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Aliases for SH3D21 Gene

Aliases for SH3D21 Gene

  • SH3 Domain Containing 21 2 3 5
  • C1orf113 3 4
  • SH3 Domain-Containing Protein C1orf113 3
  • Chromosome 1 Open Reading Frame 113 2
  • SH3 Domain-Containing Protein 21 3

External Ids for SH3D21 Gene

Previous HGNC Symbols for SH3D21 Gene

  • C1orf113

Previous GeneCards Identifiers for SH3D21 Gene

  • GC01P036772

Summaries for SH3D21 Gene

GeneCards Summary for SH3D21 Gene

SH3D21 (SH3 Domain Containing 21) is a Protein Coding gene. An important paralog of this gene is SH3KBP1.

Additional gene information for SH3D21 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3D21 Gene

Genomics for SH3D21 Gene

GeneHancer (GH) Regulatory Elements for SH3D21 Gene

Promoters and enhancers for SH3D21 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J036299 Promoter/Enhancer 2 Ensembl ENCODE dbSUPER 658.6 -1.9 -1943 8.8 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 SH3D21 AGO3 STK40 SNORA63C OSCP1 TRAPPC3 MAP7D1 LSM10 RNU4-27P LOC100128093
GH01J036320 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.4 +17.0 16985 5.4 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A YY1 ZNF766 CBX5 ZNF143 ENSG00000116883 EVA1B SH3D21 AGO3 GC01P036318
GH01J036384 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 16.9 +82.4 82407 7.8 CLOCK MLX FEZF1 DMAP1 YY1 E2F8 ZNF416 ZNF143 SP3 NFYC STK40 THRAP3 EVA1B AGO3 LOC105378647 TRAPPC3 ENSG00000116883 SH3D21 SNORA63C OSCP1
GH01J036339 Enhancer 1.1 Ensembl ENCODE dbSUPER 18.4 +36.7 36725 6.8 BCOR CTCF RB1 JUN ARID4B ZIC2 KDM3A ZNF48 RAD21 HIC1 PIR49451 SH3D21 SNORA63C OSCP1 LSM10 RNU4-27P MAP7D1 TRAPPC3 ENSG00000116883 PIR56403
GH01J036148 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.1 -154.9 -154878 4.9 ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 SP3 TRAPPC3 SFPQ MAP7D1 AGO3 THRAP3 COL8A2 RPL5P4 EVA1B STK40 ZMYM4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SH3D21 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SH3D21 Gene

Genomic Locations for SH3D21 Gene
19,161 bases
Plus strand
18,497 bases
Plus strand

Genomic View for SH3D21 Gene

Genes around SH3D21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH3D21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH3D21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3D21 Gene

Proteins for SH3D21 Gene

  • Protein details for SH3D21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH3 domain-containing protein 21
    Protein Accession:
    Secondary Accessions:
    • B4DLI6
    • D3DPS6
    • J3KQM5
    • Q5VTK7
    • Q86XZ6
    • Q8N445
    • Q96DN4
    • Q9H5W5

    Protein attributes for SH3D21 Gene

    640 amino acids
    Molecular mass:
    70519 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI01677.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAI01679.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAB15504.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB71191.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=CAH71860.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAX07375.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAX07376.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SH3D21 Gene


neXtProt entry for SH3D21 Gene

Post-translational modifications for SH3D21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SH3D21 Gene

Domains & Families for SH3D21 Gene

Gene Families for SH3D21 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SH3D21 Gene

Suggested Antigen Peptide Sequences for SH3D21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SH3D21: view

No data available for UniProtKB/Swiss-Prot for SH3D21 Gene

Function for SH3D21 Gene

Phenotypes From GWAS Catalog for SH3D21 Gene

Phenotypes for SH3D21 Gene

genes like me logo Genes that share phenotypes with SH3D21: view

Animal Model Products

miRNA for SH3D21 Gene

miRTarBase miRNAs that target SH3D21

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SH3D21 Gene

Localization for SH3D21 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SH3D21 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SH3D21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005886 plasma membrane IDA --
GO:0070062 extracellular exosome HDA --
genes like me logo Genes that share ontologies with SH3D21: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SH3D21 Gene

Pathways & Interactions for SH3D21 Gene

SuperPathways for SH3D21 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SH3D21 Gene


No data available for Pathways by source and SIGNOR curated interactions for SH3D21 Gene

Drugs & Compounds for SH3D21 Gene

No Compound Related Data Available

Transcripts for SH3D21 Gene

Unigene Clusters for SH3D21 Gene

SH3 domain containing 21:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH3D21 Gene

No ASD Table

Relevant External Links for SH3D21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SH3D21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SH3D21 Gene

mRNA differential expression in normal tissues according to GTEx for SH3D21 Gene

This gene is overexpressed in Thyroid (x6.1), Skin - Not Sun Exposed (Suprapubic) (x4.5), and Skin - Sun Exposed (Lower leg) (x4.0).

Protein differential expression in normal tissues from HIPED for SH3D21 Gene

This gene is overexpressed in Liver (64.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SH3D21 Gene

Protein tissue co-expression partners for SH3D21 Gene

NURSA nuclear receptor signaling pathways regulating expression of SH3D21 Gene:


SOURCE GeneReport for Unigene cluster for SH3D21 Gene:


Evidence on tissue expression from TISSUES for SH3D21 Gene

  • Nervous system(4.4)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with SH3D21: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SH3D21 Gene

Orthologs for SH3D21 Gene

This gene was present in the common ancestor of animals.

Orthologs for SH3D21 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SH3D21 34 33
  • 99.07 (n)
(Canis familiaris)
Mammalia SH3D21 34 33
  • 79.15 (n)
(Monodelphis domestica)
Mammalia SH3D21 34
  • 76 (a)
(Bos Taurus)
Mammalia SH3D21 34 33
  • 75.72 (n)
(Mus musculus)
Mammalia Sh3d21 16 34 33
  • 71.2 (n)
(Rattus norvegicus)
Mammalia Sh3d21 33
  • 67.13 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 28 (a)
(Anolis carolinensis)
Reptilia SH3D21 34
  • 23 (a)
(Danio rerio)
Actinopterygii SH3D21 34
  • 28 (a)
fruit fly
(Drosophila melanogaster)
Insecta cindr 34
  • 14 (a)
(Caenorhabditis elegans)
Secernentea Y44E3A.4 34
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 29 (a)
Species where no ortholog for SH3D21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SH3D21 Gene

Gene Tree for SH3D21 (if available)
Gene Tree for SH3D21 (if available)
Evolutionary constrained regions (ECRs) for SH3D21: view image

Paralogs for SH3D21 Gene

Paralogs for SH3D21 Gene

(3) SIMAP similar genes for SH3D21 Gene using alignment to 3 proteins:

  • SH321_HUMAN
  • D6RD64_HUMAN
genes like me logo Genes that share paralogs with SH3D21: view

Variants for SH3D21 Gene

Sequence variations from dbSNP and Humsavar for SH3D21 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000004463 -- 36,306,432(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000056539 -- 36,327,299(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000294102 -- 36,314,678(+) A/G intron_variant
rs1000297447 -- 36,322,118(+) C/G/T downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000429875 -- 36,321,480(+) C/T downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SH3D21 Gene

Variant ID Type Subtype PubMed ID
nsv834702 CNV loss 17160897
nsv545997 CNV loss 21841781
nsv444 CNV deletion 18451855
nsv1119678 CNV deletion 24896259
esv3585733 CNV loss 21293372
esv2758931 CNV loss 17122850

Variation tolerance for SH3D21 Gene

Gene Damage Index Score: 4.96; 68.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SH3D21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH3D21 Gene

Disorders for SH3D21 Gene

Additional Disease Information for SH3D21

No disorders were found for SH3D21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH3D21 Gene

Publications for SH3D21 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M … Moll S (Journal of proteomics 2013) 3 58
  5. Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra. (PMID: 17924679) Yu LR … Veenstra TD (Journal of proteome research 2007) 3 58

Products for SH3D21 Gene

Sources for SH3D21 Gene

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