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SH2D4A (SH2 Domain Containing 4A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphatase binding. An important paralog of this gene is SH2D4B.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 16189514 |
GO:0019902 | phosphatase binding | IBA,IDA | 19389623 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005829 | cytosol | IDA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0010923 | negative regulation of phosphatase activity | IBA,IDA | 19389623 |
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11a | · | 11b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||||
SP5: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SH2D4A 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SH2D4A 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Sh2d4a 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Sh2d4a 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SH2D4A 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | SH2D4A 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SH2D4A 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SH2D4A 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SH2D4A 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | sh2d4a 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | sh2d4a 30 31 |
|
OneToOne | |
zgc56186 30 |
|
||||
Worm (Caenorhabditis elegans) |
Secernentea | F13B12.6 30 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs34608771 | - |
p.Ser275Asn |
|||
rs35647122 | - |
p.Glu209Gly |
|||
rs4921637 | - |
p.Glu216Gly |
|||
rs877386 | - |
p.Gly263Ala |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1003522 | CNV | deletion | 20482838 |
esv1412941 | CNV | deletion | 17803354 |
esv34007 | CNV | loss | 18971310 |
esv3616532 | CNV | gain | 21293372 |
esv3891369 | CNV | gain | 25118596 |
nsv1016482 | CNV | gain | 25217958 |
nsv398156 | CNV | deletion | 16902084 |
nsv522185 | CNV | gain | 19592680 |
nsv522774 | CNV | loss | 19592680 |
nsv523271 | CNV | loss | 19592680 |
nsv528004 | CNV | loss | 19592680 |
nsv6103 | CNV | insertion | 18451855 |
nsv610751 | CNV | loss | 21841781 |
nsv951109 | CNV | duplication | 24416366 |
No disorders were found for SH2D4A Gene.