Aliases for SH2D3A Gene

Aliases for SH2D3A Gene

  • SH2 Domain Containing 3A 2 3 5
  • NSP1 2 3 4
  • SH2 Domain-Containing Protein 3A 3 4
  • Novel SH2-Containing Protein 1 3 4
  • SH2 Domain-Containing 3A 2
  • SH2D3A 5

External Ids for SH2D3A Gene

Previous GeneCards Identifiers for SH2D3A Gene

  • GC19M006846
  • GC19M006692
  • GC19M006703
  • GC19M006514

Summaries for SH2D3A Gene

GeneCards Summary for SH2D3A Gene

SH2D3A (SH2 Domain Containing 3A) is a Protein Coding gene. Diseases associated with SH2D3A include Severe Acute Respiratory Syndrome and Eastern Equine Encephalitis. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and SH3/SH2 adaptor activity. An important paralog of this gene is BCAR3.

UniProtKB/Swiss-Prot Summary for SH2D3A Gene

Gene Wiki entry for SH2D3A Gene

Additional gene information for SH2D3A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SH2D3A Gene

Genomics for SH2D3A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SH2D3A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J006765 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 647.9 -2.7 -2747 10.5 SP1 CREB1 CTCF TEAD4 PRDM10 ZNF629 ZNF512 KDM1A ZNF692 POLR2A SH2D3A VAV1 RF00017-2777 C3 XAB2 DUS3L KHSRP ZNF557 ENSG00000267571 VMAC
GH19J006751 Promoter/Enhancer 1.7 ENCODE CraniofacialAtlas dbSUPER 31.8 +14.7 14681 3.3 SP1 HNRNPL GATAD2A CTCF TEAD4 TFE3 LEF1 NFKBIZ KDM1A RCOR2 ENSG00000269680 SH2D3A DUS3L piR-56355 TRIP10 lnc-SH2D3A-1
GH19J007514 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 6.3 -748.5 -748529 3.1 ARHGAP35 PRDM10 ZNF512 SIX5 MTA2 ZNF143 RBFOX2 POLR2A SP1 ZNF24 ZNF358 HNRNPM XAB2 ZNF557 ELAVL1 TRIP10 ZNF414 MAP2K7 ENSG00000269680 SH2D3A
GH19J006776 Promoter/Enhancer 0.9 Ensembl dbSUPER 10.2 -9.1 -9087 1.2 IKZF1 YBX1 ZBTB17 EHMT2 HDGF ZFHX2 ZNF366 EGR2 HDAC1 IKZF2 SH2D3A VAV1 piR-57133-299 ADGRE1
GH19J006777 Enhancer 0.7 Ensembl dbSUPER 10.5 -12.5 -12487 4.4 EGR1 ZNF623 ELF1 IKZF1 TAL1 ZSCAN16 ZMYM3 KDM1A CBFA2T3 ARID1B SH2D3A VAV1 piR-57133-299 ADGRE1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SH2D3A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SH2D3A

Top Transcription factor binding sites by QIAGEN in the SH2D3A gene promoter:
  • AML1a

Genomic Locations for SH2D3A Gene

Genomic Locations for SH2D3A Gene
15,354 bases
Minus strand
15,429 bases
Minus strand

Genomic View for SH2D3A Gene

Genes around SH2D3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH2D3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH2D3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH2D3A Gene

Proteins for SH2D3A Gene

  • Protein details for SH2D3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH2 domain-containing protein 3A
    Protein Accession:
    Secondary Accessions:
    • A8K9R6
    • B4DRS7
    • Q9Y2X4

    Protein attributes for SH2D3A Gene

    576 amino acids
    Molecular mass:
    63093 Da
    Quaternary structure:
    • Interacts with BCAR1.

    Alternative splice isoforms for SH2D3A Gene


neXtProt entry for SH2D3A Gene

Post-translational modifications for SH2D3A Gene

No data available for DME Specific Peptides for SH2D3A Gene

Domains & Families for SH2D3A Gene

Gene Families for SH2D3A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SH2D3A Gene

  • SH2 domain signature

Suggested Antigen Peptide Sequences for SH2D3A Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54935, highly similar to SH2 domain-containing protein 3A (B4DRS7_HUMAN)
  • Novel SH2-containing protein 1 (SH23A_HUMAN)
genes like me logo Genes that share domains with SH2D3A: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SH2D3A Gene

Function for SH2D3A Gene

Molecular function for SH2D3A Gene

UniProtKB/Swiss-Prot Function:
May play a role in JNK activation.

Phenotypes From GWAS Catalog for SH2D3A Gene

Gene Ontology (GO) - Molecular Function for SH2D3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity TAS --
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
GO:0005515 protein binding IPI 24658140
genes like me logo Genes that share ontologies with SH2D3A: view
genes like me logo Genes that share phenotypes with SH2D3A: view

Animal Model Products

CRISPR Products

miRNA for SH2D3A Gene

miRTarBase miRNAs that target SH2D3A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SH2D3A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SH2D3A Gene

Localization for SH2D3A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SH2D3A gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (2)
  • Microtubules (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SH2D3A Gene

Pathways & Interactions for SH2D3A Gene

PathCards logo

SuperPathways for SH2D3A Gene

No Data Available

Gene Ontology (GO) - Biological Process for SH2D3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007254 JNK cascade TAS 10187783
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0009967 positive regulation of signal transduction IEA --
GO:0033138 positive regulation of peptidyl-serine phosphorylation IBA 21873635
genes like me logo Genes that share ontologies with SH2D3A: view

No data available for Pathways by source and SIGNOR curated interactions for SH2D3A Gene

Drugs & Compounds for SH2D3A Gene

(1) Drugs for SH2D3A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for SH2D3A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SH2D3A: view

Transcripts for SH2D3A Gene

mRNA/cDNA for SH2D3A Gene

9 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SH2D3A

Alternative Splicing Database (ASD) splice patterns (SP) for SH2D3A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b ^ 12
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - -

Relevant External Links for SH2D3A Gene

GeneLoc Exon Structure for

Expression for SH2D3A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SH2D3A Gene

mRNA differential expression in normal tissues according to GTEx for SH2D3A Gene

This gene is overexpressed in Esophagus - Mucosa (x5.2) and Skin - Not Sun Exposed (Suprapubic) (x4.1).

Protein differential expression in normal tissues from HIPED for SH2D3A Gene

This gene is overexpressed in Stomach (29.7), Placenta (23.8), and Pancreas (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SH2D3A Gene

Protein tissue co-expression partners for SH2D3A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SH2D3A

SOURCE GeneReport for Unigene cluster for SH2D3A Gene:


mRNA Expression by UniProt/SwissProt for SH2D3A Gene:

Tissue specificity: Weakly expressed in placenta, fetal kidney, fetal lung, adult pancreas, adult kidney and adult lung.

Evidence on tissue expression from TISSUES for SH2D3A Gene

  • Kidney(2.8)
  • Skin(2.6)
  • Intestine(2.4)
  • Nervous system(2.4)
  • Lung(2.3)
  • Muscle(2.2)
  • Lymph node(2.2)
  • Blood(2.2)
  • Spleen(2.1)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with SH2D3A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SH2D3A Gene

Orthologs for SH2D3A Gene

This gene was present in the common ancestor of animals.

Orthologs for SH2D3A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SH2D3A 30 31
  • 99.25 (n)
(Bos Taurus)
Mammalia SH2D3A 30 31
  • 84.03 (n)
(Canis familiaris)
Mammalia SH2D3A 30 31
  • 83.54 (n)
(Monodelphis domestica)
Mammalia SH2D3A 31
  • 46 (a)
(Danio rerio)
Actinopterygii CABZ01115881.1 31
  • 23 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta CG9098 31
  • 16 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10354 31
  • 22 (a)
Species where no ortholog for SH2D3A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SH2D3A Gene

Gene Tree for SH2D3A (if available)
Gene Tree for SH2D3A (if available)
Evolutionary constrained regions (ECRs) for SH2D3A: view image

Paralogs for SH2D3A Gene

Paralogs for SH2D3A Gene

(3) SIMAP similar genes for SH2D3A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SH2D3A: view

Variants for SH2D3A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SH2D3A Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
VAR_035989 A breast cancer sample p.Glu265Gly
rs12608960 - p.Asp223Gly
rs7258236 - p.Asn32Asp

Additional dbSNP identifiers (rs#s) for SH2D3A Gene

Structural Variations from Database of Genomic Variants (DGV) for SH2D3A Gene

Variant ID Type Subtype PubMed ID
dgv14e196 CNV duplication 17116639
esv2661790 CNV deletion 23128226
esv3643564 CNV loss 21293372
nsv1055253 CNV gain 25217958
nsv470120 CNV loss 18288195
nsv519561 CNV loss 19592680
nsv519827 CNV loss 19592680

Variation tolerance for SH2D3A Gene

Residual Variation Intolerance Score: 96.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.47; 85.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SH2D3A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH2D3A Gene

Disorders for SH2D3A Gene

MalaCards: The human disease database

(17) MalaCards diseases for SH2D3A Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with SH2D3A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SH2D3A Gene

Publications for SH2D3A Gene

  1. NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway. (PMID: 10187783) Lu Y … Stewart TA (The Journal of biological chemistry 1999) 2 3 4 23
  2. AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology. (PMID: 17427198) Near RI … Lerner A (Journal of cellular physiology 2007) 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4

Products for SH2D3A Gene

Sources for SH2D3A Gene