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Aliases for SH2D7 Gene

Aliases for SH2D7 Gene

  • SH2 Domain Containing 7 2 3 5
  • Putative SH2 Domain-Containing Protein LOC646892 3
  • SH2 Domain-Containing Protein 7 3
  • HCG38941 3

External Ids for SH2D7 Gene

Previous GeneCards Identifiers for SH2D7 Gene

  • GC15P076158
  • GC15P078370
  • GC15P055142

Summaries for SH2D7 Gene

GeneCards Summary for SH2D7 Gene

SH2D7 (SH2 Domain Containing 7) is a Protein Coding gene. An important paralog of this gene is SH2D2A.

Additional gene information for SH2D7 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH2D7 Gene

Genomics for SH2D7 Gene

GeneHancer (GH) Regulatory Elements for SH2D7 Gene

Promoters and enhancers for SH2D7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I078092 Promoter/Enhancer 1 EPDnew ENCODE 550.4 +15.6 15596 2.1 JUND POLR2A ZNF341 RCOR1 FOS RAD21 SH2D7 LOC645752 GC15M078092 ENSG00000199633 PIR50456 GC15M078021
GH15I078146 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.7 +70.8 70830 5.2 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A IRF4 YY1 POLR2B ZNF213 IDH3A SH2D7 TBC1D2B ENSG00000199633 CIB2 ENSG00000260988 GC15P078155 GC15M078021
GH15I078046 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 13.1 -24.5 -24464 14.3 HDGF IRF4 THRB ZNF48 SCRT2 ZNF143 ATF7 RCOR1 ETV6 FOS TBC1D2B LOC645752 SH2D7 ADAMTS7P3 ENSG00000199633 CIB2 LOC440292 IREB2 GC15M078026 PIR50223
GH15I078042 Enhancer 1.2 Ensembl ENCODE dbSUPER 13 -33.8 -33797 3.9 HDGF PKNOX1 SMAD1 INSM2 FEZF1 ZBTB40 ZNF2 ZNF366 ATF7 IKZF2 LOC645752 TBC1D2B SH2D7 ENSG00000199633 ADAMTS7P3 CIB2 GC15M078026 PIR50223 GC15M078021
GH15I077943 Promoter/Enhancer 1.5 Ensembl ENCODE 10.3 -133.3 -133344 1.5 ZFP64 ARID4B DMAP1 ZNF48 GLIS2 ATF7 SP3 RXRA SP5 NCOA1 LOC440292 LOC645752 ENSG00000259562 TBC1D2B IREB2 WDR61 ENSG00000260988 SH2D7 ENSG00000199633
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SH2D7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SH2D7 gene promoter:

Genomic Locations for SH2D7 Gene

Genomic Locations for SH2D7 Gene
chr15:78,077,805-78,104,909
(GRCh38/hg38)
Size:
27,105 bases
Orientation:
Plus strand
chr15:78,370,150-78,397,251
(GRCh37/hg19)

Genomic View for SH2D7 Gene

Genes around SH2D7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH2D7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH2D7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH2D7 Gene

Proteins for SH2D7 Gene

  • Protein details for SH2D7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NKC9-SH2D7_HUMAN
    Recommended name:
    SH2 domain-containing protein 7
    Protein Accession:
    A6NKC9

    Protein attributes for SH2D7 Gene

    Size:
    451 amino acids
    Molecular mass:
    49807 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SH2D7 Gene

Post-translational modifications for SH2D7 Gene

No Post-translational modifications

Other Protein References for SH2D7 Gene

No data available for DME Specific Peptides for SH2D7 Gene

Domains & Families for SH2D7 Gene

Gene Families for SH2D7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SH2D7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SH2D7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SH2D7: view

No data available for UniProtKB/Swiss-Prot for SH2D7 Gene

Function for SH2D7 Gene

Phenotypes From GWAS Catalog for SH2D7 Gene

Phenotypes for SH2D7 Gene

GenomeRNAi human phenotypes for SH2D7:
genes like me logo Genes that share phenotypes with SH2D7: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SH2D7 Gene

Localization for SH2D7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SH2D7 gene
Compartment Confidence
nucleus 3
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SH2D7 Gene

Pathways & Interactions for SH2D7 Gene

SuperPathways for SH2D7 Gene

No Data Available

Interacting Proteins for SH2D7 Gene

Gene Ontology (GO) - Biological Process for SH2D7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SH2D7 Gene

Drugs & Compounds for SH2D7 Gene

No Compound Related Data Available

Transcripts for SH2D7 Gene

mRNA/cDNA for SH2D7 Gene

(6) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SH2D7 Gene

SH2 domain containing 7:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH2D7 Gene

No ASD Table

Relevant External Links for SH2D7 Gene

GeneLoc Exon Structure for
SH2D7
ECgene alternative splicing isoforms for
SH2D7

Expression for SH2D7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SH2D7 Gene

mRNA differential expression in normal tissues according to GTEx for SH2D7 Gene

This gene is overexpressed in Testis (x14.2), Colon - Transverse (x8.8), and Small Intestine - Terminal Ileum (x5.0).

Protein differential expression in normal tissues from HIPED for SH2D7 Gene

This gene is overexpressed in Adipocyte (61.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SH2D7 Gene



Protein tissue co-expression partners for SH2D7 Gene

NURSA nuclear receptor signaling pathways regulating expression of SH2D7 Gene:

SH2D7

SOURCE GeneReport for Unigene cluster for SH2D7 Gene:

Hs.569511
genes like me logo Genes that share expression patterns with SH2D7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SH2D7 Gene

Orthologs for SH2D7 Gene

This gene was present in the common ancestor of animals.

Orthologs for SH2D7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SH2D7 33 34
  • 90.17 (n)
cow
(Bos Taurus)
Mammalia SH2D7 33 34
  • 79.97 (n)
rat
(Rattus norvegicus)
Mammalia Sh2d7 33
  • 76.54 (n)
mouse
(Mus musculus)
Mammalia Sh2d7 33 16 34
  • 76.36 (n)
dog
(Canis familiaris)
Mammalia SH2D7 33 34
  • 73.2 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 41 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii SH2D7 (1 of 2) 34
  • 3 (a)
OneToMany
SH2D7 (2 of 2) 34
  • 3 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F13B12.6 34
  • 8 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 7 (a)
OneToMany
Species where no ortholog for SH2D7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SH2D7 Gene

ENSEMBL:
Gene Tree for SH2D7 (if available)
TreeFam:
Gene Tree for SH2D7 (if available)

Paralogs for SH2D7 Gene

Paralogs for SH2D7 Gene

genes like me logo Genes that share paralogs with SH2D7: view

Variants for SH2D7 Gene

Sequence variations from dbSNP and Humsavar for SH2D7 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000086620 -- 78,095,561(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000229205 -- 78,089,927(+) G/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000359340 -- 78,095,859(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000530432 -- 78,100,334(+) T/A/C intron_variant
rs1000568180 -- 78,091,360(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SH2D7 Gene

Variant ID Type Subtype PubMed ID
nsv1116464 OTHER inversion 24896259
esv3636978 CNV loss 21293372

Variation tolerance for SH2D7 Gene

Residual Variation Intolerance Score: 94.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.30; 53.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SH2D7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SH2D7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH2D7 Gene

Disorders for SH2D7 Gene

Additional Disease Information for SH2D7

No disorders were found for SH2D7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH2D7 Gene

Publications for SH2D7 Gene

  1. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 3 4 58
  2. The sequence of the human genome. (PMID: 11181995) Venter JC … Zhu X (Science (New York, N.Y.) 2001) 3 58

Products for SH2D7 Gene

Sources for SH2D7 Gene

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