMP | 20696164 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005794 | Golgi apparatus | IEA | -- |
GO:0005829 | cytosol | IDA | 21586138 |
GO:0030027 | lamellipodium | ISS | -- |
GO:0042995 | cell projection | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Class I MHC mediated antigen processing and presentation | ||
2 | TGF-Beta Pathway |
JNK Pathway
.51
|
|
3 | ERK Signaling |
MAPK Signaling
.58
|
|
4 | Apoptotic Pathways in Synovial Fibroblasts |
Rac1 Pathway
.65
|
|
5 | Innate Immune System |
.61
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001764 | neuron migration | ISS | -- |
GO:0006915 | apoptotic process | IEA | -- |
GO:0016032 | viral process | IEA | -- |
GO:0016567 | protein ubiquitination | IEA | -- |
GO:0043066 | negative regulation of apoptotic process | IMP | 21586138 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Guanosine triphosphate | Experimental | Pharma | 0 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ | 15 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||||||||||||||
SP6: | - | ||||||||||||||||||||||||||||||||||||||||||
SP7: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SH3RF1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SH3RF1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Sh3rf1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Sh3rf1 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SH3RF1 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | SH3RF1 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SH3RF1 30 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SH3RF1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SH3RF1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | sh3rf1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | sh3rf1 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | POSH 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | sorb-1 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | NBP2 33 |
|
|
|
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1236515 | CNV | deletion | 17803354 |
esv1943131 | CNV | deletion | 18987734 |
esv2728720 | CNV | deletion | 23290073 |
esv2728721 | CNV | deletion | 23290073 |
esv2728722 | CNV | deletion | 23290073 |
esv2728723 | CNV | deletion | 23290073 |
esv3564979 | CNV | deletion | 23714750 |
esv3564980 | CNV | deletion | 23714750 |
esv3603115 | CNV | loss | 21293372 |
nsv1112082 | CNV | deletion | 24896259 |
nsv1120843 | CNV | deletion | 24896259 |
nsv1128109 | CNV | deletion | 24896259 |
nsv290567 | CNV | insertion | 16902084 |
nsv4599 | CNV | insertion | 18451855 |
nsv964112 | CNV | duplication | 23825009 |
No disorders were found for SH3RF1 Gene.