Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SH2D4B Gene

Aliases for SH2D4B Gene

  • SH2 Domain Containing 4B 2 3 5
  • SH2 Domain-Containing Protein 4B 3 4
  • Novel SH2 Domain-Containing Protein 3

External Ids for SH2D4B Gene

Previous GeneCards Identifiers for SH2D4B Gene

  • GC10P081962
  • GC10P082287
  • GC10P076140
  • GC10P082297
  • GC10P080634
  • GC10P080676
  • GC10P081965
  • GC10P080679
  • GC10P080692
  • GC10P080831
  • GC10P080914
  • GC10P081081
  • GC10P081094
  • GC10P081531
  • GC10P081858

Summaries for SH2D4B Gene

GeneCards Summary for SH2D4B Gene

SH2D4B (SH2 Domain Containing 4B) is a Protein Coding gene. Diseases associated with SH2D4B include Lymphocytic Vasculitis. An important paralog of this gene is SH2D4A.

Additional gene information for SH2D4B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH2D4B Gene

Genomics for SH2D4B Gene

GeneHancer (GH) Regulatory Elements for SH2D4B Gene

Promoters and enhancers for SH2D4B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J080535 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 600.7 -1.9 -1889 1.6 ZFX NKRF GTF2F1 ZNF687 ELF1 POLR2A SP1 MLLT1 RAD21 IKZF1 LOC101929574 SH2D4B TSPAN14
GH10J080537 Enhancer 0.7 ENCODE dbSUPER 600.7 -0.4 -442 0.2 CBFA2T2 IKZF1 NCOR1 RCOR1 TCF12 TAL1 CBFA2T3 LOC101929574 SH2D4B
GH10J080538 Enhancer 0.4 ENCODE dbSUPER 600.7 -0.8 -802 0.2 LOC101929574 SH2D4B
GH10J080539 Enhancer 1.1 FANTOM5 Ensembl ENCODE 18.8 +3.1 3070 3.3 ZNF687 MLLT1 IKZF1 PKNOX1 IKZF2 ZIC2 TRIM22 DPF2 EED RUNX3 SH2D4B LOC101929574 ANXA11 LOC105378387
GH10J080192 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.1 -336.6 -336625 16.8 ZFX CC2D1A SP1 CTCF ELF3 CBFA2T2 ZNF148 NKRF POLR2A MLLT1 ANXA11 MBL1P LOC642361 ENSG00000235858 LINC00857 ENSG00000272489 MAT1A DYDC2 PLAC9 SH2D4B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SH2D4B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SH2D4B gene promoter:
  • AML1a
  • FOXC1
  • Ik-3
  • IRF-1
  • Lhx3a
  • NRSF form 1
  • NRSF form 2
  • RSRFC4

Genomic Locations for SH2D4B Gene

Genomic Locations for SH2D4B Gene
108,659 bases
Plus strand
108,659 bases
Plus strand

Genomic View for SH2D4B Gene

Genes around SH2D4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH2D4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH2D4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH2D4B Gene

Proteins for SH2D4B Gene

  • Protein details for SH2D4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH2 domain-containing protein 4B
    Protein Accession:
    Secondary Accessions:
    • Q5SQS5
    • Q6ZVW9
    • Q6ZVZ3

    Protein attributes for SH2D4B Gene

    431 amino acids
    Molecular mass:
    51232 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SH2D4B Gene


neXtProt entry for SH2D4B Gene

Post-translational modifications for SH2D4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SH2D4B Gene

No data available for DME Specific Peptides for SH2D4B Gene

Domains & Families for SH2D4B Gene

Gene Families for SH2D4B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SH2D4B Gene


Suggested Antigen Peptide Sequences for SH2D4B Gene

GenScript: Design optimal peptide antigens:
  • SH2 domain-containing protein 4B (SH24B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SH2D4B: view

No data available for UniProtKB/Swiss-Prot for SH2D4B Gene

Function for SH2D4B Gene

Phenotypes From GWAS Catalog for SH2D4B Gene

genes like me logo Genes that share phenotypes with SH2D4B: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for SH2D4B - Now 50% OFF >
  • * SH2D4B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * SH2D4B tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SH2D4B Gene

Localization for SH2D4B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SH2D4B gene
Compartment Confidence
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for SH2D4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with SH2D4B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for SH2D4B Gene

Pathways & Interactions for SH2D4B Gene

PathCards logo

SuperPathways for SH2D4B Gene

No Data Available

Interacting Proteins for SH2D4B Gene

Gene Ontology (GO) - Biological Process for SH2D4B Gene


No data available for Pathways by source and SIGNOR curated interactions for SH2D4B Gene

Drugs & Compounds for SH2D4B Gene

(4) Drugs for SH2D4B Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for SH2D4B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SH2D4B: view

Transcripts for SH2D4B Gene

mRNA/cDNA for SH2D4B Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for SH2D4B Gene

SH2 domain containing 4B:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for SH2D4B - Now 50% OFF >
  • * SH2D4B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * SH2D4B tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for SH2D4B Gene

No ASD Table

Relevant External Links for SH2D4B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SH2D4B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SH2D4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SH2D4B Gene

This gene is overexpressed in Testis (x8.1) and Whole Blood (x5.9).

NURSA nuclear receptor signaling pathways regulating expression of SH2D4B Gene:


SOURCE GeneReport for Unigene cluster for SH2D4B Gene:

genes like me logo Genes that share expression patterns with SH2D4B: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SH2D4B Gene

Orthologs for SH2D4B Gene

This gene was present in the common ancestor of animals.

Orthologs for SH2D4B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SH2D4B 35 34
  • 99.35 (n)
(Bos Taurus)
Mammalia SH2D4B 35 34
  • 91.5 (n)
(Canis familiaris)
Mammalia SH2D4B 35 34
  • 90.48 (n)
(Mus musculus)
Mammalia Sh2d4b 17 35 34
  • 85.77 (n)
(Rattus norvegicus)
Mammalia Sh2d4b 34
  • 85.57 (n)
(Monodelphis domestica)
Mammalia SH2D4B 35
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia SH2D4B 35
  • 54 (a)
(Gallus gallus)
Aves SH2D4B 35 34
  • 68.4 (n)
(Anolis carolinensis)
Reptilia SH2D4B 35
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sh2d4b 34
  • 64.29 (n)
(Danio rerio)
Actinopterygii LOC100330227 34
  • 63.14 (n)
SH2D4B (1 of 2) 35
  • 43 (a)
sh2d4b 35
  • 42 (a)
(Caenorhabditis elegans)
Secernentea F13B12.6 35
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 17 (a)
Species where no ortholog for SH2D4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SH2D4B Gene

Gene Tree for SH2D4B (if available)
Gene Tree for SH2D4B (if available)
Evolutionary constrained regions (ECRs) for SH2D4B: view image

Paralogs for SH2D4B Gene

Paralogs for SH2D4B Gene

(1) SIMAP similar genes for SH2D4B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SH2D4B: view

Variants for SH2D4B Gene

Sequence variations from dbSNP and Humsavar for SH2D4B Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000006326 -- 80,573,560(+) G/T intron_variant
rs1000019902 -- 80,592,096(+) A/C intron_variant
rs1000068690 -- 80,596,508(+) T/C intron_variant
rs1000081878 -- 80,586,967(+) C/G/T intron_variant
rs1000187285 -- 80,614,128(+) GTGTGTG/GTGTG intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SH2D4B Gene

Variant ID Type Subtype PubMed ID
esv1010104 CNV insertion 20482838
esv2669158 CNV deletion 23128226
esv2761609 CNV loss 21179565
esv3305386 CNV mobile element insertion 20981092
esv3390706 CNV insertion 20981092
esv3578993 CNV loss 25503493
esv3584622 CNV loss 24956385
esv3623952 CNV loss 21293372
nsv1042808 CNV gain 25217958
nsv1048827 CNV gain 25217958
nsv1141879 OTHER inversion 24896259
nsv469837 CNV loss 16826518
nsv469860 CNV gain+loss 16826518
nsv470967 CNV loss 18288195
nsv7354 CNV deletion 18451855
nsv831924 CNV loss 17160897

Variation tolerance for SH2D4B Gene

Residual Variation Intolerance Score: 88.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.70; 93.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SH2D4B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH2D4B Gene

Disorders for SH2D4B Gene

MalaCards: The human disease database

(1) MalaCards diseases for SH2D4B Gene - From: GeneCards

Disorder Aliases PubMed IDs
lymphocytic vasculitis
  • vasculitis lymphocytic, nodular
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SH2D4B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SH2D4B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SH2D4B Gene

Publications for SH2D4B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Identification of novel germline polymorphisms governing capecitabine sensitivity. (PMID: 22864933) O'Donnell PH … Dolan ME (Cancer 2012) 3 58
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 58
  5. Identification of key cytosolic kinases containing evolutionarily conserved kinase tyrosine-based inhibitory motifs (KTIMs). (PMID: 20043942) Abu-Dayyeh I … Olivier M (Developmental and comparative immunology 2010) 23 58

Products for SH2D4B Gene

Sources for SH2D4B Gene

Loading form....