Aliases for SH3GL2 Gene
External Ids for SH3GL2 Gene
Previous GeneCards Identifiers for SH3GL2 Gene
GeneCards Summary for SH3GL2 Gene
SH3GL2 (SH3 Domain Containing GRB2 Like 2, Endophilin A1) is a Protein Coding gene. Diseases associated with SH3GL2 include Childhood Pilocytic Astrocytoma and Parkinson Disease, Late-Onset. Among its related pathways are Development HGF signaling pathway and Clathrin-mediated endocytosis. Gene Ontology (GO) annotations related to this gene include identical protein binding and lipid binding. An important paralog of this gene is SH3GL1.
UniProtKB/Swiss-Prot Summary for SH3GL2 Gene
Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes.