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Aliases for SH3BGRL Gene

Aliases for SH3BGRL Gene

  • SH3 Domain Binding Glutamate Rich Protein Like 2 3 5
  • SH3 Domain Binding Glutamic Acid-Rich Protein Like 2 3
  • SH3 Domain-Binding Glutamic Acid-Rich-Like Protein 3
  • SH3-Binding Domain Glutamic Acid-Rich Protein Like 3
  • Epididymis Secretory Protein Li 115 3
  • HEL-S-115 3
  • SH3BGR 3

External Ids for SH3BGRL Gene

Previous GeneCards Identifiers for SH3BGRL Gene

  • GC0XP076003
  • GC0XP077419
  • GC0XP078498
  • GC0XP079213
  • GC0XP080263
  • GC0XP080457
  • GC0XP074037

Summaries for SH3BGRL Gene

GeneCards Summary for SH3BGRL Gene

SH3BGRL (SH3 Domain Binding Glutamate Rich Protein Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include SH3 domain binding and SH3/SH2 adaptor activity. An important paralog of this gene is SH3BGR.

Gene Wiki entry for SH3BGRL Gene

Additional gene information for SH3BGRL Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3BGRL Gene

Genomics for SH3BGRL Gene

GeneHancer (GH) Regulatory Elements for SH3BGRL Gene

Promoters and enhancers for SH3BGRL Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI081200 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.8 +1.0 960 3.7 BRCA1 YY1 TCF12 ZNF143 ATF7 ZNF548 IKZF2 SMAD5 ELF1 REST SH3BGRL HMGN5 BRWD3 GC0XP081328
GH0XI081120 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 5.1 -80.5 -80504 2.6 PKNOX1 DEAF1 RAD21 YY1 RFX5 ZNF335 ZNF366 SCRT2 FOS CREM HMGN5 BRWD3 LOC100422286 SH3BGRL GC0XP081187 GC0XP081188 GC0XP081189 GC0XP081190 GC0XP081191 PIR53765
GH0XI081258 Enhancer 0.5 Ensembl ENCODE 5 +57.5 57497 1.4 ATF2 SH3BGRL HMGN5 GC0XP081328
GH0XI081002 Enhancer 0.2 Ensembl 6.1 -198.7 -198703 1.4 ENSG00000284618 SH3BGRL GC0XP080988
GH0XI081208 Enhancer 0.5 ENCODE 0.4 +6.8 6833 0.2 ZNF217 CTBP1 GATA3 CUX1 FOXA1 TCF7L2 HMGN5 SH3BGRL GC0XP081328
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SH3BGRL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SH3BGRL gene promoter:

Genomic Locations for SH3BGRL Gene

Genomic Locations for SH3BGRL Gene
96,744 bases
Plus strand

Genomic View for SH3BGRL Gene

Genes around SH3BGRL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH3BGRL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH3BGRL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3BGRL Gene

Proteins for SH3BGRL Gene

  • Protein details for SH3BGRL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH3 domain-binding glutamic acid-rich-like protein
    Protein Accession:
    Secondary Accessions:
    • Q3SYL1
    • Q5JT50
    • Q6FIE8
    • Q9H0N8

    Protein attributes for SH3BGRL Gene

    114 amino acids
    Molecular mass:
    12774 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SH3BGRL Gene

neXtProt entry for SH3BGRL Gene

Post-translational modifications for SH3BGRL Gene

  • Ubiquitination at posLast=111111
  • Modification sites at PhosphoSitePlus

Other Protein References for SH3BGRL Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for SH3BGRL
  • Santa Cruz Biotechnology (SCBT) Antibodies for SH3BGRL

No data available for DME Specific Peptides for SH3BGRL Gene

Domains & Families for SH3BGRL Gene

Gene Families for SH3BGRL Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SH3BGRL Gene

Suggested Antigen Peptide Sequences for SH3BGRL Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SH3BGR family.
  • Belongs to the SH3BGR family.
genes like me logo Genes that share domains with SH3BGRL: view

Function for SH3BGRL Gene

Molecular function for SH3BGRL Gene

GENATLAS Biochemistry:
SH3 domain binding,glutamic acid protein-like,widely expressed

Gene Ontology (GO) - Molecular Function for SH3BGRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity TAS 9642120
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with SH3BGRL: view

Phenotypes for SH3BGRL Gene

GenomeRNAi human phenotypes for SH3BGRL:
genes like me logo Genes that share phenotypes with SH3BGRL: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SH3BGRL Gene

Localization for SH3BGRL Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SH3BGRL gene
Compartment Confidence
extracellular 5
nucleus 5
mitochondrion 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SH3BGRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA,IDA 23580065
GO:0005634 nucleus TAS 16130169
GO:0005737 cytoplasm TAS 16130169
GO:0070062 extracellular exosome IDA,HDA 19056867
genes like me logo Genes that share ontologies with SH3BGRL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SH3BGRL Gene

Pathways & Interactions for SH3BGRL Gene

SuperPathways for SH3BGRL Gene

No Data Available

Gene Ontology (GO) - Biological Process for SH3BGRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009967 positive regulation of signal transduction IEA --
genes like me logo Genes that share ontologies with SH3BGRL: view

No data available for Pathways by source and SIGNOR curated interactions for SH3BGRL Gene

Drugs & Compounds for SH3BGRL Gene

No Compound Related Data Available

Transcripts for SH3BGRL Gene

Unigene Clusters for SH3BGRL Gene

SH3 domain binding glutamic acid-rich protein like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH3BGRL Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - -
SP5: - - - - - - -
SP6: -
SP7: - - - - -

Relevant External Links for SH3BGRL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SH3BGRL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SH3BGRL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SH3BGRL Gene

Protein tissue co-expression partners for SH3BGRL Gene

NURSA nuclear receptor signaling pathways regulating expression of SH3BGRL Gene:


SOURCE GeneReport for Unigene cluster for SH3BGRL Gene:


mRNA Expression by UniProt/SwissProt for SH3BGRL Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for SH3BGRL Gene

  • Nervous system(4.9)
  • Kidney(4.5)
  • Bone marrow(4.4)
  • Lung(3.5)
  • Heart(2.3)
  • Gall bladder(2.1)
  • Lymph node(2.1)
  • Muscle(2.1)
  • Blood(2)
  • Spleen(2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with SH3BGRL: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SH3BGRL Gene

Orthologs for SH3BGRL Gene

This gene was present in the common ancestor of animals.

Orthologs for SH3BGRL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SH3BGRL 33 34
  • 99.71 (n)
(Monodelphis domestica)
Mammalia SH3BGRL 34
  • 96 (a)
(Bos Taurus)
Mammalia SH3BGRL 33 34
  • 94.15 (n)
(Canis familiaris)
Mammalia SH3BGRL 33 34
  • 93.57 (n)
(Rattus norvegicus)
Mammalia Sh3bgrl 33
  • 92.98 (n)
(Mus musculus)
Mammalia Sh3bgrl 33 16 34
  • 92.69 (n)
(Ornithorhynchus anatinus)
Mammalia SH3BGRL 34
  • 91 (a)
(Gallus gallus)
Aves SH3BGRL 33 34
  • 80.12 (n)
(Anolis carolinensis)
Reptilia SH3BGRL 34
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sh3bgrl 33
  • 78.95 (n)
(Danio rerio)
Actinopterygii SH3BGRL 34
  • 77 (a)
zgc:64130 33
  • 72.02 (n)
zgc64130 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8940 33
fruit fly
(Drosophila melanogaster)
Insecta Sh3beta 34
  • 9 (a)
(Caenorhabditis elegans)
Secernentea Y105E8A.1 34
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
Species where no ortholog for SH3BGRL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SH3BGRL Gene

Gene Tree for SH3BGRL (if available)
Gene Tree for SH3BGRL (if available)

Paralogs for SH3BGRL Gene

Paralogs for SH3BGRL Gene

(4) SIMAP similar genes for SH3BGRL Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SH3BGRL: view

Variants for SH3BGRL Gene

Sequence variations from dbSNP and Humsavar for SH3BGRL Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000047803 -- 81,207,116(+) G/T genic_upstream_transcript_variant, intron_variant
rs1000055491 -- 81,232,605(+) CTCTCTCTCTCTC/CTCTCTCTCTCTCTC genic_upstream_transcript_variant, intron_variant
rs1000070790 -- 81,206,640(+) T/G genic_upstream_transcript_variant, intron_variant
rs1000102812 -- 81,293,727(+) G/A intron_variant
rs1000167202 -- 81,296,873(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SH3BGRL Gene

Variant ID Type Subtype PubMed ID
esv2674896 CNV deletion 23128226
esv3574122 CNV loss 25503493
nsv6973 CNV insertion 18451855

Variation tolerance for SH3BGRL Gene

Residual Variation Intolerance Score: 46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SH3BGRL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH3BGRL Gene

Disorders for SH3BGRL Gene

Additional Disease Information for SH3BGRL

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SH3BGRL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH3BGRL Gene

Publications for SH3BGRL Gene

  1. Identification and characterization of a new human gene encoding a small protein with high homology to the proline-rich region of the SH3BGR gene. (PMID: 9642120) Egeo A … Scartezzini P (Biochemical and biophysical research communications 1998) 2 3 4 22 58
  2. Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes. (PMID: 20532202) Naukkarinen J … ENGAGE Consortium (PLoS genetics 2010) 3 44 58
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  4. Crystal structure of human SH3BGRL protein: the first structure of the human SH3BGR family representing a novel class of thioredoxin fold proteins. (PMID: 16080146) Yin L … Wang DC (Proteins 2005) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for SH3BGRL Gene

Sources for SH3BGRL Gene

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