Aliases for SH3BP5L Gene

Aliases for SH3BP5L Gene

  • SH3 Binding Domain Protein 5 Like 2 3 5
  • SH3 Domain-Binding Protein 5-Like 3 4
  • SH3BP-5-Like 3 4
  • KIAA1720 4

External Ids for SH3BP5L Gene

Previous GeneCards Identifiers for SH3BP5L Gene

  • GC01M245316
  • GC01M247071
  • GC01M249104

Summaries for SH3BP5L Gene

GeneCards Summary for SH3BP5L Gene

SH3BP5L (SH3 Binding Domain Protein 5 Like) is a Protein Coding gene. An important paralog of this gene is SH3BP5.

UniProtKB/Swiss-Prot Summary for SH3BP5L Gene

Additional gene information for SH3BP5L Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SH3BP5L Gene

Genomics for SH3BP5L Gene

GeneHancer (GH) Regulatory Elements for SH3BP5L Gene

Promoters and enhancers for SH3BP5L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SH3BP5L on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SH3BP5L

Top Transcription factor binding sites by QIAGEN in the SH3BP5L gene promoter:
  • AML1a
  • C/EBPalpha
  • CREB
  • deltaCREB
  • ER-alpha
  • Evi-1
  • Nkx5-1
  • Olf-1
  • RSRFC4
  • Sox5

Genomic Locations for SH3BP5L Gene

Genomic Locations for SH3BP5L Gene
chr1:248,810,446-248,825,955
(GRCh38/hg38)
Size:
15,510 bases
Orientation:
Minus strand
chr1:249,104,648-249,120,832
(GRCh37/hg19)
Size:
16,185 bases
Orientation:
Minus strand

Genomic View for SH3BP5L Gene

Genes around SH3BP5L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH3BP5L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH3BP5L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3BP5L Gene

Proteins for SH3BP5L Gene

  • Protein details for SH3BP5L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L8J4-3BP5L_HUMAN
    Recommended name:
    SH3 domain-binding protein 5-like
    Protein Accession:
    Q7L8J4
    Secondary Accessions:
    • B4DQ94
    • Q96FI5
    • Q9BQH8
    • Q9C0E3

    Protein attributes for SH3BP5L Gene

    Size:
    393 amino acids
    Molecular mass:
    43499 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB21811.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SH3BP5L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SH3BP5L Gene

Post-translational modifications for SH3BP5L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SH3BP5L Gene

No data available for DME Specific Peptides for SH3BP5L Gene

Domains & Families for SH3BP5L Gene

Gene Families for SH3BP5L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SH3BP5L Gene

Blocks:
  • SH3-binding 5
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SH3BP5L Gene

GenScript: Design optimal peptide antigens:
  • SH3 domain-binding protein 5-like (3BP5L_HUMAN)
  • cDNA FLJ56359, highly similar to Homo sapiens SH3-binding domain protein 5-like (SH3BP5L), mRNA (B4DQ94_HUMAN)
  • SH3BP5L protein (Q96ET3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7L8J4

UniProtKB/Swiss-Prot:

3BP5L_HUMAN :
  • Belongs to the SH3BP5 family.
Family:
  • Belongs to the SH3BP5 family.
genes like me logo Genes that share domains with SH3BP5L: view

Function for SH3BP5L Gene

Molecular function for SH3BP5L Gene

UniProtKB/Swiss-Prot Function:
Functions as guanine nucleotide exchange factor (GEF) for RAB11A.

Phenotypes From GWAS Catalog for SH3BP5L Gene

Gene Ontology (GO) - Molecular Function for SH3BP5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity IBA 21873635
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
GO:0005515 protein binding IPI 15161933
GO:0017112 Rab guanyl-nucleotide exchange factor activity IDA 30217979
genes like me logo Genes that share ontologies with SH3BP5L: view
genes like me logo Genes that share phenotypes with SH3BP5L: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SH3BP5L Gene

Localization for SH3BP5L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SH3BP5L gene
Compartment Confidence
nucleus 3
golgi apparatus 2
endosome 1
cytosol 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SH3BP5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with SH3BP5L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SH3BP5L Gene

Pathways & Interactions for SH3BP5L Gene

PathCards logo

SuperPathways for SH3BP5L Gene

No Data Available

Gene Ontology (GO) - Biological Process for SH3BP5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035556 intracellular signal transduction IBA 21873635
GO:0061099 negative regulation of protein tyrosine kinase activity IBA 21873635
genes like me logo Genes that share ontologies with SH3BP5L: view

No data available for Pathways by source and SIGNOR curated interactions for SH3BP5L Gene

Drugs & Compounds for SH3BP5L Gene

No Compound Related Data Available

Transcripts for SH3BP5L Gene

mRNA/cDNA for SH3BP5L Gene

4 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH3BP5L Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c
SP1: -
SP2: - - - - - -
SP3:
SP4: - - - - - - - - - - - - - -
SP5: -

Relevant External Links for SH3BP5L Gene

GeneLoc Exon Structure for
SH3BP5L

Expression for SH3BP5L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SH3BP5L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SH3BP5L Gene

This gene is overexpressed in Whole Blood (x4.4).

Protein differential expression in normal tissues from HIPED for SH3BP5L Gene

This gene is overexpressed in Peripheral blood mononuclear cells (31.9) and Prostate (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SH3BP5L Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SH3BP5L

SOURCE GeneReport for Unigene cluster for SH3BP5L Gene:

Hs.298573

Evidence on tissue expression from TISSUES for SH3BP5L Gene

  • Nervous system(4.8)
  • Lung(4.3)
  • Intestine(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with SH3BP5L: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SH3BP5L Gene

Orthologs for SH3BP5L Gene

This gene was present in the common ancestor of animals.

Orthologs for SH3BP5L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SH3BP5L 31 30
  • 99.41 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Sh3bp5l 17 31 30
  • 86.99 (n)
rat
(Rattus norvegicus)
Mammalia Sh3bp5l 30
  • 86.82 (n)
cow
(Bos Taurus)
Mammalia SH3BP5L 31 30
  • 86.63 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SH3BP5L 31
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SH3BP5L 31 30
  • 85.29 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SH3BP5L 31
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sh3bp5l 30
  • 66.55 (n)
zebrafish
(Danio rerio)
Actinopterygii sh3bp5lb 31 30
  • 68.05 (n)
OneToMany
sh3bp5la 31
  • 45 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta pcs 31
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C03C10.4 31
  • 26 (a)
OneToMany
K03E6.7 31
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 28 (a)
OneToOne
Species where no ortholog for SH3BP5L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SH3BP5L Gene

ENSEMBL:
Gene Tree for SH3BP5L (if available)
TreeFam:
Gene Tree for SH3BP5L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SH3BP5L: view image

Paralogs for SH3BP5L Gene

Paralogs for SH3BP5L Gene

(1) SIMAP similar genes for SH3BP5L Gene using alignment to 3 proteins:

  • 3BP5L_HUMAN
  • B4DQ94_HUMAN
  • Q96ET3_HUMAN
genes like me logo Genes that share paralogs with SH3BP5L: view

Variants for SH3BP5L Gene

Additional dbSNP identifiers (rs#s) for SH3BP5L Gene

Structural Variations from Database of Genomic Variants (DGV) for SH3BP5L Gene

Variant ID Type Subtype PubMed ID
dgv631n100 CNV gain 25217958
esv2145823 CNV deletion 18987734
esv2750832 CNV gain 17911159
esv2750835 CNV gain 17911159
nsv1009216 CNV gain 25217958
nsv5398 CNV insertion 18451855
nsv999043 CNV gain 25217958

Variation tolerance for SH3BP5L Gene

Residual Variation Intolerance Score: 13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SH3BP5L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SH3BP5L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SH3BP5L Gene

Disorders for SH3BP5L Gene

Additional Disease Information for SH3BP5L

No disorders were found for SH3BP5L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH3BP5L Gene

Publications for SH3BP5L Gene

  1. Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5. (PMID: 30217979) Jenkins ML … Burke JE (Nature communications 2018) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 54
  4. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 54
  5. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 54

Products for SH3BP5L Gene

Sources for SH3BP5L Gene