Aliases for SH3GL2 Gene
External Ids for SH3GL2 Gene
Previous GeneCards Identifiers for SH3GL2 Gene
GeneCards Summary for SH3GL2 Gene
SH3GL2 (SH3 Domain Containing GRB2 Like 2, Endophilin A1) is a Protein Coding gene. Diseases associated with SH3GL2 include Childhood Pilocytic Astrocytoma and Vulva Squamous Cell Carcinoma. Among its related pathways are Clathrin derived vesicle budding and Listeria monocytogenes entry into host cells. Gene Ontology (GO) annotations related to this gene include identical protein binding and lipid binding. An important paralog of this gene is SH3GL1.
UniProtKB/Swiss-Prot for SH3GL2 Gene
Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes.