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Aliases for SH3BP5L Gene

Aliases for SH3BP5L Gene

  • SH3 Binding Domain Protein 5 Like 2 3 5
  • SH3BP-5-Like 3 4
  • SH3 Domain-Binding Protein 5-Like 3
  • KIAA1720 4

External Ids for SH3BP5L Gene

Previous GeneCards Identifiers for SH3BP5L Gene

  • GC01M245316
  • GC01M247071
  • GC01M249104

Summaries for SH3BP5L Gene

GeneCards Summary for SH3BP5L Gene

SH3BP5L (SH3 Binding Domain Protein 5 Like) is a Protein Coding gene. An important paralog of this gene is SH3BP5.

Additional gene information for SH3BP5L Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3BP5L Gene

Genomics for SH3BP5L Gene

GeneHancer (GH) Regulatory Elements for SH3BP5L Gene

Promoters and enhancers for SH3BP5L Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I248820 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 565.3 +1.7 1693 9.8 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 SH3BP5L MIR3124 PGBD2 ENSG00000227237 ZNF692 RNU6-1205P RPL23AP25 GC01P248810
GH01I248871 Enhancer 1.5 Ensembl ENCODE dbSUPER 18.5 -46.7 -46661 3.2 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 PGBD2 PIR45492 TRE-CTC2-1 TRL-CAA4-1 SH3BP5L ZNF692 RNU6-1205P
GH01I248803 Enhancer 1 Ensembl ENCODE 20.5 +21.1 21119 3.9 HDGF RB1 BATF IRF4 ZNF48 RAD21 ARID2 ZNF207 ZNF143 BCLAF1 SH3BP5L RNU6-1205P OR2T1 GC01P248810 LOC100131533
GH01I248924 Enhancer 1.1 Ensembl ENCODE 10.7 -99.3 -99312 2.5 HDAC1 HDGF PKNOX1 ATF1 TAF9B ARNT BATF RAD21 RFX5 TCF12 ZNF672 ENSG00000227237 ZNF692 PGBD2 SH3BP5L PIR45582 PIR40629 GC01P248921
GH01I248862 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 6.5 -36.7 -36668 1.4 ATF1 RB1 ARID4B SIN3A DMAP1 ZNF48 ZSCAN9 RARA YY1 ZNF335 SH3BP5L ZNF692 OR14I1 ZNF672 ENSG00000227237 PGBD2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SH3BP5L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SH3BP5L gene promoter:

Genomic Locations for SH3BP5L Gene

Genomic Locations for SH3BP5L Gene
16,188 bases
Minus strand

Genomic View for SH3BP5L Gene

Genes around SH3BP5L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH3BP5L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH3BP5L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3BP5L Gene

Proteins for SH3BP5L Gene

  • Protein details for SH3BP5L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH3 domain-binding protein 5-like
    Protein Accession:
    Secondary Accessions:
    • B4DQ94
    • Q96FI5
    • Q9BQH8
    • Q9C0E3

    Protein attributes for SH3BP5L Gene

    393 amino acids
    Molecular mass:
    43499 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB21811.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SH3BP5L Gene


neXtProt entry for SH3BP5L Gene

Post-translational modifications for SH3BP5L Gene

No Post-translational modifications

Other Protein References for SH3BP5L Gene

No data available for DME Specific Peptides for SH3BP5L Gene

Domains & Families for SH3BP5L Gene

Gene Families for SH3BP5L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SH3BP5L Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SH3BP5 family.
  • Belongs to the SH3BP5 family.
genes like me logo Genes that share domains with SH3BP5L: view

Function for SH3BP5L Gene

Phenotypes From GWAS Catalog for SH3BP5L Gene

Gene Ontology (GO) - Molecular Function for SH3BP5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity IBA --
GO:0017124 SH3 domain binding IBA --
genes like me logo Genes that share ontologies with SH3BP5L: view
genes like me logo Genes that share phenotypes with SH3BP5L: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SH3BP5L Gene

Localization for SH3BP5L Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SH3BP5L gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SH3BP5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with SH3BP5L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SH3BP5L Gene

Pathways & Interactions for SH3BP5L Gene

SuperPathways for SH3BP5L Gene

No Data Available

Interacting Proteins for SH3BP5L Gene

Gene Ontology (GO) - Biological Process for SH3BP5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035556 intracellular signal transduction IBA --
GO:0061099 negative regulation of protein tyrosine kinase activity IBA --
genes like me logo Genes that share ontologies with SH3BP5L: view

No data available for Pathways by source and SIGNOR curated interactions for SH3BP5L Gene

Drugs & Compounds for SH3BP5L Gene

No Compound Related Data Available

Transcripts for SH3BP5L Gene

Unigene Clusters for SH3BP5L Gene

SH3-binding domain protein 5-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH3BP5L Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c
SP1: -
SP2: - - - - - -
SP4: - - - - - - - - - - - - - -
SP5: -

Relevant External Links for SH3BP5L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SH3BP5L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SH3BP5L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SH3BP5L Gene

This gene is overexpressed in Whole Blood (x4.4).

Protein differential expression in normal tissues from HIPED for SH3BP5L Gene

This gene is overexpressed in Peripheral blood mononuclear cells (31.9) and Prostate (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SH3BP5L Gene

NURSA nuclear receptor signaling pathways regulating expression of SH3BP5L Gene:


SOURCE GeneReport for Unigene cluster for SH3BP5L Gene:


Evidence on tissue expression from TISSUES for SH3BP5L Gene

  • Nervous system(4.8)
  • Lung(4.3)
  • Intestine(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with SH3BP5L: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SH3BP5L Gene

Orthologs for SH3BP5L Gene

This gene was present in the common ancestor of animals.

Orthologs for SH3BP5L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SH3BP5L 33 34
  • 99.41 (n)
(Mus musculus)
Mammalia Sh3bp5l 33 16 34
  • 86.99 (n)
(Rattus norvegicus)
Mammalia Sh3bp5l 33
  • 86.82 (n)
(Bos Taurus)
Mammalia SH3BP5L 33 34
  • 86.63 (n)
(Monodelphis domestica)
Mammalia SH3BP5L 34
  • 86 (a)
(Canis familiaris)
Mammalia SH3BP5L 33 34
  • 85.29 (n)
(Anolis carolinensis)
Reptilia SH3BP5L 34
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sh3bp5l 33
  • 66.55 (n)
(Danio rerio)
Actinopterygii sh3bp5lb 33 34
  • 68.05 (n)
sh3bp5la 34
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta pcs 34
  • 28 (a)
(Caenorhabditis elegans)
Secernentea C03C10.4 34
  • 26 (a)
K03E6.7 34
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
Species where no ortholog for SH3BP5L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SH3BP5L Gene

Gene Tree for SH3BP5L (if available)
Gene Tree for SH3BP5L (if available)

Paralogs for SH3BP5L Gene

Paralogs for SH3BP5L Gene

(1) SIMAP similar genes for SH3BP5L Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SH3BP5L: view

Variants for SH3BP5L Gene

Sequence variations from dbSNP and Humsavar for SH3BP5L Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000285507 -- 248,814,141(-) AAA/AAAA intron_variant
rs1000603834 -- 248,811,366(-) G/C 3_prime_UTR_variant
rs1000808697 -- 248,811,125(-) G/A 3_prime_UTR_variant
rs1000903703 -- 248,818,098(-) A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000977060 -- 248,827,552(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SH3BP5L Gene

Variant ID Type Subtype PubMed ID
dgv631n100 CNV gain 25217958
esv2145823 CNV deletion 18987734
esv2750832 CNV gain 17911159
esv2750835 CNV gain 17911159
nsv1009216 CNV gain 25217958
nsv5398 CNV insertion 18451855
nsv999043 CNV gain 25217958

Variation tolerance for SH3BP5L Gene

Residual Variation Intolerance Score: 13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SH3BP5L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH3BP5L Gene

Disorders for SH3BP5L Gene

Additional Disease Information for SH3BP5L

No disorders were found for SH3BP5L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH3BP5L Gene

Publications for SH3BP5L Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  3. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58
  4. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for SH3BP5L Gene

Sources for SH3BP5L Gene

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