This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different ... See more...

Aliases for SH2D3C Gene

Aliases for SH2D3C Gene

  • SH2 Domain Containing 3C 2 3 5
  • NSP3 2 3 4
  • SH2 Domain-Containing Eph Receptor-Binding Protein 1 3 4
  • Cas/HEF1-Associated Signal Transducer 3 4
  • SH2 Domain-Containing Protein 3C 3 4
  • Novel SH2-Containing Protein 3 3 4
  • Chat-H 3 4
  • SHEP1 3 4
  • SH2 Domain-Containing 3C 2
  • PRO34088 3
  • SH2D3C 5
  • CHAT 3

External Ids for SH2D3C Gene

Previous GeneCards Identifiers for SH2D3C Gene

  • GC09M121615
  • GC09M122147
  • GC09M123954
  • GC09M125876
  • GC09M127580
  • GC09M129540
  • GC09M130501
  • GC09M100117

Summaries for SH2D3C Gene

Entrez Gene Summary for SH2D3C Gene

  • This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for SH2D3C Gene

SH2D3C (SH2 Domain Containing 3C) is a Protein Coding gene. Diseases associated with SH2D3C include Stxbp1 Encephalopathy and Developmental And Epileptic Encephalopathy 4. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and SH3/SH2 adaptor activity. An important paralog of this gene is BCAR3.

UniProtKB/Swiss-Prot Summary for SH2D3C Gene

  • Acts as an adapter protein that mediates cell signaling pathways involved in cellular functions such as cell adhesion and migration, tissue organization, and the regulation of the immune response (PubMed:12432078, PubMed:20881139). Plays a role in integrin-mediated cell adhesion through BCAR1-CRK-RAPGEF1 signaling and activation of the small GTPase RAP1 (PubMed:12432078). Promotes cell migration and invasion through the extracellular matrix (PubMed:20881139). Required for marginal zone B-cell development and thymus-independent type 2 immune responses (By similarity). Mediates migration and adhesion of B cells in the splenic marginal zone via promoting hyperphosphorylation of NEDD9/CASL (By similarity). Plays a role in CXCL13-induced chemotaxis of B-cells (By similarity). Plays a role in the migration of olfactory sensory neurons (OSNs) into the forebrain and the innervation of the olfactory bulb by the OSN axons during development (By similarity). Required for the efficient tyrosine phosphorylation of BCAR1 in OSN axons (By similarity).
  • [Isoform 1]: Important regulator of chemokine-induced, integrin-mediated T lymphocyte adhesion and migration, acting upstream of RAP1 (By similarity). Required for tissue-specific adhesion of T lymphocytes to peripheral tissues (By similarity). Required for basal and CXCL2 stimulated serine-threonine phosphorylation of NEDD9 (By similarity). May be involved in the regulation of T-cell receptor-mediated IL2 production through the activation of the JNK pathway in T-cells (By similarity).
  • [Isoform 2]: May be involved in the BCAR1/CAS-mediated JNK activation pathway.

Gene Wiki entry for SH2D3C Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SH2D3C Gene

Genomics for SH2D3C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SH2D3C Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SH2D3C on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SH2D3C

Top Transcription factor binding sites by QIAGEN in the SH2D3C gene promoter:
  • p300
  • p53
  • STAT3

Genomic Locations for SH2D3C Gene

Latest Assembly
chr9:127,738,317-127,778,710
(GRCh38/hg38)
Size:
40,394 bases
Orientation:
Minus strand

Previous Assembly
chr9:130,500,596-130,540,945
(GRCh37/hg19 by Entrez Gene)
Size:
40,350 bases
Orientation:
Minus strand

chr9:130,500,596-130,541,020
(GRCh37/hg19 by Ensembl)
Size:
40,425 bases
Orientation:
Minus strand

Genomic View for SH2D3C Gene

Genes around SH2D3C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH2D3C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH2D3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH2D3C Gene

Proteins for SH2D3C Gene

  • Protein details for SH2D3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5H7-SH2D3_HUMAN
    Recommended name:
    SH2 domain-containing protein 3C
    Protein Accession:
    Q8N5H7
    Secondary Accessions:
    • A8K5S8
    • E9PG48
    • Q5HYE5
    • Q5JU31
    • Q6UY42
    • Q8N6X3
    • Q9Y2X5

    Protein attributes for SH2D3C Gene

    Size:
    860 amino acids
    Molecular mass:
    94411 Da
    Quaternary structure:
    • Component of a complex comprised of SH2D3C, BCAR1/CAS, and CRK (PubMed:12432078). Within the complex, interacts with CRK and (via C-terminus) with BCAR1/CAS (via C-terminus) (PubMed:12432078, PubMed:17174122, PubMed:22081014). Interacts with NEDD9/HEF1 (By similarity). Interacts with EPHB2 (By similarity).
    • [Isoform 1]: Interacts with NEDD9/HEF1 (By similarity). Interacts with BCAR1/CAS (By similarity). Interacts with PTK2B (By similarity).
    • [Isoform 2]: Interacts (via C-terminus) with BCAR1/CAS (via C-terminus) (By similarity). Interacts with IGF1 (PubMed:20881139).
    SequenceCaution:
    • Sequence=AAQ88456.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SH2D3C Gene

    Alternative splice isoforms for SH2D3C Gene

neXtProt entry for SH2D3C Gene

Post-translational modifications for SH2D3C Gene

  • [Isoform 1]: Phosphorylated by MAPK/ERK upon T-cell receptor stimulation in T-cells.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibodies for research

  • Abcam antibodies for SH2D3C
  • Boster Bio Antibodies for SH2D3C
  • Santa Cruz Biotechnology (SCBT) Antibodies for SH2D3C

No data available for DME Specific Peptides for SH2D3C Gene

Domains & Families for SH2D3C Gene

Gene Families for SH2D3C Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SH2D3C Gene

InterPro:
Blocks:
  • SH2 domain signature
  • Guanine-nucleotide dissociation stimulator CDC25
ProtoNet:

Suggested Antigen Peptide Sequences for SH2D3C Gene

GenScript: Design optimal peptide antigens:
  • SH2 domain containing 3C (Q5JU30_HUMAN)
  • cDNA FLJ31506 fis, clone NT2NE2005876, highly similar to SH2 domain-containing protein 3C (Q5JU31_HUMAN)
  • Novel SH2-containing protein 3 (SH2D3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N5H7

UniProtKB/Swiss-Prot:

SH2D3_HUMAN :
  • The C-terminal Cdc25-homology/Ras-GEF domain adopts a closed conformation rendering it incapable of carrying out canonical exchange factor function, this closed conformation is required for interaction with BCAR1.
Domain:
  • The C-terminal Cdc25-homology/Ras-GEF domain adopts a closed conformation rendering it incapable of carrying out canonical exchange factor function, this closed conformation is required for interaction with BCAR1.
genes like me logo Genes that share domains with SH2D3C: view

Function for SH2D3C Gene

Molecular function for SH2D3C Gene

UniProtKB/Swiss-Prot Function:
Acts as an adapter protein that mediates cell signaling pathways involved in cellular functions such as cell adhesion and migration, tissue organization, and the regulation of the immune response (PubMed:12432078, PubMed:20881139). Plays a role in integrin-mediated cell adhesion through BCAR1-CRK-RAPGEF1 signaling and activation of the small GTPase RAP1 (PubMed:12432078). Promotes cell migration and invasion through the extracellular matrix (PubMed:20881139). Required for marginal zone B-cell development and thymus-independent type 2 immune responses (By similarity). Mediates migration and adhesion of B cells in the splenic marginal zone via promoting hyperphosphorylation of NEDD9/CASL (By similarity). Plays a role in CXCL13-induced chemotaxis of B-cells (By similarity). Plays a role in the migration of olfactory sensory neurons (OSNs) into the forebrain and the innervation of the olfactory bulb by the OSN axons during development (By similarity). Required for the efficient tyrosine phosphorylation of BCAR1 in OSN axons (By similarity).
UniProtKB/Swiss-Prot Function:
[Isoform 1]: Important regulator of chemokine-induced, integrin-mediated T lymphocyte adhesion and migration, acting upstream of RAP1 (By similarity). Required for tissue-specific adhesion of T lymphocytes to peripheral tissues (By similarity). Required for basal and CXCL2 stimulated serine-threonine phosphorylation of NEDD9 (By similarity). May be involved in the regulation of T-cell receptor-mediated IL2 production through the activation of the JNK pathway in T-cells (By similarity).
UniProtKB/Swiss-Prot Function:
[Isoform 2]: May be involved in the BCAR1/CAS-mediated JNK activation pathway.

Phenotypes From GWAS Catalog for SH2D3C Gene

Gene Ontology (GO) - Molecular Function for SH2D3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001784 phosphotyrosine residue binding IEA --
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
GO:0005515 protein binding IPI 24728074
genes like me logo Genes that share ontologies with SH2D3C: view
genes like me logo Genes that share phenotypes with SH2D3C: view

Animal Models for SH2D3C Gene

MGI Knock Outs for SH2D3C:

Animal Models for research

  • Taconic Biosciences Mouse Models for SH2D3C

miRNA for SH2D3C Gene

miRTarBase miRNAs that target SH2D3C

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SH2D3C

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SH2D3C Gene

Localization for SH2D3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for SH2D3C Gene

Cytoplasm. Cell membrane. Peripheral membrane protein. Cell projection, axon. Cell projection, ruffle membrane. Note=Associated with the membrane when EGF-stimulated (By similarity). Expressed at the cortical actin ring in B cells (By similarity). {ECO:0000250 UniProtKB:Q9QZS8}.
[Isoform 1]: Cell membrane. Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SH2D3C gene
Compartment Confidence
plasma membrane 4
mitochondrion 3
cytosol 3
nucleus 2
endoplasmic reticulum 2
endosome 2
extracellular 1
cytoskeleton 1
peroxisome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SH2D3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0030424 axon IEA --
GO:0032587 ruffle membrane IEA --
genes like me logo Genes that share ontologies with SH2D3C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SH2D3C Gene

Pathways & Interactions for SH2D3C Gene

PathCards logo

SuperPathways for SH2D3C Gene

No Data Available

Gene Ontology (GO) - Biological Process for SH2D3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007254 JNK cascade TAS 10187783
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0033138 positive regulation of peptidyl-serine phosphorylation IBA 21873635
GO:0050790 regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with SH2D3C: view

No data available for Pathways by source and SIGNOR curated interactions for SH2D3C Gene

Drugs & Compounds for SH2D3C Gene

No Compound Related Data Available

Transcripts for SH2D3C Gene

mRNA/cDNA for SH2D3C Gene

7 REFSEQ mRNAs :
24 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SH2D3C

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for SH2D3C Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^
SP1: - - - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - -
SP4: - - - - - - - - - - - - - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - -
SP8: -
SP9: - - -
SP10: - - - -
SP11: - - - - - - - - - - -
SP12: - - - - - - - - - - - -
SP13: - - - - - -
SP14: - - - - -
SP15: - - -
SP16: -
SP17: -
SP18:
SP19: - - - - - - - - - - - - - - - -

ExUns: 13a · 13b · 13c ^ 14a · 14b · 14c · 14d · 14e · 14f · 14g ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - - - - - - - - - - -
SP5: - - -
SP6: -
SP7: - -
SP8: - -
SP9:
SP10:
SP11: -
SP12: - -
SP13: - -
SP14: -
SP15: - -
SP16: - -
SP17:
SP18:
SP19: - - - - - - - - - - -

Relevant External Links for SH2D3C Gene

GeneLoc Exon Structure for
SH2D3C

Expression for SH2D3C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SH2D3C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SH2D3C Gene

This gene is overexpressed in Whole Blood (x9.1).

Protein differential expression in normal tissues from HIPED for SH2D3C Gene

This gene is overexpressed in Lymph node (16.3), Peripheral blood mononuclear cells (14.7), CD8 Tcells (9.7), and Plasma (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SH2D3C Gene



Protein tissue co-expression partners for SH2D3C Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SH2D3C

SOURCE GeneReport for Unigene cluster for SH2D3C Gene:

Hs.306412

mRNA Expression by UniProt/SwissProt for SH2D3C Gene:

Q8N5H7-SH2D3_HUMAN
Tissue specificity: [Isoform 1]: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for SH2D3C Gene

  • Nervous system(4.8)
  • Pancreas(4)
  • Kidney(2.5)
  • Lung(2.4)
  • Spleen(2.3)
  • Lymph node(2.2)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with SH2D3C: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SH2D3C Gene

Orthologs for SH2D3C Gene

This gene was present in the common ancestor of animals.

Orthologs for SH2D3C Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SH2D3C 30 31
  • 99.34 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SH2D3C 30 31
  • 88.99 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SH2D3C 30 31
  • 88.81 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Sh2d3c 30 17 31
  • 85.5 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Sh2d3c 30
  • 85.32 (n)
Oppossum
(Monodelphis domestica)
Mammalia SH2D3C 31
  • 80 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SH2D3C 31
  • 72 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SH2D3C 30 31
  • 71.42 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SH2D3C 31
  • 57 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia sh2d3c 30
  • 65.03 (n)
African clawed frog
(Xenopus laevis)
Amphibia sh2d3c-prov 30
Zebrafish
(Danio rerio)
Actinopterygii sh2d3ca 30 31
  • 64.43 (n)
OneToMany
sh2d3cb 31
  • 48 (a)
OneToMany
zgc56490 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG9098 31 32
  • 22 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10354 31
  • 25 (a)
OneToMany
Species where no ortholog for SH2D3C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SH2D3C Gene

ENSEMBL:
Gene Tree for SH2D3C (if available)
TreeFam:
Gene Tree for SH2D3C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SH2D3C: view image

Paralogs for SH2D3C Gene

Paralogs for SH2D3C Gene

(3) SIMAP similar genes for SH2D3C Gene using alignment to 4 proteins:

  • SH2D3_HUMAN
  • E7EUN5_HUMAN
  • H0Y5X5_HUMAN
  • Q5JU32_HUMAN
genes like me logo Genes that share paralogs with SH2D3C: view

Variants for SH2D3C Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SH2D3C Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs2233513 Benign: not provided 127,744,627(-) C/T
NM_170600.3(SH2D3C):c.1737G>A (p.Lys579=)
SYNONYMOUS
rs10760500 - p.Leu23Phe

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SH2D3C Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SH2D3C Gene

Variant ID Type Subtype PubMed ID
dgv12879n54 CNV loss 21841781
esv3891727 CNV gain 25118596
nsv466571 CNV loss 19166990
nsv466573 CNV loss 19166990
nsv466575 CNV loss 19166990
nsv471323 CNV loss 18288195
nsv615369 CNV loss 21841781
nsv615371 CNV loss 21841781
nsv615373 CNV loss 21841781
nsv615374 CNV loss 21841781
nsv825094 CNV gain 20364138

Variation tolerance for SH2D3C Gene

Residual Variation Intolerance Score: 63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.63; 65.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SH2D3C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SH2D3C

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH2D3C Gene

Disorders for SH2D3C Gene

MalaCards: The human disease database

(16) MalaCards diseases for SH2D3C Gene - From: CVR and COP

Disorder Aliases PubMed IDs
stxbp1 encephalopathy
  • dee4
developmental and epileptic encephalopathy 4
  • dee4
dravet syndrome
  • drvt
early infantile epileptic encephalopathy
  • early infantile epileptic encephalopathy with burst-suppression
eastern equine encephalitis
  • eee
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SH2D3C

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SH2D3C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SH2D3C Gene

Publications for SH2D3C Gene

  1. NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway. (PMID: 10187783) Lu Y … Stewart TA (The Journal of biological chemistry 1999) 2 3 4
  2. NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. (PMID: 22081014) Mace PD … Riedl SJ (Nature structural & molecular biology 2011) 3 4
  3. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. (PMID: 20583170) Letra A … Vieira AR (American journal of medical genetics. Part A 2010) 3 41
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for SH2D3C Gene

Sources for SH2D3C Gene