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Aliases for SH2D5 Gene

Aliases for SH2D5 Gene

  • SH2 Domain Containing 5 2 3 5

External Ids for SH2D5 Gene

Previous GeneCards Identifiers for SH2D5 Gene

  • GC01M020917
  • GC01M021046
  • GC01M019291

Summaries for SH2D5 Gene

GeneCards Summary for SH2D5 Gene

SH2D5 (SH2 Domain Containing 5) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SH2D5 Gene

  • May be involved in synaptic plasticity regulation through the control of Rac-GTP levels.

Additional gene information for SH2D5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH2D5 Gene

Genomics for SH2D5 Gene

GeneHancer (GH) Regulatory Elements for SH2D5 Gene

Promoters and enhancers for SH2D5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I020730 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 555 +0.5 533 4.2 PKNOX1 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 FOS SH2D5 ENSG00000233069 HP1BP3 EIF4G3 KIF17
GH01I020784 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.9 -54.0 -54030 4.2 HDGF PKNOX1 CLOCK SMAD1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 HP1BP3 EIF4G3 ENSG00000233069 SH2D5 GC01P020738
GH01I020678 Enhancer 0.7 Ensembl 11.1 +53.9 53936 0.6 EBF1 IRF4 RELA FOXK2 NFATC1 ATF7 ETV6 PRDM10 BCLAF1 IKZF2 PINK1 ENSG00000233069 SH2D5 CDA MUL1 ENSG00000235432 DDOST KIF17
GH01I020683 Enhancer 0.7 Ensembl ENCODE 11.1 +47.7 47709 2.6 ZSCAN4 MAX NR2F2 EGR2 PINK1 SH2D5 ENSG00000233069 UBXN10-AS1 EIF4G3 ENSG00000235432 DDOST KIF17
GH01I020932 Enhancer 0.7 ENCODE 10.5 -199.8 -199757 1.1 EBF1 BATF IRF4 ZNF316 NFATC1 ATF7 ETV6 MAFK IKZF2 RUNX3 HP1BP3 EIF4G3 ENSG00000233069 SH2D5 LOC105376829 MIR1256
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SH2D5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SH2D5 gene promoter:

Genomic Locations for SH2D5 Gene

Genomic Locations for SH2D5 Gene
13,107 bases
Minus strand

Genomic View for SH2D5 Gene

Genes around SH2D5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH2D5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH2D5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH2D5 Gene

Proteins for SH2D5 Gene

  • Protein details for SH2D5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH2 domain-containing protein 5
    Protein Accession:
    Secondary Accessions:
    • B7Z3W3
    • Q5SSJ2

    Protein attributes for SH2D5 Gene

    423 amino acids
    Molecular mass:
    46797 Da
    Quaternary structure:
    • Interacts with BCR.
    • Sequence=BAC85974.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI23392.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SH2D5 Gene


neXtProt entry for SH2D5 Gene

Post-translational modifications for SH2D5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SH2D5 Gene

Domains & Families for SH2D5 Gene

Gene Families for SH2D5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SH2D5 Gene

Suggested Antigen Peptide Sequences for SH2D5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SH2D5: view

No data available for UniProtKB/Swiss-Prot for SH2D5 Gene

Function for SH2D5 Gene

Molecular function for SH2D5 Gene

UniProtKB/Swiss-Prot Function:
May be involved in synaptic plasticity regulation through the control of Rac-GTP levels.

Phenotypes for SH2D5 Gene

MGI mutant phenotypes for SH2D5:
inferred from 1 alleles
GenomeRNAi human phenotypes for SH2D5:
genes like me logo Genes that share phenotypes with SH2D5: view

Animal Models for SH2D5 Gene

MGI Knock Outs for SH2D5:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SH2D5 Gene

Localization for SH2D5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SH2D5 Gene

Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SH2D5 gene
Compartment Confidence
plasma membrane 3
cytosol 3
nucleus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SH2D5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014069 postsynaptic density ISS --
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
GO:0045202 synapse IEA --
GO:0045211 postsynaptic membrane IEA --
genes like me logo Genes that share ontologies with SH2D5: view

Pathways & Interactions for SH2D5 Gene

SuperPathways for SH2D5 Gene

No Data Available

Interacting Proteins for SH2D5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q6ZV89-SH2D5_HUMAN ENSP00000406026 for SH2D5 Gene via IID STRING UniProtKB

Gene Ontology (GO) - Biological Process for SH2D5 Gene


No data available for Pathways by source and SIGNOR curated interactions for SH2D5 Gene

Drugs & Compounds for SH2D5 Gene

(1) Drugs for SH2D5 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Gemcitabine Approved Pharma Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 2100
genes like me logo Genes that share compounds with SH2D5: view

Transcripts for SH2D5 Gene

Unigene Clusters for SH2D5 Gene

SH2 domain containing 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH2D5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9
SP1: - -
SP3: -

Relevant External Links for SH2D5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SH2D5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SH2D5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SH2D5 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x8.4), Brain - Cortex (x7.3), Brain - Putamen (basal ganglia) (x6.2), Brain - Frontal Cortex (BA9) (x5.8), Brain - Caudate (basal ganglia) (x5.7), and Brain - Anterior cingulate cortex (BA24) (x4.8).

Protein differential expression in normal tissues from HIPED for SH2D5 Gene

This gene is overexpressed in Placenta (55.8) and Frontal cortex (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SH2D5 Gene

Protein tissue co-expression partners for SH2D5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SH2D5 Gene:


SOURCE GeneReport for Unigene cluster for SH2D5 Gene:


Evidence on tissue expression from TISSUES for SH2D5 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with SH2D5: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SH2D5 Gene

Orthologs for SH2D5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SH2D5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SH2D5 33 34
  • 97.97 (n)
(Canis familiaris)
Mammalia SH2D5 33 34
  • 89.05 (n)
(Bos Taurus)
Mammalia SH2D5 33 34
  • 88.42 (n)
(Mus musculus)
Mammalia Sh2d5 33 16 34
  • 84.95 (n)
(Rattus norvegicus)
Mammalia Sh2d5 33
  • 84.95 (n)
(Monodelphis domestica)
Mammalia SH2D5 34
  • 67 (a)
(Gallus gallus)
Aves SH2D5 33 34
  • 67.56 (n)
(Danio rerio)
Actinopterygii sh2d5 33 34
  • 53.82 (n)
Species where no ortholog for SH2D5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SH2D5 Gene

Gene Tree for SH2D5 (if available)
Gene Tree for SH2D5 (if available)

Paralogs for SH2D5 Gene

No data available for Paralogs for SH2D5 Gene

Variants for SH2D5 Gene

Sequence variations from dbSNP and Humsavar for SH2D5 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000069532 -- 20,731,308(-) A/C 5_prime_UTR_variant, intron_variant
rs1000131132 -- 20,731,232(-) T/G 5_prime_UTR_variant, intron_variant
rs1000184567 -- 20,724,034(-) GGG/GGGGG intron_variant
rs1000236633 -- 20,726,166(-) C/A intron_variant
rs1000294533 -- 20,731,646(-) T/A 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SH2D5 Gene

Variant ID Type Subtype PubMed ID
nsv520013 CNV loss 19592680
nsv545731 CNV gain 21841781
nsv834369 CNV loss 17160897

Variation tolerance for SH2D5 Gene

Residual Variation Intolerance Score: 58.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.54; 29.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SH2D5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH2D5 Gene

Disorders for SH2D5 Gene

Additional Disease Information for SH2D5

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SH2D5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH2D5 Gene

Publications for SH2D5 Gene

  1. Src homology 2 domain containing protein 5 (SH2D5) binds the breakpoint cluster region protein, BCR, and regulates levels of Rac1-GTP. (PMID: 25331951) Gray EJ … Pawson T (The Journal of biological chemistry 2014) 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for SH2D5 Gene

Sources for SH2D5 Gene

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